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Hyeonseok Jung,Hoeseok Yang 대한전자공학회 2016 IEIE Transactions on Smart Processing & Computing Vol.5 No.4
As more mobile devices are equipped with multi-core CPUs and are required to execute many compute-intensive multimedia applications, it is important to optimize the systems, considering the underlying parallel hardware architecture. In this paper, we implement and optimize ray-tracing application tailored to a given mobile computing platform with multiple heterogeneous processing elements. In this paper, a lightweight ray-tracing application is specified and implemented in Kahn process network (KPN) model-of-computation, which is known to be suitable for the description of real-time applications. We take an open-source C/C++ implementation of ray-tracing and adapt it to KPN description in the Distributed Application Layer framework. Then, several possible configurations are evaluated in the target mobile computing platform (Exynos 5422), where eight heterogeneous ARM cores are integrated. We derive the optimal degree of parallelism and a suitable distribution of the replicated tasks tailored to the target architecture.
Design Considerations of Real-time Radar Sensor Modeling for Unmanned Surface Vehicle (USV)
Hyeonseok Lee,Hyeonhee Yi,Jung-Dong Park 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
We present a design of the real-time radar sensor model for unmanned surface vehicles (USV). To construct an efficient learning environment of an unmanned surface vehicle (USV) for the swarm operation, accurate virtual modeling of the radar sensor with a light processing load is necessary. To achieve real-time modeling of the marine radar operations with a high level of modeling accuracy under a limited computational power, our work is to extract the signal-to-clutter noise ratio (SCNR) by considering physical radar specifications with pre-extracted target radar cross-section (RCS) using a 3D-EM simulator (HFSS). Modeling of various clutters such as rain, snow, fog as well as sea clutter has been carried out for each range bin with the generated clutter matrix with Rayleigh distribution. The standard deviations of the modeled clutter were calculated with widely adopted RCS estimation formulae. Also, the signal processing unit was modeled by implementing a cell average constant false alarm rate (CA-CFAR) engine to virtualize the signal processing effects of the physical radar on filtering backscattering clutters. The presented approach on maritime radar modeling can be useful in implementing a virtual environment with less computational complexity in developing various unmanned vehicles.
MCF-7 Derived Exosome as Anticancer Drug Delivery Platform into Breast Cancer
Hyeonseok KIM,Mi-Kyeong JANG 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Breast cancer, one of the frequently diagnosed cancer, was ranked second among causes for cancer related death in women. Especially, it was low rate of complete treatment due to three types of receptors: estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/neu). Although many natural or synthetic drugs were useful for cure of breast cancers, many obstacles, such as low biocompatibility, low aqueous solubility, and high toxicity, were occurred inducing side effects containing immunogenicity. Therefore, it is need a new nanoplatform to minimize side effects. Exosome was well-known extracelluar vesicle that is approximately 50 - 150 ㎚ sized particles and released by variety of cell types and consists of lipid bilayer involving various soluble factors such as proteins, DNA, and RNA. Their properties, low immunogenicity, high biocompatibility and stable storage were emerged as promising drug delivery vehicles. Present study isolated extracellular exosomes from MCF-7 cell culture media and doxorubicin, an antitumor drug, was loaded by two types of method, incubation and extrusion. Subsequently, we investigated specific cell selectivity between HaCaT and MCF-7 cells. The results indicated that tumor-derived exosomes was useful as a specific drug delivery carrier (NRF-2020R1A2C1013069).
( Hyeonseok Ko ),( Sun-joong Kim ),( So Hee Shim ),( Hyoihl Chang ),( Chang Hoon Ha ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.5
Shikonin, which derives from Lithospermum erythrorhizon, has been traditionally used against a variety of diseases, including cancer, in Eastern Asia. Here we determined that shikonin inhibits proliferation of gastric cancer cells by inducing apoptosis. Shikonin’s biological activity was validated by observing cell viability, caspase 3 activity, reactive oxygen species (ROS) generation, and apoptotic marker expressions in AGS stomach cancer cells. The concentration range of shikonin was 35-250 nM with the incubation time of 6 h. Protein levels of Nrf2 and p53 were evaluated by western blotting and confirmed by real-time PCR. Our results revealed that shikonin induced the generation of ROS as well as caspase 3-dependent apoptosis. c-Jun-N-terminal kinases (JNK) activity was significantly elevated in shikonin-treated cells, thereby linking JNK to apoptosis. Furthermore, our results revealed that shikonin induced p53 expression but repressed Nrf2 expression. Moreover, our results suggested that there may be a co-regulation between p53 and Nrf2, in which transfection with siNrf2 induced the p53 expression. We demonstrated for the first time that shikonin activated cell apoptosis in AGS cells via caspase 3- and JNK-dependent pathways, as well as through the p53-Nrf2 mediated signal pathway. Our study validates in partly the contribution of shikonin as a new therapeutic approaches/ agent for cancer chemotherapy.
Hyeonseok Oh,Daeun Yu,Yoon-Ho Choi,Namgi Kim 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.11
With advancements in network technologies, network virtualization has been proposed to efficiently provide a large number of services and flexible management by utilizing limited resources over existing networks as much as possible. Network virtualization has been proposed as a new paradigm for networks, as it simplifies complicated network configurations for convenient maintenance through the maximum utilization of limited network resources. However, problems have arisen due to network virtualization, such as how to assign real network components that are compatible with virtual network components over a large number of virtual machines existing in a network. In particular, the service-chaining concept—where a network flow only passes through needed services—has been newly introduced by combining the recently highlighted Software-Defined Network with a virtualization concept called Network Function Virtualization. As a result, studies on which virtual machines are selected and how to connect them have increased ever more. Accordingly, this paper aims to identify virtual machines that are compatible with service chaining in a virtual network environment where virtual machines are dispersed, and it proposes a method of how to create a path by connecting virtual machines.