관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

영구형 항서맥 심박조율기 환자의 장기추적관찰

최현석,이무용,최영진,최성준,김효수,손대원,오병희,이명묵,박영배,최윤식,이영우,이명용 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.5

Novel Methylation Biomarker for Non-invasive Diagnostics in Lung Cancer

오태정,( Chang Hun Lee2 ),( Min Ki Lee ),( Yeul Hong Kim ),( Sang Yull Lee ),( Hyo Sung Jeon ),( Shin Yup Lee ),( Seung Soo Yoo ),( Jae Yong Park ),( Sung Whan An ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

To identify aberrantly hypermethylated DNA in lung cancer cells we established a genome-wide analysis for hypermethylation sites, namely Methyl DNA Isolation and Amplification (MeDIA) coupled-CpG microarray analysis. In the comprehensive methyaltion profiling analysis between human lung cancer, A549 cells and normal NHBE cells, we observed that several clusters of genes show a significant level of aberrancy in CpG island methylation pattern in cancer cells compared to normal cells. We further identified PCDHGA12 gene as a new marker of non-invasive diagnostics for lung cancer based on followings. 1) Transcription of PCDHGA12 gene is reactivated after treatment of A549 cells with demethylating agent. 2) Bisulfide clonal-sequencing reveals that CpG island of PCDHGA12 shows a distinctive differential methylation between two cell lines. 3) Pyrosequencing-based quantitative methylation assay for such region in tumor and non-tumorous tissues from lung cancer patients shows aberrant hypermethylation in 37 (92%) of the 40 tumor tissues. In clinical validation by pyrosequencingin induced-sputum of lung cancer patients (n=87) and healthy controls (n=51), we observed aberrant hypermethylation incident at significantly elevated level in samples derived from lung cancer patients. According to the optimal threshold calculated by ROC curve analysis, sensitivity and specificity of PCDHGA12 was 86.2% and 82.4%, respectively. PCDHGA12 methylation status could be a potential methylation biomarker alone or combined with others for the screen and the detection of relapse of lung cancer.

들잔디 성숙종자로부터 캘러스배양 및 식물체 재분화에 미치는 몇 가지 요인의 영향

이상훈,김범수,원성혜,조진기,김기용,박근제,성병렬,이효신,이병현 Plant molecular biology and biotechnology research 2004 Plant molecular biology and biotechnology research Vol.2004 No.-

In an effort to optimize tissue culture responses of zoysiagrass (Zoysia japonica Steud.) for genetic transformation, factors affecting callus induction and plant regeneration were investigated. MS medium containing 3 ㎎/L 2,4-D was optimal for embryogenic callus induction from mature seed. The plant regeneration frequency of 73.3% was observed when embryogenic calli induced in this medium were transferred to N6 medium supplemented with 0.1 ㎎/L 2,4-D and 5 ㎎/L BA. Among several basic media, MS and N6 medium were optimal for callus induction and plant regeneration, respectively. Regenerated plants were grown normally when shoots transplanted to the soil. A rapid and efficient plant regeneration system established in this study will be useful for molecular breeding of turfgrass through genetic transformation.

Methylphenidate 투약에 따른 주의력결핍 과잉운동장애 아동의 정량화 뇌파의 변화

이병대,정성훈,이만기,장수민,백지령,임효덕 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.1

자발성 뇌간 혈종(출혈) 5예 : Especially in Midbrain, in Pons, and in Ponto-mesencephalon

이현개,호종수,이승재,박효일 인제대학교 1982 仁濟醫學 Vol.3 No.4

자발성 뇌간 혈종은 흔하지 않으며 특히 중뇌에 생긴 자발성 혈종은 대단히 드물다. 뇌간에 생긴 혈종은 생긴 장소와 크기에 따라서 다양한 신경학적 증상과 vital sign의 변화를 보인다. ocular sign 및 vital sign의 변화와 의식상태 등에 의해서 뇌간 혈종의 위치를 식별할 수도 있다. 뇌간 혈종이 있는 환자를 치료하는 중에 환자의 의식상태는 혈압과 밀접한 관계를 보이며 수축기 혈압이 140mmHg이거나 이보다 약간 높은 상태에서 비교적 안정될 때는 환자의 의식이 호전되었고 강하시에는 의식의 악화를 보였으며 또한 혈압에 따라 이외의 신경학적 증상의 변화를 보였다. 본 교실에서는 Brain CT에 의해서 자발성 뇌간 혈종 5예, 즉 중뇌 혈종 1예, 뇌교 혈종 2예 및 뇌교-중뇌 혈종 2예를 경험하였다. Spontaneous brain stem hematoma is not common, especially spontaneous midbrain hematoma is extremely rare. Brain stem hematoma leads to variable neurological deficits and wide variations of vital signs correspending to its location and volume. It is possible to localize the hematoma in the brain stem by means of changes of ocular signs and vital signs, and the level of consciousness. During treatment of the patients with brain stem hematomas we found that the level of patient's consciousness was closely related to the level of blood pressure. At or slightly above 140mmHg of systolic pressure the patient's consciousness was markedly improved, but the decreased systolic pressure caused its deterioration. Also according to level of blood pressure other neurological findings were slightly variable. We hove experienced five cases of spontaneous brain stem hematoma which were diagnosed with brain CT. They were a case of midbrain hematoma, two cases of pontine hematoma and two cases of pontomesencephalic hematoma.

韓國勞動市場의 勞動移動構造 : 斷層勞動市場構造下에서의 勞動移動

李孝秀 嶺南大學校社會科學硏究所 1984 社會科學硏究 Vol.4 No.1

相對的 分配分의 訣定과 그 趨勢에 관한 硏究

李孝秀 嶺南大學校 社會科學硏究所 1985 社會科學硏究 Vol.5 No.1

The purpose of this paper is to develop a simple model of relative shares and examine the behavior of income shares over time in a country that has a dual economy and stratified labor markets. Our models do not start from the economics of the firm but from aggregative models of the economy. This suggests that labor and capital shares are closely linked to the rate of economic growth. The basic relations in our system are Y=W+R+F ?? W=W?+W?= αβ·ωL+αγ(1-β)·ωL = α( β+γ- β·γ)·ωL 0< α<1, 0< β<1, 0<γ<1, β·γ<β+γ S=I ?? where, Y=Aggregate income, R=Total profits ??=Total profits going to the workers ??=Total profits going to the capitalists W=Total wages W₁=Total wages going to upper strata workers, who can save. W₂=Total wages going to lower strata workers, who save nothing at all. ω=Average wage of upper strata workers F=Income of the traditional sector L=Total employment α=Number of employees over total employment β=Number of upper strata workers over total employees γ=Average wage difference between strata From this, we can get the following equations ?? (1) ?? (1') ?? (2) ?? (3) ?? (3') ?? (4) Equation (1) and (3) are the equations of the profit share and the capitalist share in the case where the traditional sector has no capital stocks, equation (1') and (3') are where traditional sector has capital stocks. Equation (1) states that the profit share of income depends on the radio of investment to output and on the capitalist's own saving propensity. Equation (2) determines the share of wage in aggregate income. The wage share of income depends on number of employees over total employment, number of upper strata workers over total employees, average wage difference between strata, and the ratio of wages to productivity. In Equation (3), the capitalist share of income depends on the savings propensities of the capitalists and the workers, the ratio of investment to output, number of employees over total employment, number of upper strata workers over total employees, and the ratio of wages to productivity. Similary equation (4) suggests that the workers share of income is influenced by number of employees over total employment, number of upper strata over total employees, the average wage difference between strata, the savings propensities of the capitalists and the workers, and the ratio of wages to productivity. In applying our models to the Korean economy, we come to the following conclusions, but unfortunately we can not test class shares empirically for want of data. (1) We find that the profit share of income is linked directly to the ratio of investment to output in the long-run, and thus to the growth rate of output. A high-level growth path goes along with a high investment rate and a large profit(property) share of income. The evidence on short-run changes, however, is less clear. (2) We can explain the changes of relative shares in the Korean economy by using independent variables in our models. (3) The profit share and the wage share change in the same direction, and the income share of the traditional sector in an opposite direction. (4) During recession years, the wage share falls, and during a boom, the tendency in reversed.

미래지향적 가치창조형 실업대책

이효수 嶺南大學校 社會科學硏究所 1999 社會科學硏究 Vol.18 No.2

요약문이 논문은 1998년부터 한국경제의 최대과제로 부각되고 있는 대량실업의 발생원인과 전망, 그리고 그 대책에 대하여 논의 하고 있다. 이 논문은 특히 대량실업기의 실업대책이 '구빈적 차원'에서 단편적·단기적·소모적으로 추진되어서 안되고, '미래지향적 가치창조적 차원'에서 입안되고 추진되어야 한다는 점을 강조하고 있다. 즉, 실업정책은 단기적으로 실업자들을 구제하면서 동시에 그들의 능력개발에 도움이 되고, 장기적으로 새로운 산업과 가치를 창출할수 있도록 설계·추진되어야 한다. 이를 위해서 정부는 '官·學協同體制'를 구축하여 실태분석, 미래지향적 가치창조형 사업개발, 실업정책의 모니터링·평가·피드백 시스템의 구축 등을 통하여 실업정책을 과학적으로 접근하여야 한다. 미래지향적 가치창조형 실업대책의 관점은 ① 일자리 제공, ② 고용안정, ③ 직업훈련과 취업알선, ④ 실업자 생활보호 등 모든 실업정책에서 견지되어야 한다. 공공근로사업이 지나치게 단편적이고 단기적인 잡다한 사업으로 분산되어서는 안된다. 공공근로사업이 미래지향적이고 가치창조적 사업으로 되기 위해서는 사업을 대형화 체계화 하고 인적·물적 자원을 집중 투입하여야 한다. 우리는 이러한 전략의 예로서 공공근로사업을 지역개발사업과 연계 추진하는 전략과 정보화사회 건설을 위한 대규모 기반조성사업 등을 제시하고 있다. 이러한 사업들은 오늘의 대량실업문제를 해결하고 동시에 내일의 국가경쟁력을 제고 시키게 될 것이다.

賃金構造分析에 의한 中·下位斷層의 斷層性 檢證

李孝秀,柳在述 嶺南大學校社會科學硏究所 1988 社會科學硏究 Vol.8 No.1