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( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.
Evaluation of Activity in Muscle Cells using Fractions of Various Ginseng Species
Jun Kee Hong(홍준기),EunYoung Hong(홍은영),Jun Hee Park(박준희),Jae Ho Myeong(명재호),Seung Ah Lee(이승아),Byung Ju Jeon(전병주),Ji Won Lee(이지원),Sung Su Kim(김성수),Dong Yun Hyun(현동윤),Ji Won Moon(문지원),Wan Kyunn Whang(황완균) 한국약용작물학회 2020 한국약용작물학회 학술대회논문집 Vol.2020 No.1
Profiling of the Components in Various Ginseng Differences in Species and Cultivation
Jun Kee Hong(홍준기),Eun Young Hong(홍은영),Jun Hee Park(박준희),Jae Ho Myeong(명재호),Byung Ju Jeon(전병주),Ji Won Lee(이지원),Sung Su Kim(김성수),Wan Kyunn Whang(황완균),Dong Yun Hyun(현동윤),Ji Won Moon(문지원) 한국약용작물학회 2020 한국약용작물학회 학술대회논문집 Vol.2020 No.1
( Ji Won Han ),( Pil Soo Sung ),( Seon-hui Hong ),( Eui-cheol Shin ),( Myeong Jun Song ),( Su-hyung Park ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: There is a possibility that small amount of HCV RNA in the liver and circulation, risk of relapse, and risk of reinfection still remain in patients with SVR after DAA treatment; however, it remains unclear whether functionally exhausted HCV-specific T cells can be restored after complete viral clearance and its association with clinical outcomes. In this study, we prospectively investigated the functional restoration of HCV-specific CD8+ T cells, which is most important immune cells in anti-HCV immunity, in 33 DAA-treated patients with chronic hepatitis C. Methods: 33 HCV-genotype Ib patients, who treated with Daclatasvir/ Asunaprevir from Daejeon St. Mary`s hospital were recruited. PBMC samples were collected at regular clinical visits at pre-treatment, week 4, week 12, week 24, and week 36 after treatment. To assess T cell responses, IFN-γ ELISpot assay was performed, stimulated with HCV OLPs or HLA-A2 restricted HCV immunodominent epitopes. To characterize HCV-specific CD8 T cells, fluorochrome-conjugated monoclonal antibodies with pentamer or dextramer corresponding HCV-immunodominent epitopes were used for multicolor low cytometry. Results: By using ELISpot with overlapping peptides corresponding non-structural proteins of HCV, which are relatively well conserved than other HCV proteins, we found that early, transient restoration of CD8+ dominant, HCV-specific IFN-γ responses. Restored CD8+ T cells also showed polyfunctionality, which expressed TNF-α and CD107a simultaneously after HCV-peptide stimulation; Interestingly, in 3 patients with viral breakthrough, this transient T cell restoration was not observed. In addition, in line with previous study, proliferative capacity of HCV-specific CD8+ T cells also tended to be improved after DAA treatment, especially at 12 weeks of treatment. HCV-specific T cell exhaustion, represented by PD-1 expression, had a tendency to be improved and maintained after DAA treatment also at the early timepoint, but terminally differentiated phenotype of HCV-specific T cells was maintained constantly. Conclusions: These results suggest that transiently increased T cell responses may have a role to clear HCV completely at early timepoint. Furthermore, even in patients with SVR, due to insufficient immune response at late timepoint, the possibility of re-infection and relapse still exists. In conclusion, long-term, careful observation is needed in patients with chronic hepatitis C after DAA treatment.
Ji Hee Jun,Hye Won Lee,Jiae Choi,Tae-Young Choi,Ju Ah Lee,Ho-Yeon Go,Myeong Soo Lee 한국한의학연구원 2019 Integrative Medicine Research Vol.8 No.4
Background: Most women experiencing menopause have sought out traditional treatment options to relieve their symptoms. The aim of this study, which used a web-based survey, was to investigate perceptions of Korean medicine doctors (KMDs) on managing menopausal symptoms with herbal medicines. Methods: We developed and then sent a questionnaire via email to a total 497 KMDs in obstetrics and gynecology affiliated with the Society of Korean Medicine. The questionnaire consisted of three categories and a total of 26 items focusing on major menopausal symptoms, prescriptions, pattern identification, and background characteristics. Results: Out of the 497 KMDs, we received responses from 48 doctors, a response rate of 9.7%. The most common symptoms of menopausal disorder perceived by responded KMDs were hot flashes (22.9%), sleep disorders (18.2%), systemic fatigue (12.5%), and sweating (12.0%). The herbal medicines reported to be the most effective when treating patients with menopausal disorders were Jiawei shaoyao-san (12.5%), Jiawei guipi-decoction (11.8%). The responding KMDs recommended one to two months of treatment for female menopausal disorder, using two to three doses of herbal medicine per day in combination with traditional Korean medicine (KM) therapies such as acupuncture, moxibustion, cupping, and pharmacopuncture. Conclusion: The results of this survey may provide information about doctor’s perceptions on using herbal medicines to manage patient’s menopausal symptoms. Future studies should be done with a larger sample size to overcome the limitation of this study and to examine how KM is used for treating menopausal symptoms in clinical practice.