간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

Linearly Wavenumber-Swept Active Mode Locking Short-Cavity Fiber Laser for In-Vivo OCT Imaging

Hwi Don Lee,Myung Yung Jeong,Chang-Seok Kim,Jun Geun Shin,Byeong Ha Lee,Tae Joong Eom IEEE 2014 IEEE journal of selected topics in quantum electro Vol.20 No.5

<P>We demonstrate a highly linearly wavenumber-swept active mode locking (AML) fiber laser in the 1.3 μm region for in-vivo imaging in optical coherence tomography (OCT) without wavenumber space resampling. In this all-electric AML wavenumber-swept mechanism, the conventional wavelength selection filter is eliminated, and instead a suitable programmed electric modulation signal is applied directly to the gain medium. For a high sweep rate (up to 1 MHz) along the wavenumber, the fiber cavity structure is made as short as possible (0.88 m in air). A 15 ps/nm chirped fiber Bragg grating and a circulator are used for a shorter ring cavity configuration. A linewidth of 0.1 nm and tuning range of 42 nm are obtained under the mode-locking condition. Various types of wavenumber (or wavelength) tunings can be implemented because of the filterless cavity configuration. Therefore, we successfully demonstrate a linearly wavenumber-swept AML fiber laser with 26.5 mW of output power for obtaining in-vivo OCT images at a sweep rate of 100 kHz.</P>

유창한말에 대한 인식연구

이서하(Lee Seo Ha),하다영(Ha Da Young),남채린(Nam Chae Rin),곽솔휘(Kwak Sol Hwi),신예랑(Shin Ye Rang),한지우(Han Ji Woo),박현(Hyun Park),이명순(Myung Soon Lee) 한국언어치료학회 2021 한국언어치료학회 학술발표대회 논문집 Vol.2021 No.11

메카넘 바퀴 볼 로봇의 자세제어 및 주행

황승익(Seung-Ik Hwang),하휘명(Hwi-Myung Ha),이장명(Jang-Myung Lee) 제어로봇시스템학회 2015 제어·로봇·시스템학회 논문지 Vol.21 No.4

This paper proposes a balancing and driving control system for a Mecanum wheel ball robot which has a two axis structure and four motors. The inverted pendulum control method is adopted to maintain the balance of the ball robot while it is driving. For the balancing control, an anon-model-based controller has been designed to control the device simply without the need of a complex formula. All the gains of the controller are heuristically adjusted during the experiments. The tilt angle is measured by IMU sensors, which is used to generate the control input of the roll and pitch controller to make the tilt angle zero. For the driving control, the PID control algorithm has been adopted with angles of the wheels and the encoder data. The performance of the designed control system has been verified through the real experiments with the suggested ball robot.

Differential toxic responses between pristine and functionalized multiwall nanotubes involve induction of autophagy accumulation in murine lung.

Yu, Kyeong-Nam,Kim, Ji Eun,Seo, Hwi Won,Chae, Chanhee,Cho, Myung-Haing Taylor Francis 2013 Journal of toxicology and environmental health. Pa Vol.76 No.23

<P>Carbon nanotubes (CNT) are becoming commonly used in industrial applications. However, the toxicity associated with this material remains to be established. The aim of this study was to investigate the potential toxic mechanisms associated with multiwall carbon nanotubes (MWCNT) in normal mouse lung. A total of 100 μg of two types of MWCNT, namely, pristine MWCNT (PMWCNT) and acid-treated-MWCNT (TMWCNT), was administered to male C57BL/6 mice via intratracheal (IT) instillation for a period of 6 mo. Our results indicated that PMWCNT induced pulmonary autophagy accumulation and resulted in more potent tumorigenic effects compared to TMWCNT. Accordingly, MWCNT may exert differential toxicity attributed to various physicochemical properties. Data emphasize the need for careful regulation of production and use of CNT.</P>

효율적인 의약품 평가를 위한 약물계량학 분석법 도입의 전략 방안

( Sang Min Lee ),( Boyoon Choi ),( Hwi Yeol Yun ),( Da Hae Jun ),( Myung Gou Kim ),( Ji Hye Ha ),( Young Hoon Kim ),( Eun Hee Ji ),( Won Ku Kang ),( Na Young Han ),( Wan Gyoon Shin ),( Jung Mi Oh ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0

Over the past few decades, drug regulatory agencies in advanced countries have been emphasizing pharmacomctrics as a tool for an effective and efficient drug evaluation. Despite this international movement, the value of pharmacometrics is still poorly recognized by the Korean drug evaluation system. This study aimed to analyze the current state of utiliza-tion of pharmacometrics by foreign drug regulatory agencies and develop a road map to guide the implementation phar- macometrics into the Krean drug evaluation system. MEDLINE and foreign drug regulatory agency database were extensively searched to obtain scientific research articles, guidance, regulations and pharmacometric review reports on foreign pharmacometric drug evaluation system. A systematic roadmap comprised of 3 stages to implement pharmaco-metrics in Lorean drug evaluation system was formulated after analyzing the collected data in tune with the current evaluation system. Pharmacometrics is an urgently required tool to achieve an efficient drug evaluation and review in Korea. The road map developed by this study is expected to aid in setting up a policy to implement and utilize phar-macometrics in Korea.

Pharmaceutical Evaluation of Genistein-loaded Pluronic Micelles for Oral Delivery

Kwon, Suk-Hyung,Kim, Sun-Young,Ha, Kyoung-Wook,Kang, Myung-Joo,Huh, Jin-Seo,Im, Tae-Jong,Kim, Yong-Min,Park, Young-Mi,Kang, Kyoung-Hoon,Lee, Sang-Kil,Chang, Jung-Yun,Choi, Young-Wook,Lee, Jae-Hwi 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9

The purpose of the present study was to determine whether Pluronic F127 polymeric micelles could improve the oral bioavailability of a poor water-soluble drug, such as genistein. Genistein is a phytoestrogen that has estrogenic activity. F127 triblock copolymer consists of $PEO_{100}-PPO_{65}-PEO_{100}$. Genistein was incorporated in the Pluronic F127 polymeric micelles by a solid dispersion method. The genistein release of genistein-loaded polymeric micelles was studied in vitro (in pH 1.2 and pH 6.8). And the oral bioavailabilities of genistein powder and genisteinloaded micelles were estimated at a dose of 4.0 mg/kg as genistein in rats. Drug loading amount and drug loading efficiency were 11.18% and 97.41%, respectively. The average size of the genistein-loaded polymeric micelles was 27.76 nm. And genistein release of the genistein-loaded polymeric micelles in vitro was 58% (pH 1.2) and 82% (pH 6.8). The bioavailability of genistein-loaded polymeric micelles was better than genistein powder. Consequently, Pluronic F127 polymeric micelles are an effective delivery system for the oral administration of genistein.

Vision Based Robot for Recognizing and Grasping Fast Moving Conveyor Products

Longtan Wang,Zhitao Wang,Ho-Yun Yu,Hwi-Myung Ha,Yun-Ki Kim,Jang-Myung Lee 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10

This paper presents a vision guided robot for recognizing and grasping moving objects on the conveyor belt. An industrial camera is utilized to capture the image of moving objects. A robust vision system is applied for recognizing and estimating the moving object in real time. Objects are recognized by using SURF(Speeded-Up Robust Features) key point detector and FLANN(Fast Library for Approximate Nearest Neighbor) based matcher. Then Rotating calipers algorithm is adopted to estimate the centroid position and orientation of the objects. A simple path planning scheme will thus be assigned based on the information obtained from vision system. Experimental result demonstrates that the approach is efficient and reliable.

CD74-immunoreactive activated M1 microglia are shown late in the gerbil hippocampal CA1 region following transient cerebral ischemia

Hwang, In Koo,Park, Joon Ha,Lee, Tae-Kyeong,Kim, Dae Won,Yoo, Ki-Yeon,Ahn, Ji Hyeon,Kim, Yang Hee,Cho, Jun Hwi,Kim, Young-Myeong,Won, Moo-Ho,Moon, Seung Myung SPANDIDOS PUBLICATIONS 2017 MOLECULAR MEDICINE REPORTS Vol.15 No.6

<P>Activated M1 microglia secrete proinflammatory cytokines into damaged brain areas. The present study examined activated M1 microglial morphology and expression in the hippocampal Cornu Ammonis (CA) 1 region, which is vulnerable to transient ischemia. Transient cerebral ischemia was performed for 5 min in gerbils, and neuronal death in the CA1 region following transient cerebral ischemia was confirmed using cresyl violet staining, neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B histofluorescent staining. In addition, CA1 regions were stained for cluster of differentiation (CD) 74, a marker for activated M1 microglia and a ligand for macrophage migration inhibitory factor In sham-operated animals, no CD74 immunoreactivity was observed in the hippocampal CA1 region. CD74 immunoreactivity was not observed in the hippocampal CA1 region until 3 days post-ischemic insult; however, elevated CD74 immunoreactivity was detected in the CA1 region from 5 days post-ischemia. Double immunofluorescence staining for CD74 and ionized calcium-binding adapter molecule 1, a marker for M1 microglial cells, confirmed the expression of CD74 on this microglial subtype. These results indicated that M1 microglia are activated late in the hippocampal CA1 region following ischemic stroke. Therefore, optimizing the timing of therapeutic intervention may reduce activated M1 microglial-induced neuronal damage.</P>

중성자 모니터링을 위한 전도성 ¹⁰B 박막 개발

임창휘,김종열,이수현,정용주,최영현,백철하,문명국,Lim, Chang Hwy,Kim, Jongyul,Lee, Suhyun,Jung, Yongju,Choi, Young-Hyun,Baek, Cheol-Ha,Moon, Myung-Kook 대한방사선방어학회 2014 방사선방어학회지 Vol.39 No.4

중성자 검출분야에서$^3He$는 높은 중성자 검출효율 때문에 아주 많이 사용되고 있다. 하지만 2009년 초반부터 발생하고 있는 전세계적인 $^3He$의 품귀현상으로 인하여 가격이 급등하고 수급이 어려워졌기 때문에 대체 중성자 검출물질에 대한 필요성이 높아졌다. 그러므로 중성자 검출물질로 사용될 수는 있지만 $^3He$에 비해 반응효율이 낮아 중성자 검출용으로 주로 사용되지 않던 물질들을 사용하여 검출기를 제작하는 연구가 다시 활발하게 진행되고 있다. $BF_3$, $^6Li$, $^{10}B$, $Gd_2O_2S$ 등과 같은 $^3He$ 대체 물질들 중 하나인 $^{10}B$은 손쉬운 감마선 구별, 무독성, 낮은 가격 등과 같은 여러 장점으로 인하여 여러 연구그룹에서 연구되고 있다. $^{10}B$ 박막을 이용한 중성자 검출은 중성자와 반응하여 발생되는 2차 방사선을 측정하여 간접적으로 중성자를 측정하는 검출기법이다. 반응을 통해 생성된 알파입자의 비정은 고체 내에서 아주 짧기 때문에 $^{10}B$ 층은 박막 형태로 얇게 제작해야 한다. 그러므로 중성자와 박막의 반응을 통해 발생되는 알파입자의 검출효율을 증가시키기 위해서는 $^{10}B$ 박막의 두께를 얇게 제작하는 것이 중요하다. 하지만 박막의 두께를 얇게 제작하는 것은 중성자와 반응하여 생성되는 알파입자의 수집효율을 증가시키는 장점이 있지만 또한 중성자와 반응할 단면적을 감소시키는 단점이 있다. 본 논문에서는 리튬이온전지에 사용되는 초박막 극판 제조 기술을 이용하여 중성자 검출을 위한 대략 $60{\mu}m$ 두께의 얇은 $^{10}B$ 박막을 제작하였다. 그리고 전도성, 분포, 점착력, 유연성와 같은 간단한 물리적 실험을 통해 제작된 $^{10}B$ 박막의 물성을 확인하였다. 또한, 제작된 $^{10}B$ 박막을 사용하여 중성자 모니터링을 위한 비례계수기 제작하고 이를 이용하여 한국원자력연구원의 중성자 조사시설의 중성자 파고 스펙트럼을 측정하였다. 또한, 중성자 검출효율을 증가시킬 수 있는 방법 중 하나인 다층 박막을 이용한 중성자 측정 방법을 이용하여 박막 층수에 따른 중성자 검출효율의 변화를 몬테칼로 전산모사 기법을 이용하여 계산하였고 실험을 통해 박막층의 증가에 따른 신호변화를 측정하였다. In the field of neutron detections, $^3He$ gas, the so-called "the gold standard," is the most widely used material for neutron detections because of its high efficiency in neutron capturing. However, from variable causes since early 2009, $^3He$ is being depleted, which has maintained an upward pressure on its cost. For this reason, the demands for $^3He$ replacements are rising sharply. Research into neutron converting materials, which has not been used well due to a neutron detection efficiency lower than the efficiency of $^3He$, although it can be chosen for use in a neutron detector, has been highlighted again. $^{10}B$, which is one of the $^3He$ replacements, such as $BF_3$, $^6Li$, $^{10}B$, $Gd_2O_2S$, is being researched by various detector development groups owing to a number of advantages such as easy gamma-ray discrimination, non-toxicity, low cost, etc. One of the possible techniques for the detection is an indirect neutron detection method measuring secondary radiation generated by interactions between neutrons and $^{10}B$. Because of the mean free path of alpha particle from interactions that are very short in a solid material, the thickness of $^{10}B$ should be thin. Therefore, to increase the neutron detection efficiency, it is important to make a $^{10}B$ thin film. In this study, we fabricated a $^{10}B$ thin film that is about 60 um in thickness for neutron detection using well-known technology for the manufacturing of a thin electrode for use in lithium ion batteries. In addition, by performing simple physical tests on the conductivity, dispersion, adhesion, and flexibility, we confirmed that the physical characteristics of the fabricated $^{10}B$ thin film are good. Using the fabricated $^{10}B$ thin film, we made a proportional counter for neutron monitoring and measured the neutron pulse height spectrum at a neutron facility at KAERI. Furthermore, we calculated using the Monte Carlo simulation the change of neutron detection efficiency according to the number of thin film layers. In conclusion, we suggest a fabrication method of a $^{10}B$ thin film using the technology used in making a thin electrode of lithium ion batteries and made the $^{10}B$ thin film for neutron detection using suggested method.