산국 (Chrysanthemum boreale) 휘발성 추출액 및 EDTA가 미생물 및 인체 치은 섬유아세포에 미치는 영향

차정단,김태영,우원홍,전병훈,김해경,유용욱,김강주,길봉섭 원광대학교 생체재료·매식연구소 2000 원광생체재료·매식 Vol.9 No.1

Chrysanthemum boreale (C. boreale) has been used for the treatment of furuncles, carbuncles, sores, conjunctivitis, headache, vertigo and swollen throats as a folk medicine in Korea, but there is little report about experiment evidence of antimicrobial activity. To investigate the antifungal and antibacterial activity of Chrysanthemum boreale(C. boreale) volatile substance and EDTA, the growth inhibition against Aspergillus nidulans (A. nidulans), Fusarium oxysporum (F. oxysporum), Alternaria mali(Al. mali), Candida albicans (C. albicans), staphylococcus aureus (S. aureus), Streptococcus pyogenes(S. pyogenes), streptococcus mutans (S. mutans), Escherichia coli(E. coli), Helicobacter pylori (H. pylori) and Porphyromonas gingivalis (P. gingivalis) was monitored by agar dilution and broth microdilution method. The antifungal effect of C. boreale on A. nidulans, F. oxysporum, Al. mali and C. albicans was shown at the concentration of 0.04%. The antibaterial effect of C. boreale on S. aureus, S. pyogenes, S. mutans and H. pylori was shown at the concentration of 0.04%. However, the growth was inhibited at the concentration of 0.04% irrespective of the presence of EDTA 0.125% was much higher than higher than that of several concentration of volatile substance. The minimum inhibitory concentrations of volatile substance were 0.16% against S. aureus, 0.04% against S. pyogenes, 0.02% against S. mutans, 0.40% against E. coli, and 0.18% against C. albicans. The growth of human gingival fibroblasts was not affected by C. boreale volatile substances at the concentration of 0.04%. These results indicate that volatile substance from C. boreale may have biologically toxic activities to the microorganisms.

Image Evaluation of CT Brain Angiography by Changes of Injection Rate of Saline

Jeon-Yeong Kang(),Seong-Hwan Kim(),Jeong Dan Kim(),In-Suk Lee() 대한CT영상기술학회 2019 대한CT영상기술학회지 Vol.21 No.1

목적: CT Brain angiography 의 정확한 진단을 위해 정맥상을 감소시키기 위한 방법으로 조영제 주입 후 chaser 역할을 하는 saline 의 주입속도를 변화시켜 최대한 뇌동맥에만 조영증강이 되는 영상을 찾고자 한다. 대상 및 방법: 2018년 3월부터 6월까지 본원에서 CT Brain angiography 를 시행한 환자 118명을 대상으로 A(남자 23명, 여자 36명, 평균연령 55.2세), B(남자 23명, 여자 36명, 평균연령 58.2세) 두 그룹으로 나눠 saline의 주입속도를 5ml/s 와 2ml/s 로 변화시켜 검사를 진행하고 영상의 상시상정맥동 Hounsfield Unit(HU) 측정값으로 영상을 평가한다. 결과: 상시상정맥동 HU 측정은 A(5ml/s)군의 평균 139.9 HU(81~260 HU)로 측정되었고 B(2ml/s)군은 평균 114.8 HU(71~194 HU)으로 측정되었다. A군에 비해 B군에서 18% 감소되었다. A군과 B군의 상시상정맥동의 HU 측정값을 독립 T검정을 사용한 결과 유의확률 p<0.001 이므로 통계적으로 유의하였다. 결론: 일반적인 angiography에서의 chaser saline은 조영제의 사용량을 줄이고 다소 늘어질 수 있는 artery phase를 감소시키기 위해 조영제와 같은 속도로 주입하지만, brain쪽은 angiography에서는 오히려 vein phase를 빠르게 포함시켜 영상의 질을 저해한다. 그리하여 이번 검사 방법에서는 chaser saline 주입속도를 감소시켜 CT brain angiogram 에서 불필요한 정맥상을 감소 시켜 영상의 질을 높이고, 진단의 용이함을 도울 수 있었다. Purpose: In order to accurately diagnose CT Brain angiography, we want to find images that increase contrast only to the cerebral artery as much as possible by changing the injection speed of saline, which acts as a chaser after injecting the contrast agent, in order to reduce the venous phase. Material and method: From March to June, 2018, 118 patients who underwent CT Brain angiography were divided into two groups, A and B, and the infusion flow rate of saline was changed to 5 ml / s and 2 ml / s. The angiogram is evaluated with the Hounsfield Unit (HU) measurement of the normal phase of the superior sagittal sinus. Result: Group A(5 ml/s) averaged 139.9 HU, and group B(2 ml/s) was measured at an average of 114.8 HU, down 18% from group B compared to group A. Conclusion: The reduction of saline infusion flow rate could reduce unnecessary venous phase in CT brain angiography. As a method for acquiring proper images, we need to think about the method of change of saline as well as the importance of the contrast agent that we generally think.

Silicone implants capable of the local, controlled delivery of triamcinolone for the prevention of fibrosis with minimized drug side effects

Jeon, Beom Su,Shin, Byung Ho,Huh, Beom Kang,Kim, Byung Hwi,Kim, Se-Na,Ji, Han Bi,Lee, Seung Ho,Kang, Soo Im,Shim, Jung Hee,Kang, So Min,Lee, Jae Chul,Lee, Kyu Sang,Heo, Chan Yeong,Choy, Young Bin Elsevier 2018 Journal of industrial and engineering chemistry Vol.63 No.-

<P><B>Abstract</B></P> <P>We propose silicone implants capable of the local, controlled release of a glucocorticoid drug, triamcinolone acetonide (TA), for the prevention of fibrosis. The shells of these silicone implants were coated with two different loading amounts of TA, which could release the drug in a sustained manner for 12 weeks. The drug-loaded implants were inserted into the subcutaneous space in living rats, and the tissues were biopsied at scheduled times during 12 weeks. For the drug-coated implants, the capsule thickness and collagen density decreased compared with those of the non-coated implant. Because of the effect of TA, inflammation and the expression of pro-inflammatory cytokines were downregulated, thereby decreasing the number of monocytes during acute inflammation. This effect in turn decreased the number of macrophages at the later stage of inflammation, leading to the expression of less TGF-β and consequently fewer fibroblasts and myofibroblasts. Our findings also revealed that with an appropriate dose control, skin and muscle atrophy, major side effects of TA, could be avoided while still effectively reducing fibrosis. Therefore, we conclude that the local, sustained release of an appropriate dose of a glucocorticoid drug can be a promising strategy for safely preventing fibrosis around silicone implants.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Dosimetric evaluation of magnetic resonance imaging-guided adaptive radiation therapy in pancreatic cancer by extent of re-contouring of organs-at-risk

Jun Yeong Song(Jun Yeong Song),Eui Kyu Chie(Eui Kyu Chie),Seong-Hee Kang(Seong-Hee Kang),Yeon-Jun Jeon(Yeon-Jun Jeon),Yoon-Ah Ko(Yoon-Ah Ko),Dong-Yun Kim(Dong-Yun Kim),Hyun-Cheol Kang(Hyun-Cheol Kang) 대한방사선종양학회 2022 Radiation Oncology Journal Vol.40 No.4

Purpose: The safety of online contouring and planning for adaptive radiotherapy is unknown. This study aimed to evaluate the dosimetric difference of the organ-at-risk (OAR) according to the extent of contouring in stereotactic magnetic resonance image-guided adaptive RT (SMART) for pancreatic cancer. Materials and Methods: We reviewed the treatment plan data used for SMART in patients with pancreatic cancer. For the online contouring and planning, OARs within 2 cm from the planning target volume (PTV) in the craniocaudal direction were re-controlled daily at the attending physician's discretion. The entire OARs were re-contoured retrospectively for data analysis. We termed the two contouring methods the Rough OAR and the Full OAR, respectively. The proportion of dose constraint violation and other dosimetric parameters was analyzed. Results: Nineteen patients with 94 fractions of SMART were included in the analysis. The dose constraint was violated in 10.6% and 43.6% of the fractions in Rough OAR and Full OAR methods, respectively (p = 0.075). Patients with a large tumor, a short distance from gross tumor volume (GTV) to OAR, and a tumor in the body or tail were associated with more occult dose constraint violations—large tumor (p = 0.027), short distance from GTV to OAR (p = 0.061), tumor in body or tail (p = 0.054). No dose constraint violation occurred outside 2 cm from the PTV. Conclusion: More occult dose constraint violations can be found by the Full OAR method in patients with pancreatic cancer with some clinical factors in the online re-planning for SMART. Re-contouring all the OARs would be helpful to detect occult dose constraint violations in SMART planning. Since the dosimetric profile of SMART cannot be represented by a single fraction, patient selection for the Full OAR method should be weighted between the clinical usefulness and the time and workforce required.

바이오 가스 생산을 위한 미세조류 바이오매스로서의 Dunaliella salina

전나영 ( Na Yeong Jeon ),김대희 ( Dae Hee Kim ),안준영 ( Jun Yeong An ),김태영 ( Tae Young Kim ),김근호 ( Geun Ho Gim ),강창민 ( Chang Min Kang ),김덕진 ( Duk Jin Kim ),김시욱 ( Si Wouk Kim ),장인섭 ( In Seop Chang ) 한국미생물생명공학회(구 한국산업미생물학회) 2012 한국미생물·생명공학회지 Vol.40 No.3

본 연구는 혐기성 소화조에서 바이오 가스 생산을 위한 바이오매스 자원으로서 Chlorella vulagaris와 Dunaliella salina의 이용능력을 확인하였다. 세포벽의 구조에 따라 전처리 후 용해성 물질의 수율이 영향을 받았는데, 이는 D. salina가 바이오 가스 생산 측면에서 C. vulgaris보다 좋은 후보라는 것을 보여준다. 혐기성 소화조에서 얻은 접종원으로부터 전처리하거나 전처리하지 않은 D. salina를 기질로서 메탄가스를 생산하는데 이용하였을 때 메탄 수율 측면에서 큰 차이가 없었다. 그러므로 D. salina는 높은 바이오매스 생산성, 단순한 전처리 필요성, 쉬운 바이오 가스전환 때문에 바이오 가스 생산을 위한 적합한 해조류 바이오매스이다. In this study, the ability of Chlorella vulgaris and Dunaliella salina to use biomass resources for anaerobic digestive biogas production was examined. The differences in cell wall structure pretreatments affecting the yield of soluble products showed that D. salina is a better candidate for biogas production than C. vulgaris. There was no significant difference between pretreated and non-pretreated D. salina in terms of methane production yield by inocula obtained from anaerobic digestion systems. Therefore, D. salina is a suitable algal biomass for biogas production due to its high biomass productivity, simple pretreatment needs, and easy con-version to biogas.

Development of Local Stem Volume Table for Pinus rigida Miller by the Best Stem Taper Equation

Jin-Taek Kang,Sun-Jeoung Lee,Ju-Hyeon Jeon,Yeong-Mo Son,Hyun Park,Hyun-Shik Moon 경상대학교 농업생명과학연구원 2015 농업생명과학연구 Vol.49 No.6

This study was conducted to develop local stem volume tables reflecting the local growth pattern and climate condition using stem taper equations for Pinus rigida. We developed the local stem volume table for P. rigida, which is the widely planted species following Pinus denisflora and Larix kamepferi in South Korea. Three Functions of Max & Burkhart, Kozak and Parresol et al. were applied and compared to derive the most suitable taper function. Their suitability was statistically analyzed by using the Fitness Index, Bias and Standard Error of Bias. The result showed that there was a significant difference in all three functions, and the Fitness Index of the Kozak’s function was the highest among the three functions for estimating the tree growth pattern of P. rigida. Therefore, the Kozak’s function was chosen for generating stem taper equation and local stem volume tables for P. rigida. The developed stem volume tables of each region were compared to the standard stem volume table that was driven by the data of tree growth obtained throughout the nation. The result showed that the local stem volume table was higher than standard volume tables in two regions of Muju and Boeun. There was a statistically significant difference (p<α=0.05), but there was no significant (p >α=0.05) between the local stem volume.

간호학 전공 대학생의 임상 실습 관련 교육 어플리케이션에 대한 사용의도의 영향요인에 대한 연구

조윤정,김영순,박계영,김혜림,최일향,강보영,백진아,정수진,전영지,정연주 이화여자대학교 간호과학대학 2015 이화간호학회지 Vol.- No.49

Purpose: This study examined perceptions and intentions of nursing undergraduates to use educational mobile applications for clinical nursing-practice training. Methods: Participants were 189 junior and senior nursing undergraduates from 14 Korean universities, experienced in clinical practice and educational nursing mobile applications. Using a convenience sampling method, the questionnaire was Sim’s Perceptions and Intentions tool. Statistical analyses were conducted by t-test, one-way ANOVA, correlation, and multiple regression analysis with SPSS 22.0 Windows software. Results: Statistically significant differences emerged between those who used smartphones for more than 4 hours (18.56 ± 4.58) and less than 2 hours (15.84 ± 4.35) per day (F = 3.25, p = .041). Perception and intention of educational-applications use correlated positively (r = .723, p < .001). Performance expectancy (β = .225, p = .002), attitude toward technology (β = .446, p < .001), facilitating condition (β = .132, p = .022), and self-efficacy (β = .168, p = .008) were statistically significant predictors of intention to use educational mobile applications (Adjusted R2 =.616, p < .001). Conclusion: Attitude toward using technology, performance expectancy, and self-efficacy will improve use of nursing educational mobile applications for clinical nursing-practice training. Developers should consider students’ experience in clinical-nursing practice and readiness to use mobile technology.

Electrical Conductivity Evaluation Techniques for Superalloy Single-Crystal Steel

Kang Jeon-Hong,Yu Kwang Min,Lee Sang Hwa,Nahm Seung Hoon,Park Jae Yeong 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.2

Superalloy single-crystal steel grade is a material for high-temperature gas turbine parts and is essential for preventing explosion accidents caused by high temperature and heat. To establish an infrastructure and a database for the characterization of gas turbine core materials, tests for thermal, mechanical, and electrical properties are required. The required thermal property tests include thermal conductivity, specific heat, and thermal expansion coefficient tests. The mechanical tests include tensile tests at room and high temperature and fatigue tests. The electrical tests include conductivity tests; also, in this study, various measurement methods were used to compare and evaluate the reliability of the evaluation results for the conductivity test. The conductivity was compared and evaluated using five methods, namely, the four-terminal, direct current comparator resistance bridge, four-point probe, van der Pauw, and eddy current. The conductivity obtained was 1.210% International Annealed Copper Standard (IACS), and the measured values for the five methods agreed with each other within 0.1% or less, with a measurement uncertainty of about 0.2% to 0.6% or less within a 95% confidence level.

Synthesis and Characterization of Conjugated Polymers based on Polyaromatic Compounds for organic electronics

Yeong-A Kim,Ye-Jin Jeon,Minji Kang,Soo-Young Jang,In-Bok Kim,Dong-Yu Kim 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2

Effect of solution temperature on the mechanical properties of dual-cure resin cements

Kang, En-Sook,Jeon, Yeong-Chan,Jeong, Chang-Mo,Huh, Jung-Bo,Yun, Mi-Jung,Kwon, Yong-Hoon The Korean Academy of Prosthodonitics 2013 The Journal of Advanced Prosthodontics Vol.5 No.2

PURPOSE. This study was to evaluate the effect of the solution temperature on the mechanical properties of dualcure resin cements. MATERIALS AND METHODS. For the study, five dual-cure resin cements were chosen and light cured. To evaluate the effect of temperature on the specimens, the light-cured specimens were immersed in deionized water at three different temperatures (4, 37 and $60^{\circ}C$) for 7 days. The control specimens were aged in a $37^{\circ}C$ dry and dark chamber for 24 hours. The mechanical properties of the light-cured specimens were evaluated using the Vickers hardness test, three-point bending test, and compression test, respectively. Both flexural and compressive properties were evaluated using a universal testing machine. The data were analyzed using a two way ANOVA with Tukey test to perform multiple comparisons (${\alpha}$=0.05). RESULTS. After immersion, the specimens showed significantly different microhardness, flexural, and compressive properties compared to the control case regardless of solution temperatures. Depending on the resin brand, the microhardness difference between the top and bottom surfaces ranged approximately 3.3-12.2%. Among the specimens, BisCem and Calibra showed the highest and lowest decrease of flexural strength, respectively. Also, Calibra and Multilink Automix showed the highest and lowest decrease of compressive strength, respectively compared to the control case. CONCLUSION. The examined dual-cure resin cements had compatible flexural and compressive properties with most methacrylate-based composite resins and the underlying dentin regardless of solution temperature. However, the effect of the solution temperature on the mechanical properties was not consistent and depended more on the resin brand.