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Alitretinoin as a promising drug in two patients of recalcitrant Twenty Nail Dystrophy
( Ji Hye Heo ),( Seon Bok Lee ),( Hee Seong Yoon ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Ji Won Byun ),( Jeonghyun Shin ),( Gwang Seong Choi ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Twenty nail dystrophy is widespread trachyonychia involving all 20 nails. The cause of this is diverse and it can occur idiopathically. There are many treatment modalities reported but no standard evidence-based approaches. The use of topical and/or systemic corticosteroids or triamcinolone intralesional injection (TA ILI) in the nail matrix can be considered as a treatment modality. We experienced complete resolution in two cases of twenty nail dystrophy with oral alitretinoin 30 mg per day. Patient 1 was a 52-year-old woman with 3-month history of twenty nail dystrophy. She treated with systemic and topical anti-fungals for 4 months and TA ILI was administered monthly, but the symptoms worsened. Treatment with alitretinoin 30 mg per day was added. After 4 months, there was improvement of the nails, and the complete improvement was observed at the end of the treatment with a total of 9 months of alitretinoin. Patient 2 was a 62-year-old woman with 10-year history of twenty nail dystrophy. Previously she had treated with TA ILI, but it had not been effective. Treatment with alitretinoin 30 mg per day was added and the nails improved after 10 months. 18 months after the alitretinoin treatment, it was almost completely cured. To our best knowledge, this is the first case reports on improvement with alitretinoin treatment in idiopathic twenty nail dystrophy in dermatologic literature.
A Case of Immunoglobulin A Pemphigus: Intraepidermal Neutrophilic Dermatosis Type
( Ji Hye Heo ),( Hee Seong Yoon ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Lucia Kim ),( Soo-chan Kim ),( Ji Won Byun ),( Jeonghyun Shin ),( Gwang Seong Choi ) 대한피부과학회 2019 대한피부과학회지 Vol.57 No.8
Immunoglobulin A (IgA) pemphigus is a rare variant of an autoimmune bullous disease with IgA antibodies. IgA pemphigus is divided into 2 major subtypes: the subcorneal pustular dermatosis (SPD) type and intraepidermal neutrophilic (IEN) dermatosis type. We documented a case of an 18-year-old woman with recurrent generalized blisters and pustules that were especially severe in the intertriginous areas. Some half-and-half blisters and coalesced pustules in an annular pattern with crusts were simultaneously observed. A biopsy specimen from one of the halfand- half blister lesions showed intraepidermal separation with multiple neutrophils. Direct immunofluorescence staining revealed lace-like intercellular deposition of IgA in the entire epidermis. IgA antibody deposits were also observed in the patient's serum. The eruptions cleared with systemic steroids and colchicine 0.6 mg for 1 week, and the patient remained in partial remission at the 8-month follow-up. Herein, we report a case of IEN-type IgA pemphigus, clinically mimicking SPD with half-and-half blisters. (Korean J Dermatol 2019;57(8):492∼495)
A case of mixed basosquamous cell carcinoma of the face
( Ji Hye Heo ),( Seon Bok Lee ),( Hee Seong Yoon ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Jeonghyum Shin ),( Gwang Seong Choi ),( Ji Won Byun ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Basosquamous cell carcinoma (BSCC) is a variant of basal cell carcinoma (BCC) which shows the histopathologic characteristics of BCC and squamous cell carcinoma (SCC) with or without transition zone between them. In transition zone, basaloid cells have eosinophilic cytoplasm and variable keratinization and often lack peripheral palisading. Fibroblast-rich, collagenized stroma is also characteristic. In recent studies, it is considered BCC occurs first, followed by differentiation of basaloid cells derived from germinative progenitor epithelia into squamous cells. It is good to make a final diagnosis with a large specimen obtained by removing the tumor because of misdiagnosis with superficial biopsy. We report a case of a 50-year-old white man presented a skin colored nodule on the right side of the nose for three years. Histopathologic findings of skin biopsy from other hospital were consistent with BCC. The patient was treated with Mohs micrographic surgery and involvement of suspicious SCC was showed in a resection margin. Overlying epidermis permeating down into the dermis with atypical squamous cell, horn cysts and individual keratinization were observed. There were clefts around the tumor nests and palisading atypical basaloid cells. But, there was no metatypical cell showing intermediate characteristics of basaloid cells of BCC and spinous cells of SCC. Considering the above findings, a collision tumor (mixed BSCC) was diagnosed.
The Efficacy of Bisphosphonates for Prevention of Osteoporotic Fracture: An Update Meta-analysis
Byun, Ji-Hye,Jang, Sunmee,Lee, Sumin,Park, Suyeon,Yoon, Hyun Koo,Yoon, Byung-Ho,Ha, Yong-Chan The Korean Society for Bone and Mineral Research 2017 대한골대사학회지 Vol.24 No.1
<P><B>Background</B></P><P>The efficacy of bisphosphonates for osteoporotic fracture has been consistently reported in recent randomized controlled trials (RCTs) enrolling hundreds of patients. The objective of this study was to update knowledge on the efficacy of available bisphosphonates in the prevention of vertebral and non-vertebral fractures.</P><P><B>Methods</B></P><P>An approach “using systematic reviews” on PubMed and Cochrane Library was taken. Twenty-four RCTs investigating the effects of bisphosphonates for the prevention of osteoporotic fracture were included in final analysis. A pairwise meta-analysis was conducted with a random effects model. Subgroup analysis was performed according to the type of bisphosphonate.</P><P><B>Results</B></P><P>The use of bisphosphonate decrease the risk of overall osteoporotic fracture (odds ratio [OR] 0.62; <I>P</I><0.001), vertebral fracture (OR 0.55; <I>P</I><0.001) and non-vertebral fracture (OR 0.73; <I>P</I><0.001). Subgroup analysis indicated that zoledronic acid showed the lowest risk reduction (OR 0.61; <I>P</I><0.001) for overall osteoporotic fractures but no significance was observed for etidronate (OR 0.34; <I>P</I>=0.127).</P><P><B>Conclusions</B></P><P>This update meta-analysis re-confirmed that bisphosphonate use can effectively reduce the risk of osteoporotic fracture. However, there is a lack of evidence regarding etidronate for the prevention of osteoporotic fracture.</P>
A case of spindle cell hemangioma
( Ji Hye Heo ),( Seon Bok Lee ),( Hee Seong Yoon ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Jeonghyun Shin ),( Gwang Seong Choi ),( Ji Won Byun ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Spindle cell hamangioma is an uncommon benign vascular tumor. It usually presents as dermal or subcutaneous nodule and most commonly arises in distal extremities. The histopathologic findings are coexistence of dilated and congested cavernous space and more solid area composed of spindle-shaped cells consisting epithelioid type in part. Immunohistochemical findings show variable positivity with endothelial markers depending on the composition of vascular endothelial cells and epithelioid cells in solid area. Surgical excision is treatment of choice and follow-up is necessary because of the possibility of recurrence. We report a case of a 56-year-old woman presented with tender bluish to skin colored mass on the left sole for several months ago. Ultrasound of the lesion revealed an well defined hypoechoic mass at subcutaneous layer with no vascularity. Surgical removal was performed. Histopathologic findings showed dermal tumor composing of spindle cells with cytologic atypia but no mitosis and dilated and thin-walled vascular spaces. There were hemosiderin deposition and collagen dissection. As differential diagnoses, spindle cell hemangioma, Kaposi sarcoma, angiosarcoma, hobnail hemangioma and hemangioendothelioma can be considered. Immunohistochemical stains for CD31, ERG and SMA were positive but CD34 and HHV-8 were negative. Ki-67 was presented approximately 1% positivity. A final diagnosis of spindle cell hemangioma was made.