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Mycophenolic Acid와 Rapamycin이 흰쥐 사구체 혈관간세포증식과 세포외기질 생성에 미치는 영향
김명수,박제현,하헌주,허규하,서지연,김유선,김혜진,박기일 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14
Background: Excess proliferation and extracellular matrix (ECM) accumulation of mesenchymal cells such as vascular smooth muscle cells (VSMC) and glomerular mesangial cells cause chronic allograft nephropathy showing transplant vascular sclerosis and glomerulosclerosis. Mycophenolic acid (MPA) and rapamycin (RPM) are well known as strong inhibitors of VSMC proliferation, but their effects on the glomerular mesangial cells are not yet clearly understood. This study examined the effects of MPA or RPM on PDGF-induced proliferation and ECM accumulation in rat glomerular mesangial cells. Methods: Mesangial cells isolated from the glomeruli of Sprague-Dawley rats were cultured with DMEM containing 20% fetal bovine serum. Growth arrested and synchronized cells were administered with test drugs (MPA10 nM-10μM, RPM 0.1 nM-1μM) before the addition of PDGF 10 ng/mL. Cell proliferation was assessed by [³H]thymidine incorporation, collagen by [³H]proline incorporation, and fibronectin, ERK, and p38 MAPK by Western blot analysis. Results: PDGF increased mesangial cell proliferation by 4.64-fold. Compared to stimulated control, MPA above 500 nM and RPM above 10nM showed a significant inhibitory effect in a dose-dependent manner. The IC_(50) of MPA and RPM against PDGF-induced mesangial cell proliferation were around 500 nM and 100 nM, respectively. The collagen synthesis was also inhibited by MPA and RPM, but the fibronectin secretion was inhibited by MPA alone. The proliferation of mesangial cell correlated with activation of ERK and. p38 MAPK. MPA, but not RPM, inhibited ERK and p38 MAPK activation. Conclusion: This study demonstrated that MPA and RPM significantly inhibited PDGF-induced proliferation and ECM production in rat glomerular mesangial cells. The inhibitory effects of MPA, but not RPM, are correlated with ERK and p38 MAPK.
Performance evaluation using reduced neighbor lists in cellular based multi-hop relay network
Hun-je Yeon,Eunhyun Kwon,Sung-gook Lim,Jaiyong Lee,Mi-Sun Do,Rakesh Taori 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
In this paper, we introduce neighbor list composition scheme that organizes small numbers of adjacent neighbors for cellular based multi-hop relay network so that the neighbor advertisement with small number of neighbors could increase average transmission rate of MR network. Wireless multi-hop environment based on cellular system, such as 802.16j, requires an algorithm that organizes neighbor lists dynamically due to the mobility and impermanancy of relay station. From the study, we’ve concluded that the location based neighbor lists composition could reduces the wastage of wireless resources, which improves the transmission rate of cellular based wireless multi-hop network.
Erlotinib (Tarceva(R)) 복용 후 생긴 여드름양 발진 및 조갑주위염
연제호 ( Je Ho Yeon ),민성욱 ( Seong Uk Min ),이동훈 ( Dong Hun Lee ),최유성 ( Yu Sung Choi ),서대헌 ( Dae Hun Suh ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.11
Erlotinib (Tarceva(R)) is a new anti-cancer agent which acts by inhibiting epidermal growth factor receptor (EGFR) signal transduction. It is currently used in the treatment of advanced stage non-small cell lung cancer and pancreatic cancer. We report a case of acneiform eruption and paronychia induced by erlotinib in a 69-year-old man. The patient visited our clinic with multiple erythematous papules and pustules on the face, periungual erythema and pus discharge, xerosis, fissures on the sole. He had taken erlotinib for the treatment of recurred lung cancer for 4 weeks. The skin lesions were partially improved with oral pyridoxine, corticosteroid and topical antibiotics. (Korean J Dermatol 2007;45(11):1180∼1182)
조재훈(Je Hun Jo),박영복(Young Bock Park),박태형(Tae Hyoung Park),장원연(Won Yeon Jang),김도균(Do Gyun Kim),김경원(Kyoung Won Kim),이동기(Dong Ki Lee),윤혜원(Hae Won Yoon),김동훈(Dong Hun Kim),김미운(Mi Woon Kim),박성태(Sung Tae Park 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
The Complete testicular feminization syndrome is a hereditary syndrome characterized clinically by female phenotype with 46, XY karyotype and bilateral testes. There is a congenital insensitivity to androgens, transmitted by means of a maternal X-linked recessive gene responsible for the androgen intracellular receptor. Therefore, androgen induction of Wolffian duct development does not occur. However, anti-mullerian hormone activity is present and the individual does not have mullerian development. Principle of treatment is reinforced to live normal female life. This is a case report of testicular feminization syndrome with rudimentary salpinx with the brief review of literatures.
Yeon-Keon Moon,Sih Lee,김도현,Je-Hun Lee,정창오,박종완 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.1
We investigated the fabrication and the characteristics of thin-lm transistors with InGaZnO active channel layers (IGZO-TFTs) deposited at various oxygen partial pressures. Also, we explain the operation mechanism for IGZO-TFTs with channel layers fabricated at various oxygen partial pressures. The IGZO thin lms were deposited on SiO2/n-Si substrates by dc magnetron sputtering at various oxygen partial pressures from 0.5 % to 40 %. The eects of the oxygen partial pressures during the IGZO thin-lm deposition on the electrical characteristics of IGZO-TFTs, which were fabricated with bottom gate structures, were investigated. IGZO-TFTs with active channel layers deposited at an oxygen partial pressure of 6 % exhibited good performance. IGZO-TFTs exhibited a depletion-mode and the TFT turn-on voltage, on-o current ratio and eld eect mobility were -8 V, ~10^7 and 9.21 cm^2/Vs, respectively. Moreover, we evaluated the eect of bias stress on the transistor performance. Our research results will contribute to applications of select transistors to active-matrix liquid-crystal displays. We investigated the fabrication and the characteristics of thin-lm transistors with InGaZnO active channel layers (IGZO-TFTs) deposited at various oxygen partial pressures. Also, we explain the operation mechanism for IGZO-TFTs with channel layers fabricated at various oxygen partial pressures. The IGZO thin lms were deposited on SiO2/n-Si substrates by dc magnetron sputtering at various oxygen partial pressures from 0.5 % to 40 %. The eects of the oxygen partial pressures during the IGZO thin-lm deposition on the electrical characteristics of IGZO-TFTs, which were fabricated with bottom gate structures, were investigated. IGZO-TFTs with active channel layers deposited at an oxygen partial pressure of 6 % exhibited good performance. IGZO-TFTs exhibited a depletion-mode and the TFT turn-on voltage, on-o current ratio and eld eect mobility were -8 V, ~10^7 and 9.21 cm^2/Vs, respectively. Moreover, we evaluated the eect of bias stress on the transistor performance. Our research results will contribute to applications of select transistors to active-matrix liquid-crystal displays.
Hepatotoxicity assay using human hepatocytes trapped in microholes of a microfluidic device
Yeon, Ju Hun,Na, Dokyun,Park, Je-Kyun WILEY-VCH Verlag 2010 Electrophoresis Vol.31 No.18
<P>Hepatocytes have been used for in vitro hepatotoxicity assays because of their ability to sustain intact liver-specific functions. Here, we demonstrate a hepatotoxicity assay system using primary human hepatocytes trapped in microholes of a microfluidic device, providing a microscale in vivo liver-like environment. We performed microfluidic hepatotoxicity assays of several drugs, including acetaminophen, verapamil, diclofenac, and benzopyrene, all of which are known to specifically affect hepatic function. The drug sensitivities in hepatocytes and HepG2 cells were measured by calculating the live cell fraction at various drug concentrations. The results indicated that hepatocytes were more sensitive to these drugs than HepG2 cells. The lethal concentration 50 values for all drugs tested were similar to those from the in vitro toxicity data with human hepatocytes obtained from the literature. Furthermore, we developed a mathematical hepatotoxicity model based on the time-dependent cell death profiles measured by our device. This novel assay system enabled us to analyze in vivo-like hepatotoxicity in a microfluidic device by exploiting microstructures to mimic the microenvironment of the liver.</P>
Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures.
Yeon, Ju Hun,Na, Dokyun,Choi, Kyungsun,Ryu, Seung-Wook,Choi, Chulhee,Park, Je-Kyun Kluwer Academic Publishers 2012 BIOMEDICAL MICRODEVICES Vol.14 No.6
<P>Since most of the bioavailable drugs are impermeable through the blood-brain barrier (BBB), development of a rapid and reliable permeability assay system has been a challenge in drug discovery targeting central nervous system (CNS). Here, we designed a microfluidic device to monitor the drug permeability into the CNS. Human umbilical vein endothelial cells (HUVECs) were shortly (2?~?3 h) incubated with astrocyte-conditioned medium after being trapped on microholes in the microfluidic device and tested for chip-based permeability measurement of drugs. The measured permeability values were highly correlated with those measured by conventional in vitro methods and the brain uptake index representing the quantity of transported substances across the in vivo BBB of rats. Using the microfluidic device, we could easily monitor the effect of hydrogen peroxide on the trans-endothelial permeability, which are consistent with the finding that the same treatment disrupted the formation of tight junctions between endothelial cells. Considering relatively short period of time needed for endothelial cell culture and ability to monitor the BBB physiology continuously, we propose that this novel system can be used as an invaluable first-line tool for CNS-related drug development.</P>