Association Between Gut Regulatory Hormones and Post-operative Weight Loss Following Gastrectomy in Patients With Gastric Cancer

Hye-Kyung Jung,Chung Hyun Tae,Hye Ah Lee,Ko Eun Lee,Chang Mo Moon,Seong Eun Kim,Ju Young Seoh,Joo-Ho Lee 대한소화기 기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.3

Background/AimsPost-operative weight loss in patients with gastric cancer lead to a poor quality of life and long-term survival. This study aims to evaluate the effects of gut regulatory hormones on post-operative weight loss in patients with subtotal gastrectomy for gastric cancer. MethodsThis prospective study was conducted for 12 months post-surgery in 14 controls and 13 gastrectomy patients who underwent subtotal gastrectomy for gastric cancer. Serum plasma ghrelin, glucagon-like peptide-1, gastric inhibitory peptide-1, peptide YY, insulin, and homeostatic model assessment for insulin resistance responses to a standardized test meal were recorded at multiple time points before and after gastrectomy at 4 and 12 months. ResultsThe mean weight difference between the pre-operative state and the 4-month period was significantly reduced to 6.6 kg (P = 0.032), but significant weight reduction was not observed from 4 months to 12 months. The plasma levels of glucagon-like peptide-1, gastric inhibitory peptide-1, and peptide YY were significantly increased 4 months postoperatively compared to the pre-operative state (all P = 0.035); however, pre-operative levels and relative changes over a period of 0-4 months of hormones were not correlated with body weight changes. Only the pre-operative ghrelin at peak had a negative correlation with changes in weight reduction in the 4 months after surgery (ρ = −0.8, P = 0.024). ConclusionsSignificant weight reduction was common after subtotal gastrectomy for gastric cancer with a negative correlation pre-operative plasma ghrelin levels. Incretin hormones are modestly but significantly increased after subtotal gastrectomy; however, these changes did not affect the weight changes.

Five 2030 Scenarios for the Family and Related Policy Implications

Hye-kyung Chang,Eun-ji Kim,Young-ran Kim,So-young Kim,Bo-young Sun 한국여성정책연구원(구 한국여성개발원) 2014 Gender Studies and Policy Review Vol.7 No.-

This research has been designed as the second-year project of the four-year Special Research (2011-2014) effort. The main purpose of this current project is to develop potential scenarios regarding families of the future by predicting directions of change. In order to elaborate these scenarios, the five areas of demographic environment, labor and economic environment, science and technology, political environment, and perceptions of the family were singled out as major areas affecting the outlook on the future family. Next, the Delphi technique was applied in order to identify key drivers behind future changes in the family for each respective area. Next, the trend in changes was forecasted for each area and hypotheses were crafted regarding the impact of these changes on the lives of women and their families. Caretaking, inequality, and family values were selected as the main axes of the scenarios, based on a combination of the hypotheses. Next, the three axes were juxtaposed, resulting in a total of eight scenarios from which five were selected. These five scenarios include the conflict between personal values and family life scenario, the polarization of family life scenario, the loose but intimate family scenario, the coexistence of equal society and unequal family scenario, and the maximized familial burden scenario. According to a nation-wide survey of 5,000 people regarding these five scenarios, the loose but intimate family scenario was identified as the most preferred. In order for South Korea to progress toward this scenario, this research suggests reinforcement of social security policy, evaluation of overall care policy and future directions, and refinement of laws and institutions in accordance with the strengthening perception of an individual-oriented family.

건강신념모델에 근거한 노인 대상 식품안전·영양교육 프로그램 효과 평가

최정화(Jung-Hwa Choi),이은실(Eun-Sil Lee),이윤진(Yoon-Jin Lee),이혜상(Hye-Sang Lee),장혜자(Hye-Ja Chang),이경은(Kyung-Eun Lee),이나영(Na-Young Yi),안윤(Yoon Ahn),곽동경(Tong-Kyung Kwak) 한국식품영양과학회 2016 한국식품영양과학회지 Vol.45 No.9

노인은 면역취약집단으로 다른 인구 집단보다 만성질환과 식품매개 질병에 걸릴 위험이 크며 식행동은 오랜 세월 굳어져 왔기 때문에 변화하기가 쉽지 않다. 노인을 대상으로 건강신념모델을 적용하여 식품안전・영양교육 프로그램을 시범 적용하고 그 효과를 평가하였다. 식품안전·영양 시범 교육은 서울 마포, 충북 청주, 경북 의성, 충북 진천의 노인복지관을 이용하는 65세 이상 노인을 대상으로 2011년 7월 28일부터 9월 9일까지 총 5주간 매주 1회, 35~40분씩 교육을 시행하였다. 교육 전후 조사가 완료된 최종 연구대상은 교육군이 5회 교육 중 3회 이상 교육에 참여하고 교육 전후 평가를 마친 대상자로 137명, 대조군은 사후 설문조사를 하지 않거나 불성실한 응답자를 제외한 83명으로 총 220명이었다. 교육은 건강신념모델을 적용하여 노인들이 식습관을 변화하지 않을 경우 질병 가능성을 알려 심각성을 인지하도록 하였으며 노인들이 식행동 수정 시 얻게 되는 이들을 알려주고 행동을 실행할 수 있도록 자아효능감을 제공해주고자 하였다. 교육 후 식품안전·영양지식은 모든 항목에서 향상을 보였으며, 식품안전 영역 5문항 중 4문항, 영양 영역 3문항 중 2문항에서는 유의적인 향상을 보였다. 식행동은 교육군에서 ‘고기, 생선류는 조리 시 속까지 완전히 익힌다’를 제외한 모든 항목에서 유의적인 향상을 보였다. 건강신념은 식품안전의 영역에서는 인지된 심각성과 자아효능감, 영양 영역에서는 인지된 민감성, 인지된 장애, 자아효능감에서 유의적인 향상을 보였다. 지식, 식행동, 건강신념 변화량의 상관관계를 분석한 결과 건강신념의 변화량과 식행동의 변화 가능성 간의 유의적인 상관관계를 보였다(P<0.001). 본 연구의 참여 대상자들이 일반 재가 노인보다 복지관에서 봉사하거나 활동하는 노인이었기 때문에 표본의 대표성이 떨어져 결과를 일반화하기에 어려움이 있다. 또한, 교육기간이 5주로 비교적 짧았기 때문에 오랜 기간에 걸쳐 형성된 식행동이 쉽게 변화하거나 개선되기 어려우므로 장기간에 걸친 반복교육이 필요할 것으로 생각한다. 본 연구에서 개발된 교육 프로그램을 향후 보건소나 복지관 등을 통해 지속해서 시행된다면 노인의 식품안전・영양에 대한 인식을 높이고 바람직한 식행동 변화에 긍정적인 기여를 할 수 있을 것으로 생각된다. Most elderly have difficulties in managing food safety and nutrition by themselves. Various nutrition educations for the elderly have been developed, but food safety and nutrition education program and educational tools for the elderly are very limited. The aim of the study was to evaluate a food safety and nutrition education program based on the Health Belief Model (HBM) for the elderly. Education program was implemented for 220 seniors (137 educated group and 83 control group) aged over 65 years at senior welfare community centers. The intervention study was carried out on a weekly basis during each of 5 weeks, and each session lasted about 35 or 40 minutes. The effectiveness of the program was assessed with a questionnaire before and after education. Education program consisted of a 5 week program, and topics were ‘Dietary changes for the elderly"s healthy life’, ‘Prevention of food poisoning in everyday life’, ‘Safe food handling for my health’, ‘Healthy dietary life to prevent chronic disease’, and ‘Safety! nutrition! healthy dietary life’. Education program materials such as slides, handouts, videos, leaflet, and booklets were developed. As a result, there were score improvements in knowledge, dietary behaviors, and health belief after intervention in the intervention group, which were higher than those of the control group. In particular, there was a meaningful interrelation between dietary behavior and health belief (r=0.520, P<0.001). This finding suggests that changing beliefs is very important to make desirable dietary behavioral changes. For this reason, we can conclude HBM theory is an effective model to educate nutrition and food safety for the elderly. Furthermore, food safety and nutrition education programs are implemented and delivered continuously at various settings such as a health center or community welfare center, and those will contribute significantly to enhance perception and change their desirable dietary behaviors for the elderly.

무증상 갑상선기능저하증 환자에서 Thyroxine 치료에 따른 혈청 지질 및 아포지단백의 변화

조보연,신찬수,김원배,고창순,김성연,박혜영,박건상,이홍규,박형규,김숙경 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.1

Background: Subclinical hypothyroidism(SCH) is a common biochemical abnormality which can be found in routine screening tests of thyroid function. We are increasingly faced with the question of whether its an indication for thyroxine replacement therapy. The effect of thyroxine replacement on lipid profile in SCH has aroused a great interest because of an association of overt hypothyroidism(OVH) with hyperlipidemia and increased risk of coronary artery disease. Method: We prospectively evaluated the changes in lipids and apoproteins before and after thyroxine replacement therapy in 23 patients with SCH and in 37 patients with OVH. We measured serum total cholesterol and triglyceride using autoanalyzer, high density lipoprotein(HDL) chole-sterol by dextran sulfate method, Apo A1 and Apo B by immunonephelometric assay. Results: Thyroxine replacement therapy significantly decreased total cholesterol, low density lipoprotein(LDL) cholesterol and apo B levels, but did not affect the level of triglyceride, HDL cholesterol or apo AI in patients with OVH. In SCH, thyroxine replacement therapy with the doses to normalize serum TSH concentrations also decreased significantly the level of cholesterol and LDL cholesterol albeit apo B levels did not change. Moreover, in most of patients with OVH (11 of 12) and in all of patients with SCH(5 of 5) who had had hyperchlesterolemia before treatment, thyroxine replament normalized their cholesterol and LDL cholesterol levels. Conclusion: In regard to the beneficial changes in blood lipid levels, patients with SCH should be treated, especially in cases who have other risk factors for the development of atherosclerosis. If thyroxine replacement only will reduce the incidence of coronary artery disease in SCH remains to be elucidated by long-term prospective studies(J Kor Soc Endocrinol 11:41-51, 1996).

Effectiveness of HACCP-based Training on the Food Safety Knowledge and Behavior of Hospital Foodservice Employees

Chang, Hye-Ja,Lee, Jaung-Sook,Kwak, Tong-Kyung The Korean Nutrition Society 2003 Nutritional Sciences Vol.6 No.2

To prevent food-borne diseases and ensure food safety, foodservice operators have been implementing the HACCP system in their facilities. Employees' knowledge of food safety can be improved through training and, as a result, their food safety behavior can be positively changed. A nonequivalent pretest and posttest control group model was designed to investigate the effectiveness of HACCP-based training on hospital foodservice employees' food safety knowledge and behavior, and to determine relationships between food safety knowledge and food safety behavior. The subjects used in this study were 84 hospital foodservice employees, assigned either to the intervention group (n=44) or the control group (n=40). Data were analyzed using the Statistical Package for the Social Sciences (SPSS). Descriptive statistics were computed, while the Student's t-test and ANCOVA (Analysis of Covariance) were used to investigate significant differences between groups, and the Pearson correlation was used to determine significant correlations. There were significant gains in both food safety knowledge and behavior, after the HACCP-based training. However, no significant correlation was found between food safety knowledge and food safety behavior. Based on this study we conclude that HACCP-based training is effective in improving both the food safety knowledge and food safety behavior of hospital foodservice employees.

Single Oral Dose Toxicity Evaluation of Leejung-tang, a Korean Traditional Herbal Formula, in Crl:CD (SD) rats

Hye-Sun Lim,Mee-Young Lee,Chang-Seob Seo,In-Sik Shin,Hye-Kyung Ha,Jung-Im Huh,Hyeun-Kyoo Shin 대한한의학회 2011 대한한의학회지 Vol.32 No.3

호산구성 간농양 54예의 임상상

강혜련,권혁수,송우정,이상민,김태범,박혜경,장윤석,김윤근,조상헌,민경업,김유영 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

Single Oral Dose Toxicity Evaluation of Leejung-tang, a Korean Traditional Herbal Formula, in Crl:CD (SD) rats

Lim, Hye-Sun,Lee, Mee-Young,Seo, Chang-Seob,Shin, In-Sik,Ha, Hye-Kyung,Huh, Jung-Im,Shin, Hyeun-Kyoo The Society of Korean Medicine 2011 대한한의학회지 Vol.32 No.3

Objective: Leejung-tang (Rechu-to in Japanese) is a traditional Korean herbal formula used for treatment of gastrointestinal disorders such as vomiting, stomach pain, chronic gastritis and gastrointestinal ulceration. The present study was carried out to investigate the potential acute toxicity of Leejung-tang water extract (LJT) by a single oral dose in Crl:CD (SD) rats in compliance with current guidelines. Methods: In the preliminary study, there were no adverse effects such as death, clinical signs, and body weight changes at dose levels of 500, 1000, and 2000 mg/kg/day body weight. Based on the results, a dose of 2000 mg/kg was selected as the toxicological limited dose. LJT was administered once by gavage to male and female rats at dose levels of 0 and 2000 mg/kg bodyweight. During the study period, mortalities, clinical findings, and body weight changes were observed for 14 days following the administration. On day 14 after the treatment, the animals were sacrificed by carbon dioxide overdose and complete gross postmortem examinations were performed. Results: In present study, no treatment-related deaths were observed. There were no adverse effects on clinical signs and body weight changes. In addition, there were no observed gross findings in all groups except for a kidney cyst in the 2000 mg/kg/day female group. Conclusion: The results indicated that LJT did not induce toxic effects at a dose level up to 2000 mg/kg in rats and its median lethal dose ($LD_{50}$) was considered to be over 2000 mg/kg/day body weight for both genders.

깊은 신경망 훈련 및 규제 기법을 이용한 요추 환자의 CT 영상에서 요추 분할

장민혜(Min Hye Chang),양정원(Jeongwon Yang),차보경(Bo Kyung Cha),김진성(Jin-Sung Kim),김은(Eun Kim),Yanting Liu,이경희(Kyeong-Hee Lee) 대한전자공학회 2021 대한전자공학회 학술대회 Vol.2021 No.6

In this paper, DNN training and regularization techniques have been explored for lumbar vertebrae segmentation in CT images of patients with degenerative lumbar spine disease. Combinations of loss function, learning rate schedule, normalization, dropout, moving average, weight decay, and squeeze-and-excitation were empirically tested. The results confirmed that the DNN with optimized training and regularization techniques can improve lumbar vertebrae segmentation without complex structural changes.

지속가능발전목표(SDGs) 내 성평등 독자 목표의 국내이행을 위한 지표 연구

장은하(Eun Ha Chang),문유경(You Kyung Moon),조혜승(Hye Seung Cho),김정수(Jung Soo Kim),김지현(Ji Hyun Kim) 한국여성정책연구원(구 한국여성개발원) 2018 여성연구 Vol.98 No.3

2015년 국제사회는 새천년개발목표 (Millennium Development Goals, 이하 MDGs)를 대체 할 새로운 국제개발목표로 지속가능발전목표(Sustainable Development Goals, 이하 SDGs)를 채택하였다. SDGs는 17개 목표(goals)와 169개의 세부목표(targets), 그리고 244개의 지표로 구성되었으며 2030년까지 달성을 목표로 한다. MDGs에서와 마찬가지로, SDGs에서는 성평등을 위한 독자 목표(Goal 5)로 “양성평등 및 여성과 여아의 권한강화”가 채택되었다. 독자 목표인 5번의 경우 MDGs와는 달리 구조적 변화를 촉구하는 항목들이 대거 포진되어 성평등 달성에 있어서 전환적(transformative)인 변화를 추구하고 있다. 본고는 SDGs의 국내이행의 착수를 앞두고, SDGs 성평등 목표의 이행 점검을 위한 국내 가용통계를 점검하고, 향후 SDGs 성평등 목표의 국내이행점검을 위한 기초 매핑을 제시함으로써, 국내이행을 위한 지표 수립에 기여하고자 한다. 이를 위해 이론적 배경으로 SDGs 내 지표 수립과정을 소개하고 특히 성평등 목표의 범위와 지표 수립 과정을 보다 자세히 서술한다. 이어서 SDGs 국내이행을 위한 거버넌스 체계를 소개하고 현재까지 수행된 연구들을 개괄한다. 본 연구의 분석을 위해서는 SDGs 글로벌 지표의 정의의 완성도와 현재 국내통계의 가용상태를 고려하여 4가지의 범주로 구성된 분석틀을 고안하였다. 연구방법으로는 국내･외 관련 문헌을 검토하였다. 연구결과, SDGs의 효과적인 국내이행을 위해서는 정의가 불확실한 지표에 대해 조작적 정의가 선행될 필요가 있으며, 국내 가용통계가 부재하거나 미흡한 지표의 경우 이에 대한 추가개발의 필요함이 드러났다. 결론에서는 분석내용을 토대로 국내 SDGs 이행을 위한 시사점을 도출하여 논의하였다. This research explores the status and future tasks of national implementation of Sustainable Development Goal (SDG) 5 in South Korea by especially focusing on indicators. Among its 17 goals and 169 targets, SDGs sets forth gender equality and empowerment of women and girls as a stand-alone goal 5, and gender issues are also cross cut in other goals as well. The independent as well as cross cutting nature of gender related issues imply the quintessential nature of gender in attaining the overall SDG targets. In particular, SDG goal 5, unlike Millennium Development Goals (MDGs), pursues transformative changes in achieving gender equality with a number of indicators urging structural changes. Given this context, this paper examines the meaning and the availability of national data corresponding to SDG 5’global indicators, and provides implications for South Korea’s establishment of SDG 5 indicators for national implementation. As a theoretical background, we first outline the process of setting up the indicators of SDGs with particular focus of Goal 5, and then we introduce the governance system for SDGs implementation in South Korea and analyze the existing literature for this study. For methods, this study employs document reviews. We created an analytical matrix, using two pillars ; indicators’ definitions and availability of national data. Based on this matrix, this research categories each indicators into four groups. As results, this study reveals that several indicators require operational definition for domestic implementation and development of gender-sensitive domestic data for future implementation in South Korea. In conclusion, we present practical implications for future implementation of SDG goal 5 and its indicators in South Korea. The results of this study can be used as basic research for establishing national indicators for the implementation of gender-related SDG targets in South Korea, and ultimately to achieve the goal of gender equity in SDGs.