유한요소법에 의한 원형드로오비드의 인출특성에 관한 연구

신양호,심현보 한국공작기계학회 1997 한국생산제조학회지 Vol.6 No.3

In this study, the drawing characteristics of circular drawbead are examined with the plane strain elastic-plastic FE Method. Both the clamping load and the drawing load are investigated by varying the process variables such as drawbead radius, closing depth and friction condition. The effective strain induced by the draw bead is also investigated. In order to verity the results, the computed results are compared with the existing experimental results. It has been found that both the clamping load and drawing loads are related with the geometry of the bead rather the lubrication conditions.

한국인에서 CC-SIT와 비교한 KVSS Test의 임상적 유용성 평가 : 예비연구 Pilot study

김진국,장현종,임채형,남태욱,심대보 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-

Background and Objectives: Sniffin' Sticks test is the test of nasal chemosensory performance based on pen-like odor dispensing devices. KVSS(Korean Version of Sniffin' Sticks) Test was developed as the "Korean olfactory test" using the odorants which are familiar to Korean. Authors evaluated the clinical validity of KVSS Test compared with CC-SIT (Cross-Cultural Smell Identification Test) in Korean. Materials and Methods: The subjects of this study were 25 normosmic volunteers who were divided into five groups according to age. Each group was 5 normosmic volunteers. And they consisted of 12 men and 13 women. KVSS Test and CC-SIT were used for the evaluation of olfactory function. Results: Our study showed the negative correlation between age and olfactory function test (CC-SIT score, KVSS Test I score and KVSS Test II score). Normosmia rate of KVSS Test was more higher than that of CC-SIT. Also KVSS Test had more familiar items for Koreans compared with that of CC-SIT. CC-SIT score and KVSS Test score showed showed the positive corrclation. And each test revealed high reliability in test-retest evaluation. Conclusion: The KVSS Test can be used as an olfactory function test for Koreans.

항정신병약물을 처음으로 사용하는 초발 정신증 환자에서 나타나는 체중 및 대사성 지표의 변화 : 후향적 연구

김우진,심주철,공보금,강제욱,문정준,김정은,김민걸,박민경,김성진,김현정,정도운 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use. Method:In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain. Results:First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain. Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.

비·부비동 양성 종양의 임상적 고찰

김진국,신향애,임채형,장현종,심대보 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-

Background and Objectives: Benign tumors of the nose and paranasal sinues are rare in comparison with malignant growths. Authors aimed to investigate the incidence and characteristics of benign sino-nasal tumors. Materials and Methods: From 1994 through 2004, 25 cases of benign sino-nasal tumors (17 men and 8 women) were diagnosed and cared at the Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konkuk University. We reviewed medical records of patients to find out clinical features, radiologic findings, operative findings, therapeutic options, and outcomes. Postoperative observation was given for fifteen months on the average. Results: The most common symptom was nasal obstruction, followed by nasal mass, frequent nasal bleeding, headache, and rhinorrhea, and the mass mainly placed in the lateral nasal wall. There were 12 cases (48%) of inverted papilloma, 4 (16%) cases of squamous papilloma, 4 (16%) cases of hemangioma, 1 (4%) case of pleomorphic adenoma, 1 (4%) case of leiomyoma, 1 (4%) case of lipoma. All the tumors were surgically removed. For the treatment of inverted papilloma, medial maxillectomy had been performed before 1997(2 cases); however, most cases have been managed with endonasal endoscopic technique since 1997. Recurrence was observed in two patients with inverted papilloma and one patients with squamous papilloma. Conclusion: Inverted papilloma is the most common benign tumor in the nose and paranasal sinuses, followed by squamous papilloma and hemangioma. The optimal management of benign tumors is complete excision of tumor and endonasal endoscopic surgery is an effective treatment for an inverted papilloma.

Surgical treatment of Lip hypertrophy secondary to port-wine stain

( Hyun Chul Shim ),( Geon Kim ),( Ji Hyun Choi ),( Ji Hye Kim ),( Bo Kyung Koh ),( Eun Jung Kim ),( Hyang Joon Park ),( Ok Ja Joh ) 대한피부과학회 2011 초록집 Vol.49 No.20

Enhanced Efficiency of Transmit and Receive Module with Ga Doped MgZnO Semiconductor Device by Growth Thickness

Shim, Bo-Hyun,Jo, Hee-Jin,Kim, Dong-Jin,Chae, Jong-Mok The Institute of Electronics and Information Engin 2016 Journal of semiconductor technology and science Vol.16 No.1

The structural, electrical properties of Ga doped MgZnO transparent conductive oxide (TCO) films by ratio-frequency(RF) magnetron sputtering were investigated. Ga doped MgZnO TCO films were deposited on the sapphire substrates at $200^{\circ}C$ varying growth thickness 200 to 600 nm. The optical properties of Ga doped MgZnO TCO films were showed above 85% transmittance from 300 to 1000 nm region. In addition, the current density ($J_{SC}$) of $Cu(In,Ga)Se_2$ (CIGS) solar cells was improved by using the MgZnO:Ga films of 500 nm thickness because of outstanding electrical properties. The $Cu(In,Ga)Se_2$ solar cells with MgZnO:Ga transparent conducing layer yielded an efficiency of 9.8% with current density ($31.8mA/cm^2$), open circuit voltage (540.2 V) and fill factor (62.2) under AM 1.5 illumination.

Fatigue Life Assessment of KC-1 Membrane Considering the Effects of Cryogenic Temperature and Plastic Deformation

Hyun Bo Shim,Ihn Soo Yoon 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.5

In this study, fatigue life assessment was conducted on a KC-1 membrane, considering cryogenic operation temperature,eff ect of stamping, and very long service period. KC-1 membranes are produced through a process of stamping, and theymake direct contact with LNG fi lled within a containment system at − 162 °C. The high waves that LNG carriers encounterduring sailing, and even when at anchor, cause rolling motions of the hull, which result in resonant fl uid motions that generatea sloshing phenomenon; such sloshing motions expose containment systems to a high level of repeated stress. To assessthe very high cycle fatigue (VHCF) life of the membrane, the eff ects of plastic deformation and the mechanical propertiesof STS304L, a membrane material, were examined at cryogenic temperatures. To identify the eff ects of plastic deformationand cryogenic temperatures on their mechanical properties, tensile and VHCF tests were conducted at cryogenic temperatureson a sheet to which plastic strain was applied through cold-rolling. Through forming analysis, changes in the thicknessand plastic strain of a membrane caused during the process of stamping were examined. The results of earlier studies thatperformed fl ow analysis and fl uid–structure interaction analysis to measure the stress applied to each component of theKC-1 containment system were cited, and the VHCF life of the membrane was assessed based on the surveyed mechanicalproperties, and the results of forming analysis.

Improving Formability to Develop Miniature Stamping Technologies

Hyun Bo Shim 한국정밀공학회 2009 International Journal of Precision Engineering and Vol.10 No.2

In contrast to traditional manufacturing applications, small-scale manufacturing process usually require sophisticated equipment, which generally involves high cost and low productivity. On the other hand, miniature stamping processes of thin materials can yield high productivity with relatively inexpensive equipment. However, it is well known that the formability of thin material using this type of process is not very good, and the possible shapes that can be produced via miniature stamping have, unlil now, been relatively simple. This study was motivated by the presumption that, if the problems related to formability can be solved, then miniature-scale stamping of complicated shapes can be realized. This research was carried out to demonstrate the feasibility of miniature stamping, and mainly focused on formability aspects. To improve formability, annealing was chosen as a means of improving the material properties, and the use of optimal blank shapes was chosen as a means of addressing process issues, Optimal annealing conditions were identified by examining the microstructures of the annealed material, and the optimal shape of the blanks was determined using the radius vector method. The combination of the annealing improvements and the use of optimal blanks improved the formability considerably. Therefore, both the annealing process and the blank shape are key technologies in the development of more effective miniature stamping processes.

Enhanced Efficiency of Transmit and Receive Module with Ga Doped MgZnO Semiconductor Device by Growth Thickness

Bo-Hyun Shim,Hee-Jin Jo,Dong-Jin Kim,Jong-Mok Chae 대한전자공학회 2016 Journal of semiconductor technology and science Vol.16 No.1

The structural, electrical properties of Ga doped MgZnO transparent conductive oxide (TCO) films by ratio-frequency(RF) magnetron sputtering were investigated. Ga doped MgZnO TCO films were deposited on the sapphire substrates at 200℃ varying growth thickness 200 to 600 nm. The optical properties of Ga doped MgZnO TCO films were showed above 85% transmittance from 300 to 1000 nm region. In addition, the current density (JSC) of Cu(In,Ga)Se2 (CIGS) solar cells was improved by using the MgZnO:Ga films of 500 nm thickness because of outstanding electrical properties. The Cu(In,Ga)Se2 solar cells with MgZnO:Ga transparent conducing layer yielded an efficiency of 9.8% with current density (31.8 mA/cm<SUP>2</SUP>), open circuit voltage (540.2 V) and fill factor (62.2) under AM 1.5 illumination.

One target, different effects: a comparison of distinct therapeutic antibodies against the same targets

Shim, Hyun-Bo Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.10

To date, more than 30 antibodies have been approved worldwide for therapeutic use. While the monoclonal antibody market is rapidly growing, the clinical use of therapeutic antibodies is mostly limited to treatment of cancers and immunological disorders. Moreover, antibodies against only five targets (TNF-${\alpha}$, HER2, CD20, EGFR, and VEGF) account for more than 80 percent of the worldwide market of therapeutic antibodies. The shortage of novel, clinically proven targets has resulted in the development of many distinct therapeutic antibodies against a small number of proven targets, based on the premise that different antibody molecules against the same target antigen have distinct biological and clinical effects from one another. For example, four antibodies against TNF-${\alpha}$ have been approved by the FDA - infliximab, adalimumab, golimumab, and certolizumab pegol - with many more in clinical and preclinical development. The situation is similar for HER2, CD20, EGFR, and VEGF, each having one or more approved antibodies and many more under development. This review discusses the different binding characteristics, mechanisms of action, and biological and clinical activities of multiple monoclonal antibodies against TNF-${\alpha}$, HER-2, CD20, and EGFR and provides insights into the development of therapeutic antibodies.