호알칼리성 Bacillus sp. No. 4의 Cyclodextrin Glycosyltransferase에 의한 Glycosyl Sucrose의 생산과 저충치성 당으로서의 응용

손천배,유미경,김명희,문숙경 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-

Action of a cyclodextrin glycosyltransferase (CGTase) produce from alkalophilic Bacillus sp. No. 4 was studied in a solution containing starch and sucrose to prepare glycosyl sucrose syrup with good sweetness and antidecaying properties of teeth. In the initial stage of the reaction the CGTase produced cyclodextrin, however, the cyclodextrin disappeared and glycosyl sucrose was formed with the lapse of reaction time. The best proportion of sucrose to starch for prodution of glycosyl sucrose was about 1 : 1. The optimum pH and temperature of the coupling reaction was pH 6.0 and 60℃, respectively. Main composition of glycosyl sucrose syrup prepared with 20% starch and 20% sucrose was sucrose 18%, glucosyl sucrose (G_2F) 15.3% and amltosyl sucorse (G_3F) 11.3%. And glucose, maltose and maltotriose were produced very little. Smaller amounts of acid and insoluble glucan were formed in the syrup by Streptococcus mtans OMZ176 than in the sucrose. Therefore, the prepared glycosyl sucrose sucrose syrup is expected to prevent teeth from decaying.

피부 병변을 동반한 악성조직구증 1예

조은택,박용관,김진호,강정원,천영욱,전익섭,박유환,전춘해 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

Malignant histiocytosis, originally described in 1939 as histiocytic medullary reticulosis by Scott and Robb-Smith, is a rare histiocytic proliferative disorder that often shows an acute onset and used to progress to death within a few months. This disorder characterized clinically by fever, generalized weakness, lymphadenopathy and hepatosplenomegaly, and shows a variable range of pancytopenia. Extranodal involvement is common, with an incidence ranging from 50% to as high as 90%, skin involves8ment was noted in 10% to 15%. Typical skin lesions were mainly founded in extremity. i.e. erythematous papule and nodule occasionally become to necrosis and ulceration. We experienced one case of malignant histiocytosis in a 46-years-old female. The major clinical findings are fever, malaise, hepatosplenomegaly and erythematous skin lesion. In the laboratory study, pancytopenia is noted on the peripheral blood. And also aggregation of many atypical histiocytes were shown on skin and bone marrow biopsy. So we reported one related case with malignant histiocytosis as well as reviewing literature .

λ-경쇄형 다발성 골수종 1예

박용관,김태원,장영,김진호,강정원,천영욱,박유환,정춘해 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

Multiple myeloma is a disease caused by neoplastic plasma cells that synthesize abnormal amouts of immunoglobulin or immunoglobulin fragments. Light chain myeloma are regarded as a separate category characterized by a more malignant clinical course. Light chain myelomas are said to grow fastest of all and are associated with more osteolytic lesions, more hypercalcemia, and a higher incidence of renal failure and amyloidsis than either the IgG, IgA varienties The authors experienced a case of patients with λ-light chain myeloma. A 43-year-old male patient admitted to our hospital with the chief complaint of both rib and lower back pain. The radiologic findings showed multiple pathologic fracture in ribs. osteolytic lesions in 2nd, 3rd cervical spineimmuture plasma cells. Serum electrophoresis showed normal finding. Urine electrophoresis evealed an M-spike. Urine immunoelectrophoress demonstrated λ-monoclonal protein. With the cycle of melphalan, prednisone and α-interferon chemotherapy improved of pain was observed. So we reported the case with brief review of previous literature.

SENIORITY PAY , TURNOVER AND JOB TRAINING IN KOREA(JEL Classification : J41)

CHEON, BYUNG YOU 한국경제학회 1998 The Korean Economic Review Vol.14 No.1

Therapeutic effect of subconjunctival injection of bevacizumab in the treatment of corneal neovascularization

You, In-Cheon,Kang, In-Seong,Lee, Seung-Hyun,Yoon, Kyung-Chul Blackwell Publishing Ltd 2009 Acta ophthalmologica Vol.87 No.6

<P>Abstract.</P><P>Purpose: </P><P>To investigate the efficacy of subconjunctival injection of bevacizumab in the treatment of patients with corneal neovascularization.</P><P>Methods: </P><P>Twenty-nine eyes of 29 patients with corneal neovascularization were treated with subconjunctival injection [1.25 mg/0.05 ml (seven eyes), 2.5 mg/0.1 ml (15 eyes) and 5.0 mg/0.2 ml (seven eyes)] of bevacizumab. Best-corrected visual acuity, intraocular pressure and area of corneal neovascularization were measured before injection and at 1 week, 1 month and 3 months after treatment.</P><P>Results: </P><P>At 1 week, the mean neovascularized corneal area decreased significantly to 85.5 ± 18.0% (<I>p</I> =<I> </I>0.01) in the eyes treated with 2.5 mg bevacizumab and to 73.1 ± 23.4% (<I>p</I> =<I> </I>0.02) in the eyes treated with 5.0 mg bevacizumab. At 3 months, the mean neovascularized corneal area was 93.6 ± 10.6% (<I>p</I> =<I> </I>0.10 compared to baseline; <I>p</I> <<I> </I>0.01 compared to 1 week) in the eyes treated with 2.5 mg bevacizumab and 83.3 ± 25.8% (<I>p</I> =<I> </I>0.03 compared to baseline; <I>p</I> =<I> </I>0.02 compared to 1 week) in the eyes treated with 5.0 mg bevacizumab. However, there were no significant changes in the areas of the eyes injected with 1.25 mg bevacizumab.</P><P>Conclusion: </P><P>Subconjunctival injection of bevacizumab can partially reduce corneal neovascularization in the short term, and the efficacy of this treatment correlates with the injection dose.</P>

A Case Report of Herpes Zoster Ophthalmicus and Meningitis After COVID-19 Vaccination

You In-Cheon,Ahn Min,Cho Nam-Chun 대한의학회 2022 Journal of Korean medical science Vol.37 No.20

There are several reports that herpes zoster characterized by reactivation of varicella zoster virus (VZV) following coronavirus disease 2019 (COVID-19) vaccines can occur. Herein, we report VZV meningitis, herpes zoster ophthalmicus (HZO), and late neurotrophic keratitis after receiving a second dose of messenger RNA (mRNA) COVID-19 vaccine. A 74-year-old man developed a vesicular skin rash on the forehead, scalp, nose, and left upper eyelid with a severe headache. Five days earlier, he received a second dose of the BNT162b2 mRNA vaccine on his left arm. Ocular examination revealed conjunctival hyperemia and pseudodendrite in the peripheral cornea. VZV was detected in the cerebrospinal fluid using polymerase chain reaction. The patient was diagnosed with HZO and meningitis. The patient was treated with intravenous acyclovir and topical acyclovir ointment and levofloxacin 1.5% eye drops. One month later, he developed a central epithelial defect with a rolled margin, typical of a neurotrophic ulcer. Treatment with a therapeutic contact lens and a combination of topical recombinant human epithelial growth factor and ofloxacin ointment was initiated. At six months after vaccination, the slit-lamp examination findings were stable with a mild corneal superficial stromal haze.

멀티미디어디자인에서 정보디자인 주요 특성

류시천(You Si-Cheon),김병욱(Kim Byung-Uk) 한국디자인학회 2003 한국디자인학회 학술발표대회 논문집 Vol.- No.-

멀티미디어디자인에서 정보 위계 표출 방식

류시천(You Si-Cheon) 한국디자인학회 2005 한국디자인학회 학술발표대회 논문집 Vol.2005 No.5

액체-액체 동축형 스월 인젝터의 수치적 모사를 위한 SPH 코드 개발 및 검증

김유천(You-Cheon Kim),Fedir V. Sirotkin,여재익(Jai-ick Yoh) 한국항공우주학회 2015 韓國航空宇宙學會誌 Vol.43 No.1

지금까지 인젝터의 수치적 시뮬레이션은 대부분 Eulerian 기법의 바탕위에서 이루어져 왔다. 그러나 액체제트의 미립화현상과 복잡한 공기와의 경계면 변화를 나타내는데 있어 기존의 기법들이 갖는 선천적인 단점이 존재하며 따라서 본 연구에서는 새로운 Smoothed Particle Hydrodynamics(SPH)라는 입자 기법을 도입하였다. 수치적 시뮬레이션을 위해 먼저 해석을 위한 SPH 코드를 개발하였으며 본 논문에서는 인젝터 문제를 정확하게 나타내는데 있어 필수적인 알고리즘중 하나인 다상유동모사에 대한 검증문제가 제시 되어 있다. 마지막으로 다양한 인젝터 종류 중 하나인 액체-액체 동축형 스월 인젝터에 대한 시뮬레이션이 수행되었으며 실제실험과의 비교를 진행하였다. Most jet spray and atomization simulations are done with the Eulerian method which has inherent disadvantage in representing jet breakups and droplets. Full Lagrangian particles method called Smoothed Particle Hydrodynamics(SPH) is used in this work. We develop the SPH code and perform validations that confirm the suitability of our SPH method for simulating liquid jet atomization problem. Then, we conduct the simulation of liquid-liquid swirl coaxial injector for comparison against the experimental data.

임금 불평등 변화의 요인분해: 2006-2015년

정준호 ( Cheon Byung-you ),전병유 ( Jeong Jun-ho ),장지연 ( Chang Jiyeun ) 한국산업노동학회 2017 산업노동연구 Vol.23 No.2

이 글에서는 2000년대 중반 이후 한국의 임금불평등을 지니계수의 변화와 이를 초래한 요인들의 기여도를 분석하였다. 자료와 임금 지표에 따라 추세가 달라지지만, 주당 35시간 미만 일하는 파트타임의 증가로 전체근로자 임금총액의 지니계수는 증가하는 추세를 보여주는 반면, 시간당임금 지니계수와 풀타임근로자의 임금총액 지니계수는 하락하는 추세를 나타냈다. 파트타임 증가가 임금총액 기준의 불평등은 높였지만, 파트타임의 시간당임금 증가는 시간당임금 기준의 불평등을 낮추었다. 풀타임 노동자만을 대상으로, 지니계수 감소 요인을 분해한 결과, 불평등 감소에 절대적으로 기여가 큰 요인은 근속, 경력, 직종 등의 변수였고, 고용형태 변수는 불평등 감소에 미미하게 기여하는 것으로, 사업체 규모 변수는 불평등을 오히려 높이는 것으로 나타났다. 업종이나 연령, 교육 등의 변수는 불평등 변화에 유의미한 크기의 기여를 하지 못한 것으로 분석되었다. 여기에는 장기근속과 관리전문직종에 대한 임금프리미엄의 감소와 대규모사업체의 임금프리미엄 증가 등이 작용한 것으로 분석되었다. This paper analyzes the changes in wage inequality and its contributing factors since the mid-2000s. Although trends vary by data and wage indices, the Gini coefficient of the total wage of all workers shows an increasing trend due to the part-time increase of less than 35 hours per week, while the wage Gini coefficient of hourly wages and the total wage Gini coefficient of full-time workers showed a declining trend. Part-time increases have increased inequality based on total wages, but part-time hourly wage increases can be considered to have reduced hourly wage inequality. Therefore, as a result of decomposing the factor of Gini coefficient reduction only for full-time workers, factors that contributed absolutely to inequality reduction were variables such as job tenure, career, and occupation, and employment type variable has little effects, and the establishment size variable deepens inequality. The variables such as industry, age, and education did not contribute significantly to the inequality change. This is attributed to the decline in wage premiums for job tenure and management and professional jobs and the increase in wage premiums for large-scale businesses.