유방통을 호소하는 한국 여성에서 Gamma Linolenic acid의 임상적인 효과

정재헌,김권천,조현진,민영돈,김성환,김정용,장정환 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background and Objectives : Recently, the incidence of breast cancer is gradually increasing in korea. Many patients visit the hospital with a fear of breast cancer, if she had the pain in her breast. But Breast pain is not a cardinal sign of breast cancer. Only 7% of patient in breast cancer has breast pain. Materials and Method : To know the clinical effects of gamma-linolenic acid(GLA), we analyzed the medical records of 55 cases with breast pain, who visited the outpatient clinic of Chosun university hospital, between July of 1999 to December of 1999. Of the 55cases of breast pain, we analyzed 26 cases of patient with breast pain who was treated with GLA for 2 month and we excluded patients of breast pain who had breast mass or were treated with other drug. Results : 2 Patients we are dropped out because nausea and vomiting were developed, 4 Patient with breast pain were treated with GLA for 1 month, and relieved completely from mastalgia and 8 patients with breast pain were treated with GLA for 2 months and breast pain was relieved completelys. 4 patient had treatment for 2 months, were relieved slightly. But 8 patients with breast pain didn't reveal the relief of symptom after the intake of GLA. Conclusion : We conclude that GLA could be considered a first line drug in patients with mastalgia.

결장직장암 환자의 임상적 고찰 : 조선대학교 부속병원의 10년 간의 결과

나은종,문성표,장정환,김권천,민영돈,김성환,조현진,김정용,김경종 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives: The colorectal cancer rates 4th in the total cancer prevalence in Korea. The clinical patient demographics were considered with the incidence rate of the colon and rectal cancer. The clinicopathological factors were analyzed for the 5 year survival rate. Materials Methods: Of the 282 patients who were operated from Jan. 1, 1992 to Dec. 31, 2001 and diagnosed by pathological biopsy as colo-rectal cancer, 234 patients were followed up. The age, sex, location of the cancer, TNM stage, operation method, histopathological classification, metastatic region, complications after operation and the survival rate were investigated. Results: Of the 234 patients, male and female consisted of 120 cases (51.3%) and 114 cases (46.7%), with an average age of 61.6 years. The average follow up period was 52.3 months and the peri operative mortality was 5.6%. The site of the cancer was most frequent at the rectum with 127 cases (54.3%). The patients were classified according to the TNM stages with 38 cases of stage 1 (16.2%), 98 cases of II (41.9%), 72 cases of III (30.8%) and 26 cases of IV (11.1%). The 5 year survival rate in the age group older than 50 was 63.3 % and 73.5% in the group younger than 50. In regard to the operation type, the 5 year survival rate was 65.4% for elective operation and 65.8% for emergency operation. The 5 year survival rate for well differentiated, moderately differentiated, poorly differentiated cancer, and mucinous adenocarcinoma was 73.7%, 60.2%, 58.3%, and 92.6%, respectively. The 5 year survival rate of each of the TNM stage is 81.1%, 74.8%, 57.0%, and 11.5% for Classes I, II, III, and IV, respectively. Conclusion: The clinical factors were analyzed for the 5 year survival rate with no statistical significance for the age, sex, and location of the cancer. The TNM stage and histopathological differentiation were statistically significant. The colon cancer showed better prognosis compared to the rectal cancer.

위암의 근치절제술 후 생존율과 예후인자

차윤정,박진영,장정환,김성환,김권천,조현진,민영돈 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

Background and Objectives: Gastric cancer is still the leading cause of cancer death in Korea, and surgery remains the only method of treatment that offers the potential for a cure. Purpose: The aims of this study are to examine the outcome of the patients with gastric adenocarcinoma who underwent curative resection and to identify the prognostic factors leading to improved survival rates in these patients. Materials and Methods: The medical records of 278 patients with gastric adenocarcinoma, treated curatively at the Chosun University Hospital between January 1990 and December 1994, were reviewed retrospectively from January 2000 to March 2000. Follow-up was obtained for 250 patients(89.9%). The survival rates were calculated by the Kaplan-Meier method, and the significance of differences between patient factors(age and sex), tumor factors(location, size, gross type, tumor depth, lymph node metastasis, and stage) and treatment factors(operation method and reconstruction type) were evaluated statistically by the log-rank test. Results: The overall five-year survival probability was 59.6%. There was no survival difference according to age and sex. The 5-year survival rates according to the tumor depth were 97.0% for Tl, 74.5% for T2, 39.6% for T3, and 23.1% for T4(p=0.0000); to the lymph node metastasis were 81,4% for N0, 51.9% for N1, and 21.2% for N2(p=0.0000); to the TNM stage were 96.7% for stage I a, 79.5% for stage I b, 68.8% for stage II, 52.9% for stage III a, 25.9% for stage III b, and 7.5% for stage IV(p=0.0000). Other statistically significant differences were shown in tumor location, size, gross type, operation method, and reconstruction type after subtotal gastrectomy. Conclusion: The most definitive prognostic factors affecting the survival rate of gastric adenocarcinoma were tumor depth, lymph node metastasis, and tumor stage. The keys to successful outcome includes early diagnosis and curative resection with radical lymph node dissection at early stage as possible.

The Comparison between Human Hertwig`s Epithelial Root Sheath Cells and Periodontal Ligament Stem Cells

( Hyun Nam ),( Hyun Jeong Kweon ),( Soo Yeon You ),( Dae Hyun Jeon ),( Jae Jin Cho ),( Gene Lee ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4

It is well known that the interactions between epithelial and mesenchymal components are very important event for tooth development, and their coordination is crucial to tooth development. Recently it has been reported that human PDLSC might be a mesenchymal component for regeneration of periodontal tissue. In contrast, characteristics of human HERS cells and their roles in development and regeneration of tooth are not well elucidated. In this study, we investigated the phenotypes and the differentiation potentials of human HERS cells and PDLSCs. First of all, we simultaneously isolated human HERS cells and PDLSCs from the same periodontal ligament tissues. Hence we established the method for primary isolation of human HERS cells and PDLSC at the same time. Human HERS cells and PDLSCs showed different cell morphology and growth patterns from each other. In particular, human HERS cells showed epithelial cell-like morphology, while human PDLSCs showed fibroblast-like morphology. In the immunophenotype analysis of cell surface markers, human PDLSCs were positive for the mesenchymal stem cell markers but human HERS cells showed different expressions. Human PDLSCs were able to differentiate into osteoblasts and adipocytes by appropriate induction. On the other hand, human HERS cells acquired mesenchymal phenotypes by TGF-β1 through EMT. Taken together, our data suggest that human HERS cells and PDLSCs might play a role as a epithelial component or a mesenchymal component for the tooth regeneration,v respectively.

배추좀나방과 담배거세미나방 유충에 대한 한방식물체의 살충활성 및 섭식저해활성

Jeong Hyun Kweon,Young Joon Ahn,Hyung Wook Kwon,Kyung Soo Jang,Kwang Yun Cho 한국응용곤충학회 1994 한국응용곤충학회지 Vol.33 No.4

배추좀나방과 담배거세미나방 유충에 대한 30종 한방 식물체 메탄올 조추출몰의 살충활성 및 섭식 저해활성을 잎침지법을 이용하여 5,000ppm으로 검정하였다. 황련의 추출물은배추좀나방에 대해 살충작용을 보였다. 길경, 사삼, 세신, 오배자 및 자초의 추출물은 배추좀나방 유충에 대해, 목통 및 속새의 추출물은 담배거세미나방 유충에 대한 강한 섭식저해활성을 보였으나, 오배자와 황련의 추출물은 이들 나비목 유충 모두에 강한 섭식저해활성을 나타내었다. The methanol extracts from 30 species of oriental medicinal plants belonging to 24 families were tested for their lhicidal and antifeeding activit~es against diamondback moth (Plutello xylostella L) and tobacco cutworn (Spodoptera litura F.) by a leaf-dipping method at a concentration of 5, 000 ppm. The methanol extract from Copti chinensis only showed a potent larvicidal activity against P xylostello. Strong antifeeding activity against P. xylostello was observed from the extmds from Platycodon grandiflorurn, Codonopsis pilosula, Asomm sieboldii, Rhus chinensis and Uthospermum erythrorhizon And a potent antifeeding activity against S. liturn was obtained from Akebia quinata and Equlsetum hyemale extracts. A significant antifeeding activity against both species was obtained from R chinensis and C. chinensis extracts.

신장이식술을 받은 여성의 산과적 예후

이현정(Hyun Jung Lee),이지현(Jee Hyun Lee),배정훈(Jeong Hoon Bae),정선영(Sun Young Jeong),안현영(Hyun Young Ahn),권인(In Kweon),신종철(Jong Chul Shin),나종구(Jong Gu Ra),김수평(Soo Pyung Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.7

Objective : To evaluate the outcome of pregnancy in kidney transplanted women, and correlate this with the time of transplantation to conception. Material and Methods : We analyzed the outcome of 31 pregnancies from 21 allograft recipients at Kangnam St. Mary`s Hospital, Catholic Medical Center from January 1990 through December 2000. For each reported pregnancy we reviewed obstetrical, medical and pediatric records. For children follow-up and for those whose obstetric procedures were taken in other hospitals, we did a questionarie and telephone interviews. Results : Of the 31 pregnancies followed by us, there were 23 live-born offspring delivered by 21 mothers and 8 stillborn/abortuses, including five artificial abortuses. The mean gestational age at delivery was 36.18±0.6 weeks and the mean birth weight of the offspring was 2,525±137gm. Only 43.4% was delivered after 37weeks of gestation. Preterm delivery rate (delivered before 37weeks of gestation) was 56.5%. Common obstetric complications were intrauterine growth restriction (39.1%) preterm labor (35%), premature rupture of membrane (30%), preeclampsia (30%), and maternal complications were deterioration of renal function (5%) and rejection of allograft (18%) after delivery. Mean interval from transplantation to pregnancy was 4.7 years. Twelve pregnancies occurred within the first 2 years of transplantation, while 19 pregnancies occurred after that period. No difference was noted in neonatal body weight between 2 groups (p=0.824). There was no difference in mean interval from transplantation to pregnancy in the delivery group (5.21±0.9 years) vs. the abortion group (4.57±1.1 years) (p=0.207). All women continued with her medication during pregnancy, based on cyclosporine and/or azathioprine and steroids. No congenital anomaly was noted in the newborn. When follow up lately, one boy with neurofibromatosis and a girl with recurrent hematuria were noted. Conclusion : Although pregnancy in renal allograft patient is hazardous, good outcome can be expected if function of the allograft is good before conception.

임신성 융모성 질환에서 혈청 β-hCG 의 소실기간과 양상에 관한 연구

강정권(Jung Kweon Kang),구인상(In Sang Ku),차진영(Jin Young Cha),김현희(Hyun Hee Kim),김영재(Young Jae Kim),이유석(Yoo Seock Ree),배은경(Eun Kyung Bae),나영정(Young Jeong Na),김경태(Kyung Tai Kim),조수현(Soo Hyun Cho),조삼현(Sam Hyun 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.4

Objectives : It is now conventional practice to use human chorionic gonadotropin (hCG) as the marker of tumor activity in gestational trophoblastic disease (GTD). The interpretation of serial serum β-hCG regression patterns is important in monitoring the course of the disease. The purpose of this study was to establish a regression time and pattern of the serum β-hCG in which GTD is divided into hydatidiform mole and malignant trophoblastic disease. Materials & Methods : During the period from January 1990 through December 2000, 46 patients with GTD were histopathologically diagnosed and treated at the department of Obstetrics and Gynecology in Hanyang University Hospital. For the purpose of analysis and comparison, patients were divided into 19 cases of hydatidiform mole and 27 cases of malignant trophoblastic disease which was subdivided into nonmetastatic (17) and metastatic (10). Patients were followed clinically and by weekly estimations of quantitative serum β-hCG until negative (<3 mIU/ml). After three consecutive negative β-hCG, serum β-hCG were drawn monthly in all patients for one year. The level of serum β-hCG was detected by two-site sandwich immunoassay (Chiron Diagnostics Automated Chemiluminescence System 180). The obtained data were analyzed using t test and ANOVA test by SPSS. Results : The incidence of the GTD compared with delivery was one per 182.7 deliveries. The mean value of serum β-hCG regression time in hydatidiform mole was 12.8±1.1 (SEM) weeks (7.0-26.0 weeks) and 17.9±1.4 (SEM) weeks (8.0-34.0 weeks) in malignant trophoblastic disease. The regression time was significantly shorter in hydatidiform mole than that of malignant trophoblastic disease (P<0.01). The differences of mean value of serum β-hCG regression time between the groups with nonmetastatic (18.0 weeks) and metastatic (17.8 weeks) were not statistically significant(P =0.946). The mean values of serum β-hCG in both hydatidiform mole and malignant trophoblastic disease declined following a log-normal distribution. Conclusions : The regression pattern of serum β-hCG in present study was similar to that of which in Western and also similar to that of which in Korea in 1980s. The present study supports the continued use of individual patients serum β-hCG regression curve to make treatment decision and to recognize malignant trophoblastic disease promptly.

Elbow의 Superficial Radial Nerve에 발생한 결절종 1례 보고

권석현,김동철,김정우 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.2

Effect of Surface Morphology on Dimerization of tert-Butyl Mercaptan on the Surface of Amorphous Aluminosilicate Impregnated with Mn and Cu

Kweon, Jeong-Eun,Joo, Hyun-ha,Park, Dong-Gon Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.1

A powder of destructive adsorbent was prepared by impregnating Mn and Cu on the surface of amorphous aluminosilicate. It catalytically dimerized tert-butyl mercaptan into di-tert-butyl disulfide on its surface. Turnover of the dimerization was strongly dependent on the surface morphology of the adsorbent, which could be altered by modification of aluminosilicate support. During the process of impregnation, which involved heat treatment at 500 ${^{\circ}C}$, the shape of the pore was preserved, though large fraction of micropores were eliminated. The reactive sites on the surface were poisoned as dimerization products strongly adhered on them. Therefore, high surface area was not always desirable. When the surface was heavily populated with “inkbottled” pores with a narrow entrance in uniform size, heavy poisoning of the reactive sites turned the destructive adsorbents almost useless.

소규모 아파트의 욕실공간의 이용실태

권지현,김정,송남희,이윤정,정은옥 연세대학교 생활과학대학 1993 婦學 Vol.26 No.-

우리나라 소규모 아파트 거주자의 욕실 실태를 조사한 결과, 욕실은 생리 위생 행위뿐 아니라 세탁, 야채씻기 등 가사 노동 행위에도 적극적으로 이용되고 있었다. 그러므로, 이들을 수용해 줄 수 있는 공간의 확보가 필요하다. 욕실 기존의 설비-세면대, 양변기, 욕조-가 반드시 있어야 한다는 고정 관념에도 불구하고 실제 사용에 있어서는 많은 사람들이 전통적인 생활 양식을 고수하고 있음을 알 수 있었다. 따라서 꼭 이러한 설비가 있어야 한다는 생각을 지양하고 우리의 생활 양식을 고려한 융통적인 계획이 이루어져야 한다. 욕식에서의 세탁이나 야채 씻기 등의 가사 노동 행위시 많은 주부들이 공간의 부족을 지적했는데, 이를 위해 욕조의 형태와 크기에 대한 변화가 요구된다. 특히 아파트 설계시 욕조의 시설 여부를 선택 사양으로 하는것도 생각해 볼수 있는 문제이다. 욕실에서 이루어지는 가사 노동 행위의 특징은 물을 사용한다는 것인데, 욕실 내의 수도전은 이에 대한 고려가 전혀 되어있지 않다. 따라서, 이러한 행위 특징이에 부합되는 위치에 수도전의 설치가 필요하다.