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Kim, Yu Jeong,Lee, Hyun Ju,Ryu, Jin Suk,Kim, Yun Hee,Jeon, Saewha,Oh, Joo Youn,Choung, Ho Kyung,Khwarg, Sang In,Wee, Won Ryang,Kim, Mee Kum Masson Pub. USA 2018 Cornea Vol.37 No.1
PURPOSE:: To investigate the efficacy and safety of transplantation with biomaterial-free cultured oral mucosal epithelial cell sheets (COMECs) for ocular reconstruction in subjects with total limbal stem cell deficiency. METHODS:: A prospective clinical trial (NCT02149732) was conducted in 8 subjects with total limbal stem cell deficiency after approval from the institutional review board of Seoul National University Hospital (H-0707-043-213) and the Ministry of Food and Drug Safety of Korea. COMECs were prepared in a culture system without the use of any temperature-sensitive polymers or carriers. The COMECs were transplanted without suture fixation. Four subjects underwent penetrating keratoplasty after stabilization of the COMEC transplant. Stable epithelialization, changes in visual acuity, and postoperative complications were evaluated for 6 months. Corneal cytokeratins (K) of 4 subjects who underwent penetrating keratoplasty were stained with an immunofluorescent agent. RESULTS:: The ocular surface was successfully reconstructed in 6 eyes. Complete stable epithelialization was achieved within a mean of 53.6 days. Visual improvement (≥2 lines) was achieved in 62.5% of the eyes. K12 (corneal phenotype), K4, and K13 (mucosal phenotype) were well expressed in grafts after keratoplasty, whereas K1, K8, and K19 were barely expressed. No ocular infections, local tumor formation, or remarkable systemic complications were observed. Ocular reconstruction using COMECs failed in 2 eyes, which had full symblepharon in 4 quadrants. CONCLUSIONS:: Transplanting biomaterial-free COMECs seems to be an efficient and safe procedure to reconstruct the ocular surface in patients who are completely limbal stem cell deficient without a full symblepharon.
Sung-Min Rhee,Yun Hee Kim,Joo Hyun Park,Hyun Jang Jeong,Jikhyon Han,Saewha Jeon,Joo Han Oh 대한견주관절의학회 2021 대한견주관절학회 학술대회논문집 Vol.2021 No.3
Introduction and Background The purpose of this study was to compare the efficacy between allogenic dermal fibroblasts (ADFs) and platelet-rich plasma (PRP) for the tendon-to-bone healing in a rabbit model of a chronic rotator cuff tear. Material and Method A total of 32 rabbits were randomly allocated into four groups (n=8 each). In two groups, torn supraspinatus tendons which were detached and left for 6 weeks were repaired in a transosseous manner with the injection of 5x10<sup>6</sup> ADFs with fibrin on left shoulder and PRP with fibrin on right shoulder (Figure 1 and 2). The expression (relative ratio to control) of genes including type 1 collagen (COL1), type 3 collagen (COL3), bone morphogenic protein-2 (BMP-2), scleraxis (SCX), SOX9, and aggrecan (ACAN) was assessed at 4 weeks (Group A), and at 12 weeks (Group B) after repair. Same surgical procedures were performed with ADFs injection on both shoulder in Group C, and PRP injection in Group D for the histological and biomechanical evaluations of tendon-to-bone healing at 12 weeks after repair, Results Seven rabbits died before the evaluation (Group A,B,C,D;n=2,1,2,2, respectively). At four weeks after repair, mRNA expression of COL1 and BMP-2 was higher in ADFs injected shoulders (1.6±0.8 and 1.0±0.3, respectively) than PRP injected shoulders (1.0±0.3 and 0.6±0.3; p=0.019 and 0.013, respectively). At 12 weeks after repair, all genes did not show differences between ADFs and PRP injected shoulders (all p>0.05). In the histologic evaluation, the collagen continuity and maturation of tendon-to-bone interface were better in Group C than Group D (p=0.008, and 0.048, respectively) at 12 weeks after repair. The mean load-to-failure resulted 32.3±6.2 N/kg in Group C, and 24.4±5.2 N/kg in Group D at 12 weeks after repair (p=0.015). Conclusions ADFs seems to have better enhancement of healing than PRP in repaired tendon of chronic rotator cuff tear model of rabbits.
Effects of Allogenic Dermal Fibroblasts on Rotator Cuff Healing in a Rabbit Model of Chronic Tear
Kwon, Jieun,Kim, Yun Hee,Rhee, Sung-Min,Kim, Tae In,Lee, Jimin,Jeon, Saewha,Oh, Joo Han SAGE Publications 2018 AMERICAN JOURNAL OF SPORTS MEDICINE - Vol.46 No.8
<P>Conclusion: This controlled laboratory study verified, on the basis of biomechanics and histology, the potential for the use of ADFs in rotator cuff healing. The current results suggest a new biological supplement to increase the rate of rotator cuff healing.</P>
Moisture Wound Healing Characteristics of Alginate Sponge and Hydrogel
Ga Young Park(박가영),Jeong Hyun Yeum(염정현),Dong Joon Yang(양동준),Guen Oh Park(박근오),Yun Hee Kim(김윤희),Saewha Jeon(전세화),Tae Jung Kim(김태정),Eun Jung Oh(오은정),Ho Yun Chung(정호윤),Jin Hyun Choi(최진현) 한국고분자학회 2018 폴리머 Vol.42 No.1
건조/가교법으로 제조한 알지네이트 스폰지 및 하이드로젤의 물리적, 생물학적 특성 및 창상치유 특성을 고찰하였다. 하이드로젤은 스폰지 대비 높은 평형 함수율을 보유하였고, 자체적으로 수분을 함유하고 있기 때문에 상대적으로 우수한 습윤 창상치유 환경을 제공할 수 있었다. 알지네이트 스폰지 및 하이드로젤의 사이토카인 결속효과에 기인하여 대식세포로부터 분비되는 전염증성 사이토카인의 함량이 감소됨을 확인하였으며, 특히 하이드로젤의 사이토카인 억제효과가 더욱 두드러지게 나타났는데, 이는 보다 팽윤된 상태에서 알지네이트 분자의 사이토카인에 대한 결속력이 증가함을 의미한다. 창상형성 초기 하이드로젤에 의한 창상치유 및 수축 효과가 스폰지에 비해 우수한 것으로 나타났으나, 상피화는 스폰지를 적용했을 때 보다 우세하게 진행되었다. 조직학적 평가와 RNA 발현 분석으로부터 알지네이트 스폰지 및 하이드로젤은 혈관 및 콜라겐 섬유의 형성, 상피조직의 재생 및 단백질의 생성 등을 촉진함을 확인하였다. Alginate sponge and hydrogel were prepared by a drying/crosslinking method and their wound healing characteristics were investigated comparatively. The alginate hydrogel had a higher equilibrium water content than the sponge, providing a moist wound healing condition without absorbing exudate from a wound. The amounts of proinflammatory cytokines released by macrophages were lowered due to the cytokine-binding effects of the alginate sponge and hydrogel. The hydrogel lowered the cytokine level more dominantly than the sponge, suggesting that the affinity of alginate molecules to cytokines increases at a more swollen state. The hydrogel allowed superior wound healing and contraction at the early stage of application. However, epithelialization was conspicuous when the sponge was applied. It was confirmed through histological examination and RNA expression analysis that angiogenesis, formation of collagen fibers, regeneration of epithelium, and production of protein were promoted using the alginate sponge and hydrogel as wound dressing materials.