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Kim, Yong Beom,Song, Yong Sang,Jeon, Yong Tark,Park, Jong Sup,Um, Soo Jong,Kim, Jae Weon,Park, Noh Hyun,Kang, Soon Beom,Lee, Hyo Pyo National Hellenic Research Foundation 2005 ONCOLOGY REPORTS Vol.14 No.2
<P>In this study, we investigated the sequence variation and different transcriptional activities of the upstream regulatory region (URR) in HPV 16 E7 variants in cervical cancer tissue from Korean women. Using PCR-directed sequencing, the presence of sequence variations in URRs were analyzed and the sites of sequence variation were matched with the known transcriptional factor binding site (TFBS) in 26 HPV 16 E7 variants, 21 cases with A647G (KE7-1, high oncogenic potential) and 5 cases with T732C (KE7-2, low oncogenic potential). In addition, we determined the transcriptional activity of URR in a HPV 16 prototype, and in 4 cases of HPV 16 E7 variants, by using the functional chloramphenicol acetyl transferase (CAT) assay. The 26 HPV 16 E7 variants showed more than 11 sites of sequence variation in the URR. Ten sites of sequence variation were located in the known TFBS and the distribution of sequence variations in the URR showed clear differences between KE7-1 and KE7-2. The sequence variations T7781C and C7786T were matched with YY1 binding sites, G7193T and C7689A were matched with TEF1 binding sites, and C7394T and C7395T were matched with GRE binding sites. The other sequence variations, which were matched with the TFBS, were A7485C, G7489A, T7743G and G7842A. The URR activity of KE7-1 was significantly lower than that of the HPV 16 prototype, whilst KE7-2 was similar. Taken together with the results of the transcriptional activities of KE7-1 and KE7-2, our results suggest that the functional activity and sequence variations of HPV 16 URR may not be related to the oncogenic potential of HPV 16 E7 variants.</P>
Lightscape를 이용한 독립형 외부 차양장치의 주광 분포에 관한 평가
엄재용(Um. Jae-Yong),최원기(Choi. Won-Ki),장월상(Jang. Weol-Sang),서승직(Suh. Seung-Jik) 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1
The authors carried out a study on the evaluation of daylighting distributions for separated exterior shading device from the building using the Lightscape 3.2. As a comparison of Lightscape 3.2 and another commercial software, it was excellent software in exactness.<br/> The results were proved to be an effective daylight control system for improvement of building environment. Especial1y, separated exterior shading device could control according to variable factors of shading device. For examples, distance and width of shading device, building distance and etc.<br/> Consequently, we verified that separated exterior shading device is much better off than existing shading devices in evaluation of uniformity factor for daylight control.
지하 공간을 위한 반사 거울 이용의 응용과 주광 시스템의 개관에 관한 연구
엄재용(Um. Jae-Yong),유경돈(Yoo. Kyoung-Don),박혜란(Park. Hea-Ran),서승직(Suh. Seung-Jik) 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1
The purpose of this study is to apply a heliostat system for improvement of daylight environment in underground space and overview of daylight systems were reviewed. The underground space should be applied a daylight in order to improvement of environment quality and building energy conservation. In this paper, new application model of heliostat system was proposed. the evaluation of heliostat performance was performed a simulation using Lightscape and theoretical studies.<br/> The results were proved to be an effective application method for improvement of daylight environment in underground space. Consequently, new application method of heliostat can be improved a better than conventional method.
승모판협착증 환자에서 경피적 풍선확장판막성형술의 폐기능 및 운동부하 검사에 대한 효과
김용태 ( Yong Tae Kim ),김우성 ( Woo Sung Kim ),임채만 ( Chae Man Um ),진재용 ( Jae Yong Chin ),고윤석 ( Youn Suck Koh ),김재중 ( Jae Joong Kim ),박성욱 ( Seong Wook Park ),박승정 ( Seung Jung Park ),이종구 ( Jong Koo Lee ),김원동 대한결핵 및 호흡기학회 1994 Tuberculosis and Respiratory Diseases Vol.41 No.1