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Suh, Yoon Seok,Ko, Kwang Jin,Kim, Tae Heon,Lee, Hyo Serk,Sung, Hyun Hwan,Cho, Won Jin,Lee, Kyu-Sung Korean Continence Society 2017 International Neurourology Journal Vol.21 No.4
<P><B>Purpose</B></P><P>The aim of this study was to investigate urinary nerve growth factor (NGF) as a biomarker of treatment efficacy and recurrence in overactive bladder (OAB) patients.</P><P><B>Methods</B></P><P>We enrolled 189 OAB subjects who visited our outpatient clinic from February 2010 to February 2015. All subjects with OAB received antimuscarinic treatment. A 3-day voiding diary and questionnaire were collected from each patient. Urinary levels of NGF were evaluated at baseline, the beginning of antimuscarinic treatment, and the end of antimuscarinic treatment. Urinary NGF was normalized to urine creatinine (Cr). Between-group comparisons of baseline characteristics were made using the Mann-Whitney U-test. Multivariate logistic regression analyses were used to predict responses to anticholinergic treatment and recurrence. The Wilcoxon signed-rank test with the Bonferroni correction was used for intragroup comparisons. A receiver operating characteristic curve was used to analyze the utility of this biomarker.</P><P><B>Results</B></P><P>Urinary levels of NGF/Cr tended to decrease in patients who responded to treatment (n=62), but this was not significant (P=0.260). Urinary NGF levels were higher at baseline in patients who did not experience recurrence than in those who did (P=0.047). In those who did not experience recurrence (n=29), urinary NGF/Cr decreased at the end of treatment compared to baseline, and this reduction was maintained at 12 weeks after the end of treatment (P<0.05).</P><P><B>Conclusions</B></P><P>Urinary NGF is a potential biomarker for predicting the outcome of antimuscarinic treatment in OAB patients. This may provide useful information when deciding to stop antimuscarinic treatment in responders.</P>
구연 : 버드-키아리 증후군에 동반된 간세포암의 특징적 임상상: B형 간염 관련 간세포암과의 비교
( Won Beom Choi ),( Young Hwa Chung ),( Sang Hyo Shin ),( Dong Dae Suh ),( Sung Hoon Kim ),( Myoung Kuk Jang ),( In Sook Kim ),( Jung Woo Shin ),( Soo Hyung Ryu ),( Neung Hwa Park ),( Han Chu Lee ),( 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.3(S)
Background/Aims: Budd-Chiari syndrome (BCS) has been known as a risk factor of hepatocellular carcinoma (HCC). Considering the pathophysiologic mechanism of BCS, HCC associated with BCS may have a different carcinogenic process resulting in characteristic
Suh. Suk-Hyo,Park. Yee-Tae,Lee. Dong-Chul,Seo. Pil-Won,Kim. Ki-Whan 대한생리학회 1995 대한생리학회지 Vol.29 No.2
This study was designed 1) to develop a hypertensive animal model in which the blood pressures (BPs) of symmetric regions (right and left upper extremities) are significantly different and 2) to test the effect of BP per se on the contractility and endothelium-dependent relaxation of vascular smooth muscle. Rabbits were anesthetized with sodium pentobarbital and ventilated with room air via animal respirator. The transverse aorta was exposed through the left second intercostal space and the lumen of the aorta was narrowed partially by ligation using 3-0 silk and a probe at a point between the origins of the brachiocephalic trunk and the left subclavian artery. Four to eight weeks postoperatively, BPs were measured in the carotid artery as the high BP area (proximal to coactation site) and in the femoral artery as the low BP area (distal to coarctation site). In the animal model, pressure-overload hypertension was developed and the BP of the right subclavian artery was higher than that of the left subclavian artery. The concentrations of circulating epinephrine, norepinephrine, angiotensin I, and angiotensin II were measured. The right and left subclavian arteries and their branches were used for isometric tension recording in organ baths and their responsiveness to phenylephrine, serotonin, acetylcholine, and sodium nitroprusside were examined. The BPs of carotid and femoral artery in control animals were 116± 12/75±9 mmHg (mean ±SEM) and 130±16/68±9 mmHg respectively, while those of carotid and femoral artery in the hypetensive animals were 172±6/111±10 mmHg and 136± 4/100 ±9 mmHg respectively. There were no significant differences in the concentrations of circulating epinephrine, norepinephrine, angiotensin I, and angiotensin II between controls and the animal models. No significant differences were found in the vascular sensitivities to phenylephrine and serotonin between the high pressure-exposed vessels and the low pressure-exposed vessels. However, the endothelium-dependent relaxation to acetylcholine and nitroprusside-induced relaxation showed significant differences between the high pressure-exposed and the low pressure-exposed subclavian arteries. From the above results, we suggest that the contractility of vascular smooth muscle is unchanged by the elevated pressure per se. However, the endothelium-dependent relaxation to acetylcholine and the nitroprusside-induced relaxation are attenuated by pressure.