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Lee, J.Y.,Na, W.H.,Choi, H.Y.,Lee, K.H.,Ju, B.G.,Yune, T.Y. Academic Press Inc 2016 Neurobiology of disease Vol.95 No.-
<P>The disruption of the blood-spinal cord barrier (BSCB) by matrix metalloprotease (MMP) activation is a detrimental event that leads to blood cell infiltration, inflammation, and apoptosis, thereby contributing to permanent neurological disability after spinal cord injury (SCI). However, the molecular mechanisms underlying Mmp gene regulation have not been fully elucidated. Here, we demonstrated the critical role of histone H3K27 demethylase Jmjd3 in the regulation of Mmp gene expression and BSCB disruption using in vitro cellular and in vivo animal models. We found that Jmjd3 up-regulation, in cooperation with NF-kappa B, after SCI is required for Mmp-3 and Mmp-9 gene expressions in injured vascular endothelial cells. In addition, Jmjd3 mRNA depletion inhibited Mmp-3 and Mmp-9 gene expressions and significantly attenuated BSCB permeability and the loss of tight junction proteins. These events further led to improved functional recovery, along with decreased hemorrhage, blood cell infiltration, inflammation, and cell death of neurons and oligodendrocytes after SCI. Thus, our findings suggest that Jmjd3 regulation may serve as a potential therapeutic intervention for preserving BSCB integrity following SCI. (C) 2016 Elsevier Inc. All rights reserved.</P>
윤승호,배진선,이동규,곽태완 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2
The objects of university hospital are medical education, medicial research, residency trainung and patient cares. The university hospital is a nonprofit organization, but in the financial aspect, it is similar to commercial organization because the management is based on a profit from the patient care. The management of university hospital do not persue a profit but for the maintenance and development as a public corporation, there must be a balance or a littie profit between incomings and outgoings. For doing its best role, university hospital must perform the, management analysis and must correct the problems hindering effective management. We performed management analysis of Chung-Nam National University Hospital by various methods. With above management analysis, we propose some problems that must be corrected for effective management of Chung-Nam National University Hospital. This is a preliminary report searching for problems that hinder effective management of university hospital. So, there must be an another detailed management analysis to solve the problems that are proposed this management analysis.
윤천호,안병준,전학제,C. H. Yune,B. J. Ahn,Hakze Chon 대한화학회 1981 대한화학회지 Vol.25 No.1
양이온 교환 및 알루미늄 추출시킨 모더나이트와 제올라이트 Y 촉매에서 m-크실렌의 반응이 마이크로펄스방법으로 연구되었다. H-모더나이트 촉매에서 전처리온도가 높아지거나 Si/Al비가 증가할 때 동종간 주고 받기반응생성물이 크게 증가했다. $Ba^{2+}-, Mg^{2+}- $이온교환한 모더나이트촉매에서 양이온교환정도가 증가할에따라 트리메틸벤젠의 생성량이 급격히 감소했다. m-크실렌의 동종간 주고 받기반응에서는 모더나이트의 산성도의 영향과 아울러 촉매 유효세공의 크기에 따른 형상 선택성을 보여준다. Reactions of m-xylene were studied in a fixed-bed type micropulse reactor over cation-exchanged dealuminated mordenite and zeolite Y catalysts. Over H-mordenite catalysts higher catalyst pretreatment temperature as well as dealumination resulted in the increase of the formation of disproportionation product. $Ba^{2+}- and Mg^{2+}-$exchanged mordenite catalysts showed the shape selectivity in the disproportionation reaction of m-xylene, that is, the formation of trimethylbenzene decreasing sharply as the degree of cation exchange increased.
Control of magnetic anisotropy by ion-beam-mixing method under external magnetic field
Yune, J.-H.,Kim, H. B.,Kim, S. H.,Whang, C. N.,Chae, K. H. WILEY-VCH Verlag 2004 Physica status solidi. A, Applied research Vol.201 No.8
<P>Manipulation of magnetic anisotropy in ferromagnetic thin films was tried with ion-beam-mixing technique. Co/Pt multilayered films were deposited on Si(100) by electron beam evaporation and mixed with an energetic Ar<SUP>+</SUP> ion-beam under external magnetic field which was parallel to the sample surface. The magnetic easy axis was observed from the ion-beam-mixed samples along the direction of applied external magnetic field. When the ion dose was less than a critical dose, a small peak was measured along the magnetic hard axis. The small peak disappeared after ion-beam-mixing with a dose higher than the critical one. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)</P>
Lee, J.Y.,Choi, H.Y.,Ahn, H.J.,Ju, B.G.,Yune, T.Y. American Association of Pathologists and Bacteriol 2014 The American journal of pathology Vol.184 No.11
After spinal cord injury (SCI), blood-spinal cord barrier (BSCB) disruption by matrix metalloproteinases (MMPs) leads to BSCB permeability and blood cell infiltration, contributing to permanent neurological disability. Herein, we report that MMP-3 plays a critical role in BSCB disruption after SCI in mice. MMP-3 was induced in infiltrated neutrophils and blood vessels after SCI, and NF-κB as a transcription factor was involved in MMP-3 expression. BSCB permeability and blood cell infiltration after injury were more reduced in Mmp3 knockout (KO) mice than in wild-type (WT) mice, which was significantly inhibited by Mmp3 siRNA or a general inhibitor of MMPs, N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid. The level of tight junction proteins, such as occludin and zonula occludens-1, which decreased after SCI, was also higher in Mmp3 KO than in WT mice. Exogenously, MMP-3 injection into the normal spinal cord also induced BSCB permeability. Furthermore, MMP-9 activation after injury was mediated by MMP-3 activation. Finally, improved functional recovery was observed in Mmp3 KO mice compared with WT mice after injury. These results demonstrated the role of MMP-3 in BSCB disruption after SCI for the first time and suggest that the regulation of MMP-3 can be considered a therapeutic target to inhibit BSCB disruption and hemorrhage, and thereby enhance functional recovery after acute SCI.
Lee, J.Y.,Choi, H.Y.,Yune, T.Y. Pergamon Press 2016 Neuropharmacology Vol.109 No.-
Recently we reported that fluoxetine (10 mg/kg) improves functional recovery by attenuating blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). Here we investigated whether a low-dose of fluoxetine (1 mg/kg) and vitamin C (100 mg/kg), separately not possessing any protective effect, prevents BSCB disruption and improves functional recovery when combined. After a moderate contusion injury at T9 in rat, a low-dose of fluoxetine and vitamin C, or the combination of both was administered intraperitoneally immediately after SCI and further treated once a day for 14 d. Co-treatment with fluoxetine and vitamin C significantly attenuated BSCB permeability at 1 d after SCI. When only fluoxetine or vitamin C was treated after injury, however, there was no effect on BSCB disruption. Co-treatment with fluoxetine and vitamin C also significantly inhibited the expression and activation of MMP-9 at 8 h and 1 d after injury, respectively, and the infiltration of neutrophils (at 1 d) and macrophages (at 5 d) and the expression of inflammatory mediators (at 2 h, 6 h, 8 h or 24 h after injury) were significantly inhibited by co-treatment with fluoxetine and vitamin C. Furthermore, the combination of fluoxetine and vitamin C attenuated apoptotic cell death at 1 d and 5 d and improved locomotor function at 5 weeks after SCI. These results demonstrate the synergistic effect combination of low-dose fluoxetine and vitamin C on BSCB disruption after SCI and furthermore support the effectiveness of the combination treatment regimen for the management of acute SCI.