제5차 아시아 태평양지역 수도회의 참관기

Janssens, J.G. 한국상하수도협회 1986 水道 Vol.36 No.-

이 글은 85. 9. 16-21 서울에서 개최된 사단법인 한국수도협회 주최 제 5차 아시아태평양지역수도회의 및 전시회에 참석하였던 벨지움 앤트워프시 수도국의 J.G. Janssens박사가 국제수도협회지 AQUA No.2/1986에 기고한 전문을 번역한 것이다.

Surface acoustic wave driven quantized current transport

F.J.Ahlers,J.Ebbecke,N.E.Fletcher,T.J.B.M.Janssen 한국물리학회 2004 Current Applied Physics Vol.4 No.5

The piezoelectric potential of a surface acoustic wave (SAW) can drive carriers in a semiconductor device over macroscopic distances. An application where optically generated electron-hole pairs are separated, transported and deliberately recombined was demonstrated a few years ago [Phys. Rev. Lett. 78 (1997) 4099]. Also around that time it was shown that the longitudinal con-nement provided by the potential minima of a SAW travelling along a one-dimensional channel may combine with the lateralchannel connement to form moving quantum dots with a well dened numbern of electrons in each dot [J. Phys.: Condens. Matter8 (1996) L531]. This gives rise to a quantized currentI ¼ n .e.f. This dynamic version of the Single Electron Tunneling operates atGHz frequencies and delivers currents in the nA range. The obvious application of the eect is in basic metrology, where it wouldenable the so called ‘Electrical Triangle’ experiment which combines Josephson eect, quantum Hall eect and a quantized currentto check the relationðh=2e2Þ.e ¼ h=2e self consistently. This paper reviews the experimental work on SAW driven currents and indetail the work done at the PTB, Germany, and NPL, UK, as well as suggested applications in other areas like single-photongeneration [Phys. Rev. A 58 (1998) R2680], quantized charge pumping through carbon nanotubes [Phys. Rev. Lett. 87 (2001)276802] or quantum computing [Phys. Rev. B62 (2000) 8410].

System 12 Software Production for Distributed Control

J. Janssens 대한전자공학회 1987 TENCON 87 - Computers and Communications Technolog Vol.- No.-

Invited Lecture 2 : The Stratum Corneum Lipid Composition is Key Factor for the Skin Barrier: An Integrated Approach

( J. A. Bouwstra ),( M. Janssens ),( A. P. M. Lavrijsen ),( J. Van Smeden ) 한국피부장벽학회 2015 한국피부장벽학회지 Vol.17 No.2

The skin barrier function is primarily located in the stratum corneum (SC) comprised of corneocytes and lipids The main lipid classes in the stratum corneum are ceramides, free fatty acids (FFAs), and cholesterol. These lipids form crystalline lipid lamellae. The composition and organization of these lipids are crucial for a proper skin barrier function, but the importance of the chain length distribution of the ceramides and FFAs for the impaired skin barrier is not known. We performed a clinical study in which the SC lipids and their importance for the skin barrier function was examined in atopic eczema patients and compared with control subjects. The lipid composition was examined with mass spectrometry. In particular the carbon chain length of the ceramides and FFAs was investigated in relation to the density of the SC lipid organization (examined by infrared spectroscopy) and the transepidermal water loss (TEWL), a marker for the skin permeability barrier. In addition we used lipid membrane studies to examine whether the changes observed in atopic dermatitis skin also results in an increased permeation across these membranes. In addition we examined whether inflammation that occurs in lesional AD skin could account for changes in lipid composition. This was done by supplementation culture medium of human skin equivalents with cytokines. A reduction was observed in the FFA and ceramide chain lengths for both non-lesional and lesional SC of AD patients compared to control skin. In lesional skin the reduction in chain length was more pronounced than in non-lesional skin(1). Furthermore, in lesional skin an increased level of unsaturated fatty acids was observed. The reduction in lipid chain length correlated excellent with a less dense lipid organization and a reduced skin barrier function. Besides, we examined the effect of mutations in the filaggrin gene on the lipids properties, a major predisposition factor for development of AD(2). However, no association was observed between lipid properties and filaggrin mutations. In order to examine whether the changes in lipid composition may be an important underlying factor for the reduced skin barrier in AD, we performed lipid membrane studies and showed that changes similar as observed in AD can account for on increased permeability of (model) drugs through these lipid membranes. In addition, we noticed that using human skin equivalents inflammation may induced changes in the lipid composition resulting in a compromised skin barrier. The current studies provides insights into the role of the SC lipid chain length and shows that the lipids play a role in the impaired skin barrier of AD patients. These results may provide opportunities for studies on skin barrier repair by topical treatments and shows evidence that normalisation of the lipid synthesis may enhance normalisation of the skin barrier function.

Stabilization of single-electron pumps by high magnetic fields

Fletcher, J. D.,Kataoka, M.,Giblin, S. P.,Park, Sunghun,Sim, H.-S.,See, P.,Ritchie, D. A.,Griffiths, J. P.,Jones, G. A. C.,Beere, H. E.,Janssen, T. J. B. M. American Physical Society 2012 Physical review. B, Condensed matter and materials Vol.86 No.15

Approximately dual Gabor frames and almost perfect reconstruction based on a class of window functions

Christensen, Ole,Janssen, Augustus J. E. M.,Kim, Hong Oh,Kim, Rae Young Springer-Verlag 2018 Advances in computational mathematics Vol.44 No.5

Multispectral intravital microscopy for simultaneous bright-field and fluorescence imaging of the microvasculature

Barry G. H. Janssen,Mohamadreza Najiminaini,Yan Min Zhang,Parsa Omidi,Jeffrey J. L. Carson 한국현미경학회 2021 Applied microscopy Vol.51 No.1

Intravital video microscopy permits the observation of microcirculatory blood flow. This often requires fluorescent probes to visualize structures and dynamic processes that cannot be observed with conventional bright-field microscopy. Conventional light microscopes do not allow for simultaneous bright-field and fluorescent imaging. Moreover, in conventional microscopes, only one type of fluorescent label can be observed. This study introduces multispectral intravital video microscopy, which combines bright-field and fluorescence microscopy in a standard light microscope. The technique enables simultaneous real-time observation of fluorescently-labeled structures in relation to their direct physical surroundings. The advancement provides context for the orientation, movement, and function of labeled structures in the microcirculation.

Higher Plasma Sclerostin and Lower Wnt Signaling Gene Expression in White Adipose Tissue of Prediabetic South Asian Men Compared with White Caucasian Men

Laura G.M. Janssen,Andrea D. van Dam,Mark J.W. Hanssen,Sander Kooijman,Kimberly J. Nahon,Hanneke Reinders,Ingrid M. Jazet,Wouter D. van Marken Lichtenbelt,Patrick C.N. Rensen,Natasha M. Appelman-Dijks 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.2

Background: South Asians generally have an unfavourable metabolic phenotype compared with white Caucasians, including central obesity and insulin resistance. The Wnt protein family interacts with insulin signaling, and impaired Wnt signaling is associated with adiposity and type 2 diabetes mellitus. We aimed to investigate Wnt signaling in relation to insulin signaling in South Asians compared with white Caucasians. Methods: Ten Dutch South Asian men with prediabetes and overweight or obesity and 10 matched Dutch white Caucasians were included. Blood samples were assayed for the Wnt inhibitor sclerostin. Subcutaneous white adipose tissue (WAT) and skeletal muscle biopsies were assayed for Wnt and insulin signaling gene expression with quantitative reverse transcription polymerase chain reaction (Clinicaltrials.gov NCT02291458). Results: Plasma sclerostin was markedly higher in South Asians compared with white Caucasians (+65%, P<0.01). Additionally, expression of multiple Wnt signaling genes and key insulin signaling genes were lower in WAT in South Asians compared with white Caucasians. Moreover, in WAT in both ethnicities, Wnt signaling gene expression strongly positively correlated with insulin signaling gene expression. In skeletal muscle, WNT10B expression in South Asians was lower, but expression of other Wnt signaling and insulin signaling genes was comparable between ethnicities. Wnt and insulin signaling gene expression also positively correlated in skeletal muscle, albeit less pronounced. Conclusion: South Asian men with overweight or obesity and prediabetes have higher plasma sclerostin and lower Wnt signaling gene expression in WAT compared with white Caucasians. We interpret that reduced Wnt signaling could contribute to impaired insulin signaling in South Asians.

Distal biceps tendon injection

Jacqueline van der Vis,Stein J. Janssen,Ronald L.A.W. Bleys,Denise Eygendaal,Michel P.J. van de Bekerom 대한견주관절의학회 2021 대한견주관절의학회지 Vol.24 No.2

Background: Injection therapy around the distal biceps tendon insertion is challenging. This therapy may be indicated in patients with a partial distal biceps tendon tear, bicipitoradial bursitis and tendinopathy. The primary goal of this study was to determine the accuracy of manually performed injections without ultrasound guidance around the biceps tendon. Methods: Seven upper limb specialists, two general orthopedic specialists, and three orthopedic surgical residents manually injected a cadaver elbow with acrylic dye using an anterior and a lateral infiltration approach. After infiltration the cadaveric elbows were dissected to determine the location of the acrylic dye. Results: In total, 79% of the injections were localized near the biceps tendon. Of these injections, 20% were localized on the radius near the bicipitoradial bursa. In total, 53% of the performed infiltrations were injected by anterior and 47% by lateral approaches. Of the injections near the distal biceps (79%), 47% were injected by an anterior and 53% by a lateral approach. Of the injections on the radius (20%), 33% were injected by anterior and 67% by lateral approach. Of the inaccurate injections (21%), 75% were injected anterior and 25% lateral. Conclusions: Manual infiltration without ultrasound guidance for distal biceps pathology lacks accuracy. We therefore recommend ultrasound guidance for more accurate infiltration.

Switching from Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF) in Virally Suppressed Chronic Hepatitis B (CHB) Patients with Moderate or Severe Renal Impairment, or in End-Stage Renal Disease (ESRD) Patients on Hemodialysis (HD): Week 2

( Jeong Heo ),( Harry L.A. Janssen ),( Young-suk Lim ),( Edward J. Gane ),( Claire Fournier ),( Sang Hoon Ahn ),( Owen Tsang ),( Wan-long Chuang ),( Aric Josun Hui ),( Magdy Elkhashab ),( Chi-yi Chen 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: TAF, a novel tenofovir prodrug, has demonstrated noninferior efficacy to TDF with superior bone and renal safety in virally suppressed CHB patients with eGFR (by Cockcroft-Gault; eGFR_CG) ³50 mL/min when switched from TDF. The efficacy and safety of virally suppressed patients on TDF with renal impairment who were switched to TAF were evaluated in this Phase 2 study. Methods: CHB patients with renal impairment taking TDF for ³48 weeks and virally suppressed for ³6 months with HBV DNA <20 IU/mL at screening were enrolled into 2 cohorts: 1) moderate-severe renal impairment (eGFR_CG 15 to <60mL/min) and 2) ESRD (eGFR_CG <15 mL/min) patients on chronic HD. All patients were switched to TAF 25 mg QD for 96 weeks. Co-primary endpoints were proportion with HBV DNA <20 IU/mL and graded adverse events (AEs)/lab abnormalities at Week 24. Results: 93 patients (Mod-severe impairment 78; ESRD 15) were enrolled from 26 sites in 8 countries. Median age was 65 years, 74% male, 77% Asian, 83% HBeAg-negative, up to 60% had low BMD at hip and/or spine, and 60% and 24% had a history of HTN and/or diabetes, respectively. Key efficacy/safety results at Week 24 are summarized in the Table. All patients on treatment at Week 24 maintained HBV DNA <20 IU/mL and a high proportion had normal ALT levels. Relative to baseline levels, switching to TAF from TDF resulted in increases in hip/spine BMD, decreases in bone turnover markers, as well as increases in eGFR_CG and decreases in renal tubular markers. TAF was well tolerated with few having Grade 3 or 4 AEs (8%) and no discontinuations due to AEs. Conclusions: In renally-impaired CHB patients, including ESRD patients on HD, viral suppression was well maintained and the bone and renal safety were improved 24 weeks after switching from TDF to TAF.