생약추출물 유도형 Nitric Oxide Synthase 저해활성 검색

류재하,이소영,박재현,이화진,장세란,은진희,김남이,정연수,장미경,최영은,이숙현,손행자,안한나,고혜진 숙명여자대학교 약학연구소 2001 약학논문집-숙명여자대학교 Vol.17 No.-

Nitric Oxide (NO), derived from L-arginine, is produced by two types (constitutive and inducible) of nitric oxide synthase (NOS: cNOS and iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of herbal drugs which have been used for the treatment of inflammation in oriental medicine. We have screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among the 81 kinds of extracts of herbal drugs, 34 extracts showed potent inhibitory activity of NO production above 50% at the concentration of 50 (μg/ml. The inhibitory activities of NO production were also evaluated for several solvent fractions at three different concentrations. Especially, hexane soluble fractions of Agrimonia pilosa, Hydrangea serrata, Machilus thunbergii, Prunella vulgaris, Saussurea lappa, Tussilago farfara, and ethyl acetate soluble fractions of Angelica gigas, Ostericum koreanum, Torilis japonica, Perilla frutescence showed moderate activity at 10 and/ or 25 (μg/ml. These fractions are promising candidates for the study of the activity-guided chromatographic purification of active compounds.

What makes hybrid insourcing successful: A new public–private partnership model for social welfare services

Yang Jae‐jin,Kim Hey Sung,Choi Seong Eun,Ryu Lanhee,Choi Young Jun 한국사회복지학회 2020 Asian Social Work and Policy Review Vol.14 No.1

Outsourcing has been a key policy tool for delivering a range of social services, and regarded as more effective than insourcing or direct government provision. At the same time, it has also caused many delivery issues such as principal‐agent problems, a lack of policy coordination, and poor‐quality welfare services. While the pendulum continues to swing between insourcing and outsourcing, we aim to propose a new public–private partnership model called the “hybrid insourcing model” and examine which factors influence the performance of the model. In South Korea, around 2010, the local government in Namyangju City was the first to implement the “Hope Care Center model,” a kind of hybrid insourcing model, which has been praised for its innovation and widely emulated by central and local governments. Our analysis utilizes data collected between December 2017 and January 2018 from public sector employees and civilian staff in Namyangju and a comparable city, A. From this, we draw a number of implications, both for theory and for policy. We argue that, for public–private partnerships, active cooperation and equality are the biggest factors in contributing to positive performance. These work alongside leaders with a clear vision and with employees' positive attitude

담도 및 췌장 악성종양에서의 CAl9-9의 진단적 가치에 대한 평가

명승재,최승목,김은옥,최호순,이성구,김명환,민영일,류진숙 大韓消化器病學會 1995 大韓消化器病學會誌 Vol.27 No.3

다목적홀의 음향설계를 위한 1/10 축척모형의 제작 및 평가

류종관,신동재,전진용 대한건축학회 2004 대한건축학회논문집 Vol.20 No.9

A 1/10 scale model was introduced as an efficient tool to predict acoustical qualities of multi-purpose halls It was constructed to predict the acoustical properties, and to complement and adjust the architectural components on room acoustical characteristics of K-performing arts center The materials of scale model such as seats and audiences, absorption banners were selected through measurements of absorption coefficient In a 1/10 reverberation chamber and the absorption coefficients due to air-absorption With relative humidity was also Investigated As a result, It showed that types and parts of material and arrangement of specimen had much effects on absorption coefficient, and air absorption resulted In a significant decrease In absorption coefficient at high frequency In addition, the reverberation time of scale model was measured In occupied seats and the effect of absorption banners on the ceiling and side walls was also investigated Results showed that reverberation time of scale model showed a decrease of 0.5s by banners on the ceiling, whereas those on side walls had a little effect on reverberation time

흰쥐에서 경피적 전기 신경자극이 신경병리성통증에 미치는 영향

유재욱,이은우,김봉옥,이배환,손진훈 大韓再活醫學會 1999 Annals of Rehabilitation Medicine Vol.23 No.3

PbO-SiO_2계 유리에서의 유동 특성

차재민,김웅식,송현진,이병철,류봉기 釜山大學校生産技術硏究所 2002 生産技術硏究所論文集 Vol.61 No.-

유리에 관한 연구에 있어 점도는 가장 중요한 특성중의 하나로 여겨지며, 용융 상태, 작업 온도, 서냉 온도 또는 결정화 속도에 등과 같은 인자와도 크게 관계가 있다. 특히 각기 다른 조성을 가진 유리에서도 점도는 매우 다양하며, 온도에 크게 영향을 받는다. PbO-SiO_2 이성분계 유리에서는 PbO가 첨가됨에 따라 점도의 온도의존성이 커지고 표면장력이 감소하였다. 온도와 시간에 따른 spreading ratio를 비교한 결과 PbO의 함량이 증가함에 따라 유동성이 증가하였고 온도에 따른 유동성의 증가율도 크게 증가하였다. 그리고 일정한 온도에서 시간의 경과에 따른 유동성의 증가율은 감소하였다. The viscosity of a glass is one of the most important properties. It determines the melting conditions, the temperatures of working and annealing, fining behavior and devitrification rate. The viscosities of different glasses vary enormously with composition and are strong functions of temperature. On adding PbO in the PbO-SiO_2 binary system, the temperature dependence of the viscosity was large, the surface tension decreased. In the temperature and time dependence of spreading ratio, the spreading ratios of glass increased with increase PbO content and the rate in its increase decreased with time at constant temperature.

의과대학생의 불안 및 자아강도가 스트레스 대처방식에 미치는 영향

박재석,류설영,장은진,김정범 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.1

解放 이후 工業高等學校 敎育課程의 變遷過程 硏究

李載元,金振淳,盧泰天,柳彰烈 충남대학교 공업교육연구소 1985 論文集 Vol.8 No.2

The purposes of this study was to : 1) review the curriculum changes in technical high school from the 1945 Liberation to 1984, 2) examine the characteristics, objectives and organizations of the curriculum and, 3) search for the future directions of the curriculum development. Development of technical high school education programs was divided into four periods. The characteristics of THS curriculum during these periods was summarized as follows. 1. Embryonic Period (1945-1962)-After the foundation of the Republic of Korea, the technical high schools were included in high school system according to the Education Law promulgated in 1949. The technical high schools were created to develop competent industrial production workers. General subjects of the technical high schools were same as the general high schools during this period. Specialized subjects accounted for more than 30 percent of the total school hours. 2. Established Period (1963-1972)-Ministry of Education responding to the first Five-Year Plan for economic development, established a new technical high school curriculum in 1963. General course were modified to meet the needs of technical high school students. The educational aim of THS was the training skilled worker and technicians. THS placed stress on specialized subjects which were made-up than 50 percent of total school hours. Also, more hours were spent in practice compared to theory in specialized courses. 3. Developed Period (1973-1979)-Remarkable development was achieved by THS during this period. Technical high schools were subdivided into general, mechanical, special and model technical high schools. Their graduates were eligible for technical qualification and licences after passing test. THS had given the more consideration to the specialized subjects and practice than general subjects and theory. 4. Converting Period (1980-1984)-A change in educational policy in 1980 created a turning point for THS's. The new policy emphasizes educating Industrial Technicians more than training skilled workers. Technical high schools were again included in the high school system. THS placed increased emphasis on general subjects which comprise 43-60 percent of total school hours. The 1981 curriculum revision established elective subjects (e.g., General Mechanics, General Electrics, Computer, Industrial English, Industrial Safety). All THS students are able to select elective subjects outside their own major.

재조합 균주 Bacillus subtilis LKS88에 의한 Streptomyces albus KSM-35 Amylase의 생산조건

최원진,유도진,이재우,소명환,김영배 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.4

Streptomyces albus KSM-35의 amylase의 유전자를 Bacillus subtilis LKS88에서 발현시킨 균주를 사용하여 amylase의 생산에 미치는 몇가지 요인들을 조사하였다. 본 실험에 사용한 탄소원들중에서 sodium citrate와 왕겨의 효소 생산량이 가장 높았고, 이들을 1:1의 비율로 혼합하여 첨가하였을 때 효소의 생산량은 대조군으로 사용한 가용성 전분에 비하여 20배 이상 증가하였다. 질소원으로 대두박을 사용하였을 경우 yeast extract의 첨가량을 줄이면서 효소의 생산량을 증가시켰다. 배양을 위한 초기 pH를 60으로 조절하고 SDS를 0.01%첨가하였을 때 대조구조보다 높은 효소 생산량을 나타내었다. Bacillus subtilis LKS88 (pASA240)을 sodium citrate와 왕겨 각각 1.5%, K_2HPO_4 0.66%, yeast extract 0.3%, 대두박 0.7%, SDS 0.01% 및 초기 pH를 6.0으로 조절한 배지에서 37℃에서 배양시 최대 효소 활성은 배양 후 36시간에서 나타났으며 이때 효소 활성은 56.6 U/ml이었다. The effects of culture conditions on the production of amylase expressed by Bacillus subtilis LKS88 with a cloned gene from Streptomyces albus KSM-35 were investigated The production of amylase was increased significantly by using sodium citrate and rice hull as a carbon source. In addition, the use of a mixture of sodium citrate and rice hull(1:1) resulted in increase of enzyme production by 20-fold when compared to that of soluble starch. The soybean meal as the nitrogen source could be partially replaced with yeast extract without changing the enzyme production yield. The amylase production was also increased by adjusting initial pH to 6.0 or by adding 0.01% SDS. Maximum amylase production was observed in the medium containing 1.5% sodium citrate, 1.5% rice hull, 0.7% soybean meal, 0.3% yeast extract, 0.66% K_2HPO_4, 0.05% MgSO_4·7H_2O, 0.08% CaCl_2·2H_2O, 0.01% SDS with initial pH of 6.0. The maximum yield of amylase reached 56.6 U/ml when B. subtilis LKS88(pASA 240) was cultured at 37℃ for 36 hr.

함입된 상악 중절치의 외과적 재위치 후 예후

민성진,최형준,류정아,김성오,이제호,최병재,손흥규 대한소아치과학회 2006 大韓小兒齒科學會誌 Vol.33 No.3