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Ahn, Jae-Il,Lee, Doo-Hoon,Ryu, Yang-Hwan,Jang, In-Keun,Yoon, Mun-Young,Shin, Youn Ho,Seo, Young-Kwon,Yoon, Hee-Hoon,Kim, Jae-Chan,Song, Kye-Yong,Yang, Eun-Kyung,Kim, Ki-Ho,Park, Jung-Keug Blackwell Publishing Inc 2007 Artificial Organs Vol.31 No.9
<P>Abstract: </P><P>Rabbit corneal epithelium was reconstructed using tilting dynamic culture with a self-manufactured, amniotic membrane (AM) supporter and a lyophilized amniotic membrane (LAM). Rabbit corneal epithelial (RCE) cells were cultured and cryopreserved after isolation from the limbus. The second- and third-passage RCE cells were plated onto the epithelial side of the LAM of Ahn's AM supporter. Two days later, the air–liquid interface culture was maintained with third-passage RCE cells for 6 days and second-passage corneal epithelial cells for 9 days. The average viability of thawed RCE cells, assessed using trypan blue dye exclusion, was 77.42%. The reconstructed corneal epithelium was characterized by histological (hematoxylin and eosin) and immunohistochemical staining (proliferating cell nuclear antigen) for light microscopy, and by reverse transcriptase-polymerase chain reaction, glucose assay, and transmission electron microscopy. The basal layer of the reconstructed corneal epithelium was well formed, and the epithelium was tightly constructed due to the increase in cell proliferation and differentiation caused by the tilting dynamic culture, as opposed to static culture. Tilting dynamic culture was useful for the reconstruction of the epithelium using easily damaged epithelial cells and resulted in more stratum cell layers. Moreover, cytokeratin (CK3) mRNA expression in tilting dynamic cultured third-passage RCE cells seeded onto AM was greater than in static cultured third-passage RCE cells. The morphology of the reconstructed corneal epithelium on LAM by tilting dynamic culture for 9 days resembled that of the skin epidermis. This was thought to be because the tilting dynamic culture not only accelerated the proliferation and differentiation of cells by physical or mechanical stimulation, but also ensured that the supply of medium was delivered to the basal cells more efficiently. Thus, the reconstruction of the corneal epithelium using LAM and tilting dynamic culture was considered to be a good in vitro model for autologous or allogeneic transplantation of corneal epithelium and skin epidermis in patients with damaged epithelia. </P>
손등 정맥 패턴의 회전 왜곡을 보상한 개인 식별 알고리즘의 연구
최환수,안장용 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-
This paper proposes an enhanced algorithm for person identification system utilizing hand vein pattern. The conventional algorithm does not cope with distortion caused by image rotation caused by misplaced hands on the imaging device. A straightforward approach to consider the rotaional compensation required too much computational load, thus, we devised an approach to expect the rotation direction along with image translation, reducing the compuational requirement dramatically. In this paper, we present the detail of the algorithm with experimental results with the new algorithm.
Enhanced organic photovoltaic cells with MoOx nanorods as a hole transfer layer
Ahn, Jeong-Hwan,Ahn, Joon-Sub,Jang, Myeong-Jun,Han, Eun-Mi Informa UK (TaylorFrancis) 2017 Molecular Crystals and Liquid Crystals Vol.654 No.1
<P>Molybdenum oxide(MoOx) nanorods have been used as a hole transfer layer(HTL) for an organic photovoltaic(OPV) cell because it has a bandgap similar to that of PEDOT:PSS. The structure of OPV is a fluorine-doped tin oxide(FTO) / MoOx nanorod / P3HT:PCBM / ZnO / Ag. The morphology of the MoOx layer was controlled by the hydrothermal reaction time and the concentration of the precursor. The photoelectric conversion efficiency(PCE) was affected by widening the hole transfer surface between the HTL and the active layer. A device with 0.24 wt% MoOx precursor and a 20-min reaction time had a highest efficiency of 2.7%.</P>
( Young-hwan Ahn ),( Heirim Lee ),( Do Young Kim ),( Hye Won Lee ),( Su Jong Yu ),( Young Youn Cho ),( Jeong Won Jang ),( Byoung Kuk Jang ),( Chang Wook Kim ),( Hee Yeon Kim ),( Hana Park ),( Hyo Jung 대한간학회 2021 Gut and Liver Vol.15 No.3
Background/Aims: This study was performed to evaluate the efficacy of direct-acting antivirals (DAAs) in Korean patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) and to investigate the risk factors associated with HCC recurrence. Methods: A total of 100 patients with HCV-related HCC, who were treated with DAAs between May 2015 and December 2016, were recruited from seven university hospitals in Korea. Claim data of 526 patients with HCC obtained from the Health Insurance Review and Assessment Service in South Korea were used for external validation of the results. Results: Among the 100 patients, 88% achieved a sustained virological response (SVR) 12 weeks after the end of DAA therapy (SVR12), and 37% experienced HCC recurrence after DAA therapy. Short last HCC treatment durability (<12 months) before DAA commencement was independently associated with HCC recurrence (hazard ratio [HR], 2.89; p=0.011). In the nationwide validation cohort, 20.3% of the patients experienced HCC recurrence. The last HCC treatment with a noncurative method, a short last HCC treatment durability (<12 months), and a longer total duration of HCC treatment (≥18 months) were independently related with HCC recurrence (HR 3.73, p<0.001; HR 3.34, p<0.001; and HR 1.74, p=0.006; respectively). Conclusions: DAA therapy showed an acceptable SVR12 rate in patients with HCV-related HCC. Short last HCC treatment durability (<12 months) was associated with HCC recurrence after DAA therapy. This finding suggests that the last HCC treatment durability is an important predictor of HCC recurrence after DAA therapy. (Gut Liver 2021;15:410-419)
Jang, In-Keun,Ahn, Jae-Il,Shin, Jun-Seop,Kwon, Young-Sam,Ryu, Yang-Hwan,Lee, Jeong-Kyu,Park, Jung-Keug,Song, Kye-Yong,Yang, Eun-Kyung,Kim, Jae-Chan Blackwell Publishing Inc 2006 Artificial Organs Vol.30 No.6
<P>Abstract: </P><P>The purpose of this article was to evaluate the graft efficacy of reconstructed corneal layer, composed of autologous corneal epithelium and fibroblasts on a lyophilized amniotic membrane (LAM), in a severely alkali-burned corneal model. After biopsy specimens were obtained from the left eyes of 24 rabbits, the corneal epithelial cells and fibroblasts were expanded in vitro and the corneal layer was reconstructed on LAM. Thirty-six eyes of rabbits underwent alkali burn (1 N NaOH, 30 s) to create a limbal deficiency and a deeply damaged corneal stroma. Four weeks later, group 1 underwent a graft of the reconstructed corneal layer composed of autologous corneal epithelium and fibroblasts on LAM. Group 2 was transplanted with a graft of the reconstructed autologous corneal epithelium, and group 3 served as a control without surgery. Wound healing and stabilization of the ocular surfaces occurred much faster in group 1 than in groups 2 and 3. The eyes in group 3 revealed typical limbal deficiencies with conjuctivalization and persistent corneal epithelial defects. However, the corneas in group 1 developed only mild peripheral neovascularization. Immunohistochemical staining in group 1 demonstrated that p63, cytokeratin 3, E-cadherin, transforming growth factor (TGF)-&bgr;1, and collagen IV were expressed strongly in the corneal epithelium and basement membrane. On the basis of these results, transplantation of the reconstructed corneal layer, composed of autologous corneal epithelium and fibroblasts on LAM, partially accelerated the recovery of the alkali-injured rabbit ocular surface, and might be useful therapeutically for the treatment of patients with severely damaged cornea.</P>
Jang, Mi-Ok,Jang, Hee-Chang,Kim, Uh Jin,Ahn, Joon Hwan,Kang, Seung-Ji,Jung, Sook-In,Shin, Hee-Young,Park, Kyung-Hwa American Society for Microbiology 2014 Antimicrobial Agents and Chemotherapy Vol.58 No.3
<P>There are no well-matched, controlled studies comparing azithromycin with doxycycline for the treatment of complicated scrub typhus. A retrospective propensity score-matched case-control study was performed for patients who presented with complicated scrub typhus and were treated with doxycycline or azithromycin between 2001 and 2011. Data on comorbidities, clinical manifestations, laboratory studies, treatments, and outcomes were extracted for analysis. The clinical characteristics and outcomes of the azithromycin-treated group (<I>n</I> = 73) were compared to those of the doxycycline-treated group (<I>n</I> = 108). Of 181 patients, 73 from each group were matched by propensity scores. There were no significant differences in baseline characteristics between the matched groups. The treatment success and survival rates were not significantly different (89% [65/73 patients] versus 96% [70/73 patients] and 96% [70/73 patients] versus 96% [70/73 patients], respectively [<I>P</I> > 0.05]). No difference was observed in the time to defervescence or length of hospital stay between the two groups (<I>P</I> > 0.05). In complicated scrub typhus patients (<I>n</I> = 181), multivariate analysis showed that only APACHE II score was an independent risk factor for mortality (95% confidence interval, 1.11 to 1.56; <I>P</I> < 0.001). Our data suggest that outcomes of azithromycin therapy are comparable to those of doxycycline therapy in patients with complicated scrub typhus.</P>