일부 흡연 대학생의 지각된 스트레스와 흡연실태에 대한 상관관계 연구

강초록,권시내,권혜림,박수경,송인혜,오해인,이미지,한승아,황선아,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

In spite of the seriousness of smoking harm has been developed these days. the increase of national smoking rate and that the people in the twenties are especially leading the rise of national smoking rate is an important issue of national health. Smoking of the university students can occur health problem and cause loss of manpower and expenses in their social activity period. So then the actual state for prevention of smoking and development of a program to prohibit smoking has to be seized urgently and starting with the study of the realities of university students, the effort to find a related fluent of smoking has to be studied. Related to this, the purpose of this study is to seize the general characteristics of smoking university students and to find out the relationship between perceived stress and smoking status among smoking university students. In addition, by collating the relationship between perceived stress and smoking status among smoking university students we have the purpose to furnish the basal data of stress care, the best way to cope with stress through group training and the plan for nursing implementation to decrease the smoking rate. For this study, a survey was conducted for 204 smoking university students of 13 universities in Seoul from 9th of May to 16th of May, 2003. The collected data was analyzed by t-test, Pearson Correlation and ANOVA in the statistical packages SPSS/PC. Major findings of this study are as follows; 1. Of the 204 respondents 85.4% of them were male and 14.6% of them were female. The average age of the sample was 23.19 years old and 41.8% of them were in senior, 21.4% in junior, 16.9% in sophomore, 19.9% in freshman grade. The major motivation to start smoking was 'because of curiosity'(33.8%) and the first smoking experience was at 'senior high school' (41.9%) and at 'college' (41.9%). 2 The highest scored stress factor of smoking university students were stresses about school work. 3. 72.7% had experience to quit smoking at least one or more times. Most of the reason to keep on smoking was 'short will to quit'(51.0%) and the smoking place was usually at 'school' (41.4%). Most respondents for the number ofsmoking friends were '5 people and above' (73.2%). 4. There was a negative relationship between the general characteristics and the entire perceived stress, however, there was a positive relationship between the general characteristics and the perceived stress in 4 categories which is 'sex distinction', 'major of study', 'residence form' and' inmate'. 5. There was a negative relationship between the general characteristics and the entire smoking status, however, there was a positive relationship between the general characteristics and the smoking status in 2 categories which is 'presence of hobby' and 'number of smoking friends'. 6. There was a negative relationship between the perceived stress and the smoking status. Through this study we have seized the relationship between the general characteristics, perceived stress and the smoking status of smoking university students. There was a positive relationship between some of the general characteristics with the perceived stress and the smoking status of smoking university students. Also there was a negative relationship between the perceived stress and the smoking status.

일부 지방대학 흡연 남자대학생과 비흡연 남자대학생의 혈청 및 식이 Ca, P섭취 수준 및 혈압의 비교 연구

김애정,박수진,이혜인 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.2

This study was performed to observe the levels of serum and dietary Ca and P, and blood pressure in rural university male students(smoker: 35 persons, non smoker: 32 persons). Three-day dietary record and blood samples were collected for measurements of the Ca and P levels of dietary intake and serum. The results were as follows : 1) There were no significant differences between smokers and non-smokers in terms of height, weight, and BMI. 2) Mean blood pressures on smokers and non-smokers were 131.33/93.75㎜Hg, 119.37/80. 62㎜Hg, respectively. Blood pressure of smokers was higher than that of non-smokers(p<0.05). 3) There were no significant difference between smokers and non-smokers in calcium, phosphorus, and Ca/P ratio of dietary intake and serum. The results of this study suggest that non-smoking education programs for smokers including the information on the desirable food habits for prevention of hypertension should be developed.

한약재의 보관 , 절단 , 수치 , 전탕법에 관한 연구 1 : 육계 Cortex Cinnamomi

金仁洛,黃今熙,朱慧庭 대한본초학회 1998 大韓本草學會誌 Vol.13 No.2

To improve the quality control of frequantly used oriental medicinal plants, the stroage, cutting, processing and decokting methods of Cinnamomum cassia were examined. The contents of cinnamic acid and cinnamaldehyde of Cinnamomum cassia were analysed by HPLC at various conditions as the standard components. Standard components decreased in aerobic condition more than in anaerobic storage condition. The cinnamic acid decreased and the cinnamaldehyde increased during the aerobic and anaerobic storage condition. Especialy, cinnamaldehyde was conciderably increased at aerobic storage condition. The soaking and steaming processing for easy cutting resulted in the loss of the standard components. The best decokting conditions which were determined by the yield of cinnamic acid were as follows : the size was below 0.5㎝, soaking time was 90 minutes, decokting time was 15 minutes after boiling.

Quantitative in‐line monitoring of solvent‐mediated polymorphic transformation of sulfamerazine by near‐infrared spectroscopy

Lee, Min‐,Jeong,Seo, Da‐,Young,Wang, In‐,Chun,Chun, Nan‐,Hee,Lee, Hea‐,Eun,Jeong, Myung‐,Yung,Kim, Woo‐,Sik,Choi, Guang J. Wiley Subscription Services, Inc., A Wiley Company 2012 journal of pharmaceutical sciences Vol.101 No.4

<P><B>Abstract</B></P><P>The in‐line monitoring of pharmaceutical processes with high risk, such as crystallization, has been one of the most popular research topics in recent years. Sulfamerazine (SMZ), a well‐known sulfonamide antibacterial agent was investigated to examine the mechanism of polymorphic conversion by solvent‐mediated polymorphic transformation (SMPT). The primary purpose of this study is to monitor the polymorphic transformation through in‐line near‐infrared (NIR) measurements and concurrently interpret the whole process quantitatively with off‐line characterizations. Samples taken at every hour during SMPT were analyzed by X‐ray diffractometry (XRD) and differential scanning calorimetry (DSC). NIR spectra in the range of 7500–4900 cm<SUP>−1</SUP> were taken into account for multivariate analysis, which included partial least square (PLS) regression and principal component analysis (PCA). In brief, the form II content was estimated very accurately and reproducibly during the SMPT process not only by XRD but also by the DSC measurements. In addition, the form II content values were predicted very accurately by separate experiments at two designated time points. In a separate study, it was demonstrated that PCA could be employed to explain a complicated process such as SMPT mechanistically by several stages. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:1578–1586, 2012</P>

Benz[f]indole-4,9-dione 유도체의 Topoisomerase I-DNA에 대한 결합형태와 저해작용 간의 상관관계

최인희,우선아,박혜숙,박혜영,김춘미 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.16

We present binding modes of newly eethesized benzlflindole4,94ione analogs with topoisomerase I (TOPI)-DNA complex The compounds were tested for cytotoxicity and 10pl inhibitory activity in our previous study. Camptothecin (CPI) and each of the 15 analogs were docked into the X-ray crystal stucture of human TOPI-DNA binary complex to develop the temary complex of TOP1-DNA-ligand using FlexiDock The results demonstrated that two compounds with N_(1)-attached halogens intercalated exactly between the -1 and +1 DNA bases, deeply toward the cleavage site and were stabilized by three H-bonds each and an array of hydrophobic interactions with both the enzyme and the DNA. The most potent intbiery activities they showed in the test agree well with the proper docking results. Six compounds which did not intenalate and formed no H-bond showed no or very low inhibitory activities. Seven compounds that intercalated between the bases with one to four H-bonds but not deeply enough toward the cleavage site showed intermediate activities. The structure-activity relationship was consistent with the experimental data The ternary complex presented potential binding mode of each compound and thus could provide a rational basis far novel inhibitor design to develop potent anticancer drugs targeting TOP1 enz[f]indole-4,9-dione 유도체와 topoisomerase I(TOP1)-DNA 복합체의 결합형태를 규명하기 위해 세포독성과 TOP1저해작용이 검사된 15개의 유도체와 camptothecin을 TOP1-DAN복합체의 X-선 구조에 FlexiDock을 사용하여 docking하였다, 그결과 N_(1)에 할고겐 이 결합된 두화합물은 -1/+1 염기 사이에 끼어들어 깊숙이 결합되었고 각각 3개의 수고결합과 다수의 소수성 상호작용으로 안정화되었다. 활성검사에서 가장 강한 작용이 나타나 고유한 docking결과와 잘 부합되었다. 염기사이에 끼어들지 않고 수소결합도 형성하지 않은 6개의 화합물에서는 활성이 거의 나타나지 않았다. 한개 내지 4개의 수소결합을 형성하면서 염기 사이에 끼어들었으나 TOP1에 의해 잘라지는 위치에 깊게 결합하지 못한 7개의 화합물은 중간 정도의 활성을 나타내어 구조 활성 관계가 실험 치와 잘 일치 하였다, 이 결과는 TOP1을 목표로 하는 새로운 항암제의 구조를 고안하는데 합리적인 근거를 제공할 것이다.

리마틸 정(부시라민 100㎎)에 대한 부시린 정의 생물학적 동등성

조혜영,이문석,오인준,김동현,문재동,이용복 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.2

Bucillamine is a novel cysteine derivative with two free intramolecular sulfhydryl groups, and has a preventive and therapeutic effect on adjuvant arthritis, suggesting its antirheumatic action. With respect to the effect on the immune system, bucillamine-exerted such immunoregulating actions are to nomalize an excessive reduction or acceleration in immune reaction. It is useful not only in patients with early stage of rheumatoid arthritis (RA) but also in those with active RA retained for more than 10 years. The purpose of the present study was to evaluate the bioequivalence of two bucillamine tablets, Rimatil^TM (Chong Kun Dang Pharmaceutical Co., Ltd.) and Bucilin^TM (Kuhn Il Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, 23.67±2.09 years in age and 65.03±6.73 kg in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After three tablets containing 100 mg of bucillamine per tablet were orally administered, blood was taken at predetermined time intervals and the concentrations of bucillamine in serum were determined using GC/MS with mass selective detector. Pharmacokinetic parameters such as AUC_t, C_max, and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were -0.29%, -3.20% and 8.22%, respectively, when calculated against the Rimatil^TM tablet. The powers (1-β) for AUC_t and C_max were 84.31 % and 91.16%, respectively. Minimum detectable differences (Δ) at α=0.10 and 1-β=0.8 were less than 20% (e.g., 18.58% and 16.51% for AUC_t and C_max respectively). The 90% confidence intervals were within ±20% (e.g., -12.77∼12.20 for AUC_t and -14.30∼7.90 for C_max). Two parameters met the criteria of KFDA for bioequivalence, indicating that Bucilin^TM tablet is bioequivalent to Rimatil^TM tablet.

삼세대 동거주택에 관한 의식조사 연구 : 95년, 2002년 조사결과를 중심으로

김인회 협성대학교 2003 협성논총 Vol.15 No.-

초등학생의 환경 의식 변화에 관한 종단적 경향성 조사

김영호,류재인,정진수,이혜정,박국태 한국초등과학교육학회 2003 초등과학교육 Vol.22 No.3

The purpose of this study was to survey the change of environmental awareness of elementary school students under the longitudinal-sectional research design. For this study, the questionnaire was used for 599 fifth and sixth grade students living in Seoul, Anseong, and Yangjugun. The results of this survey, compared and analyzed with those of 1987, 1992, 1996, and 2000, were summarized as follows: In the point of environmental awareness, the interest for animal protection and conservation of nature increase but the interest for environmental pollution decreased. There was a high awareness about water pollution, and the awareness about the exhaust of automobile was constantly increasing. Regarding students' knowledge about the environment, their attitudes, and changes of practice, the rate of interest for environmental pollution decreased but the rate of interest for animal protection and conservation of nature increased. As a result of this study, it was found that the students' awareness about the environment varied according to the survey year. By changing the environment education according to this variation, it can be possible to effectively teach students to increase their environmental awareness and develop a habit of environmental protection.

한약재의 절단 , 수치 , 전탕법에 관한 연구 Ⅲ : 厚朴 Cortex Magnoliae

金仁洛,黃今熙,朱蕙庭 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1

To improve the quality control of frequantly used oriental medicinal plants, the cutting, processing and decokting methods of Magnolia obovata were examined. The contents of magnolol of Magnolia obovata were analysed by HPLC at various conditions as the standard component. The content of magnolol increased about 3% in baked Magnolia obovata. The soaking and steaming processing for easy cutting resulted in the loss of the standard components about 10%. The best decokting conditions which were determined by the yield of magnolol were as follows : the size was below 0.5㎝, soaking time was 0 minutes, decokting time was 75 minutes after boiling.

남녀 고등학생의 교복과 자율복의 대한 태도 연구

김미정,김영숙,배지혜,신영옥,장명희,황인순 효성여자대학교 가정대학 학도호국단 1984 家政大論集 Vol.3 No.-

The purpose of this study was to investigate the attitude difference toward the school uniform, it was supposed that clothing acceptance was differentiated according to subjects. The subjects were grouped by 3 types which were students, teachers(school governors) and parents groups. The results were as follows; 1. Boy students reguired the more freedom of clothing than girls. 2. Teachers and parents groups considered that clothing affected student's behavior and self-esteem. 3. The acceptance of school plain dress was affected by atomosphere of home and school. 4. According to socioeconomic levels, there were differences in clothing acceptance and fashion acceptance.