말라리아박멸을 위한 조사연구 : 1. 말라리아 유행지역 주민의 항체보유율 변화 1. The study for the malaria eradication 1. The seasonal changes of antibodies of inhabitants lived in malaria epidemic areas

김동수,이형우,조신형,인태숙,이혜정,이욱교,김남렬,신민철,문승욱,임현정,고승연,이종수 국립보건연구원 2000 국립보건원보 Vol.37 No.-

Distinct prognostic impacts of both atrial volumes on outcomes after radiofrequency ablation of nonvalvular atrial fibrillation: Three-dimensional imaging study using multidetector computed tomography

Moon, J.,Lee, H.J.,Shim, J.,Uhm, J.S.,Kim, J.Y.,Pak, H.N.,Lee, M.H.,Kim, Y.J.,Joung, B. Elsevier/North-Holland Biomedical Press 2013 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.168 No.6

Background: Left atrial (LA) enlargement is associated with atrial fibrillation (AF) recurrence after radiofrequency ablation (RFA). However, impact of right atrial (RA) size on outcomes after RFA is unclear. Methods: Patients who underwent RFA of AF (n=242, 197 men, 57+/-11years) were enrolled (159 paroxysmal [PaAF] and 83 persistent [PeAF]). Three-dimensional RA and LA volumes were measured before RFA with multidetector computed tomography and indexed to body surface area (RAVI and LAVI). Results: After a 3-month blanking period, 66 patients (27%) failed to maintain sinus rhythm during follow-up (556+/-322days). Despite similar clinical characteristics, LAVI was larger (77+/-21 vs. 91+/-27ml/m<SUP>2</SUP>, P<0.001) and RAVI showed a trend to be greater (85+/-26 vs. 92+/-25ml/m<SUP>2</SUP>, P=0.06) in patients with future recurrence than without recurrence. Additionally, patients with larger RA or LA experienced recurrences more frequently and earlier during follow-up (log rank, P<0.05 for all). In Cox regression analysis, LAVI was independently associated with outcomes (10ml/m<SUP>2</SUP> increase; HR: 1.22, 95% CI: 1.09-1.36, P<0.001), whereas RAVI was not. In subgroup analysis, 25 PaAF patients (16%) experienced recurrence and both atrial volumes failed to predict the outcome independently, despite borderline significance of RAVI (10ml/m<SUP>2</SUP> increase; HR: 1.21, 95% CI: 1.00-1.48, P=0.05). Meanwhile, 41 patients (49%) in PeAF group experienced AF recurrence and LAVI was an independent prognosticator (10ml/m<SUP>2</SUP> increase; HR: 1.19, 95% CI: 1.03-1.36). Conclusions: RA size might affect the outcome after RFA in PaAF patients. LA enlargement, rather than RA size, influence outcomes after RFA, especially in PeAF.

1970年 慶北 聞慶地域에 發生한 腸티브스 疫學調査報告

李元榮,韓王洙,洪在雄,李京男,金貞順,文玉綸 서울大學校 保建大學院 1973 公衆保健雜誌 Vol.10 No.1

Epidemiology team, School of Public Health, Seoul National University, was commissioned to investigate an outbreak of unknown febrile disease occurred in Moon Kyung area from Ministry of Health. The team investigated the outbreak and collected specimens of rectal swab and sera; bacteriological study was done in National Institute of Health and serological test in the serology laboratory in the School of Public Health. Followings are the results obtained: 1. The entity of unknown febrile disease was identified as Salmonella typhi, D group. 2. Most common symptoms were headache and fever. The symptoms appeared to be quite severe in the begining of the epidemic which gradually became milder as the epidemic progressed to from of walking typhoid, probably being resulted from gradual development of population immunity. 3. It was an explosive outbreak among school children; the incidence of the disease per 1000 was 619.3 for school children whereas average incidence in four villages surveyed was 170.1. 4. The source of infection was common, open well in a corner of school ground for school children, however, the source of infection for general population was either personal contact or contaminated food in the family. 5. Distribution of date of onset and diffuse case distribution among villagers other than school children strongly suggested that these were secondary cases infected from the school children who delivered the agent to their family and/or neighbours. 6. A route of spread was assumed as follow: a beautician who travelled around extensively from one village to another for weddings was the first patient so far we could trace. She got sick in the begining of March and went home where her only brother followed her and died. she got out home and lost because of her brother's death. In the middle of March the beautician's two neighbours who shared open well contracted the disease. One of these two had such sever symptoms like delirium and aphasia that she was hospitalized in a private hospital for seven days and singed out the hospital and went her mother's home. In the begining of April her mother and one of her old classmates who was principal's son became ill. The principal lived in the school campus near the well, and thus the well got contaminated. The principal was the one who brought attention to health center because of unusually high absenteeism of the school children.

Photosensitization of novel ruthenium-functionalized photoconductive polymers: Effect of ruthenium complex as photosensitizer

Moon, J.S.,Kim, C.,Kim, W.G.,Kim, I.,Kyhm, K.,Oh, J.W.,Kim, N. Elsevier Sequoia 2015 Journal of photochemistry and photobiology. A, Che Vol.310 No.-

Owing to their efficient photo-charge generation, ruthenium derivatives are emerging as an important class of photosensitizers. Despite their promising characteristics, several deficiencies, such as the relatively low quantum yield and short lifetime of the lowest energy metal-ligand charge transfer, have limited their applications. Here, we present new photoconducting polymers that contain ruthenium complexes as a photosensitizer. Ru(phen)<SUB>2</SUB>(m-COOH)(PF<SUB>6</SUB>)<SUB>2</SUB> complexes, which covalently bind the poly(N-vinyl carbazole) (PVK) side chain, provided a high quantum yield and sufficient lifetime of the lowest energy metal-ligand charge transfer state for photo-charge generation. A series of PVK-Ru(phen)<SUB>2</SUB>(m-COOH)(PF<SUB>6</SUB>)<SUB>2</SUB> complexes were thus prepared with various concentrations of Ru. We employed a helium-neon (HeNe) laser (633nm) and a xenon lamp to measure the photo-charge generation efficiency and photoconductivity of the studied complexes. The wavelength dependence of the photo-charge generation efficiency and photoconductivity was found to be similar to their metal-ligand charge transfer absorption spectra. This suggests that the Ru complexes can extend the photosensitivity of the conductive polymers to longer wavelengths due to the lowest metal-ligand charge transfer energy. The photo-charge generation efficiency and photoconductivity of these polymers was found to be greater than those of PVK-Ru-complex composites.

나노크기의 은 촉매를 이용한 프로필렌의 산화반응

정정조,문동주,김영철,박남국,신재순 한국공업화학회 2002 응용화학 Vol.6 No.2

Epoxidation of propylene to propylene oxide over the modified silver catalyst was investigated in an atmospheric fixed bed flow reactor. Promoted catalysts were prepared by deposition-precipitation, and characterized by X-ray diffraction(XRD) and N_2 Physisorption. Silver catalysts modified NaCl, BaCl_2 and CaCl_2 were higher selectivity than those modified LiCl and MgCl_2. It was found that l0wt.% NaCl/Ag catalyst was showed higher selectivity than the other catalysts under tested reaction conditions. It can be interpreted that the AgCl formed in the preparation process may be changed the property of silver catalyst, which is effective for propylene epoxidation.

Reduction of d-lactate content in sauerkraut using starter cultures of recombinant Leuconostoc mesenteroides expressing the ldhL gene

Jin, Q.,Li, L.,Moon, J.S.,Cho, S.K.,Kim, Y.J.,Lee, S.J.,Han, N.S. Society for Bioscience and Bioengineering, Japan ; 2016 Journal of bioscience and bioengineering Vol.121 No.5

<P>The n-form of lactate, which causes metabolic stress upon excessive dietary intake, is mainly produced by Leuconostoc sp., the predominant species in sauerkraut. To shift the metabolic flux of D-lactate from pyruvate to L-lactate, we expressed the L-lactate dehydrogenase (ldhL) gene in Leuconostoc mesenteroides ATCC 8293. The IdhL gene from Lactobacillus plantarum was introduced into L. mesenteroides using the shuttle vectors pLeuCM and pLeuCM42. To elevate the expression level of IdhL in L. mesenteroides, the nucleotides for pyruvate kinase promoter were fused to IdhL and cloned into above vectors to construct pLC18pkL and pLC42pkL. As results, introduction of pLC42pkL in L. mesenteroides significantly improved both L-LDH activity and L-lactate productivity during fermentation, decreasing the D-/L-lactate ratio. When used as a starter culture for sauerkraut fermentation, recombinant L. mesenteroides harboring pLC42pkL increased L-lactate concentration and decreased D-lactate concentration compared to the wild type strain. We newly developed a recombinant L. mesenteroides which has high L-lactate dehydrogenase activity and applied this strain to minimize the harmful effect of D-lactate during the sauerkraut fermentation. To the best of our knowledge, we demonstrate for the first time the effective use of recombinant Leuconostoc sp. for quality improvement of fermented foods. (C) 2015, The Society for Biotechnology, Japan. All rights reserved.</P>

체감형 가상현실 훈련(Joystim)이 뇌졸중 환자의 인지기능과 일상생활활동에 미치는 효과

양노열(N. Y. Yang),박희수(H. S. Park),윤태형(T. H. Yoon),문종훈(J. H. Moon) 한국재활복지공학회 2018 재활복지공학회논문지 Vol.12 No.1

본 연구는 체감형 가상현실 훈련이 뇌졸중 환자의 인지기능과 일상생활활동에 미치는 효과를 알고자 하였다. 급성기 뇌졸중 환자 41명이 본 연구에 참여하였다. 실험 시작 후, 모든 대상자는 실험군 20명과 대조군 21명으로 무작위로 배정되었다. 두 군은 하루 30분, 주 5회, 4주 동안 보편적인 작업치료를 총 20회기 받았다. 실험군은 체감형 가상현실 훈련을 회기 마다 30분 더 받았으며, 대조군은 보편적인 작업치료를 회기마다 30분 더 받았다. 결과측정은 중재 전과 후에 측정하였다. 인지기능을 확인하기 위하여 Loewenstein 인지평가를 측정하였으며, 집중력과 시각기억을 알아보기 위하여 선추적 검사와 시각기억을 측정하였다. 일상생활활동 능력을 알아보기 위하여 수정바델지수를 사용하였다. 연구 결과, 실험군 18명, 대조군 18명은 특정문제없이 실험을 완료하였다. 인지기능의 변화량에서 실험군은 대조군보다 집중력과 시각적 작업기억에서 유의하게 더 큰 향상이 있었다(p<.05). 일상생활활동의 변화량을 비교에서 실험군은 대조군보다 자조관리에서 유의하게 더 큰 향상이 있었다(p<.05). 본 연구의 결과는 체감형 가상현실 훈련이 보편적인 치료보다 급성기 뇌졸중 환자의 인지기능과 일상생활능력 향상에 긍정적인 효과를 나타낼 수 있음을 시사한다. The present study was to investigated the effects of motion-based virtual reality training on cognitive function and activities of daily living in patients with stroke. This study was participated in forty one patients with acute stroke. All subjects were randomly assigned into either the experimental group(n=20) or the control group(n=21). The both groups received the conventional occupational therapy during 30 min a day, 5 a week, 4 a weeks. Additionally, experimental group performed motion-based virtual reality training on each session during 30 min/day, and control group conducted conventional occupational therapy on each session during 30 min/day. The outcome measures were the LOTCA(Loewenstein Occupational Therapy Cognitive Assessment), TMT(Trail Making Test), VM(Visual Memory), K-MBI(Korean Modified Barthel Index). In comparison of change score of cognitive function, the experimental group showed a significantly greater improvements in attention and visual working memory than the control group(p<.05). As a result for change score of activities of daily living, the experimental group showed a significant greater improvement in self care than the control group(p<.05). Our findings suggest that motion-based virtual reality training may have a effects of the improvements of cognitive function and activities of daily living than conventional therapy in patients with acute stroke.

Synthesis and characterization of Al-modified SBA-15 for Fischer–Tropsch synthesis (FTS) reaction

Kim, N. Y.,Jung, J. S.,Lee, J. S.,Yang, E. H.,Hong, G. H.,Lim, S. S.,Noh, Y. S.,Hodala, J. L.,Lee, K. Y.,Moon, D. J. Springer Science + Business Media 2016 Research on chemical intermediates Vol.42 No.1

<P>In this work, we synthesized a Co-based catalyst supported on modified SBA-15 to obtain the uniform particle size of active metal and selective products with certain carbon number distribution. For the comparison, modified SBA-15 was prepared with the different molar ratios of Si/Al = 5, 7 and 10 and compared with the SBA-15 support. Catalysts were prepared by the impregnation method and prepared catalysts were characterized by various analytical techniques such as N-2 physisorption, XRD, SAXS, TPR, NH3-TPD, FT-IR, and TEM. It was found that, by adding the aluminum to SBA-15, the catalyst acid site was increased and it produced a relatively middle range of hydrocarbons. It was also found that the interaction between cobalt metal and the support was increased, affecting the catalyst activity for Fischer-Tropsch synthesis.</P>

한국인 여성의 임신과 관련된 치골 결합 관절 간격의 초음파에 의한 변화치 관찰

한정열(J.Y. Han),한병희(B.H. Han),문우남(W.N. Moon) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4

Objective : To evaluate pregnancy associated change in width of the symphysis pubis. Materials and Methods : 497 women were evaluated from Jan. 2000 to Dec. 2000. They were non-pregnant, pregnant and postpartum state without complaning of pelvis pain. Ultrasonographic measurements of the width of the symphysis pubis were performed. Results : The population study shows 29.3 year-old as the mean age., gravid 2 and parity 0.6 . They consist of non-pregnant(n=36), first trimester(n=79), second trimester(n=118), third trimester(n=94), postpartum 4 weeks(n=84) and postpartum 8 weeks(n=86) women. The width of symphyseal joint was 3.93+0.05 mm(0.8-8.8 mm) among the total population, 3.20+0.17 mm in non-pregnant, 3.76+0.14 mm in first trimester, 3.95+0.10 mm in second trimester, 4.72+0.15 mm in third trimester, 3.98+0.12 mm in postpartum 4 weeks, 3.37+0.12 mm in postpartum 8 weeks women. The difference of the symphyseal joint width is statistically significant between non-pregnant and pregnant women(P=0.00). However the width of symphyseal joint were recovered until postpartum 8 weeks. There was no statistical difference of the width between first and second trimester,however significant difference between third trimester and before(P=0.00). The equation of regression ananlysis in the width of symphyseal joint was Y=3.25+0.04 x Gestation weeks during pregnancy(P>0.05). Conclusion : The width of the symphyseal joint had increased as gestational week advanced, and recovered until postpartum 8 weeks in pregnant women not complaining of pelvic pain.

Various Isomers in Doubly Odd I Isotopes

C.-B. Moon,G. D. Dracoulis,R. A. Bark,A. P. Byrne,P. A. Davidson,T. Kibedi,G. J. Lane,A. N. Wilson 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23

Isomeric states (Isomers) in odd-odd ^(120)I, ^(122)I, and ^(124)I nuclei have been investigated using in-beam gamma-ray spectroscopy with the ^(118)Sn (^6Li, 4n), ^(120)Sn (^7Li, 5n), and ^(122)Sn (^7Li, 5n) reactions at E_(lab) = 48, 58, and 54 MeV, respectively. Several isomers with half-lives ranging from a few nanoseconds to tens of microseconds have been identified for the first time and the absolute excited energies have been established by linking the low- and high-spin levels through the feeding and decay of the isomers in these nuclei. The properties of the isomers have been discussed in terms of spin traps and high-K isomerism based on two-quasiparticle configurations. The systematics for the absolute excitation energies of the J^π = 7^- and 8^- high-K isomers based on the πg_(9/2) υh_(11/2) configuration are presented for ^(116)I to ^(124)I and compared with the 9/2^+ states in the neighboring odd-A I isotopes.