http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Inactivation of the virulence factors from 2,3-butanediol-producing Klebsiella pneumoniae
Huynh, Duyen Thi Ngoc,Kim, Ah-Young,Seol, In-Hye,Jung, Samuel,Lim, Min-Cheol,Lee, Jeong-A,Jo, Mi-Rae,Choi, Soo-Jin,Kim, Borim,Lee, Jinwon,Kim, Wooki,Kim, Young-Rok Springer-Verlag 2015 Applied microbiology and biotechnology Vol.99 No.22
Identifying the Location of a Single Protein along the DNA Strand Using Solid-State Nanopores
Yu, Jae-Seok,Lim, Min-Cheol,Huynh, Duyen Thi Ngoc,Kim, Hyung-Jun,Kim, Hyun-Mi,Kim, Young-Rok,Kim, Ki-Bum American Chemical Society 2015 ACS NANO Vol.9 No.5
<P>Solid-state nanopore has been widely studied as an effective tool to detect and analyze small biomolecules, such as DNA, RNA, and proteins, at a single molecule level. In this study, we demonstrate a rapid identification of the location of zinc finger protein (ZFP), which is bound to a specific locus along the length of a double-stranded DNA (dsDNA) to a single protein resolution using a low noise solid-state nanopore. When ZFP labeled DNAs were driven through a nanopore by an externally applied electric field, characteristic ionic current signals arising from the passage of the DNA/ZFP complex and bare DNA were detected, which enabled us to identify the locations of ZFP binding site. We examined two DNAs with ZFP binding sites at different positions and found that the location of the additional current drop derived from the DNA/ZFP complex is well-matched with a theoretical one along the length of the DNA molecule. These results suggest that the protein binding site on DNA can be mapped or that genetic information can be read at a single molecule level using solid-state nanopores.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-5/acsnano.5b00784/production/images/medium/nn-2015-00784c_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b00784'>ACS Electronic Supporting Info</A></P>