Is the Diagnostic Trial with Proton Pump Inhibitors Reasonable for School Age Children with Gastroesophageal Reflux Symptoms?

Jaeeun Yang,Jieon Lee,Hyunju Lee,Juyeon Lee,Young Mee Youn,Jae Hong Choi,Yoon-Joo Kim,Hyun Sik Kang,Kyoung Hee Han,Seung Hyo Kim,Ki-Soo Kang 대한소아소화기영양학회 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.6

Purpose: On the basis of evidence, we aimed to reevaluate the necessity of the empirical proton pump inhibitor (PPI) trial for children with suspected gastroesophageal reflux disease (GERD). Methods: We analyzed the frequency of GERD in 85 school-age children with gastroesophageal reflux (GER) symptoms, who received 24-hour esophageal pH monitoring and/or upper endoscopy. According to the reflux index (RI), the children were classified into normal (RI <5%), intermediate (5%≤ RI <10%), or abnormal (RI ≥10%) groups. Results: Fifty six were female and 29 were male. Their mean age was 12.6±0.5 (±standard deviation) years (range: 6.8–18.6). The RI analysis showed that the normal group included 76 patients (89.4%), the intermediate group included 6 patients (7.1%), and the abnormal group included 3 patients (3.5%). The DeMeester score was 5.93±4.65, 14.68±7.86 and 40.37±12.96 for the normal, intermediate and abnormal group, respectively (p=0.001). The longest reflux time was 5.56±6.00 minutes, 9.53±7.84 minutes, and 19.46±8.35 minutes in the normal, intermediate, and abnormal group, respectively (p=0.031). Endoscopic findings showed reflux esophagitis in 7 patients. On the basis of the Los Angeles Classification of Esophagitis, 5 of these patients were included in group A, 1 patient, in group B and 1 patient, in group C. Conclusion: The incidence of GERD was very low in school-age children with GER symptoms. Therefore, injudicious diagnostic PPI trials would be postponed until the actual prevalence of GERD is verified in future prospective studies.

Is the Diagnostic Trial with Proton Pump Inhibitors Reasonable for School Age Children with Gastroesophageal Reflux Symptoms?

Yang, Jaeeun,Lee, Jieon,Lee, Hyunju,Lee, Juyeon,Youn, Young Mee,Choi, Jae Hong,Kim, Yoon-Joo,Kang, Hyun Sik,Han, Kyoung Hee,Kim, Seung Hyo,Kang, Ki-Soo The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.6

Purpose: On the basis of evidence, we aimed to reevaluate the necessity of the empirical proton pump inhibitor (PPI) trial for children with suspected gastroesophageal reflux disease (GERD). Methods: We analyzed the frequency of GERD in 85 school-age children with gastroesophageal reflux (GER) symptoms, who received 24-hour esophageal pH monitoring and/or upper endoscopy. According to the reflux index (RI), the children were classified into normal (RI <5%), intermediate (5%${\leq}$ RI <10%), or abnormal (RI ${\geq}$10%) groups. Results: Fifty six were female and 29 were male. Their mean age was $12.6{\pm}0.5$ (${\pm}$standard deviation) years (range: 6.8-18.6). The RI analysis showed that the normal group included 76 patients (89.4%), the intermediate group included 6 patients (7.1%), and the abnormal group included 3 patients (3.5%). The DeMeester score was $5.93{\pm}4.65$, $14.68{\pm}7.86$ and $40.37{\pm}12.96$ for the normal, intermediate and abnormal group, respectively (p=0.001). The longest reflux time was $5.56{\pm}6.00$ minutes, $9.53{\pm}7.84$ minutes, and $19.46{\pm}8.35$ minutes in the normal, intermediate, and abnormal group, respectively (p=0.031). Endoscopic findings showed reflux esophagitis in 7 patients. On the basis of the Los Angeles Classification of Esophagitis, 5 of these patients were included in group A, 1 patient, in group B and 1 patient, in group C. Conclusion: The incidence of GERD was very low in school-age children with GER symptoms. Therefore, injudicious diagnostic PPI trials would be postponed until the actual prevalence of GERD is verified in future prospective studies.

집단지성을 활용한 POI 시맨틱 검색을 위한 시스템 설계 및 구현

이재은(Lee, Jaeeun),손화민(Son, Hwamin),양종현(Yang, Jonghyeon),유기윤(Yu, Kiyun) 한국측량학회 2016 한국측량학회지 Vol.34 No.3

알레한드로 아라베나의‘사회참여 건축’에 나타난 특성 연구

양정민 ( Jungmin Yang ),윤재은 ( Jaeeun Yoon ) 한국공간디자인학회 2016 한국공간디자인학회논문집 Vol.11 No.4

(Background and Purpose) In this era of rapid change, thought on architecture is transforming from appraisal of magnificent architecture based mainly on the exterior to strong focus on architecture``s social implications. In other words, architects`` interests have expanded from aesthetic appearance to society and the people-oriented design lying within architecture. As witnessed through recent Pritzker Architecture Prize winners and their works, architects have begun responding actively to serious social issues including natural disasters, poverty, and refugees. By encouraging user participation in the design process through communication and collaboration, they propose and execute sustainable and human-centric solutions. This study recognizes the importance of social participation in architecture and analyzes the works of 2016 Pritzker Architecture Prize winner Alejandro Aravena, who emphasizes a user participation approach. The aim of this analysis is to establish Aravena``s theoretical framework by considering characteristics of participatory design and potential development areas. (Method) This paper outlines key vocabulary related to participatory design and examines Alejandro Aravena``s architectural background and philosophy through a study of literature and previous research. Based on this, characteristics of participatory design are categorized into social, cultural, and spatial aspects to elicit keywords. Cases are selected from among public housing projects by Elemantal, a firm led by Alejandro Aravena, and their characteristics and effects are analyzed with respect to the keywords identified. (Results) Keywords elicited as representative characteristics of participatory design were consistently applicable to every case studied. From a social aspect, Aravena``s public housing was situated in the center of the city, providing easy access to economic activities and opportunities for underprivileged individuals to overcome chronic poverty. From a cultural aspect, the project created social interaction by encouraging residents`` voluntary participation. From a spatial aspect, by providing only the essential elements using a limited subsidy, the project was designed to allow residents to extend and expand the building on their own initiative, allowing for a flexible spatial composition. (Conclusions) In conclusion, Alejandro Aravena``s public housing project provided not only a temporary dwelling for underprivileged individuals but also a practical alternative to escape poverty. Based on this study, further studies on similar topics are deemed necessary to provide vitality to participatory design and to present new possibilities.

한방병원의 서비스 품질요인이 고객 만족도와 재이용의도에 미치는 영향

이재은,양종현,장동민,Lee, Jaeeun,Yang, Jonghyun,Chang, Dongmin 한국병원경영학회 2017 병원경영학회지 Vol.22 No.3

This study was performed to analyze systematically and validate empirically the influence of korean medicine service quality on satisfaction factors and revisiting intention. The candidates were patients visiting the one korean medicine hospital in Gyeongnam. We took a direct survey collected during 15 days May 1 to 15, 2016. For the survey I distributed a total of 250 questionnaire and used the final 230 of them in verifying this research model except unreliable data. The collected data were used statistics program SPSS WIN 22.0 and the research model were examined by AMOS 18.0. The main research results are follows. First, the most influencing factors on consumer satisfaction were public image factors and then human factors. and then effectiveness factors. Second, the most influencing factors on reuse intention were public image factors and then physical factors. Third, human and effectiveness factors of service quality factors in korean medicine hospital did not effect on revisiting intention directly but, effected on revisiting intention through mediation role of the customer satisfaction. Forth, satisfaction on the significant effect on reuse intention. so satisfaction has proved to be a important factor for reuse intention. The results of this study are expected to contribute to management efficiency and developmental improvement on korean medicine hospital policy and management efficiency and be used as a basis for leading to national health promotion through the development of korean medicine service.

Gain and loss of antibiotic resistant genes in multidrug resistant bacteria: One Health perspective

Kim Misung,Park Jaeeun,Kang Mingyeong,Yang Jihye,Park Woojun 한국미생물학회 2021 The journal of microbiology Vol.59 No.6

The emergence of multidrug resistance (MDR) has become a global health threat due to the increasing unnecessary use of antibiotics. Multidrug resistant bacteria occur mainly by accumulating resistance genes on mobile genetic elements (MGEs), made possible by horizontal gene transfer (HGT). Humans and animal guts along with natural and engineered environments such as wastewater treatment plants and manured soils have proven to be the major reservoirs and hotspots of spreading antibiotic resistance genes (ARGs). As those environments support the dissemination of MGEs through the complex interactions that take place at the human-animalenvironment interfaces, a growing One Health challenge is for multiple sectors to communicate and work together to prevent the emergence and spread of MDR bacteria. However, maintenance of ARGs in a bacterial chromosome and/or plasmids in the environments might place energy burdens on bacterial fitness in the absence of antibiotics, and those unnecessary ARGs could eventually be lost. This review highlights and summarizes the current investigations into the gain and loss of ARG genes in MDR bacteria among human-animal- environment interfaces. We also suggest alternative treatments such as combinatory therapies or sequential use of different classes of antibiotics/adjuvants, treatment with enzymeinhibitors, and phage therapy with antibiotics to solve the MDR problem from the perspective of One Health issues.

High Prevalence of Enterobius vermicularis Infection among Schoolchildren in Three Townships around Yangon, Myanmar

Jong-Yil Chai,Seung Koo Yang,Jae Won Kim,Soo-Lyoen Choi,Gyu-Young Song,Bong-Kwang Jung,Min-Jae Kim,Jaeeun Cho,Deok-Gyu Kim,Woon-Mok Sohn,Hoo-Gn Jeoung,Seon Cho,Jong-Bok Park,Sooji Hong,Thi Thi Htoon,H 대한기생충학열대의학회 2015 The Korean Journal of Parasitology Vol.53 No.6

In order to determine the status of Enterobius vermicularis infection among schoolchildren in suburban areas of Myanmar, 761 primary schoolchildren in 3 different townships around Yangon City were subjected to a survey using cello-tape anal swabs. The subjected schoolchildren were 383 boys and 378 girls who were 5-7 years of age. Only 1 anal swab was obtained from each child. The overall egg positive rate of E. vermicularis was 47.2% (359 positives), and sex difference was not remarkable (48.6% in boys and 45.8% in girls). However, the positive rate was the highest in South Dagon (54.6%) followed by Hlaing Thayar (43.8%) and North Dagon (34.8%). This difference was highly correlated with the living standards of the people in each township. Nucleotide sequence of the 5S rDNA from the eggs on the cello-tape (2 children) revealed 99.7% identity with that of E. vermicularis reported in GenBank. The results indicated that E. vermicularis infection is highly prevalent among primary schoolchildren around Yangon, Myanmar.

군날개에서 생체 접착제와 최소 결막 봉합을 사용한 양막이식술과 자가결막이식술의 임상결과

이수정(Su Jeong Lee),양홍석(Hong Seok Yang),최중혁(Joong Hyuk Choi),유재은(Jaeeun Yu),정유리(Yoo-Ri Chung) 대한안과학회 2021 대한안과학회지 Vol.62 No.5

목적: 군날개 절제 후 노출된 공막을 덮어주기 위하여 결막 봉합 혹은 생체 접착제를 이용한 결막피판술, 자가결막이식술, 양막이식술 등이 사용되고 있으며, 본 연구에서는 생체 접착제와 최소 결막 봉합을 사용한 양막이식술과 자가결막이식술을 이용한 군날개수술의 임상결과를 알아보고자 하였다. 대상과 방법: 2016년 5월부터 2019년 12월까지 군날개절제술 및 양막이식술 또는 자가결막이식술을 시행받은 군날개 환자 198명, 217안의 의무기록을 후향적으로 분석하여 임상결과를 비교하였다. 양 군에서 재발률과 합병증 발생 빈도를 조사하였고, 군날개 재발과 관련된 위험인자를 분석하였다. 결과: 군날개 재발은 자가결막이식술 군에서 185안 중 1안(0.5%), 양막이식술 군에서 32안 중 6명(18.8%)에서 재발하여, 자가결막이식술 군의 재발률이 통계적으로 유의하게 낮았다(p<0.001). 로지스틱 회귀분석 결과, 자가결막이식술에서 양막이식술에 비하여 유의하게 군날개 재발 위험이 낮았다(odd ratio, 0.023; 95% 신뢰구간, 0.003-0.206; p=0.001). 경과 관찰 중 화농육아종, 양막 탈락, 결막편 탈락, 공막 괴사 등의 다른 안과적 합병증은 발생하지 않았다. 결론: 군날개수술에서 생체 접착제를 사용한 자가결막이식술이 생체 접착제를 사용한 양막이식술과 비교하여 재발률이 낮아 임상적으로 보다 유용한 수술 방법으로 사료된다. Purpose: We compared clinical outcomes including recurrence rate between amniotic membrane transplantation (AMT) and conjunctival autograft using fibrin glue and minimal conjunctival sutures for pterygium surgery. Methods: We retrospectively analyzed 217 eyes of 198 patients with pterygia who underwent surgery from May 2016 to December 2019. Pterygium excision was performed with conjunctival autograft or AMT, using fibrin glue with both. Recurrence rates and complications were evaluated between the two groups. Results: Postoperative recurrences were noted in one of 185 eyes (0.5%) in the conjunctival autograft group, and in six of 32 eyes (18.8%) in the AMT group. The recurrence rate was significantly lower in the conjunctival autograft group (p < 0.001). Logistic regression analysis revealed that conjunctival autograft was associated with a significantly lower risk of pterygium recurrence compared to AMT (odds ratio, 0.023; 95% confidence interval, 0.003-0.206; p = 0.001). No ocular complication was noted in both groups during follow-up. Conclusions: Pterygium excision with conjunctival autograft using fibrin glue was more effective in preventing recurrence compared to AMT.

A Case of Ectopic Peritoneal Paragonimiasis Mimicking Diverticulitis or Abdominal Abscess

Min Jae Kim,Sung-Han Kim,Sang-Oh Lee,Sang-Ho Choi,Yang Soo Kim,Jun Hee Woo,Yong Sik Yoon,Kyung Won Kim,Jaeeun Cho,Jong-Yil Chai,Yong Pil Chong 대한기생충학열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.3

기계학습 모형을 이용한 양계 복합 악취의 요인 파악에 대한 연구

김도윤(Doyun Kim),김재훈(Jaehoon Kim),박준수(Junsu Park),서시영(Siyoung Seo),김재은(Jaeeun Kim),양병준(Byeong-jun Yang),허태영(Tae-Young Heo) 한국통계학회 2024 응용통계연구 Vol.37 No.4

현대 사회로 발전함에 따라 가축의 수가 증가하고 있으며, 악취는 심각한 사회 문제로 인식되어 지고 있다. 특히, 닭, 오리 및 칠면조와 같은 가금류 고기들의 소비량은 가파른 상승세를 보이고 양계축사 근처에서 악취 문제가 두각을 보인다. 악취 문제를 해결하기 위해, 악취 구성 인자들의 복합 악취에 대한 영향력을 파악하는 것이 중요하다. 본 연구에선 양계 농장에서 얻어진 복합 악취 데이터를 기계 학습 모형을 이용하여 복합 악취를 예측하고 복합 악취에 구성 인자들이 어떠한 영향을 주는지 분석하였다. 추가적으로, 분산분석을 이용하여 부지경계, 퇴비장, 계사내부, 계사외부에서의 주요 악취 구성 인자들의 농도 차이를 분석하였다. 분석 결과, 복합 악취에 큰 영향을 미치는 구성 인자들로는 암모니아, 트라이메틸아민, 다이메틸다이설파이드, 아세트알데하이드로 나타났다. 특히, 암모니아, 트라이메틸아민, 아세트알데하이드는 양계 위치별로 농도의 차이가 있는 것으로 나타났다. With the development of modern society, the number of livestock is increasing, and the corresponding odor is recognized as a serious social problem. In particular, the consumption of poultry meat, such as chicken, duck, and turkey, is expected to rise steeply, making odor problems near poultry farms. To address the problem, it is important to understand the influence of odor components on the complex odor. In this study, the odor data obtained from poultry farms were used to predict the complex odor using machine learning models and analyze the influence of the components. Furthermore, we analyze the differences in the amount of the odor components at the site boundary, compost site, inside the farm, and outside the farm using analysis of variance. The analysis showed that ammonia, trimethylamine, dimethyldisulfide, and acetaldehyde have a high effect on the complex odor. In particular, ammonia, trimethylamine, and acetaldehyde have dierent amount of the occurence by the location.