한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

공업계 고등학교 결손가정학생들의 진로선택에 관한 연구

정원곤,강일국 木浦大學校 敎育硏究所 2004 교육연구 Vol.16/17 No.-

The aim of this study is to offer basic information about personal counseling and educational guidance for broken home students in order to enlarge the understanding about them and protect them from a juvenile delinquent, so to grow up to a good youth by researching the present state of broken home students and the level of the satisfaction to a technical highschool choice and the view of their career choice, the degree of preparation for the future social life in school. The summary of study results is as follows; First, the research shows that 393 students (48.3%) among 813 students of 3rd grade of machine department in the technical highschool are broken home students, 420 ones (51.7%) has normal home. Second, in entrance to a technical highschool, the research shows that more than 70%(571 students) responded positive to their present school life. Third, In entrance to university, the survey revealed their high interest in it since 313 students (80.3%) responded positive to get a higher education, In preference to future career, 214 students(54.6%) prefer stable job to a large income job for the future (130 ones, 33.2%), which is related to the issue of unemployment after IMF periods. Fourth, the preparation for future social life being in school turned out relatively positive results.

이담자균 효모의 성분화 과정중 인지질의 작용과 배지조성의 제한이 성분화에 미치는 영향

정영기,강원대,남수완 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1

The action of phospholipid on the rhodotorucine A(Rh.A) acceptance by heterobasidiomyceteous yeast Rhodospori-dium toruloides mating type a cells and the effect of medium composition during sexual differentiation were investigated. Activation of trigger peptidase(TPase) was very sensitive to the originated phospholipid from R. toruloides and was more sensitive to phospholipid liposome made up of phospholipid. Phospholipid present on the membrane of mating type a cells consists of phospatidylglycerol(PG), phosphatidylethanolamine(PE), phospatidylcholine(PC), phospatidylinositol(PI), and phosphatidylserine(PS) of 12.9, suprisingly 45.4, 11.0, and 13.9%, respectively. As the result of using C-1 and N-1 mediums which limited C and N sources capable of inhibiting the synthesis of phospholipid. it resulted inhibiting sexual differentiation and production of Rh.A from mating type A cells.

슈프락스 캅셀 (세픽심 100 mg)에 대한 세피린 캅셀의 생물학적 동등성

정은주,강원구,권광일 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

Bioequivalence of two cefixime capsules, test drug (Cepirin^R capsule: Cheiljedang Corp.) and reference drug (Suprax^R capsule: Dong A Pharm. Com.), was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Sixteen healthy volunteers were divided randomly into two groups and administered the drug orally at the dose of 400mg as cefixime in a 2×2 crossover study. There was a 1-week washout period between the administrations. Blood samples were taken at predetermined time intervals for 12 hour and the plasma concentration of cefixime was determined with a HPLC method. AUC_0-12hr (area under the plasma concentration-time curve form time zero to 12 hour), C_max(maximum plasma drug concentration) and T_max (time to reach C_max) were estimated from the plasma drug concentration-time data. Analysis of variance (ANOVA) revealed no difference in AUC1-12hr, C_max and T_max between the formulations. The apparent differences of these parameters between the formulations were less than 20% (i.e., 8.62, 11.10 and 0.00% for AUC_0-12hr C_max and T_max, respectively). The powers (1-β) for AUC_0-12hr C_max and T_max. Were over 0.9. Minimal detectable difference (Δ) at α=0.05, 1-β=0.8 were less than 20% (i.e., 12.84, 11.05 and 17.99% for AUC_0-12hr C_max and T_max, respectively). The 90% confidence intervals(delta) for these parameters were also within ±20% (i.e., -0.53≤δ≤17.76. 3.23≤δ 18.97 and -12.81≤δ≤12.81 for ACU_0-12hr C_max and T_max, respectively). These results satisfied the criteria of KFDA guideline for bioequivalence, indicating the two formulations of cefixime were bioequivlent.

무형문화재 제도의 문제점과 개선책 : 예능종목을 중심으로 On the Performing Arts

강정원 서울대학교 비교문화연구소 2002 비교문화연구 Vol.8 No.1

This article aims to improve the policy for the intangible cultural heritage through analyzing various problems that are found in the designation and preservation process. The cultural property protection law in Korea was first promulgated, as Law No. 961 on January 10. 1962. It stated purpose was to ensure the traditional forms of Korean culture would be preserved or revitalized. It is normally recognized as active action for the preservation. However, I think it is a very passive policy that only protects intangible cultural heritages that were designated. To solve many problems of the intangible cultural heritage policy, the systematic studies of the traditional culture is needed. Secondly, in the modern education system the intangible cultural heritage must be transmitted from generation to generation. Thirdly, the mass media has to play a more significant role to protect it. Without these comprehensive efforts the traditional heritages of Korean culture will disappear before long.

세침 흡인술을 이용한 종창된 림프절의 세포학적 평가

백강현,윤기영,최호정,정성목,이영원,조성환,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

Fine needle aspiration(FNA) cytology is considered as the diagnostic technique of choice in the assessment of swellen lymph nodes. The aim of this study is to determine the indication and diagnostic method of FNA of lymph node lesions performed at Veterinary Medicine Teaching Hospital of Chungnam National University. The records of 16 patients which had undergone FNA during the study period were retrieved. The cytological results were classified as lymphadenitis, lymphoid hyperplasia and lymphoma. Lymphoma cases were classified as B-cell origin and T-cell by immunophenotyping. The result of the FNA cytological diagnosis showed that nine (56%) of the patients were lymphoma, five (31%) of the patients were lymphoid hyperplasia and two (13%) of the patients were lymphadenitis.

야쿠트 무복과 샤마니즘, 러시아 식민지배

강정원 서울대학교러시아연구소 2003 러시아연구 Vol.13 No.1

The pyrpose of this article is to understand firstly the symbol of the yakutian shman costume, secondly the relation between the Russian colonialism and yakutian culture through shman costume.In the studies of western anthropology siberian cultures seem to have no history and to have only shamanism that is not changed.I will argue that Saha-Yakut does have history and their shamanism is made in the historical process. Russian colonialism influenced the yakutian culture in many ways. Especially the shamanism was the main target of colonial politics and of the russian Orthodox Church.The yakutian shamanism is composed of white (ayy)and biack (abasy) shamanism .Under the Tsar regime the white shamanism was substityted for the Orthodox and the black shamanism was marginalized.In this process the shaman costume was almost burned out. Because the shaman costume constitutes the most important symbol of the shamanism,the yakut shaman was affected greatly.Now the young Yakut can not see the shaman costume in a ordinary shaman ritual.The shaman costume is exhibited only in the museum.The russiancolonialism succeeded in the elimination of the shaman costume till now, although the shamanism survived the attack of the soviet rebime and revived recently.

구리 나노접합 및 나노도선의 역학적특성에 관한 분자동력학 연구 : Classical Molecular Dynamics Simulation

강정원,황호정 중앙대학교 기술과학연구소 2000 기술과학연구소 논문집 Vol.30 No.-

본 연구에서는 구리 나노접합 및 나노도선의 역학적 특성에 관하여 분자동력학 방법을 사용하여 연구하였다. 사각형 및 원형의 나도도선 모두 길이 변형에 따라서 {100}면들은 {111} 면들로 변화되었다. {111} 면들로의 변화는 힘 이완(force relaxation)과정에서 slip 발생으로 일어났다. 사각형 나노도선의 경우가 원형의 나노도선의 경우보다 더 큰 변형과 더 큰 장력에서 항복이 발생되었다. We investigated the mechanical properties of Cu nanocontact and nanowires using a classical molecular dymanics simulation. Both rectangular and quasi-circular nanowires with {100}structure were transformed into {111}planes. A force relaxation makes {111}planes by slip occurrence. At the first yield, the strain and the tensile force in the case of rectangular nanowire were greater than that in the case of quasi-circular nanowire.

米麥混食이 Cholesterol 및 無機質代射에 미치는 影響

姜信英,孫延瑗,柳總根 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.1

This study was devised to investigate the effect of dietary fiber of barley on cholesterol metabolism and absorption of mineral on feeding either rice diets or barley mixed diets. Wistar albino rats were administered starch, rice, rice containing balrey by 10%, 30%, and 60% and barley diets for 2, 4, and 6 weeks. 1. Serum cholesterol level was higher in the rice diet group than in the barley diet group. In the meantime, fecal steroid content was highest in the barley diet group and decreased as the proportion of barley in diets became lower. 2. Correlation coefficient between the increase of fecal n-eight and the increase of fecal steroid content was 0. 988(p<0. 001). 3. Fecal Fe and Ca content was net affected by the extent of barley and rice in diets. But fecal Ka and K content was high in the barley diet group. 4. Fecal weight and fecal moisture content was highest in the barley diet group, and became lower in the diet group where barley was added in smaller proportion. The increase of fecal weight was significantly related with the increase of fecal water content(r=0.918, p<0.001). 5. Serum lipid level was lower in the diet group containing more barley than in the rice diet group. In contrast, focal lipid content was highest in the barley diet group, and decreased in proportion to the decrease of barley addition in diets. 6. Accumulation of adipose tissue was observed In the rice diet group, 2nd the more barley mixed in diets, the lower it was. 7. Length of small intestine was longer in the barley diet group than in the rice diet group.