Activated Protein C Protects Myocardium Via Activation of Anti-apoptotic Pathways of Survival in Ischemia-reperfused Rat Heart

Jia-Wang Ding,Xiao-Hong Tong,Jun Yang,Zhao-Qi Liu,Yan Zhang,Jian Yang,Song Li,Li Li 대한의학회 2010 Journal of Korean medical science Vol.25 No.11

Activated protein C (APC) is known to be beneficial on ischemia reperfusion injury in myocardium. However, the protection mechanism of APC is not fully understood. The purpose of this study was to investigate the effects and possible mechanisms of APC on myocardial ischemic damage. Artificially ventilated anaesthetized Sprague-Dawley rats were subjected to a 30 min of left anterior descending coronary artery occlusion followed by 2 hr of reperfusion. Rats were randomly divided into four groups; Sham, I/R, APC preconditioning and postconditioning group. Myocardial infarct size, apoptosis index, the phosphorylation of ERK1/2, Bcl-2, Bax and cytochrome c genes and proteins were assessed. In APC-administrated rat hearts, regardless of the timing of administration, infarct size was consistently reduced compared to ischemia/reperfusion (I/R) rats. APC improved the expression of ERK1/2 and anti-apoptotic protein Bcl-2 which were significantly reduced in the I/R rats. APC reduced the expression of pro-apoptotic genes, Bax and cytochrome c. These findings suggest that APC produces cardioprotective effect by preserving the expression of proteins and genes involved in anti-apoptotic pathways, regardless of the timing of administration.

A Retrospective Study of the Effect of Spinopelvic Parameters on Fatty Infiltration in Paraspinal Muscles in Patients With Lumbar Spondylolisthesis

Jia-Chen Yang,Jia-Yu Chen,Yin Ding,Yong-Jie Yin,Zhi-Ping Huang,Xiu-Hua Wu,Zu-Cheng Huang,Yi-Kai Li,Qing-An Zhu 대한척추신경외과학회 2024 Neurospine Vol.21 No.1

Objective: The effect on fat infiltration (FI) of paraspinal muscles in degenerative lumbar spinal diseases has been demonstrated except for spinopelvic parameters. The present study is to identify the effect of spinopelvic parameters on FI of paraspinal muscle (PSM) and psoas major muscle (PMM) in patients with degenerative lumbar spondylolisthesis. Methods: A single-center, retrospective cross-sectional study of 160 patients with degenerative lumbar spondylolisthesis (DLS) and lumbar stenosis (LSS) who had lateral full-spine x-ray and lumbar spine magnetic resonance imaging was conducted. PSM and PMM FIs were defined as the ratio of fat to its muscle cross-sectional area. The FIs were compared among patients with different pelvic tilt (PT) and pelvic incidence (PI), respectively. Results: The PSM FI correlated significantly with pelvic parameters in DLS patients, but not in LSS patients. The PSM FI in pelvic retroversion (PT > 25°) was 0.54 ± 0.13, which was significantly higher in DLS patients than in normal pelvis (0.41 ± 0.14) and pelvic anteversion (PT < 5°) (0.34 ± 0.12). The PSM FI of DLS patients with large PI ( > 60°) was 0.50 ± 0.13, which was higher than those with small ( < 45°) and normal PI (0.37 ± 0.11 and 0.36 ± 0.13). However, the PSM FI of LSS patients didn’t change significantly with PT or PI. Moreover, the PMM FI was about 0.10–0.15, which was significantly lower than the PSM FI, and changed with PT and PI in a similar way of PSM FI with much less in magnitude. Conclusion: FI of the PSMs increased with greater pelvic retroversion or larger pelvic incidence in DLS patients, but not in LSS patients.

Research on Preparation of Sheath-Core Bicomponent Composite Ion Exchange Fibers and Absorption Properties to Metal Ion

Ding, Zhi-Jia,Qi, Lu,Ye, Jian-Zhong The Polymer Society of Korea 2008 Macromolecular Research Vol.16 No.1

Based on the sheath-core bicomponent composite fibers with modified polystyrene (PS) and the modified polypropylene (PP), composite fibers obtained were further cross-linked and sulphonated with chlorosulphonic acid to produce strong acidic cation ion exchange fibers. The structures of the fibers obtained were characterized using Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC) etc. The optimal technology of the fibers obtained is discussed. The static absorption capacity of the sheath-core bicomponent composite cation exchange fibers for $Zn^{2+}$, $Cu^{2+}$ was determined. The absorption kinetics and major factors affecting the absorption capacities of $Zn^{2+}$, $Cu^{2+}$ were studied, and its chemical stability and regenerating properties were probed. The results suggest that cation exchange fibers with better mechanical properties and higher exchange capability were obtained. Moreover, this type of ion exchange fiber has good absorption properties and working stability to various metal ions. Hence, they have higher practicability.

Research on Preparation of Sheath-Core Bicomponent Composite Ion Exchange Fibers and Absorption Properties to Metal Ion

Zhi Jia Ding,Lu Qi,Jian Zhong Ye 한국고분자학회 2008 Macromolecular Research Vol.16 No.1

Associations of TNF-RII rs1061622 With Post-Traumatic Stress Disorder and Their Interplays on Serum Lipids Levels in Adolescents

Ji Cheng Zhang,Jin Hua Wang,Jun Yi Liu,Qi Wei Guo,Jia Lin,Yi Lin Shen,Ke Xin Jia,Jia Jing Cai,Guo Ming Su,Ding Zhi Fang 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.11

Objective To verify effects of rs1061622 at tumor necrosis factor-α receptor II (TNF-RII) gene (<i>TNF-RII</i>) on post-traumatic stress disorder (PTSD) and its interactive effects with PTSD on serum lipids levels in adolescents.Methods PTSD was measured by PTSD Checklist-Civilian Version (PCL-C) in 699 adolescent survivors at 6 months after Wenchuan earthquake in China. A polymerase chain reaction and restriction fragment length polymorphism assay were utilized for <i>TNF-RII</i> rs1061622 genotyping followed by verification using DNA sequencing. Serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol were tested using routine methods.Results G (deoxyguanine) allele carriers had higher PCL-C scores than TT (deoxythymidine) homozygotes in female subjects. Female adolescents had higher PCL-C scores than male subjects in TT homozygotes. Predictors of PTSD prevalence and severity were different between G allele carriers and TT homozygotes. Subjects with PTSD had lower TG, TG/HDL-C, TC/HDL-C, and higher HDL-C than adolescents without PTSD in male G allele carriers. G allele carriers had higher TG/HDL-C and TC/HDL-C than TT homozygotes in male adolescents without PTSD, and lower TG and TG/HDL-C in male PTSD patients. G allele carriers had higher TG than TT homozygotes only in female adolescents without PTSD.Conclusion These results suggest reciprocal actions of <i>TNF-RII</i> rs1061622 with other factors on PTSD severity, interplays of <i>TNF-RII</i> rs1061622 with PTSD on serum lipid levels, and novel treatment strategies for PTSD and comorbidities of PTSD with hyperlipidemia among adolescents with different genetic backgrounds of <i>TNF-RII</i> rs1061622 after experiencing traumatic events.

A New Modulation to Eliminate the Impact of Overlap Time for Three-Phase Current Source Converters

Ding Hao,Guo Xiaoqiang,He Meiling,Shi Changli,Jia Dongqiang,Chen Chao,Guerrero Josep M. 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.5

Three-phase current source converter tends to be attractive in future industrial applications. In order to ensure the continuous current for the dc-link inductor of the current source converter (CSC), an overlap time is mandatory for each switch, so as to avoid the over-voltage spike caused by the dc-link inductor current interruption. However, the overlap time results in the undesirable harmonics and current distortion, which fails to comply with the relevant IEEE Standard in terms of power quality. Especially, the negative infl uence caused by overlap time eff ect is much more serious with the increasing of the switching frequency applied to CSC. In order to solve the problem, the impact of the overlap time on the CSC is investigated, and the error resulted from the overlap time is clearly demonstrated. Based on the pulse equivalent principle and the Fourier analysis, the quantitative relationship between the current harmonic and the overlap time is obtained. And then, a new approach to eliminate the impact of overlap time on the CSC is proposed. Finally, the simulation and experimental results are carried out to verify the eff ectiveness of the proposed solution.

Application of contrast-enhanced ultrasound for evaluation of thyroid nodules

Jia Zhan,Hong Ding 대한초음파의학회 2018 ULTRASONOGRAPHY Vol.37 No.4

Contrast-enhanced ultrasound (CEUS) is widely used to evaluate tumor microcirculation, whichis useful in the differential diagnosis between benignity and malignancy. In the last 10 years, theapplicability of CEUS to thyroid nodules has greatly improved due to technological refinementsand the development of second-generation contrast agents. In this review, we summarize theapplications of CEUS for thyroid nodules, focusing on the imaging findings of malignant andbenign nodules in the existing literature and the use of those findings to predict malignancies,with an additional brief description of the utilization of CEUS for other thyroid-related diseases.

Composition modulation of Cu/Cu2O/CuO nanoparticles supported on carbon for p-nitrophenol reduction

Jia Li,Wei Liu,Yongxin Ding,Likui Liu,Fang Li,Qiming Li 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.6

Porous carbon supported Cu/Cu2O/CuO ternary catalysts were fabricated by pyrolysis, in which composition modulation of Cu/Cu2O/CuO was successfully realized by adjusting annealing atmosphere. The correlation between annealing atmosphere and composition of Cu/Cu2O/CuO ternary nanoparticles was deeply investigated. XRD and SEM measurement shows that the composition proportion of Cu/Cu2O/CuO can be effectively controlled by adjusting the annealing atmosphere. HR-TEM and EDS analysis showed that Cu/Cu2O/CuO ternary nanoparticles are highly dispersed into the carbon matrix and harvest more hetero-junction active sites. The effect of Cu/Cu2O/CuO composition on their catalytic activity was investigated in catalytic reduction from p-nitrophenol to p-aminophenol. The experimental result indicated that the catalytic activity of Cu/Cu2O/CuO ternary catalysts exhibits higher catalytic activity than Cu2O/CuO or CuO particles. This work provides a new strategy for synthesizing and modulating porous carbon-supported Cu/Cu2O/CuO ternary nanoparticles.

End Plate–Stiff ener Connection for SHS Column and RHS Beam in Steel-Framed Building Modules

Fu Jia Luo,Chenting Ding,Adam Styles,Yu Bai 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.4

This paper investigates the mechanical performance of beam-to-column connections for steel-framed building modules with RHS and SHS sections of relatively small member sizes. In the experimental program, three forms of connections are tested under static bending, including a completely welded connection (W), a bolted end plate connection (EP) and the proposed end plate–stiff ener connection (ST), and the failure modes, moment–rotation behaviours and strain responses were recorded during experiments. Results show that ST connection exhibited superior connection strength, stiff ness and ductility compared with the EP connection. In addition, a detailed fi nite element analysis was conducted to model the connection behaviours, considering bolt pretension, contact behaviours and detailed bolt geometry, showing good comparison with experiments. Furthermore, a parametric study was performed on the end plate thickness and stiff ener thickness for the proposed end plate–stiff ener connection. Such results fi nally enable a comparative study to investigate the performance of module during road transportation, highlighting the eff ects of connection stiff ness.

Analysis and Evaluation of Land Subsidence along Linear Engineering Based on InSAR Data

Pengpeng Ding,Chao Jia,Shengtong Di,Jing Wu,Ruchun Wei 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.9

Land subsidence is a worldwide geological environment problem, which can bring about lasting and serious harm to linear engineering and urban construction. In this paper, land subsidence along the linear engineering was monitored and analyzed by the Synthetic Aperture Radar (SAR) images, high-precision leveling results, groundwater level monitoring data. Combined with Small Baseline Subset (SBAS) Interferometric Synthetic Aperture Radar (InSAR) technology, spatial analysis technology of geographic information system and contribution rate method, the spatial and temporal evolution characteristics, influencing factors, and the contribution rate of each factor to land subsidence along the Lunan high-speed railway from 2016 to 2018 were researched. The accuracy of subsidence results by InSAR monitoring was verified by the linear fitting method and root mean square error method. The influence of uneven subsidence on linear engineering was discussed based on the evaluation results of subsidence gradient zoning. The results indicate that the maximum accumulated subsidence along the Lunan high-speed railway is 499 mm. Multiple subsidence center areas have been formed in the study area, with the maximum subsidence rate exceeding -55 mm/yr. The maximum subsidence gradient and curvature radius of the Lunan high-speed railway meet the requirements of line smoothness when the train speed is 350 km/h. The coal mining, compressible layer thickness, and changes in groundwater level are positively correlated with land subsidence, the total contribution rate to land subsidence is more than 90%. The research results provide scientific support for the prevention and control of land subsidence along the linear engineering.