Trends in incidence and survival of esophageal cancer in Korea: Analysis of the Korea Central Cancer Registry Database

Shin, Aesun,Won, Young‐,Joo,Jung, Hye‐,Kyung,Kong, Hyun‐,Joo,Jung, Kyu‐,Won,Oh, Chang‐,Mo,Choe, Sunho,Lee, Jihyun John Wiley and Sons Inc. 2018 Journal of gastroenterology and hepatology Vol.33 No.12

<P><B>Abstract</B></P><P><B>Background and Aim</B></P><P>The diagnostic and therapeutic modalities of esophageal cancer have recently improved in Asia, and its prognosis is expected to change. This study provides a population‐based report on the epidemiology of esophageal cancer in Korea.</P><P><B>Methods</B></P><P>Cancer incidence data from 1999 to 2013 were obtained from the Korea Central Cancer Registry, covering the entire population. Age‐standardized incidence rates and annual percent changes were calculated according to subsites and histological types. Five‐year relative survival rates were estimated for cases diagnosed between 1993 and 2013. Relative excess rates were compared between patients diagnosed from 2009 to 2013 and 2006 to 2008.</P><P><B>Results</B></P><P>The age‐standardized incidence rates decreased from 8.8 per 100 000 populations in 1999 to 5.9 in 2013 with an annual percent change of −2.6% in men and −2.2% in women. The most common histological type was squamous cell carcinoma, accounting for 90.2% of all esophageal cancers in 2013, followed by adenocarcinomas (3.1%), and their incidences decreased. The proportion of localized and regional cancer tended to increase compared with that of distant cancer. Five‐year relative survival of squamous cell carcinoma improved from 12.1% (1993–1995) to 34.6% (2009–2013). Relative excess rate was 0.72 (95% confidence interval 0.65–0.80) in localized stage and 0.88 (95% confidence interval, 0.82–0.95) in regional stage comparing patients diagnosed from 2009 to 2013 and 2006 to 2008.</P><P><B>Conclusions</B></P><P>The incidence of esophageal cancer has decreased in Korea for the past 15 years, and 5‐year survival rates have improved significantly. These increases may be attributable to more effective detection of early‐stage disease.</P>

Looking at Organizational Socialization from the Developmental Network Perspective

Jihyun Chang,Taesung Kim 한국유통과학회 2018 The Journal of Asian Finance, Economics and Busine Vol.5 No.3

Paying close attention to those new to an organization, whether fresh or experienced, whose primary interest is in (re)socialization, the current study intends to (1) further the concept of mentoring from a bilateral relationship to a community and culture fostered by developmental networks, (2) propose an integrated conceptual framework for organizational socialization, and (3) suggest implications for practice and future research. This study reviews, analyzes, and integrates research assets and subsequently re-conceptualizes the aggregate information as valid propositions and a conceptual framework. The findings include (1) 11 propositions regarding the relationships among network characteristics (embeddedness, diversity), developmental functions (career support, psychosocial support, and role modeling), and socialization outcomes (learning and attitudinal outcomes); and (2) an integrated conceptual framework that depicts a comprehensive mechanism through which developmental networks conduce to organizational socialization of newcomers. Implications are that developmental networking must be an individual’s fundamental competency and an essential part of organizational onboarding processes, and imperative for both members’ career development and innovative organizational culture. By integrating research assets on the developmental phenomenon into conceptualizations, this study furthers the concept of mentoring to organizational culture and stimulates a substantive discourse for theory-building towards organizational socialization from the developmental network perspective.

Enhanced Healing of Rat Calvarial Bone Defects with Hypoxic Conditioned Medium from Mesenchymal Stem Cells through Increased Endogenous Stem Cell Migration via Regulation of ICAM-1 Targeted-microRNA-221

Chang, Woochul,Kim, Ran,Park, Sang In,Jung, Yu Jin,Ham, Onju,Lee, Jihyun,Kim, Ji Hyeong,Oh, Sekyung,Lee, Min Young,Kim, Jongmin,Park, Moon-Seo,Chung, Yong-An,Hwang, Ki-Chul,Maeng, Lee-So Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.7

The use of conditioned medium from mesenchymal stem cells may be a feasible approach for regeneration of bone defects through secretion of various components of mesenchymal stem cells such as cytokines, chemokines, and growth factors. Mesenchymal stem cells secrete and accumulate multiple factors in conditioned medium under specific physiological conditions. In this study, we investigated whether the conditioned medium collected under hypoxic condition could effectively influence bone regeneration through enhanced migration and adhesion of endogenous mesenchymal stem cells. Cell migration and adhesion abilities were increased through overexpression of intercellular adhesion molecule-1 in hypoxic conditioned medium treated group. Intercellular adhesion molecule-1 was upregulated by microRNA-221 in mesenchymal stem cells because microRNAs are key regulators of various biological functions via gene expression. To investigate the effects in vivo, evaluation of bone regeneration by computed tomography and histological assays revealed that osteogenesis was enhanced in the hypoxic conditioned medium group relative to the other groups. These results suggest that behavioral changes of endogenous mesenchymal stem cells through microRNA-221 targeted-intercellular adhesion molecule-1 expression under hypoxic conditions may be a potential treatment for patients with bone defects.

Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases

Lee, Chang Youn,Kim, Ran,Ham, Onju,Lee, Jihyun,Kim, Pilseog,Lee, Seokyeon,Oh, Sekyung,Lee, Hojin,Lee, Minyoung,Kim, Jongmin,Chang, Woochul Hindawi Publishing Corporation 2016 Stem cells international Vol.2016 No.-

<P>Despite development of medicine, cardiovascular diseases (CVDs) are still the leading cause of mortality and morbidity worldwide. Over the past 10 years, various stem cells have been utilized in therapeutic strategies for the treatment of CVDs. CVDs are characterized by a broad range of pathological reactions including inflammation, necrosis, hyperplasia, and hypertrophy. However, the causes of CVDs are still unclear. While there is a limit to the currently available target-dependent treatments, the therapeutic potential of stem cells is very attractive for the treatment of CVDs because of their paracrine effects, anti-inflammatory activity, and immunomodulatory capacity. Various studies have recently reported increased therapeutic potential of transplantation of microRNA- (miRNA-) overexpressing stem cells or small-molecule-treated cells. In addition to treatment with drugs or overexpressed miRNA in stem cells, stem cell-derived extracellular vesicles also have therapeutic potential because they can deliver the stem cell-specific RNA and protein into the host cell, thereby improving cell viability. Here, we reported the state of stem cell-based therapy for the treatment of CVDs and the potential for cell-free based therapy.</P>

경력정체성에 대한 개발지원관계망 특성과 개발지원기능의 효과 분석

장지현 ( Jihyun Chang ) 한국지식경영학회 2016 지식경영연구 Vol.17 No.3

This study examined the cause-and-effect relationships among developmental network characteristics, developmental functions, and career identity. The study analyzed the data of employees with more than two years of experience and a college degree or over qualifications, from domestic companies. For analysis, the structural equation model was applied. Most of all, it was substantiated that the structural relationships among the developmental network characteristics, developmental functions, and career identity. The specific results were as follows. First, tie strength had a positive effect on all of developmental functions but psychosocial support mediated the relationship between the tie strength and career identity. Second, an indirect relationship between indicators of network diversity and identity was not found or the indirect relationship was very weak.

경력단절 여성의 구직경로가 성공적인 노동시장 재진입에 미치는 영향 : 학력에 따른 차이를 중심으로

장지현(Jihyun Chang),김민영(Minyoung Kim),장원섭(Wonsup Chang) 한국여성정책연구원(구 한국여성개발원) 2010 여성연구 Vol.78 No.-

본 연구는 경력단절 경험 여성의 성공적인 노동시장 재진입에 대한 구직경로의 효과와 학력별로 나타나는 차이를 살펴보고자 하였다 . 이를 위해2007 년 한국여성정책연구원에서 실시한 전국 규모의 패널 조사인 ‘ 여성 가족때널 조사’ 의 1차년도 설문 조사 자료를 활용하였다 . 먼저 , 경력단절 여성의노동시장 재진입 구직경로와 직종의 분포를 살펴본 결과 학력에 따라 구직경로와 직종 분포의 차이가 있는 것으로 나타났다 . 이에 학력수준 일치도와 임금에 대한 학력 간 차이가 구직경로와 직종 간 차이로 인한 것인지를 분석하였다. 분석 결과 , 학력수준 일치도에 대해 개인적 관계망은 경력단절 여성들에게 가장 부정적이었으며 이보다는 제도적 관계망이 긍정적이라는것을 확인하였다. 그런데 좀 더 세부적으로 고줄 이하 집단과 2-3년제 대졸이상 집단으로 학력을 나누어 분석한 결과 , 제도적 관계망은 2 -3 년제 대졸 이상 집단에서 그 어떠한 구직경로보다 가장 효과적이었지만, 고졸 이 하 집단에서는 효과적인 구직경로가 아니었다 . 다만 개인적 관계망은 고졸 이하집단에서도 비인격적 매체를 활용하는 것보다 부정적이었다 . 그리고 구직경로의 효과는 직종을 통해 간접적으로 학력수준 일치도에 영향을 주었다 .임금과 대해서는 , 고줄 이하의 경우 비인격적 매체 활용이 개인적/제도적관계망 구직경로에 비해 긍정적인 영항을 , 2-3년제 대학 졸업 이상의 경우구직경로 간 차이는 없었지만 , 학력 간 차이가 직종을 통해 간접적으로영항을 미치는 것으로 나타났다 . This study intended to investigate the effect of job-searching channels on successful reentry to labor market among career-interrupted women, focusing on differences of their educational background. The first wave data of 'Korean Longitudinal Survey ofWomen & Family', the national data from Korea Women's Development Institute (KWDI), were analyzed for this study. The frequency analysis of job-searching channels and occupational categories among career-interrupted and reentry women showed noticeable differences based on their educational background. Therefore, effect of job-searching channel on successful reentry to labor market-educational fitness and wage- was explained by comparing two groups, which were divided into one with low level of education and another with high level of education, respectively. As a result, the group with low level of education showed negative effect of personal network on educational fitness with job, and positive effect of impersonal media channel on wage. On the other hand, in the case of another group with high level of education, institutional network had positive effect and indirect effect through occupational categories on educational fitness. Also, there was no significant effect of job-searching channels on wage. Based on these research results, conclusions, implications, and suggestions for further studies are discussed.

경피적 위루관 삽입술의 임상 경과: 단일 기관에서의 관찰 연구

이지현 ( Jihyun Lee ),심기남 ( Ki-nam Shim ),이강훈 ( Kang Hoon Lee ),이고은 ( Ko Eun Lee ),장지영 ( Ji Young Chang ),태정현 ( Chung Hyun Tae ),문창모 ( Chang Mo Moon ),김성은 ( Seong-eun Kim ),정혜경 ( Hye-kyung Jung ),정성애 ( S 대한소화기학회 2018 대한소화기학회지 Vol.71 No.1

목적: 경피적 위루관 삽입술은 장기적인 경관 영양을 위해 가장 널리 사용되는 방법이다. 본 연구는 경피적 위루관 삽입술을 시행받는 환자들의 임상적인 특징과 임상 경과에 대하여 밝히고자 하였다. 대상 및 방법: 이화여자대학교 의과대학 부속 목동병원에서 2002년 1월부터 2013년 12월까지 위루관 삽입술을 시행받은 환자들의 의무기록을 후향적으로 조사하여, 환자들의 성별, 연령, 의식 상태, 기저 질환, 위루관 삽입술 시행 방법, 위루관 교체 여부 및 교체 방법, 교체 시기를 조사하였다. 결과: 대상 환자는 총 137명으로 남자가 86명(62.8%), 여자가 51명(37.2%)이었으며, 평균 연령은 67.85±16.97세였다. 위루관 삽입술이 필요한 기저 질환으로는 뇌출혈 및 뇌졸중을 포함한 뇌혈관 질환이 66명(48.2%)으로 가장 많았고, 두경부암(20명, 14.6%)과 파킨슨병(10명, 7.3%)이 그 뒤를 이었다. 133명(97.1%)이 내시경적 위루관 삽입을 받았고, 4명(2.9%)이 투시촬영 유도 위루관 삽입술을 시행받았다. 추적 기간 동안 1번이라도 위루관을 교체받은 90명의 환자 가운데 내시경적 교체를 시행받은 환자는 71명(78.9%), 투시촬영 유도 위루관 삽입술로 교체를 시행받은 환자는 4명(4.4%), 수기로 교체를 받은 환자는 15명(16.7%)이었으며 평균 교체 간격은 9.83±6.19개월이었다. 대상 환자 중 119명(86.9%)에서 위루관 삽입과 관련된 급성 합병증이 나타나지 않았으며, 9명(6.6%)의 환자에서 발생한 삽입 부위 감염이 가장 흔하게 발생한 합병증이었다. 지연 합병증은 25명(16.1%)의 환자에서 나타났으며, 가장 흔하게 발생한 합병증은 저절로 위루관이 제거된 것으로 21명(15.3%)의 환자에서 나타났다. 결론: 본 연구에서 경피적 위루관 삽입술은 장기적인 경관 영양을 위해 안전하게 사용될 수 있는 방법으로, 저자들은 본 연구가 추후 경피적 위루관 삽입술을 시행받는 환자들의 관리에 대한 지침을 마련하는 데 도움이 될 것으로 기대한다. Backgrounds/Aims: Percutaneous endoscopic gastrostomy (PEG) is a widely used method for long-term tube feeding. This study aimed to investigate the clinical characteristics and outcomes of patients who utilized long-term feeding tube via PEG. Methods: The medical records of 137 patients who underwent PEG tube insertion at Ewha Womans University Mokdong Hospital between January 2002 and December 2013 were reviewed. Results: PEG was indicated most frequently for cerebrovascular accidents (66 patients, 48.2%), followed by head and neck cancer (20 patients, 14.6%), and Parkinson’s disease (10 patients, 7.3%). The tubes were endoscopically inserted in 133 patients (97.1%); 4 patients (2.9%) underwent radiologic intervention. The tubes of 90 patients (65.7%) were exchanged at least once during the follow-up period. At the first exchange, 71 patients (78.9%) had their tubes exchanged by endoscopy, 24 patients (16.7%) by manually, and 4 patients (4.4%) by radiologic intervention. Of the 61 patients (44.5%) who had their tubes exchanged twice, 44 patients (72.1%) changed their tubes by endoscopic exchange, 13 patients (21.3%) by manually, and 4 patients (4.4%) via radiologic intervention. The mean time interval between the initial insertion and the first exchange was 9.83±6.19 months, and that between the initial insertion and the second exchange was 10.7±6.25 months. Of all the 137 patients, acute complications at initial insertion occurred in only 18 patients (13.1%), with insertion site infection (9 patients, 6.6%) being the most common acute complication. Conclusions: PEG appears to be a safe procedure for providing long-term tube feeding. Our results may help to develop strategies for further management of subjects receiving feeding tubes via PEG. (Korean J Gastroenterol 2018;71:24-30)

Quality Characteristics of Fermentation Strawberry Jam Prepared with Sugar Alcohol

Youngeun Chang,Jinsook Kim,Jihyun Lee,Bobae Lee,Gi-Chang Kim,Kyung-Mi Kim 한국식품영양과학회 2013 한국식품영양과학회 학술대회발표집 Vol.2013 No.11

준실시간 연속관측을 통한 제주 고산 PM<SUB>2.5</SUB> OC와 EC의 계절별 사례별 특성

한지현(Jihyun Han),방병조(Byungjo Bahng),이미혜(Meehye Lee),윤순창(Soon-Chang Yoon),김상우(Sang-Woo Kim),장임석(Limseok Chang),강경식(Kyeong-Sik Kang) 한국대기환경학회 2013 한국대기환경학회지 Vol.29 No.3

하수처리에서 일차 및 이차 침전지의 계면변화 비교

장신요 ( Shinyo Chang ),신풍식 ( Pungshik Shin ),김규하 ( Kyuha Kim ),이태일 ( Taeil Lee ),박지현 ( Jihyun Park ),채호승 ( Hoseung Chae ) 한국물환경학회 2021 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2021 No.-