65세 이상의 노령층에서 고지혈증의 위험요인

김용배,장원기,황보영,김화성,안규동,이병국,이용진,김세훈,김승수,김승훈,김영록,김웅빈,이성수 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

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납 노출 근로자들에서 ALAD 및 VDR의 다형질성이 조혈기능 지표에 미치는 영향

이성수,김남수,김진호,김용배,황보영,김화성,안규동,이병국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study was conducted with new workers who entered lead industries from 1992 to 2001 to evaluate the genetic susceptibility of ALAD (δ-aminolevulinic acid dehydratase) and VDR (vitamin D receptor) gene on health effect of lead exposure. Methods: Among the subjects of the database of lead industries at the Soonchunhyang University Institute of Industrial Medicine, only new workers were selected for this study. The total of eligible workers for this category was 3,540 workers, including non lead exposed workers of same lead industries. From stored blood in specimen bank of Soonchunhyang University, genotype of ALAD and VDR were measured using PCR method. Variables for this study were blood lead as an index of lead exposure, ZPP (zinc protoporphyrin in blood), urine ALA (δ-aminolevulinic acid), and hemoglobin as an index of hematopoietic effect of lead. Information on sex, job duration, and weight were collected for personal information. The data were analyzed using SAS (version 8.2) with descriptive analysis of t-test and multiple regression analysis. Results: Among 3,540 new employed study subjects during period of 1992-2001, 3,204 workers (90.5%) had ALAD genotype 1-1, while 336 workers (9.5%) had variant type of ALAD (1-2 or 2-2). For VDR genotype, 2,903 workers (89.7%) out of total tested 3,238 workers were belonged to type bb and 335 workers (10.5%) were type bB or BB. The distribution of genotype of ALAD and VDR were not different according to the job duration in male workers, but were different in female workers. The effect of ALAD and VDR genotype on blood lead were positively significant in the analysis of all cumulative data of new employed workers for 10 years. The effect of VDR genotype on blood lead were stronger than that of ALAD While the variant ALAD gene made decrease of mean ZPP and ALA in urine after controlling for blood lead and other covariate, the variant VDR gene made increased the mean ZPP and ALA in urine in all cumulative data analysis and cross sectional analysis by job duration. For hemoglobin, ALAD and VDR genotype did not affect the mean value. Conclusions: From the above our results, we found that ALAD and VDR genotype exerted significant effect in various way. We confirmed that the finding of a cross sectional study of protective effect of variant ALAD on the effect blood lead on blood ZPP in our retrospective study design. It was found that VDR did not exert protective effect for lead exposure as the variant ALAD did.

연쇄중합효소반응을 이용한 태아성별진단

이희섭,김용신,김화선,김정중,김원신 원광대학교 생명공학연구소 1996 생명공학연구소보 Vol.4 No.1

For sex determination by the PCR method, oligoprimers to Y-chromosome gene, DYZ1, SRY, and AMGL were synthesized and genomic DNA was extracted from male and female placenta for the control use. DYZ1 represented 154 bp single band to 0.001pg/ml male genomic DNA but did not represent 154 bp band in female genomic DNA, SRY represented 341 bp band to 1 pg/ml male genomic DNA but did not represent 341 bp band in female genomic DNA, and AMGL represented 977 and 788 bp double band to 1 pg/ml male genomic DNA and 977 bp single band to 1 pg/ml female genomic DNA in 2% agarose gel electrophoresis stained with ethidium bromide. DYZ1 was 1,000-fold sensitive than SRY and AMGL. DYZ1 and SRY could not identify the PCR failure from female but AMGL identified. To increase the sensitivity, the dual amplification of AMGL was performed and the sensitivity increased to 1,000-fold. During the dual amplification of female genomic DNA mixed with male genomic DNA, 0.00125pg/l, 1:400 part male genomic DNA contamination represented double bands as male. In 2 cases of 46, XY female, DYZ1 and AMGL amplification represented male band but SRY amplification did not represent male band. It was suggested that SRY gene was deleted in two 46, XY female cases. for fetal sex determination, PCR with DYZ1, SRY, and AMGL was performed in 10 cases of chorionic villi and 15 cases of amnionic cells. By the comparison with karyotyping result, fetal sex determination was achieved successfully in all 23 samples using PCR of SRY and AMGL but false result was detected in 3 cases(13%) using DYZ1. According to our results, it was concluded that DYZ1 was 1,000-fold sensitive than SRY and AMGL but could not be used because of its false results, and AMGL and SRY must be used concomitantly for precise sex determination.

경련성 환아 부모들의 인식에 대한 연구

이경화(Kyoung Hwa Lee),서은숙(Eun Sook Suh),김영창(Yong Chang Kim),김창휘(Chang Hwi Kim),이동환(Dong Whan Lee) 대한소아신경학회 1996 대한소아신경학회지 Vol.3 No.2

Convulsive disorder is the most part of the pediatric neurologic disease. As far as the treatment of convulsive disorder concerned, we must consider familys' understanding, and the close cooperation between the epileptic child, parents, and doctors. We compared to Kim's report in 1985, to study the change of parents of epileptic children thinking. A prospective study was undertaken the analysis of 100 epileptic children parents visited to the pediatric dept, of Soonchunhyang university hospital from May to July, 1995. Psychological assessment, questionnaires which contains 17 items were given them, and these items were compared to Kims report in 1985 The results were as follows: 1) Parents of epileptic children answered convulsive disorder has influenced to children growth and development( 60.8% in 1985, 65.0% in 1995 ). 2) For asking the causes of children disease, 40.5% of them in 1985 and 50.0% of them in 1995 answered to uncertain, but only 7.8% of them in 1985 and 7.0% of them in 1995 answered to relation with familial inheritance. 3) The feelings at time of the diagnosis were gloomy or uncomfortable: 52.3% in 1985, 38.0% in 1995 and shameful 28.1% in 1985, 9.0% 1995. parents had belived in the epilepsy was treatable disease: 41.0% in 1995. 4) According to the this survey, patients explained reasons why their children take the medication increased from 23.5% in 1985 to 65.0% in 1995. 5) Only family, knew that their children had the convulsive disorder about 50.3% in 1995 and 22.0% in 1995. Family, patients and other people except family knew that their children had the convulsive disorder about 6.5% in 1985 and 43.0% in 1995. 6) The parents opinion and expectation toward the medical doctors were that they wanted to get full explanation for the disease 81.0% in 1985 and 35.1% in 1995, and others were explantation about toxicity and side effects of the medication and advises for the childrens life and activities.

축산분뇨 혐기소화 잔재물의 특성 및 초지 적용성 평가

김승민(Seung Min Kim),정웅기(Woong-gi Jung),성용주(Yong Joo Sung),안희권(Hee-Kwon Ahn),김동성(Dong Sung Kim),윤도현(Do-Hyun Yoon),김동섭(Dong-Seop Kim1),정광화(Hwa Gwang Jung) 한국펄프·종이공학회 2014 펄프.종이기술 Vol.46 No.3

질소분압에 따른 TaNx coating층의 미세조직 연구

김선화,최용락 순천향대학교 부설 산업기술연구소 1998 순천향 산업기술연구소논문집 Vol.3 No.3

TaNx film were fabricated for this research by the reactive magnetron sputtering process. In order to improve TCR, it was investigated the transformation of coated TaNx film. The variables were the N₂/Ar fraction and the thermal heat-treatment. The electrical resistance and the TCR of specimen were measured. It was observed the microstructure change under thermal heat-treatment by XRD experiment. Also the morphology of TaNx film was observed by SEM. As a result, TCR was stabilized when N₂/Ar fraction were 0.166 to 0.25. The phases of as-coated TaNx film were Ta, TaN, β-Ta and amorphous. The new phases, Ta₄N and Ta₃N?? were formed after thermal heat-treatment. As the ratio of nitrogen gas was increased, the morphology of the layer was changed to a discontinuous island particle. These results were consistent with results of electrical resistance change.

석재복합제품 관련산업의 신제품 개발전략

김재명,손재영,최용훈,오정화 강원대학교 석재복합신소재제품연구센터 1998 석재연 논문집 Vol.3 No.-

본 연구는 신제품 개발이론에 대한 이론적 틀을 연구하고, 이에 기초하여 석재복합 관련제품의 신제품 개발 노선, 기술, 신제품 개발전략 구축과 선택 방안을 제시하였다. 석재복합 관련 제품의 대부분은 첨단 고도기술을 필요로 하는 영역이 한정되어 있기 때문에 이 산업 분야에서의 신제품 개발은 신제품 개발계획과 지침을 마련할 필요가 있다. 또한 유망 신제품 안건으로 계층화하여 신제품 개발의 기본전략을 구축하는 신규사업 시나리오를 작성하여 신제품 개발전략을 구축하는 것이 효과적이다. 이러한 과정을 거쳐 중소기업의 경우는 현존하는 시장, 제품, 그리고 기술우위에 기반을 둔 신제품을 개발할 경우 성공 가능성이 클 것이다. 이 이외에도 석재복합제품 개발은 석재자원과 신소재 개발에 기초한 신제품 개발에 필요한 기술 진전 사항, 즉 기술개발-제품개발-시장진입 활동간 상호 연계성을 고려해야 한다. This study suggests the theoretical framework and strategy of new product development in the avdanced mineral aggregate composite industry. The advanced mineral aggregate composite area needs to prepare the plan and guidelines on the new product development owing to the characteristic of the related technology. Alternative scenarios on the hierachy of new product idea is effective to the success of new product development strategy. Especially, the existing market, product, and the technological advantages affects the possibility of the success of new product development of the small firms. Also considering the interrelationship between the technological trends is important to the new product development of advanced mineral aggregate composite industry.

빈랑자 추출물의 염색성 및 기능성에 관한 연구

김지선,조용석,최순화 대한가정학회 2003 Family and Environment Research Vol.41 No.7

Recently there has been interested in the use of natural dyes in textile applications. Generally natural dyes can exhibit better biodegradability and have a higher compatibility with the environment. In this study, cotton wool and silk fabrics were dyed with alkali extract of Arecae semen using various mordants, and their dyeabilities were discussed. Additionally the fastness to washing, perspiration, light, rubbing, and drycleaning and UV-B protection rate were also investigated. Cotton, silk and wool fabrics dyed with alkali extract of Arecae semen were colored in reddish yellow tint. The optimum dyeing condition of the colorants extracted from the Arecae semen was three repeated dyeing at 95℃ for 1.5hrs. The dyed fabrics by using mordanting methods improved the fastness to washing, perspiration and drycleaning, but the fastness to light and rubbing were not increased. The UV-B protection rate of the wool fabrics were increased by dyeing with extract of Arecae semen.

보존료가 두부의 저장에 미치는 효과

김동한,신용서,전승호,백승화,이갑상 圓光大學校 1992 論文集 Vol.26 No.2

두부의 저장성 향상을 위해 보존료를 첨가하여 저장중 두부의 미생물상과 이화학적 변화를 검토하였다. 보존료 첨가에 의한 두부의 기호도 변화는 큰 차이가 없었으며 부패가 진행될 수록 적정산도와 amino태 및 ammonia태 질소량은 증가하였다. 두부는 acetic acid로 응고시키는 것이 CaCl₂보다 보존료에 의한 저장성 향상에 효과적이어서, acetic acid에 0.05% K-sorbate와 3% NaCl을 혼합첨가한 구는 저장중 이화학적 변화 및 호기성, 혐기성 세균수가 ?? cell/g수준인 점을 고려해 볼 때 30℃에서 48시간까지 저장이 가능하였다. In order to improve the shelf life of Tofu, the effects of preservatives on Tofu were investigated for microbiol and physicochemical changes during its storage. The sensory evaluation was not deteriorated by preservatives (0.05% K-sorbates). According to the progression of spoliage of Tofu, titratable acidity, and amino and ammonia nitrogen contents were increased. The effect of chemical preservatives on the shelf life of Tofu was shown to be stronger in the Tofu by acetic acid than in that by CaCl₂. The presence of 0. 05% K-sorbate and 3% NaCl as a preservative in Tofu by acetic acid extended it's shelf life upto 48 hrs at 30℃.

李箱 小說의 慾望構造

金用成,李鍾和 全北大學校 敎育大學院 1994 敎育論叢 Vol.14 No.-