항진균성 6-(4-브로모페닐)아미노-7-클로로-5,8-퀴놀린디온의 안전성 평가

강혜영 외 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.13

The toxicities of antifungal 6-(4-bromophenyl)amino-7-chloro-5,8-quinolinedione (RCK55) had been evaluated. RCK55 was negative in Ames test with Salmonella typhimurium and chromosomal aberration test in CHL cells. RCK55 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. These results indicate that RCK55 has no genotoxic potential under these experimental conditions. Acute oral toxicity studies of RCK55 were carried out in ICR mice of both sexes. RCK55 did not show acute oral toxicities and LD50 values were over 2,850 mg/kg in ICR mice.

외상으로 실활된 미성숙 영구치에서의 계속된 치근 형성

강유진,김혜영,김영진,김현정,남순현 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.4

치아에 외상을 받은 경우 치수 생활력의 상실은 흔한 일이다. 치수 생활력을 검사하는 방법으로는 임상적, 방사선학적으로 여러 가지가 있지만, 미성숙 외상치의 경우 일시적 현상과 가성 반응이 나타날 수 있으므로 치수 괴사에 대한 정확한 진단은 매우 어렵다. 생활력을 상실한 치아는 염증성 치근흡수, 치근단 낭종 등의 발생을 방지하기 위하여 치수 치료를 시행한다. 그러나 미성숙 영구치의 경우, 치수 치료를 시행 후 치근 성장이 정지될 수 있어 결과적으로 얇고 짧은 치근이 형성되어 장기적인 예후는 좋지 않다. 본 임상 증례에서는 외상으로 인하여 실활된 초기 영구치에서 치근단부의 최소한의 침습적 치근단 형성술로 계속된 치근 형성을 보여 이에 보고하는 바이다. In case of luxation injuries, loss of tooth vitality is common. And in case of trauma in the immature permanent teeth, precise diagnosis of pulp necrosis is very difficult. That is because limitation in distinguishing between normal dental papilla in immature permanent teeth, transient apical breakdown(TAB), which is part of normal healing process, and apical radiolucency in pulp necrosis. Especially in non-vital immature permanent tooth, the treatment is complex and requires long time. This clinical case report shows that severely infected immature teeth with periradicular periodontitis can undergo healing and apexogenesis or maturogenesis with no definative treatment or after conservative treatment. In the cases reported, we emphasize the considerable power of regeneration of the tooth, probably due to its large number of undifferentiated mesenchymal cells in the dental papilla, pulp tissue, periodontal ligament tissues. Thus, when endodontic treatment in immature permanent teeth, over instrumentation is not recommend for preserve the apical vital stem cells.

남자대학생의 흡연태도와 행동에 관한 연구

강경진,김정미,민혜영,안소진,오경숙,은경희,이현,이희선,홍주미,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

There have been so many researches about problems of cigarettes and relation of smoking and heath since 1950's and generally known that smoking is one of the worst factor of increasing disease and mortality. No matter what such many proofs about various problems of smoking have been researched, smoking rate of current male collage students has not been decreased. Besides, most of the researches about cigarette use and its addiction have been focused on the adolescent or adult women smokers or adult male, not male collage student. Therefore, the subject of this study is about smoking attitude and smoking behavior of male collage students by general features. Smoking attitude was analyzed by modifying 'Guidelines for the content of tobacco smoking surveys of the general population'(WHO, 1982). Two hundred of male collage students participated to the distributed questionnaire for one week in May. The smoking attitude was categorized into duration of smoking and number of cigarette per day(CPD), and nicotine dependency, investigated by Fagerstrom Tolerance Questionnaire(FTQ) (Fagerstorm & Schneider, 1989). All statistics were performed by procedure of SAS according to number, percentage, mean, standard deviation, and ANOVA. The results are as follows: 1. Smoking attitude level was mean 25.73±5.15 marks, ranging from 13 to 39 marks of the total 40 marks. 2. Duration of cigarettes, number of cigarette per day, and nicotine dependency were mean 5.14±2.84 years, 12.88±6.85 pieces, and 4.78±1.69, respectively. 3. Smoking attitude showed significance according to general features such as marital state and allowance, but the significance according to marital state is not valuable because the numerical difference is so big between married one and single that they cannot be compared with each other. 4. Duration of smoking was significant according to general features such as age and allowance. 5. Smoking amount showed significance the factors of age only. 6. ll1ere was no significance in nicotine dependency according to general features. As a result, smoking attitude of male collage student in this study shows moderate level. Smoking attitude and duration is significant according to allowance, and smoking amount is significant according to age. Nicotine dependency according to general features is not significant but comparing with the preceding study about adult male, male collage students in this study are respectively more nicotine-dependent than adult male smokers. In conclusion, the right allowance usage strategies and effective heath education focused on the young are needed. In addition, helpful programs and information spreading strategies are necessary for establishing higher level of smoking attitude. At last, systemic regulations in daily living for ""anti-nico-dependent"" and perspective reforming of male university student are needed for reducing nicotine dependency.

한국폴리텍대 대학생의 자기조절학습 전략 활용에 관한 연구

강혜영,유현실 한국직업능력개발원 2007 직업능력개발연구 Vol.10 No.1

본 연구의 목적은 한국폴리텍대학(구, 기능대학) 학생들이 최근 유용한 학습방법으로 제시되고 있는 자기조절학습 전략을 어느 정도 활용하는지를 살펴보려는 것이다. 이를 위하여 한국폴리텍대 학생을 대상으로 자기조절학습 측정검사(양명희, 2000)를 실시하였으며 총 8개교의 학생 781명의 자료가 분석되었다. 주요 연구결과는 다음과 같다. 첫째, 폴리텍대 학생들은 전체적으로 인지조절(M= 3.02~3.35)이나 동기조절 전략(M= 2.99~3.39)에 비해 행동조절 전략(M= 2.80~3.02)을 상대적으로 덜 사용하는 것으로 나타났다. 특히, 자기조절학습의 하위 전략 중에는 학업시간 관리 전략(M= 2.80)을 가장 덜 사용하며, 숙달목적지향성 전략(M= 3.39)을 가장 많이 사용하는 것으로 나타났다. 둘째, 연령에 따른 자기조절학습 전략 활용의 차이를 살펴본 결과, 인지조절, 동기조절, 행동조절학습전략 모두에서 17-19세 연령 집단이 자기조절학습전략을 가장 덜 사용하는 것으로 나타났다. 셋째, 출신고교에 따른 자기조절학습전략 활용의 차이를 살펴본 결과, 인지조절, 동기조절, 행동조절 학습전략 모두에서 농업고등학교 졸업자 집단이 자기조절학습전략을 가장 덜 사용하는 것으로 나타났다. 이러한 결과를 토대로 볼 때, 폴리텍대 대학생들에게 학업시간 관리 및 행동통제에 대한 교육과 상담 프로그램이 절실히 요청된다고 하겠다. 특별히, 다양한 연령대와 출신고교의 학생들이 재학하고 있는 폴리텍대학의 경우, 17-19세 연령대의 학생들과 농업고등학교 출신 학생들을 대상으로 한 학습관련 교육과 상담 프로그램이 마련될 필요가 있어 보인다. The purpose of this study is to examine the utilization of self-regulated learning strategies which have been suggested as a useful learning method for polytechnic college students, The Self-regulated Learning Inventory(Yang, 2000) was administered to 781 students selected from eight polytechnic colleges. Results were found as following. First, Polytechnic college students used strategies of behavior control (M=2.80~3.02) less than those of cognitive control (M=3.02~3.35) or motivation control (M=2.99~3.39). Specifically, study time control (M=2.80) was used the least, and mastery goal orientation strategy (M=3.39) was used the most. Second, the comparison between different age groups upon self-regulated learning showed that the age group of 17-19 years old used all the self-regulated learning strategies the least. Third, comparisons between students with different high school backgrounds upon self-regulated learning showed that students from agricultural high schools used self-regulated learning strategies the least. Implications were discussed for educational and counseling programs regarding the study time management and behavior control, specifically for students of younger age and those from agricultural high schools.

호산구성 간농양 54예의 임상상

강혜련,권혁수,송우정,이상민,김태범,박혜경,장윤석,김윤근,조상헌,민경업,김유영 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adentis) 증후군 1예

강혜련,김신우,배기범,박지현,강영모,이종명,김능수 대한감염학회 2001 감염 Vol.33 No.3

PFAPA (Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis) syndrome has characteristic features of an early onset, periodicity (interval <4 weeks), and a brisk rising high fever (>39℃) of 3 to 6 days' duration without signs of infection. An 18-year-old male was admitted for high fever, sore throat, headache, and abdominal pain. He had suffered from periodic fevers associated with pharyngitis and cervical adenitis for 14 years without any evidence of infection. The fever recurred approximately every 4 weeks lasting 4 to 7 days with intervening asymptomatic periods. Physical examination was unremarkable except for slightly injected tonsils. Most laboratory tests including CBC were normal except for elevation of Creactive protein level (3.47 mg/dL). Bacteriologic and radiologic studies were negative. The fever was spontaneously subsided in 6 days. To our knowledge, this is the first case report of PFAPA syndrome in Korea. (Korean J Infect Dis 33:219∼222, 2001)

중금속이 코스모스와 해바라기의 초기 생육반응에 미치는 영향 : the Potential for Phytoremediation

강만혜,이영현,이종화 순천향대학교 기초과학연구소 2002 순천향자연과학연구 논문집 Vol.8 No.2

This research used cosmos(Cosmos bipinnatus Cav.) and sunflower(Helianthus annuus L.) to test the potential of phytoremediation, an environmental heavy metal removal method. I examined the emergence, growth rate and physiological responses and confirmed heavy metal accumulation of Cd and Cu treatment and pH treatment-affected plants at early growing period. The emergence and growth rate was shown the lowest in the Cu 2000 μM. Chlorophyll and soluble protein content according to pH concentration were a little bad in their treatment plot compared with the control and were a little bad as pH concentration was decrease. But total nitrogen content was shown the highest in the Cu 2000 μM than other treatments and was increased as pH was decrease. Heavy metal accumulation of roots in two plants was higher than the content of shoot part. Heavy metal accumulation concentration was measured Cu 369.79㎍/g, Cd 114.99㎍/g in roots of cosmos, and Cu 318.94㎍/g, Cd 81.20㎍/g in roots of sunflower.

유방선암의 유형에 따른 c-erbB-2, p53, bcl-2, 그리고 c-myc의 발현

강영근,조현득,오미혜,김의한,양승하 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

Breast carcinoma is a common malignant tumor in female of the korea. Various oncogenes have been found in malignant tumor cells. There were many reports or correlation between the prognosis of patients and c-erbB-2, p53, bcl-2, and c-myc, but is controversial. We performed immunohistochemical stain for above antigenic protein for 80 cases of breast carcinoma and evaluated expression rate of each antigens, and we compared their correlation with prognosis of patients. The results were as follow; 1) The expression rates in breast carcinoma was c-erbB-2 80%, p53 56.3%, bcl-2 51.3% and c-myc 53.8%. 2) c-erbB-2 showed no significant difference according to histologic types, grade, and lymph node metastatic status of breast carcinoma. 3) p53 showed higher expression rate in metastatic cases compared to non-metastatic cases, and it showed higher expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 4) The expression rate of bcl-2 in breast carcinoma be lowed according to increasing of grade. There was no significant difference according to types, side, and status of lymph node metastasis. 5) c-myc showed higher expression rate in non-metastatic cases compared to and metastatic cases, and it showed decreasing expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 6) p53 and bcl-2 in breast carxinoma showed reverse corre1ation(P < 0.05), and bc1-2 and c-myc showed close correlation without statiscally significance. Above results showed that p53 may be related to poor prognosis of the patients and c-myc may be related good prognosis in breast carcinoma. There was reverse correlation between p53 and bcl-2 and bcl-2 and c-myc may be correlated closely. c-erbB-2 and bcl-2 showed no interrelation to prognosis.

지속성 외래 복막투석환자에서 발생한 장간막경색증 1예

강동구,이준상,윤재호,장원철,조영일,송종호,전혜정 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-

The mesenteric infarction, as a abdominal disease which show acute abdominal pain and almost need to emergency operation, has very high mortality. This mesenteric infarction has been reported very rarely. Also specific clinical manifestations are not clear, therefore initial diagnosis can be missed easily so that patients usually miss their opportunities for adequate treatment. Especially CAPD patients have high mortality because of their rareness and having similar symptoms like CAPD peritonitis. The authors report that the mesenteric infarction was miss-diagnosed to the CAF'D peritonitis with unspecific symptoms.

생육기별 중금속 오염에 대한 코스모스와 해바라기의 생육반응과 측정량 변화 : the Potential for Phytoremediation

강민혜,이영현,이종화 순천향대학교 기초과학연구소 2002 순천향자연과학연구 논문집 Vol.8 No.2

This research used cosmos(Cosmos bipinnatus Cav.) and sunflower(Helianthus annuus L.) to test the potential of phytoremediation. A advantage of phytoremediation is that it is a green technology and when properly implemented is both environmentally friendly and aesthetically pleasing to the public. I examined the growth rate and physiological quality and confirmed heavy metal accumulation of Cd and Cu-affected plants. Chlorophyll content was higher in the Cu treatment than the content of control, and was increased as Cu concentration was increased. Its content with 20 and 100 μM Cd treatment was reduced. Soluble protein content was shown no difference in the heavy metal treatment of low concentration in compared with the control, but its content was reduced in Cu 2000μM and Cd 100μM. Total nitrogen content was the lowest in two plants treated with Cu 2000μM and shown the tendency of reduction when their growth period passed unlike the tendency of chlorophyll and soluble protein. In the experiment of heavy metal accumulation, it was shown that the inhibition of growth rate and physiological responses were a little when its heavy metal concentration were increased, but increased the tendency metal concentration of tow plants during growing period. And the heavy metal accumulation concentration of root was investigated higher than shoot parts in two plants. Heavy metal accumulation concentration was measured Cu 453.44㎍/g, Cd 675.14㎍/g in roots of cosmos and it is Cu 353.14㎍/g, Cd 140.76㎍/g in roots of sunflower. Consequently we may be consider landscape materials which cosmos and sunflower has the potential as phytoremediator.