A novel HB-SC-MCCNN model for intelligent fault diagnosis of rolling bearing

Hui Liao,Pengfei Xie,Yan Zhao,Jinfang Gu,Lei Shi,Sier Deng,Hengdi Wang 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.12

The incompleteness and lack of bearing fault data have become important problems in bearing fault diagnosis. This paper presents an intelligent fault diagnosis method for rolling bearings based on a similarity clustering multi-channel convolution neural network with the hierarchical branch (HB-SC-MCCNN). First, the relevant features are extracted by MCCNN, and combined with the similarity clustering principle, the accurate binary classification is realized in the case of insufficient labeled data. Second, the similarity clustering module and additional loss are added to the SC-MCCNN network to form a hierarchical-branch network, which simplifies the problem of fault multi-classification into binary classification with multiple steps, and to reduces the dependence on the amount of label data in multi-classification. Finally, based on the self-learning characteristics of HB-SC-MCCNN, the unlabeled data and the missing fault types in the training set are re-labeled to realize the re-training of the network. On the benchmark dataset, the comparison experiment results with several salient deep learning models show that the method proposed in this paper successfully realizes the hierarchical diagnosis of bearing faults and presents more substantial competitiveness in the case of insufficient labeled data and missing fault types.

THE UPDATED ORBITAL EPHEMERIS OF DIPPING LOW MASS X-ray BINARY 4U 1624-49

LIAO, NAI-HUI,CHOU, YI,HSIEH, HUNG-EN,CHUANG, PO-SHENG The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

We present our analysis results for an updated orbital ephemeris for the dipping low mass X-ray binary 4U 1624-49, using the light curve collected by the All Sky Monitor (ASM) on board the Rossi X-ray Timing Explorer (RXTE) and the Monitor of All-Sky X-ray Image (MAXI). To make clear dip profiles, the light curve from the ASM and the MAXI were divided into ten 500d segments and four 400d segments for ASM and MAXI light curves, respectively, and folded with the linear ephemeris proposed by Smale et al. (2001). The phases of dip centers were determined by the method adopted from Hu et al. (2008). The phase drift was then fitted with a linear function. We obtained an updated orbital period of 0.869896(1) d and a phase zero epoch of JD 2450088.6618(57). No clear orbital period derivative is detected with a 2-sigma upper limit of $1.4{\times}10^{-6}(yr)^{-1}$ from a quadratic curve fitting of the dip phase evolution.

Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells

Xiao-hui Liao,Rui-ting Long,Jun-bo Peng,Li-li Huang,Gui-ping Jiang,Yue-juan Liao,Hang Sun,Yu-dong Hu 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.12

Mitochondria are highly dynamic organelles that constantly undergo fission and fusion processes that closely related to their function. Disruption of mitochondrial dynamics has been demonstrated in acute kidney injury (AKI), which could eventually result in cell injury and death. Previously, we reported that augmenter of liver regeneration (ALR) alleviates renal tubular epithelial cell injury. Here, we gained further insights into whether the renoprotective roles of ALR are associated with mitochondrial dynamics. Changes in mitochondrial dynamics were examined in experimental models of renal ischemia-reperfusion (IR). In a model of hypoxia-reoxygenation (HR) injury in vitro, dynamin-related protein 1 (Drp1) and mitochondrial fission process protein 1 (MTFP1), two key proteins of mitochondrial fission, were downregulated in the Lv-ALR + HR group. ALR overexpression additionally had an impact on phosphorylation of Drp1 Ser637 during AKI. The inner membrane fusion protein, Optic Atrophy 1 (OPA1), was significantly increased whereas levels of outer membrane fusion proteins Mitofusin-1 and -2 (Mfn1, Mfn2) were not affected in the Lv-ALR + HR group, compared with the control group. Furthermore, the mTOR/4E-BP1 signaling pathway was highly activated in the Lv-ALR + HR group. ALR overexpression led to suppression of HR-induced apoptosis. Our collective findings indicate that ALR gene transfection alleviates mitochondrial injury, possibly through inhibiting fission and promoting fusion of the mitochondrial inner membrane, both of which contribute to reduction of HK-2 cell apoptosis. Additionally, fission processes are potentially mediated by promoting tubular cell survival through activating the mTOR/4E-BP1 signaling pathway.

Electrical Characteristics of SiGe-base Bipolar Transistors on Thin-film SOI Substrates

Shu-Hui Liao,Shu-Tong Chang 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.57 No.61

This paper, based on two-dimensional simulations, provides a comprehensive analysis of the electrical characteristics of the Silicon germanium (SiGe)-base bipolar transistors on thin-film siliconon-insulator (SOI) substrates. The impact of the buried oxide thickness (TOX),the emitter width (WE), and the lateral distance between the edge of the intrinsic base and the reach-through region (Lcol) on both the AC and DC device characteristics was analyzed in detail. Regarding the DC characteristics, the simulation results suggest that a thicker TOX gives a larger base-collector breakdown voltage (BVCEO), whereas reducing the TOX leads to an enhanced maximum electric field at the B-C junction. As for the AC characteristics, cut-off frequency (fT) increases slightly with increasing buried oxide thickness and finally saturates to a constant value when the buried oxide thickness is about 0.15 µm. The collector-substrate capacitance (C CS) decreases with increasing buried oxide thickness while the maximum oscillation frequency (f max) increases with increasing buried oxide thickness. Furthermore, the impact of self-heating effects in the device was analyzed in various areas. The thermal resistance as a function of the buried oxide thickness indicates that the thermal resistance of the SiGe-base bipolar transistor on a SOI substrate is slightly higher than that of a bulk SiGe-base bipolar transistor. The thermal resistance is reduced by ∼37.89% when the emitter width is increased by a factor of 5 for a fixed buried oxide thickness of 0.1 µm. All the results can be used to design and optimize SiGe-base bipolar transistors on SOI substrates with minimum thermal resistance to enhance device performance.

Laser direct patterning induced the tunable optical properties of indium tin oxide micro-hole arrays films

Liao Jing,Liu Qingyou,Hong Ruijin,Tao Chunxian,Wang Qi,Lin Hui,Han Zhaoxia,Zhang Dawei 한국물리학회 2022 Current Applied Physics Vol.36 No.-

Here we introduce a facile method to fabricate patterned indium tin oxide (ITO) thin films via selective laser ablation at ambient conditions. By scanning the ITO thin films with focused Nd: YAG pulsed laser, the ITO thin films were selective ablated and patterned without using any conventional chemical etching or photolithography steps. Then we investigated the effects of scanning rate for the structure, morphology and optical properties of patterned ITO thin film. These results indicate that the epsilon-near-zero (ENZ) wavelength of ITO thin films can be tuned from 1100 nm to 1340 nm by adjusting the period of the micro-hole array in microstructure. The nonlinear absorption response of patterned ITO films was about 2.85 time than of the as-deposited ITO thin film. Additionally, the results of the Finite-Difference Time-Domain (FDTD) simulation are in good agreement with those of the experiments.

0346 Occupational Exposure to Lead and Cancer in Two Cohort Studies of Men and Women in Shanghai, China

Liao, Linda M,Friesen, Melissa C,Xiang, Yong-Bing,Cai, Hui,Koh, Dong-Hee,Ji, Bu-Tian,Yang, Gong,Li, Hong-Lan,Locke, Sarah J,Rothman, Nathaniel,Zheng, Wei,Gao, Yu-Tang,Shu, Xiao-Ou,Purdue, Mark P BMJ Publishing Group Ltd 2014 Occupational and environmental medicine Vol.71 No.suppl1

<P><B>Objectives</B></P><P>Epidemiologic studies of occupational lead exposure have suggested increased risks of cancers of the brain, kidney, lung, meninges, and stomach; however, the totality of the evidence is inconsistent. To clarify whether lead is a carcinogen, we investigated the relationship between occupational lead exposure and risks of these five cancer sites in two prospective cohort studies in Shanghai, China.</P><P><B>Method</B></P><P>Annual job/industry-specific estimates of lead fume and lead dust exposure were derived from a statistical model that combined expert ratings of lead intensity with inspection measurements collected by the Shanghai Centre for Disease Control and Prevention. The job/industry estimates were applied to the lifetime work histories of subjects from the Shanghai Women’s Health Study (73 363 participants) and the Shanghai Men’s Health Study (61 379 participants) to estimate cumulative exposure to lead dust and lead fume. Cohort-specific relative hazard rate ratios (RRs) and 95% confidence intervals (CI) were estimated using Cox proportional hazards regression models and then pooled using a random effects meta-analysis model.</P><P><B>Results</B></P><P>We observed a statistically significant increased risk of meningioma among individuals with estimated occupational exposure to lead dust or fumes (RR=2.4, 95% CI:1.1–5.0), and in particular among those with an above-median cumulative exposure to dust or fumes (RR=3.1, 95% CI:1.3–7.4). We observed suggestive associations with lead exposure for cancers of the kidney (RR=1.4, 95% CI:0.9–2.3) and brain (RR=1.8, 95% CI:0.7–4.8), and null findings for cancers of the lung and stomach.</P><P><B>Conclusions</B></P><P>Our findings provide additional evidence that occupational lead exposure increases risk of meningioma.</P>

Increase of Phosphatase and Tensin Homolog by Silymarin to Inhibit Human Pharynx Squamous Cancer

Chin-Hui Su,Li-Jen Chen,Jyh Fei Liao,Juei-Tang Cheng 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.9

Silymarin is an active principle from the seeds of the milk thistle plant and is widely used as a hepatoprotective gent due to its antioxidant-like activity. In the present study, we evaluated the potential efficacy of silymarin against oral cancer and investigated its possible mechanism of action. Cell viability assay and western blotting analyses were used to identify silymarin-induced apoptotic cell death in human pharynx squamous cell carcinoma (FaDu) cells. The short interfering RNA (siRNA) is used to confirm the role of phosphatase and tensin homolog (PTEN) in silymarin-induced apoptosis. Treatment of FaDu cells with silymarin resulted in a significant decrease in cell viability (up to 70%). Silymarin inhibited the phosphorylation of Akt (over 10-fold) with an increase in expression of PTEN (five to sixfold). Consequently, the level of Bcl-2 expression was decreased five to sixfold and caspase 3 activated to induce apoptosis. Treatment with siRNA specific to PTEN gene diminished the action of silymarin. The results suggest that silymarin inhibits the Akt signaling pathway by increasing PTEN expression in FaDu cells and directly affects Bcl-2 family members. Also, we demonstrated the inhibitory activity of silymarin for oral cancer is related to cell survival. These mechanisms may in part explain the actions of silymarin and provide a rationale for the development of silymarin as an anticancer agent.

Autophagy Inhibition Sensitizes Cisplatin Cytotoxicity in Human Gastric Cancer Cell Line Sgc7901

Zhang, Hui-Qing,He, Bo,Fang, Nian,Lu, Shan,Liao, Yu-Qian,Wan, Yi-Ye Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

We aimed to investigate the mechanism and effects of autophagy on cisplatin (DDP)-induced apoptosis in human gastric cancer cell line SGC7901. After SGC7901 cells were treated with DDP and/or chloroquine, cell proliferation was measured using MTT assay; cell apoptosis was determined by flow cytometry; autophagy and apotosis-related proteins expression were detected by Western blot; and quantitative analysis of autophagy after monodansylcadaverine (MDC) staining was performed using fluorescence microscopy. We found after treatment with 5 mg/L DDP for 24 h, the rates of cell apoptosis were ($21.07{\pm}2.12$)%. Autophagy, characterized by an increase in the number of autophagic vesicles and the level of LC3-II protein was observed in cells treated with DDP. After inhibition of autophagy by chloroquine, the rates of cell apoptosis were increased to ($30.16{\pm}3.54$)%, and the level of Caspase-3 and P53 protein were increased, and Bcl-2 protein was decreased. Therefore, autophagy protects human gastric cancer cell line SGC7901 against DDP-induced apoptosis, inhibition of autophagy can promote apoptosis, and combination therapy with DDP and chloroquine may be a promising therapeutic strategy for gastric cancer.

The Study on Stress in Clinical Practice Internship and Professional Commitment among Graduating Nursing Students of a 5-year Junior College in Southern Taiwan

Su Hui Cheng,Li-Ling Liao,I-Ju Lai 한국간호과학회 2015 한국간호과학회 학술대회 Vol.2015 No.10

Interactive Effects of Ultraviolet Radiation and Dissolved Organic Carbon on Phytoplankton Growth and Photosynthesis in Sanya Bay, Northern South China Sea

Jianzu Liao,Weihua Zhou,Jie Xu,Xiangcheng Yuan,Yuxian Liang,Yajuan Guo,Hui Huang,Sheng Liu,Aimin Long 한국해양과학기술원 2019 Ocean science journal Vol.54 No.4

The effects of a simulated climate change scenario, i.e., increased ultraviolet radiation (UVR) and dissolved organic carbon (DOC), on the growth and photosynthesis of tropical coastal phytoplankton were evaluated in Sanya Bay, northern South China Sea, in summer. Microcosm experiments were conducted at two contrasting stations (Stns S1 and S2) with three different UVR treatments and two DOC addition treatments. Our results showed that natural sunlight UVR or increased UV-B did not affect phytoplankton biomass and primary production. However, increased UV-B significantly decreased the proportion of picophytoplankton and the efficiency of carbon fixation at Stn S2. DOC enhancement caused negative effects on primary production under natural sunlight UVR only at Stn S1. Interactive effects of UVR and DOC addition on phytoplankton biomass and primary production were detected at Stn S1, due to the negative effects of DOC being eliminated under the increased UV-B condition. The lack of interactive effects at Stn S2 were likely due to the differences with Stn S1 in terms of light acclimation and biological interaction. In summary, this future climate change scenario will probably not affect the photosynthetic CO2 fixation and biomass of natural phytoplankton in Sanya Bay.