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조현이,정종철,김호성,최재욱,성대경,서지훈,김성범,이계혁 大韓顎顔面成形再建外科學會 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.1
Osteosarcoma is a primary malignant tumor arising most often in the long bone, but rare in jaw bone. Especially osteogenic sarcoma of the mandible is a rare tumor, comprising less than 0.5% of all head and neck tumors. Osteosarcoma occurs cheifly in young persons, and presenting very survival rates. Histopathologically this tumor can be classified three types, osteoblastic, fibroblastic, chondroblastic and classified from low grade to high grade by anaplasia or mitosis of the tumor cells. Sometimes, the exact diagnosis of osteosarcoma is difficult especially in low grade osteosarcoma, even if clinical or radiographical findings suggest to osteosarcoma. So suspcious to malignant bone tumor in clinical or radiological findings, biopsy should be taked from deep portion and multiple area, and sharing the patient history and radiographs with pathologist will assist in the development of the diagnosis. We report a case of low grade osteosarcoma on the mandible initially difficulty in accurate diagnosis. The patient visited our hospital for routine dental treatment but radiographic findings displayed ill-defined radiolucency with osteoid formation on the mandible. Final diagnosis was difficulty in initial biopsy but subsequent biopsy taked from deep portion presented infiltrative growth and mitosis of the tumor cell in some area with small osteoid bone formation, so we could reach final diagnosis as low grade sarcoma. We treated this patient with bloc resection of the mandible and immediate reconstruction with iliac corticocancellous block.
박성원,김정혁,홍승표,이지삼,정장용,박희성 진주산업대학교 농업기술연구소 1999 農業技術硏究所報 Vol.12 No.-
본 연구는 돼지의 체외수정에 있어서 난포란의 회수방법과 체외수정란 및 체외발달율을 조사하여 체외수정의 기본 원리를 밝히고자 본 연구를 수행하였다. 도축장으로부터 채집한 난소의 난포에서 흡입법, 세절법 및 흡입후세절법 등으로 난포란을 채취하여 등급별로 분류하여 회수율을 조사하였으며, 채취한 난포란은 액상정액과 정소상체미부 정액을 사용하여 체외수정을 시킨후 TCM-199 와 NCSU-23 배양액으로 체외배양을 실시하였다. 본 연구에서 얻은 결과를 요약하면 다음과 같다. 회수방법당 각각 37개의 난소에서 회수한 난포란의 수는 흡입법이 1,365개, 세절법이 1,884개 및 흡입후 세절법이 3.830개로써 난소당 난포란의 수는 각각 36.9, 50.9 및 103.5개로써 회수방법간에 유의적(P<0.05)인 차이가 있었다. 액상정액과 정소상체미부 정액을 사용하였을 때 수정율은 각각 83.0 및 83.% 로써 정액간에 유의적(P<0.05) 인 차이는 없었다. 체외수정이 이루어진 난자들의 분할율도 액상정액(60.8%) 과 정소상체미부 정액(69.0%) 간에 유의적(P<0.05) 인 차이는 없었다. 2-4세포기로의 발달율은 24.6 및 28.4%로써 배양액간에 위의적(P<0.05)인 차이는 없었으며, 상실배로의 발달율도 TCM-199 와 NCSU-23 배양액이 각각 14.8 및 24.5% 로써 이들간에 유의적(P<0.05)인 차이는 없었다. To improve the efficiency of in vitro production of embryos with follicular oocytes in pig, the recovery rates, in vitro fertilization and development, and the time required for collectng and processing oocytes by aspiration with or without slicing were evaluated comparatively. The oocytes were collected by aspiration of follicles(2-6mm) with or without slicing ovaries after aspiration, and classified into grade I-IV oocytes by the morpholoy of cumulus cells attached and the homogeneity of cytoplasmic granules. The grade Ⅰ-Ⅱ oocytes were matured invitro for 46 hours in TCM-199 and NCSU-23 supplemented with 1㎍/㎖ FSH, 2IU/㎖ hCG, 1㎍/㎖ estradiol-17 at 39℃ under 5% CO_2 in air. They were fertilized in vitro by epididymis sperm and ejaculated sperm treated with hypotaurin for 24 hours. and then the zygotes were co-cultured in vitro with pFF(porcine follicular fluid) for 7-9 days. The results obtained were as follows: The number of ocytes recovered per ovary was averaged 30.7 by aspiration, 50.8 by slicing and 103.5 by aspiration post slicing. The number of grade Ⅰ oocytes recovered was total 0.2% by aspiration, 0.1% by slicing and 0.1% by aspiration post slicing. The oocytes recovered per ovary was significantly(P<0.05) higher as recovery methods. The cleavage rates of the embryos obtained from 83.0(ejaculate sperm) and 83.1(epididymis sperm) respectively(P<0.05). In vitro developmental rates(9.9 and 18.6%) of embryos cultured in TCM-199 and NCSU-23 up to morula stage were non significantly(P<0.05) different between the culture media.
Liposoluble portion of the red alga Pyropia yezoensis protects alcohol induced liver injury in mice
Ji-Hyeok Lee,Ginne Ahn,Juyoung Ko,Nalae Kang,Kyungsook Jung,Eui-Jeong Han,Gwang Hoon Kim,Hee Jeong Kim,Cheol Soo Choi,You-Jin Jeon 한국조류학회I 2021 ALGAE Vol.36 No.3
The hepatoprotective effect of liposoluble portion of Pyropia yezoensis (PYLP) was investigated against alcohol-induced liver injury in mice. Fatty acids were predominant in PYLP obtained from hexane fraction of 70% EtOH extract after ultrasonication. In particular, polyunsaturated fatty acids such as eicosapentaenoic acid and linoleic acid accounted for 56.91% of the total lipids. PYLP significantly reduced liver damage induced by the alcohol treatment in mice. PYLP treatment increased the activity of antioxidant enzymes including superoxide dismutase, catalase, and glutathion peroxidase by reducing thiobarbituric acid reactive substances. Histological observations showed that PYLP minimizes damage to living tissue induced by alcohol treatment by modulating the expression level of proteins involved in the anti-apoptotic signaling pathway. Our results suggest that PYLP, rich in polyunsaturated fatty acids extracted from the red alga P. yezoensis, will be useful as a potential liver protectant in the hangover industry.
Appropriate diagnosis of biliary cystic tumors: comparison with atypical hepatic simple cysts
Seo, Jeong Kyun,Kim, Su Hyun,Lee, Sang Hyub,Park, Joo Kyung,Woo, Sang Myung,Jeong, Ji Bong,Hwang, Jin-Hyeok,Ryu, Ji Kon,Kim, Jin-Wook,Jeong, Sook-Hyang,Kim, Yong-Tae,Yoon, Yong Bum,Lee, Kuhn Uk,Kim, S Lippincott Williams Wilkins, Inc. 2010 European journal of gastroenterology & hepatology Vol.22 No.8
BACKGROUND: Biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC) are often confused with other intrahepatic cystic diseases. AIMS: The aims of this study were to investigate predictive factors of biliary cystic tumor (BCT) and clinical characteristic of BCAC. METHODS: We retrospectively reviewed preoperative diagnoses, overall characteristics and postoperative outcome of 20 BCTs and 19 cystadenoma-mimicking simple cysts that were pathologically confirmed. RESULTS: Comparing with atypical simple cysts, symptoms, left-lobe cyst, thick wall, septation, mural nodule, bile duct dilatation and an increase of serum alkaline phosphatase were associated with BCTs. However, on multivariate analysis, mural nodule, left-lobe cyst, and an increase of serum alkaline phosphatase were significantly frequent in BCTs with odds ratios of 75.5, 13.8, and 33.0, respectively. Among the 20 BCTs, seven BCACs were diagnosed. The characteristics of BCACs were mural nodule (P<0.01), intrahepatic cyst debris (P<0.01), and bile duct dilation (P=0.04). Cystic fluid analysis provided no significant differences between BCT and simple cyst. After fine needle aspiration cytology of BCTs, all except one BCAC with atypical cell showed nonspecific findings. After complete surgical excision (97.4% of patients), only one patient with BCAC had recurrence during 29 months of follow-up period. CONCLUSION: In hepatic cysts with mural nodule, left-lobe cyst or increment of serum alkaline phosphatase seem to be indicative of BCTs in the diagnosis of suspicious hepatic cyst. Intracystic debris, bile duct dilation, and mural nodule may be suggestive clinical features of malignancy in BCTs.
Lee, Ji Young,Kim, Hyo Jeong,Yoon, Nal Ae,Lee, Won Hyeok,Min, Young Joo,Ko, Byung Kyun,Lee, Byung Ju,Lee, Aran,Cha, Hee Jeong,Cho, Wha Ja,Park, Jeong Woo Oxford University Press 2013 Nucleic acids research Vol.41 No.11
<P>Tristetraprolin (TTP) and <I>let-7</I> microRNA exhibit suppressive effects on cell growth through down-regulation of oncogenes. Both TTP and <I>let-7</I> are often repressed in human cancers, thereby promoting oncogenesis by derepressing their target genes. However, the precise mechanism of this repression is unknown. We here demonstrate that p53 stimulated by the DNA-damaging agent doxorubicin (DOX) induced the expression of <I>TTP</I> in cancer cells. TTP in turn increased <I>let-7</I> levels through down-regulation of <I>Lin28a</I>. Correspondingly, cancer cells with mutations or inhibition of p53 failed to induce the expression of both <I>TTP</I> and <I>let-7</I> on treatment with DOX. Down-regulation of <I>TTP</I> by small interfering RNAs attenuated the inhibitory effect of DOX on <I>let-7</I> expression and cell growth. Therefore, TTP provides an important link between p53 activation induced by DNA damage and <I>let-7</I> biogenesis. These novel findings provide a mechanism for the widespread decrease in TTP and <I>let-7</I> and chemoresistance observed in human cancers.</P>
정지중 ( Ji Jong Jeong ),김대혁 ( Dae Hyeok Kim ),우성일 ( Seong Ill Yoo ),신성희 ( Sung Hee Shin ),이명동 ( Myung Dong Lee ),예재호 ( Jea Ho Ye ),장지훈 ( Ji Hun Jang ) 대한내과학회 2012 대한내과학회지 Vol.83 No.1
일반적으로 저나트륨혈증은 심전도계에 심각한 영향을 미치지 않는 것으로 알려져 있으나 본 저자들은 저나트륨혈 증으로 인해 완전방실차단이 발생한 사례를 경험하였고 저나트륨혈증을 교정함으로써 방실전도를 회복시킨 바 있어 문헌고찰과 함께 보고한다. We report the case of a 77-year-old woman who developed complete atrioventricular (AV) block during an episode of thiazide-induced hyponatremia. She was taking hydrochlorothiazide to treat essential hypertension; she had no definite organic disease of the heart or lungs. Generally, the serum sodium concentration does not have a marked effect on cardiac conduction. However, we experienced a case of complete AV block associated with hyponatremia. This was treated successfully by correcting the electrolyte imbalance. Complete AV block associated with hyponatremia is very rare. To our knowledge, this is the first reported case in Korea.
Flowing with Jeju heanyeo - Jeju National University High school club Tewak is floating
Hong Ji Hee,Kang Gyeong Ji,Kim Eun Hee,Kim On Yu,Lee Yu Bin,Ko Jun Hyeok,Kang Min Jae,Yang Hyeon Jeong,Yang Yeon Jae,Sim Yu Rim,Kim Min Ji,Geum Na Hyeon,Kim Geum Byeol,Heo Jeong In 제주학회 2016 제주학회 학술발표논문집 Vol.2016 No.2
Multiple Hypercoagulability Disorders at Presentation of Non-Small-Cell Lung Cancer
Lee, Jeong Min,Lim, Jun Hyeok,Kim, Jung-Soo,Park, Ji Sun,Memon, Azra,Lee, Seul-Ki,Nam, Hae-Seong,Cho, Jae-Hwa,Kwak, Seung-Min,Lee, Hong Lyeol,Kim, Hyun-Jung,Hong, Geun-Jeong,Ryu, Jeong-Seon The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.1
Hypercoagulability disorders are commonly encountered in clinical situations in patients with a variety of cancers. However, several hypercoagulability disorders presenting as first symptoms or signs in cancer patients have rarely been reported. We herein described a case of a woman with adenocarcinoma of the lung presenting with deep vein thrombosis, nonbacterial thrombotic endocarditis, recurrent cerebral embolic infarction, and heart failure.