원문 : 좌업 시간과 알코올 섭취가 30대 남자 사무직 근로자의 혈압과 혈관탄성에 미치는 영향

조봉오 ( Bong Oh Cho ),이인녕 ( In Yeong Lee ),정균근 ( Gyun Geun Jeong ),장창현 ( Chang Hyun Jang ) 한국운동생리학회(구 한국운동과학회) 2014 운동과학 Vol.23 No.3

조봉오, 이인녕, 정균근, 장창현. 좌업 시간과 알코올 섭취가 30대 남자 사무직 근로자의 혈압과 혈관탄성에 미치는 영향. 운동과학, 제23권 3호, 241-248, 2014. 본 연구의 목적은 일과 중 대부분을 좌업근무 형태로 업무를 수행하고, 스트레스로 인해 음주가 잦고, 운동이 부족한 30대 남자 사무직 음주자 15명을 대상으로 좌업 시간과 알코올 섭취가 혈압과 혈관탄성에 미치는 영향을 분석하여 사무직 근로자에게 건강관리에 필요한 정보를 제공하는데 있다. S대학 운동 생리학 실험실에서 사전 인적 사항과 설문을 작성하고, 신장, 체중, 채혈, 혈압, 혈관탄성, BMI를 측정하였다. 알코올 섭취 횟수, 섭취량, 좌업 시간, 그리고 음주 섭취 전과 후 및 시간대별 (10분, 40분, 60분) 혈압과 혈관탄성의 변화를 측정 분석한 결과를 요약하면 다음과 같다. 1) 평균 좌업시간이 9.87시간, 음주횟수 및 음주량은 월 평균 9.13회와 12.47잔 이였다. 2) 알코올 섭취횟수 및 섭취량에 따른 BMI, TC, LDL-C, HDL-C, 혈압과 혈관탄성 비교에서 알코올 섭취횟수에서 좌상지 혈관탄성은 통계적으로 유의한 차이를 나타냈다(p<.05). 3) 알코올 섭취 전, 후 비교 분석 결과 우상지와 좌상지의 혈관탄성에서 통계적으로 유의한 차이가 나타났다(p<.05). 4) 알코올 섭취 후 시간대별 우상지 혈관탄성은 통계적으로 유의한 차이를 나타냈다(p<.05). 이상의 결과를 종합해 볼 때, 좌업 시간이 혈압과 혈관탄성에 미치는 영향은 통계적으로 유의하게 나타나지 않았고, 알코올 섭취는 혈관탄성에 통계적으로 유의한 차이를 나타냄을 알 수 있었다. 따라서 이는 직장생활의 스트레스를 음주로 해소하는 경향이 있음을 보여주며 건강에 부정적인 영향을 주고 있음을 알 수 있었다. 또한, 신체가 음주에 적응되어 실험 시 섭취한 적은 양(1/2병)은 1회 12.47잔에 비해 혈압과 혈관탄성에 큰 영향을 미치지 못한 것으로 사료된다. Cho, Bong-Oh, Lee, In-Yeong, Jeong, Gyun-Geun, Jang, Chang-Hyun. Effects of Sedentary Occupation Time and Alcohol Intake on Blood Pressure and Vascular Compliance in 30s Male White-Collar Workers. Exercise Science, 23(3): 241-248. 2014. The purpose of this study was to examine effects of duration of sedentary office work and alcohol intake on blood pressure and vascular compliance in male subjects who were office workers aged between 30 to 39 and frequently drink alcoholic beverages to cope with their stress without exercising for health. The study was to provide health-related information necessary for white-collar workers. We collected data of demographic information, height, weight, blood sample, blood pressure, vascular compliance, and BMI from 15 subjects in S University`s Exercise Physiology Laboratory, and analyzed the frequency and amount of alcohol intake, duration of sedentary work, and changes in blood pressure and vascular compliance at diffident time points (10, 40, and 60 minutes post drinking) from baseline. I t was found that the average time of sedentary work was 9.87 hours, drinking 9.13 times a month on average, 12.47 glasses of alcohol beverages per drink. In comparison of BMI, TC, LDL-C, HDL-C, blood pressure and vascular compliance upon the frequency and amount of alcohol intake, the upper left limb`s vascular compliance had a statistically significant difference (p<.05). In the result of the comparative analysis of pre-and post-drinking, vascular compliance was significantly different in the upper right and left limbs (p<.05). Vascular compliance in the upper right limb after drinking significantly changed (p<.05). As a result, the duration of sedentary work had no statistically significant difference in blood pressure and vascular compliance. T he vascular compliance after drinking h ad a statistically significant difference. This suggested that the result was an index that shows the trend of the office workers releasing their work stress by drinking alcoholic beverages, and that drinking had negative impacts on them. In addition, a small amount of intake (a half bottle) at the test time, after the body was adjusted to drinking, compared with 12.47 glasses per intake, had no great impacts on blood pressure and vascular compliance.

Optimal Selection of Sedative Drug during Gastroduodenoscopy in Cirrhotic Patients to Avoid Minimal Encephalopathy: Interim-Analysis of Randomized Controlled Trial

( Jeong-ju Yoo ),( Hyeon Jeong Goong ),( Sang Gyune Kim ),( Young Seok Kim ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Baek Gyu Jun ),( Young Don Kim ),( Gab Jin Cheon 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The indiscriminate use of sedative drug during endoscopy can pose a risk of minimal hepatic encephalopathy (MHE) in patient with liver cirrhosis, . However, it has not been studied yet which drugs are safest and most inviting on these patients. The aim of this study is to evaluate which one among midazolam, propofol, or combination therapy, was the least likely to cause complications including MHE by using Stroop application in cirrhotic patients. Methods: This randomized prospective study included consecutive 32 patients who underwent upper GI endoscopy at tertiary hospitals in Korea. Patients were randomly assigned to one of three groups, midazolam, propofol, or combination group, and underwent Stroop test before endoscopy, and 2 hours after the completion of endoscopy. The vital signs was checked before and after the drug administration and the patient / physician / nurse satisfaction was scored after endoscopy. Results: Mean age of the patients was 54.0 ± 9.30 years and 81.3% were male. Fifteen patients (46.9%) were child-pugh class A, and 17 (53.1%) were child-pugh class B or C. Alcohol was the most common etiology (21, 65.6%). Patients did not show significant changes in Ontime, Offtime on Stroop test before and after drug administration, and there was no significant difference between the three treatment groups. Also, there was no significant vital sign changes after drug use in all groups. However, with respect to subjective indicators, the satisfaction scores of patient and nursing staff was higher in the combined group than in the other two groups, and time to recovery was shorter in propofol than other groups. Conclusions: In patients with cirrhosis, sedative endoscopy using midazolam, propofol, or combination therapy is relatively safe, and was not associated with increased risk of MHE. However, since there is subjective satisfaction or recovery time difference among sedative agents, it should be considered according to each individual patient.

태양광 발전시스템의 그림자 영향을 고려한 능동형 모듈 개발

정학균(Hak-Gyun Jeong),고재섭(Jae-Sub Ko),이진국(Jin-Gook Lee),정다은(Da-Eun Jeong),장미금(Mi-Geum Jang),정동화(Dong-Hwa Chung) 한국조명·전기설비학회 2012 한국조명·전기설비학회 학술대회논문집 Vol.2012 No.5

Effect of rice hull biochar treatment on net ecosystem carbon budget and greenhouse gas emissions in Chinese cabbage cultivation on infertile soil

Park Do-Gyun,Jeong Hyeon-Cheol,Jang Eun-Bin,Lee Jong-Mun,Lee Hyoung-Seok,Park Hye-Ran,Lee Sun-Il,Park Do-Gyun,Jang Eun-Bin,Oh Taek-Keun 한국응용생명화학회 2024 Applied Biological Chemistry (Appl Biol Chem) Vol.67 No.-

Biochar, with its potential to enhance soil fertility, sequester carbon, boost crop yields and reduce greenhouse gas emissions, offers a solution. Addressing the challenges posed by climate change is crucial for food security and agriculture. However, its widespread adoption in agriculture remains in its infancy. This study assessed the effects of rice hull biochar on cabbage production and greenhouse gas emissions, especially nitrous oxide (N 2 O). A trial, employing a randomized block design in triplicate was conducted from September 13 to November 23, 2022, where "Cheongomabi" cabbage was cultivated with N-P 2 O 5 -K 2 O fertilization at 32 $$-$$ - 7.8 $$-$$ - 19.8 kg 10a −1 . Additional fertilizer was applied twice post-sowing. The Biochar application rates were control = 0 ton ha −1 , B1 = 1 ton ha −1 , B3 = 3 ton ha −1 , and B5 = 5 ton ha −1 . The aboveground biomass of autumn cabbage harvested 82 days after sowing was 2.40–2.70 kg plant −1 in the control and biochar treatments (B1, B3, and B5), with no significant differences ( p  > 0.05). Cumulative CO 2 emissions during cultivation varied across treatment groups, with initial and cumulative emissions of 10.40–17.94 g m −2  day −1 and 3.63–4.43 ton ha −1 , respectively. N 2 O emissions decreased with higher biochar application: reductions of 2.9%, 25.4%, and 41.1% in the B1, B3, and B5 treatments, respectively, compared to the control. The biochar application had no significant impact on yield but curbed soil emissions, Net ecosystem carbon balance during cabbage cultivation ranged from 0.42 to 3.41 ton ha −1 for the B1, B3, and B5 treatments, respectively, compared to control. Overall, the study underscores biochar’s role in mitigating emissions and boosting soil carbon during cabbage cultivation in fall. Biochar, with its potential to enhance soil fertility, sequester carbon, boost crop yields and reduce greenhouse gas emissions, offers a solution. Addressing the challenges posed by climate change is crucial for food security and agriculture. However, its widespread adoption in agriculture remains in its infancy. This study assessed the effects of rice hull biochar on cabbage production and greenhouse gas emissions, especially nitrous oxide ( N2O). A trial, employing a randomized block design in triplicate was conducted from September 13 to November 23, 2022, where "Cheongomabi" cabbage was cultivated with N-P2O5-K2O fertilization at 32−7.8−19.8 kg 10a− 1. Additional fertilizer was applied twice post-sowing. The Biochar application rates were control = 0 ton ha− 1, B1 = 1 ton ha− 1, B3 = 3 ton ha− 1, and B5 = 5 ton ha− 1. The aboveground biomass of autumn cabbage harvested 82 days after sowing was 2.40– 2.70 kg plant− 1 in the control and biochar treatments (B1, B3, and B5), with no significant differences (p > 0.05). Cumulative CO2 emissions during cultivation varied across treatment groups, with initial and cumulative emissions of 10.40–17.94 g m− 2 day− 1 and 3.63–4.43 ton ha− 1, respectively. N2O emissions decreased with higher biochar application: reductions of 2.9%, 25.4%, and 41.1% in the B1, B3, and B5 treatments, respectively, compared to the control. The biochar application had no significant impact on yield but curbed soil emissions, Net ecosystem carbon balance during cabbage cultivation ranged from 0.42 to 3.41 ton ha− 1 for the B1, B3, and B5 treatments, respectively, compared to control. Overall, the study underscores biochar’s role in mitigating emissions and boosting soil carbon during cabbage cultivation in fall.

Design and Analysis of Collimator in Spectrophotometer for Transmission Spectroscopy of Exoplanets

Yeonho Choi,Kang-Min Kim,Chan Park,Jeong-Gyun Jang,Inwoo Han,Byeong-Cheol Lee,Bi-Ho Jang,Jong-Ung Lee,Eui-Jeong Jeong,Myeong-Gu Park 한국천문학회 2020 天文學會報 Vol.45 No.1

Development of Novel Patient-Derived Preclinical Models from Malignant Effusions in Patients with Tyrosine Kinase Inhibitor–Resistant Clear Cell Renal Cell Carcinoma ¹

Jang, Jiryeon,Rath, Oliver,Schueler, Julia,Sung, Hyun Hwan,Jeon, Hwang Gyun,Jeong, Byong Chang,Seo, Seong Il,Jeon, Seong Soo,Lee, Hyun Moo,Choi, Han-Yong,Kwon, Ghee-Young,Park, Woong Yang,Lee, Jeeyun Neoplasia Press 2017 Translational oncology Vol.10 No.3

<P><I>PURPOSE:</I> Although targeting angiogenesis with tyrosine kinase inhibitors (TKIs) has become standard of care in the treatment of clear cell renal cell carcinoma (RCC), resistance mechanism are not fully understood, and there is a need to develop new therapeutic options overcoming them. <I>METHODS AND MATERIALS:</I> To develop a preclinical model that predicts clinical activity of novel agents in 19 RCC patients, we established patient-derived cell (PDC) and xenograft (PDX) models derived from malignant effusions or surgical specimen. RESULTS: Successful PDCs, defined as cells that maintained growth following two passages, were established in 5 of 15 malignant effusions and 1 of 4 surgical specimens. One PDC, clinically refractory to TKIs, was implanted and engrafted in mice, resulting in a comparable histology to the primary tumor. The PDC-PDX model also showed similar genomic features when tested using targeted sequencing of cancer-related genes. When we examined the drug effects of the PDX model, the tumor cells showed resistance to TKIs and everolimus <I>in vitro</I>. <I>CONCLUSION:</I> The results suggest that the PDC-PDX preclinical model we developed using malignant effusions can be a useful preclinical model to interrogate sensitivity to targeted agents based on genomic alterations.</P>

Size and Location of Ruptured Intracranial Aneurysms

Jeong, Young-Gyun,Jung, Yong-Tae,Kim, Moo-Seong,Eun, Choong-Ki,Jang, Sang-Hwan The Korean Neurosurgical Society 2009 Journal of Korean neurosurgical society Vol.45 No.1

Objective : The aim of study was to review our patient population to determine whether there is a critical aneurysm size at which the incidence of rupture increases and whether there is a correlation between aneurysm size and location. Methods : We reviewed charts and radiological findings (computed tomography (CT) scans, angiograms, CT angiography, magnetic resonance angiography) for all patients operated on for intracranial aneurysms in our hospital between September 2002 and May 2004. Of the 336 aneurysms that were reviewed, measurements were obtained from angiograms for 239 ruptured aneurysms by a neuroradiologist at the time of diagnosis in our hospital. Results : There were 115 male and 221 female patients assessed in this study. The locations of aneurysms were the middle cerebral artery (MCA, 61), anterior communicating artery (ACoA, 66), posterior communicating artery (PCoA, 52), the top of the basilar artery (15), internal carotid artery (ICA) including the cavernous portion (13), anterior choroidal artery (AChA, 7), A1 segment of the anterior cerebral artery (3), A2 segment of the anterior cerebral artery (11), posterior inferior cerebellar artery (PICA, 8), superior cerebellar artery (SCA, 2), P2 segment of the posterior cerebral artery (1), and the vertebral artery (2). The mean diameter of aneurysms was $5.47{\pm}2.536\;mm$ in anterior cerebral artery (ACA), $6.84{\pm}3.941\;mm$ in ICA, $7.09{\pm}3.652\;mm$ in MCA and $6.21{\pm}3.697\;mm$ in vertebrobasilar artery. The ACA aneurysms were smaller than the MCA aneurysms. Aneurysms less than 6 mm in diameter included 37 (60.65%) in patients with aneurysms in the MCA, 43 (65.15%) in patients with aneurysms in the ACoA and 29 (55.76%) in patients with aneurysms in the PCoA. Conclusion : Ruptured aneurysms in the ACA were smaller than those in the MCA. The most prevalent aneurysm size was 3-6 mm in the MCA (55.73%), 3-6 mm in the ACoA (57.57%) and 4-6 mm in the PCoA (42.30%). The more prevalent size of the aneurysm to treat may differ in accordance with the location of the aneurysm.

Correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver: a multi-center retrospective cohort study

Jeong-Ju Yoo,유양재,Woo Ram Moon,김승업,Soung Won Jeong,박하나,Min Gyu Park,Jae Young Jang,Su Yeon Park,김범경,박준용,김도영,안상훈,한광협,Sang Gyune Kim,Young Seok Kim,Ji Hoon Kim,Jong Eun Yeon,Kwan Soo Byun 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.6

Background/Aims: The controlled attenuation parameter (CAP), based on transient elastography, is widely used for noninvasive assessment of the degree of hepatic steatosis (HS). We investigated the correlation of the degree HS between CAP and ultrasound (US) in patients with HS. Methods: In total, 986 patients with US-based HS who underwent transient elastography within 1 month were evaluated. The US-based grade of HS was categorized as mild (grade 1), moderate (grade 2), or severe (grade 3). Results: The CAP was significantly correlated with the US-based grade of HS (r = 0.458, p < 0.001). The median CAP value of each US-based HS grade showed a positive correlation with grade (271.1, 303.7, and 326.7 dB/m for grades 1, 2, and 3). In a multivariate analysis, the US-based HS grade, body mass index, serum albumin, alanine aminotransferase, and total cholesterol, and liver stiffness were all significantly correlated with the CAP value (all p < 0.05). The areas under the receiver operating characteristic curves for grade 2 to 3 and grade 3 HS were 0.749 (95% confidence interval [CI], 0.714 to 0.784) and 0.738 (95% CI, 0.704 to 0.772). The optimal cut-off CAP values to maximize the sum of the sensitivity and specificity for grade 2 to 3 and grade 3 HS were 284.5 dB/m (sensitivity 78.6%, specificity 61.7%) and 298.5 dB/m (sensitivity 84.6%, specificity 55.6%). Conclusions: The correlation of the degree of HS between CAP and US was significantly high in patients with HS, and the optimal cut-off CAP values for grade 2 to 3 and grade 3 HS were 284.5 and 298.5 dB/m.

Prediction of Histologic Immune-Tolerant Phase Chronic Hepatitis B from HBeAg-Positive with Low ALT Level Paitents

( Jeong-ju Yoo ),( Sang Gyune Kim ),( Young Seok Kim ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Baek Gyu Jun ),( Young Don Kim ),( Gab Jin Cheon ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: In general, the immune-tolerant (IT) phase is defined as HBeAg-positive patients with high HBV DNA levels and low alanine aminotransferase (ALT) levels. However, there are no clinical markers to accurately predict the true IT phase other than biopsy, and the long-term prognosis of these patients is unclear. In this study, we aimed to find the clinical factors that may help predict the true IT phase on histologic examination and investigate the long-term prognosis of these patients. Methods: This retrospective study included consecutive 276 patients who underwent liver biopsy with HBeAg-positive and high HBV DNA levels, ALT level less than 80 IU/mL and no evidence of clinically cirrhosis at three tertiary hospitals in Korea from 1994 to 2017. It was defined as a true IT phase when there is less than mild inflammation (□grade1) and mild fibrosis (□F1) by histopathological examination and the incidence of viral breakthrough (VB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC) were investigated. Results: Mean age of the patients was 42.5 ± 12.4 years and median ALT was 42 IU/mL [interquartile range (IQR) 31-56]. All of the patients had high HBV DNA, median DNA level was 1.8 x 108 copies (IQR 1.6 x 107- 8.5 x 108). Of the 276 patients who were clinically suspected of IT phase, only 85 patients (35.8%) were in true IT phase. Other biochemical factors including ALT did not predict the true IT phase. Of note, liver stiffness was the only predictor of the true IT phase after adjusting age, FIB- 4 score and APRI (adjusted odds ratio 1.35, 95% confidence interval 1.10-1.65, P=0.005). During observation period (median 103 months, IQR 51-145), VB occurred in 204 patients (73.9%), progressed to liver cirrhosis in 43 (15.6%), HCC in 17 (6.2%). In groups with ALT levels more than 2 times the upper limit of normal (≥50 U/ for female, ≥70 UL/L for male which was from recent AASLD guideline), the incidence of VB was significantly higher (P=0.006) than lower ALT groups. However, the incidence of LC or HCC was not significantly different between the two groups. Conclusions: For the prediction of the histologic IT phase, the liver stiffness value may be helpful in addition to the current standard of ALT. Also, it is necessary to lower the current pre-scription standards for antiviral agents, ALT 80.

Risk of Overestimation of Renal Function Using Estimated GFR in Patients with Liver Cirrhosis

( Jeong-juyoo ),( Sang Gyune Kim ),( Young Seok Kim ),( Bora Lee ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Young Don Kim ),( Gab Jin Cheon ),( Boo Sung Kim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: In the clinical context of the patients with liver cirrhosis, accurate evaluation of the renal function is potentially crucial. Serum creatinine (SCr) is widely used to estimate glomerular fitration rate (GFR), but discrepancy between measured GFR (mGFR) and estimated GFR (eGFR) in cirrhotic patients has not been evaluated yet. In this study, we compared performance of two common eGFR formula compared with mGFR, and evaluated factors associated with overestimation of renal function in cirrhotic patients. Methods: This retrospective study included consecutive 458 patients who were diagnosed as liver cirrhosis. 51Cr-EDTA was used for assessing actual GFR and eGFR was calculated by two different formulas; i) Modification of Diet and Renal Disease equation (MDRD), ii) CKD-EPI cystatin C equation. eGFR increase by more than 10% of mGFR in each patient was defined as overestimation of GFR. Sarcopenia was defined as an L3 skeletal muscle index of ≤38.5cm2/m2 for women and ≤52.4 cm2/m2 for men using computed tomography. Logistic regression was used to evaluate factors associated with overestimation of renal function. Results: Mean age of the patients was 53.6±11.5 years and 76.6% were male. Mean SCr was 1.1±0.9mg/dL, and the mean eGFR was 81.8±25.8ml/min by MDRD and 87.3±29.9ml/min by cystatin C. The mean mGFR was 76.0±26.6ml/min, which was significantly lower than eGFR. Cystatin C-eGFR showed better correlation and performance with mGFR compared with MDRD-eGFR (R 0.58 vs. R 0.48). MDRD-eGFR overestimated mGFR among 47% of the patients with liver cirrhosis. A multivariate analysis showed that male gender (hazard ratio [HR〕 1.63, 95% confidence interval [CI〕 1.03-2.56; P=0.04) and Child-Pugh class (HR 3.3, 95% CI 1.89-5.80; P<0.001) were independent risk factors associated with overestimation of renal function, but not associated with sarcopenia (HR 1.1, 95% CI 0.56-2.36; P=0.09). Conclusions: In patients with cirrhosis, overestimation of the GFR is common when using SCr and creatinine clearance. Isotopic measurement of GFR or eGFR by cystatin C rather than SCr can be more useful when greater accuracy is required, especially in patients with impaired liver function or male gender.