人蔘이 羊水感染에 의한 早産에 미치는 영향

尹成獻,趙亨來,金瞳一,李泰均,南景琇 대한한의학회 부인과학회 2000 大韓韓方婦人科學會誌 Vol.13 No.2

This study was performed to investigate the effect of Panax ginseng on preterm labor by amniotic infection. The results of this study were as follows; 1. Interleukin-6(IL-6) production induced lipopolysaccharide(LPS) or Interleukin-1β (IL-19) was inhibited by Panax ginseng hot water-extracts. 2. Production of tumor necrosis factor-α (TNT-α) was not inhibited by Panax ginseng on L929 cytotoxicity assay. 3. Phospholipase A_2(PLA_2) induced LPS in WISH cell was inhibited by Panax ginseng, and also induced IL-1β was inhibited low concentration. 4. PGE_2 production induced LPS and IL-1β was inhibited by Panax ginseng hot water-extracts on PGE_2 enzyme immunoassay. 5. Leukotriene C4 (LTC4) production induced LPS and also IL-1β was inhibited by Panax ginseng hot water-extracts. 6. Panax ginseng may be useful for treatment of preterm labor by amniotic infection because it can inhibit inflammation response induced infection.

Recovery of ionic liquid and sugars from hydrolyzed biomass using ion exclusion simulated moving bed chromatography

Mai, Ngoc Lan,Nguyen, Nam Trung,Kim, Jin-Il,Park, Hyuk-Min,Lee, Sung-Kyun,Koo, Yoon-Mo Elsevier 2012 Journal of Chromatography A Vol.1227 No.-

<P><B>Highlights</B></P><P>► Ionic liquid was successfully separated from aqueous sugar mixtures by ion exclusion SMB. ► Ionic liquid and sugar recovery yield depend on the SMB zone flow rates. ► Complete recovery of ionic liquid could be obtained by optimization of SMB zone configuration.</P> <P><B>Abstract</B></P><P>Efficient recovery of ionic liquid (IL) from aqueous mixture of ILs and sugars (which derived from enzymatic or chemical catalyzed hydrolysis of ILs-pretreated biomass) is a major drawback for commercialization of biofuel and platform chemicals production from biomass utilized ILs as pretreatment solvent. In this study, simulated moving bed (SMB) chromatography equipped with ion exclusion column (containing [Emim]<SUP>+</SUP> cation) was investigated to separate sugars (glucose and xylose) which are the main products from biomass hydrolysate and 1-Ethyl-3-methylimidazolium acetate (EmimAc) which is the ILs used for biomass pretreatment. A four-zone SMB system with a configuration of 2-2-2-2 (2 ion exclusion columns in each zone) was used to recover glucose, xylose and EmimAc from their aqueous mixture with yield of 71.38, 99.37 and 98.92%, respectively. Moreover, the optimization of SMB zone configuration by simulation results in a complete recovery of ILs. This result indicates that for the first time, ion exclusion SMB chromatography could be used for complete recovery of ILs from aqueous sugar mixture.</P>

The Effects of Ketorolac Tromethamine and Baicalein on the Levels of Inflammatory Factors in Human Synoviocytes

Yang, Jae-Heon,Yun, Mi-Young,Lee, Nam-Hee,Kim, Dae-Keun,Kim, Young-Il,Noh, Young-Hee,Kim, Tae-Youl,Yoon, Se-Won,Shin, Sang-Chul 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11

This study examined the effects of ketorolac tromethamine (KT) and baicalein (BE) on the levels of inflammatory factors in human synoviocytes. The fibroblast-like synoviocytes (FLS) cells were used to determine the possible regulatory effects of KT and BE (KTBE) on the levels of inflammatory factors in FLS cells. In addition, the levels of TNF-$\alpha$, IL-6, and IL-$1{\beta}$ mRNA expression in FLS cells induced by a TNF-$\alpha$ and IL-$1{\beta}$ co-treatment were largely inhibited by a KTBE treatment. The level of FLS cells proliferation was increased by IL-$1{\beta}$ and TNF-$\alpha$, and strongly inhibited by KTBE treatment. The production of oxygen species (ROS) was inhibited by KTBE in FLS cells. KTBE appears to regulate the levels of mRNA that are important for regulating RA progression.

Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10

Seung-Ha Yang,Min-Jung Park,Il-Hee Yoon,Su-Young Kim,So-Hee Hong,Jin-Young Shin,Hye-Young Nam,김용희,Bongi Kim,박정규 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.5

Mesenchymal stem cells (MSCs) can inhibit T cell proliferation; however, the underlying mechanisms are not clear. In this study, we investigated the mechanisms of the immunoregulatory activity of MSCs on T cells. Irradiated MSCs co-cultured with either naïve or pre-activated T cells in a mixed lymphocyte reaction (MLR) significantly suppressed T cell proliferation in a dose-dependent manner, irrespective of allogeneic disparity between responders and MSCs. Transwell assays revealed that the suppressive effect was primarily mediated by soluble factors that induced apoptosis. Splenocytes stimulated with alloantigen in the presence of the MSC culture supernatant (CS) produced a significant amount of IL-10, which was attributed to an increase in the number of IL-10 secreting cells, confirmed by an ELISPOT assay. The blockade of IL-10 and IL-10 receptor interaction by anti-IL-10 or anti-IL-10-receptor antibodies abrogated the suppressive capacity of MSC CS, indicating that IL-10 plays a major role in the suppression of T cell proliferation. The addition of 1-methyl-DL-tryptophan (1-MT), an indoleamine 2,3-dioxygenase (IDO) inhibitor, also restored the proliferative capacity of T cells. In conclusion, we demonstrated that soluble mediators from culture supernatant of MSCs could suppress the proliferation of both naïve and pre-activated T cells in which IL-10 and IDO play important roles.

분무건조법을 이용한 방출 제어형 케토로락 고형지질마이크로스피어의 제제설계

윤재남,이은미,김동우,박용근,전일순,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-

Ketorolac (KA) and ketorolac tromethamine (KT) is the nonsteroidal anti-inflammatory drugs (NSAIDs) and has been used widely. To improve its frequent administration by control of drug release. we prepared SLM of KA and KT using Mirj 45 and 52 as surfactants and tripalmitin and tristearin as lipids by spry drying method SLM, as a disperse system for injection, were evaluated by measurement of particle sizes. SEM and drug release pattern As a result. spherical SLM were prepared and their particle size were in the range of 25-125 μm, which were dependant on the types and contents of lipid and sururfactants. Their dissolution rate were decreased as increasing lipid contents.

호텔식당 메뉴의 開發 方案에 관한 硏究 : EVENT를 中心으로

윤일남 대구산업정보대학 2000 논문집 Vol.14 No.1

The location, merchandise of food, value making by hotel brand, good service, and highly educated personnel management should be a key in a successful factor of hotel restaurant. And so hotel restaurants not only should be satisfied desire of guests but also be the place offering opportunity of new desire through their concept, special menu and good service. The results of business of food and beverage department of recent domestic deluxe hotel should be increased every year. It should be helpful to activate food and beverage business presenting the plan for the sale promotion of more effective event menu. The first, marketing for event menu sale should be practised systematically. It is real situation practising the event with a link in the chain of program of the off season policy and hotel restaurant should be central role in order to be closely related with guests, constructing the guest data base and understanding need of guests throughly as a plan for competitive power strengthening. The second, It is very important to secure capable cook who has professional knowledge and skill. It should be the restaurant presenting the creative menu fitting in the atmosphere of event menu and restaurant; that is creative and special menu to guests developing a sort of cuisine, cooking methods, traditional local food, healthy food. The third, It should be regards of guest as reasonable cost decision. A comparative decision method to select the cost, comparing with competitive hotel, is general, but it is judged more reasonable to decide cost including food making cost and estimating goals profit, and in any case it is a case to be settled high cost in one way in order to pursue high class image.

호텔 식음료 부문의 매출촉진 방안에 관한 연구

윤일남 대구산업정보대학 2002 논문집 Vol.16 No.-

Recently characteristics of hotel management are that the food and beverage revenues are increasing remarkably and that they are greater than the revenue from rooms. As the food and beverage departments grow in quality and quantity to be comparative to the amount of sales from rooms the hotel's competitiveness is strengthened. It is further strengthened through the systematical marketing education through training professional salesmen for the sales promotion of the food and beverage departments. This study recommends an improvement plan by analyzing facts to promote the food and beverage sales, adopting methods to increase sales and to eliminate existing hotel sales problems. Hotel management has a higher dependence on manpower than other industries. Therefore, securing of a fixed clientele should be an immensely important strategy in the running of a restaurant. Techniques are needed to improve the promotion of sales of food and beverage in order to maximize overall hotel sales. When such conditions are fully attained the promotion of restaurant and hotel sales should be accomplished.

만성 C형 간염 환자에서 페그인터페론 알파2a와 리바비린 병합 치료중 발생한 벨마비 1예

김일환,장제혁,유충헌,최규남,고정해,김윤정,서광원,김지현,박성재,박은택,이연재,이상혁,설상영 인제대학교 2008 仁濟醫學 Vol.29 No.-

페그인터페론과 리바비린 병합요법은 만성 C형 간염의 일차 치료법이다. 저자들은 만성 C형 간염 환자에서 페그인터페론 과 리바비린 병합 요법 중에 발생한 벨마비 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 5년 전부터 만성 C형 간염을 앓아온 48세 남자이며, PEG-IFN α-2a 135μgm 피하주사 주1회와 하루 1200㎎의 리바비린을 투여하였다. 치료시작 후 9개월째 환자는 오른쪽 안면의 근력약화를 호소하였으며 벨마비로 진단되었다. 페그인터페론과 리바비린 병합요법을 지속하면서 관찰하였다. 환자의 벨마비는 페그인터페론 치료를 중단하지 않았음에도 3개월후 증상이 회복되고 이후 벨마비 재발 없이 현재 경과관찰 중이다. 만성 C형 간염에서 페그인터페론과 리바비린 병합 요법시 벨마비의 발생 가능성을 염두에 두어야 하겠다. A Case of Bell's Palsy Associated with Combination Therapy of Pegylated Interferon Alfa-2a (PEG-IFN) and Ribavirin for Chronic Hepatitis C Virus Infection Pegylated interferon alfa(PEG-IFN α) and ribavirin therapy is the first line treatment for chronic hepatitis C. Mild complications of the therapy are common, but more serious complications are rare. We report here a case of Bell's palsy that occurred in a patient with chronic hepatitis C virus infection during combination therapy of PEG-IFN α-2a and ribavirin. The patient was 49-year-old man with chronic hepatitis C (genotype 1b) for 8 years. He had compensated liver cirrhosis with splenomegaly. Therapy with PEG-IFN α- 2a 135mcg/week and ribavirin 1200mg/day was initiated. After 9 months of the therapy, the patient showed a loss of muscular tone on the right side of his face. A diagnosis of Bell's palsy was made. The Bell's palsy resolved over 3 months despite continuation of the combination therapy.

폴리메타크릴레이트를 이용한 케토로락 트로메타민 서방성 정제의 제조와 용출평가

전일순,윤재남,이은미,박용근,김동우,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-

To improve administration of ketolorac tromethamine, we prepared matrix tablets with Eudragit (RS 100 or 30D), diluents (avicel:lactose=l:l or Ca phosphate) and Mg stearate using wet-granulation method. Sustained release matrix tablets using Eudragit® RS 100 7 and 10% decreased dissolution rate at pH 1.2 and 68 Ca. phosphate as diluents showed more decreased dissolution rate than that of avicel:lactose (1:l). Sustained release matrix tablets using Eudragit® RS 30D also showed very effective sustained release of KT.

선행하중 재하시 지반손실 감소효과에 대한 연구

황성일,조남준,윤완식 국민대학교 생산기술연구소 2003 공학기술논문집 Vol.26 No.-

Among various methods for reducing the ground loss, this study introduces the pre-loading method which has been recently developed. Also, the major influence factos concidered fundamentlly in application of the pre-loading method are studied through hypothetical examples. In order to estimate the reduction effect of the ground loss by using the pre-loading method, three types of wall with the same ground conditions and the strut system have been considered. And each type of the walls has been clsssified again into twd categories depending on the rigidity of the temporary walls to invastigate the influence of wall rigidity on the reduction effect of ground loss owing to pre-loading in detail. The variation of underground water level has been evaluated by the seepage analysis. And the soil movement of the ground and axial force of struts in the back site of the excavation have been calculated by analyzing the soil behavior with the consideration of the underground water variation calculated by the seepage analysis. The reduced ground losses related to the magbitude of pre-loads have been determined by varying the pre-loads on the struts.