THE DEVELOPMENT OF A UV FLAME DETECTOR FOR THE AUTOMATIC FIRE SUPPRESSION SYSTEM FOR ENGINE COMPARTMENT FIRES

Lim,Sung-Mook,Jung,Ki-Chang,Kim,Eung-Sik,Kim,Hong 한국화재소방학회 1997 한국화재소방학회 학술대회 논문집 Vol.1997 No.-

In this work, a new type of UV flame detection system was developed. In order to measure the performance of UV flame detector, various kinds of experiments was performed. The results show that the maximum response time of the UV flame detector is 0.2 seconds when the detection distance is one meter The advantages of this system include wide area, high speed response and high sensitivity. After testing the W flame detector in engine compartment it detected fire within 0.09 seconds and extinguished within 5 seconds. Hence, the UV flame detector can be applied in automatic fire suppression system for automobiles.

The level of urinary aflatoxin M1 in Korean adults

Yong-Dae Kim1, Hyojin Kwon, Sun-In Moon, Sang-Yong Eom, Jung-Duk Park, Byung-Sun Choi, Seok-Joon Sohn, Young-Seoub Hong, Ho Kim, Ho-Jang Kwon, Ji-Ae Lim, Hae-Jung Yoon, Gwang-Jin Kim, Heon Kim 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.3

Competitive ELISA methods were used to measure the level of aflatoxin M1 (AFM1) from urine in 1008 Korean adults. Subjects were selected by random sampling in all areas of Korea, except Cheju-do. The recovery rate of AFM1 using this method was 105% (73-124%). The geometric mean of urinary AFM1 in all subjects was 3.43 pg/mL (3.67 ng/g creatinine). The level of AFM1 in males was statistically higher, compared with female subjects. However, the levels of AFM1 did not differ according to age. Subjects in Chungbuk-do showed the highest urinary AFM1 concentration, whereas subjects in Kyeongnam-do showed the lowest concentration. Assuming an excretion rate of 5%, this AFM1 excretion corresponds to approximately 0.1 microgram/day in Korean adults.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Progastrin-releasing peptide as a diagnostic and therapeutic biomarker of small cell lung cancer

오형주,( Ha Young Park ),( Tae Ok Kim1 ),( Chul Kyu Park ),( Hong Jun Shin ),( Hee Jung Ban ),( In Jae Oh ),( Yong Soo Kwon ),( Yu Il Kim ),( Sung Chul Lim ),( Young Chul Kim ),( Soo Hyun Kim ),( Myung G 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-

Background: Progastrin-releasing peptide (proGRP) is a recently identified biomarker of small cell lung cancer (SCLC). We aimed this study for evaluating the usefulness of automated proGRP measurement for diagnosis and treatment monitoring in patients with SCLC. Methods: From January 2011 to December 2013, plasma samples were prospectively collected from 452 [213 non-small cell lung cancer (NSCLC), 104 SCLC, 135 other diseases] patients visited for tissue diagnosis and tested by two-step automated immunoassay using the ARCHITECT proGRP assay kit (Abbott Diagnostics, USA). The cutoff level of proGRP was set at 63 pg/mL. Results: The mean proGRP was higher in SCLC (1823.0 ± 2684.0 pg/mL) than in NSCLC (61.0 ± 341.7 pg/mL) and other diseases (51.5 ± 222.6 pg/mL, p<0.001). The sensitivity of proGRP was 85.7% (90/105) in SCLC and 11.8% (25/212) in NSCLC. The specificity was 90.2%, positive predictive value was 72.5%, and negative predictive value was 95.4% in SCLC. The mean proGRP was higher in extensive disease (2158.1 ± 2980.6 pg/mL) than in limited disease (901.4 ± 1216.0 pg/mL, p=0.033). Among the 39 patients with SCLC could be followed, the mean proGRP levels of 23 responders were significantly decreased after chemotherapy (from 1651.5 ± 1386.4 pg/mL to 290.0 ± 524.8 pg/mL, p<0.001), whereas those of the 16 non-responders were not. (from 572.5 ± 790.3 pg/mL to 494.4 ± 610.9 pg/mL, p=0.583). Conclusion: Plasma proGRP could be a useful biomarker of SCLC for diagnosis and treatment monitoring. And the initial level may represent the tumor extent of SCLC.

연령증가에 따른 혈압요소들의 좌심실비대 및 관동맥질환과의 관련성

박재석,박창규,박미영,박재형,김용현,나진오,신성희,서순용,홍순준,박성미,임홍의,김응주,서홍석,오동주,노영무 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

환경관련 R&D사업 운영체계의 문제점과 개선방안 : 설문조사를 중심으로 A Survey Study

김홍균,임종수 한국환경경제학회 한국자원경제학회 2004 자원·환경경제연구 Vol.13 No.3

환경 R&D 예산의 효율성 제고 방안의 연구를 위해 전주기방법에 입각하여 환경 R&D 사업의 운영체계에 대한 문제점과 개선방안을 제시하였다. 연구결과 크게 네 가지 부문의 개선 노력이 요구되는 바, 첫째, 기술현황에 관한 기초자료를 축적·관리하는 전담조직의 운영, 둘째, 주기적 기술수요조사를 통한 과업선정체계의 강화, 셋째, 국가연구 개발사업으로 추진된 개발기술의 상용화 자금지원제도에 대한 홍보·알선 업무의 강화, 그리고 마지막으로 이전기술의 사업화를 위한 지원기관, 대상사업 및 재정지원의 확대가 가장 필요한 것으로 결론지어졌다. 그러나 R&D 지원사업의 운영체계에만 국한하여 분석한 본 연구의 한계를 극복하기 위해서는 R&D 사업의 전반에 관한 포괄적인 추후 연구를 추진할 필요가 있다. Environmental R&D management system has been analyzed with LCA method. Based on the analysis, we found the following four elements were essential for improving effciency of environmental R&D management system: establishment of an information clearinghouse that collects and distributes information on the status of the domestically owned environmental technology. Periodic survey of the environmental technology demand to give guidance in selecting the environmental R&D project that are to be subsidized, dissemination of information on the technology transfer and commercialization assistance program, and increased funding as well as the expansion of project categories eligible for R&D subsidy.

마하피닝 처리에 의한 기계구조용 합금강의 피로균열전파 지연효과

김민건,임복규,박홍기,황중각 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.A

Mach peening treatment is one of the various kinds of techniques to improve the fatigue properties. The mach peening process gives high-level work hardening and compressive residual stress near the surface layer, improving the fatigue strength. In addition, this treatment reduces slip bands that initiate the fatigue cracks near the surface. During impingement, a plastic indentation surrounded by a plastic zone is formed. Mach peening treatment characteristic is less energy consumption and is an environmental friendly processing methods that is not accompanied by pollution. It is machining process that can prevent fatigue fracture beforehand in structure using already as well as process of production. The test results showed that fatigue crack propagation delay appeared by drilling type 43%, mach peening type 110%.

계면활성제 수용액에서 임계미셀농도와 온도의 관계성

김홍운,임경희 중앙대학교 미래신기술연구소 2001 미래신기술연구소 논문집 Vol.10 No.1

계면활성제 분자가 물에 녹아 구형의 회합체인 미셀(micelle)을 형성하며, 이 때의 최소 농도를 임계미셀농도(critical micelle concentration, CMC)라 한다. CMC에 영향을 준느 여러 가지 인자들 중에서 온도의 영향은 중요하며 이미 널리 연구되었다. 그렇지만, 어떤 관계가 있는지 정확한 이론이 없어서 대부분 CMC를 온도에 대한 2차 이상의 다항식으로 표현하였다. 최근에 미셀화에 따른 엔탈피와 엔트로피가 선형적으로 변한다는 보상 현상(compensation phenomena)에 대한 이해와 대부분의 계면활성제 수용액에서 미셀화의 온도에 따른 엔탈피도 선형적으로 변한다는 실험관찰이 확인되었다. 이를 근거로 열역학적 식을 사용하여 온도에 의한 CMC의 관계식을 새롭게 정립해 보았다. Micelles are one type of surfactant aggregations. They are formed above a certain concentration calle critical micelle cincentration(CMC). Micellization is affected by seveal factors, among which surfactant solution temperature is of interest in this article. It is known that CMC is dependent of temperature, but not assured how if depends on. The correlation between CMC and temperature has been represented by polynomial fitting of CMC as a function of temperature, for which relations among thermodynamic potenials, compensation phenomena, and linearity of micellization enthalpy with temperature are used.

Lipoprotein(a)와 대동맥판막과 승모판막 경화증 및 복부 대동맥 두께의 상관관계에 대한 연구

김민수,유근배,이상운,임양희,신길자,조홍근 梨花女子大學校 醫科大學 醫科學硏究所 1998 EMJ (Ewha medical journal) Vol.21 No.3

연구배경 : Lipoprotein(a)의 농도와 대동맥판막의 두께, 승모판막의 두께 및 복부 대동맥의 두께와의 관계에 대하여 조사하고, 다른 관상동맥질환의 위험인자와의 관계를 규명해 보고자 하였다. 대상 및 연구방법 : 1995년 6월부터 1996년 5월까지 이화여자대학교 의과대학 부속 동대문병원에서 심초음파검사를 시행하였던 환자 116명을 대상으로 하였으며 이중 급성심근경색증, 갑상선질환 및 혈청 지질치에 영향을 미치는 약제를 복용중인 환자를 제외하였다. 성별, 나이, 고혈압의 유무, 흡연유무 및 혈청 콜레스테롤, 고밀도지단백콜레스테롤, 중성지방, 저밀도지단백콜레스테롤, lipoprotein(a)치를 측정하였고, 미국 휼레트 패커드사의 Sono 1000 을 이용하여 대동맥판막의 두께, 승모판막의 두께 및 대동맥의 두께를 측정하였다. 결과 : 1) Lipoprotein(a)는 남자가 34.6±34.3mg/dl, 여자가 25.6±23.4mg/dl 이었으며, 총 콜레스테롤, 저밀도 지단백콜레스테롤 및 고밀도지단백콜레스테롤, 중성지방에는 남녀간에 유의한 차이가 없었다(p>0.05). 2) Lipoprotein(a) 농도와는 대동맥판막의 두께만이 의의있는 양의 상관관계를 보였으며, 승모판막의 두께, 복부대동맥 두께 및 상행 대동맥의 내경과는 관계가 없었다. 3) Lipoprotein(a)와 일반 특성 및 생화학적인 특성과의 관계에서 Lipoprotein의 농도는 오직 흡연과 관계가 있었으며(p<0.01), 혈압, 연령, 총콜레스테롤, 중성지방, 고밀도지단백콜레스테롤 및 저밀도지단백콜레스테롤과는 무관하였다. 4) 18명의 환자에서 관상동맥조영술을 실시하여 관상동맥질환의 유무 및 정도와 대동맥 판막두께와의 관계를 분석한 결과 대동맥 판막이 두꺼울수록 관상동맥질환의 정도가 심했다(p<0.01). 결론 : 본 연구에서 lipoprotein(a)농도와 대동맥 판막의 두께가 의의있는 양의 상관관계를 보였으며, lipoprote-in(a)의 농도는 흡연력만 관계가 있었다. 또한, 대동맥 판막이 두꺼울수록 관상동맥 질환의 정도가 심한 것을 볼 때, lipoprotein(a)의 농도 및 대동맥판막의 두께가 관상동맥 질환의 위험인자가 될 것으로 생각된다. Background : An elevated serum lipoprotein(a) level is an independent risk factor for athe-rosclerotic diseases, and the lipoprotein(a) level is correlated to preclinical atherosclerosis. To evaluate the association between lipoprotein(a) and aortic selerosis, ,itral sclerosis, and abdominal aorta thickness, we measured the aortic valve thickness, mitral valve thickness and abdominal aorta thickness. Also, we assessed the relationship between the aortic valve sclerosis, mitral valve sclerosis, abdominal aorta thickness and other coronary risk factors. Method : We measured serum lipoprotein(a) in 116 patients(52 men, 64 women) with mean age of 58.7±13.9 years. Aortic valve thickness was assessed by parasternal long and short axis two dimensional echocardiography, mitral valve thickness was measured by apical 4 chamber view. The abdominal aorta thickness was measured by the subcostal view. Result : The level of lipoprotein(a) was significantly correlated with the aortic valve thickness, but not with the miral valve thickness and the abdominal aorta thickness. lipoprotein(a) level was higher in smoking patients(p<0.05), and not related to other ariables such as blood pressure, age, total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein. Coronary angiography was performed in 18 paitents, and there was a tendency of the coronary artery disease with high level of the lipoprotein(a)(p<0.005). There was no significant difference in the thickness of aortic valve in terms of sex, blood pressure, total cholesterol, high density lipoprotein, triglyceride or blodo sugar. Conclusion : We conclude that increased serum levels of lipoprotein(a) are closely related to aortic valve sclerosis and may be a risk factor for coronary artery disease.

社會體育振興을 위한 國民意識 再考方案

金柄斗,蔡鴻遠,安禹洪,李敏炯,申榮吉,金基學,鄭相澤,林銖遠 慶北大學校 體育科學硏究所 1987 체육과학연구지 Vol.3 No.-

The purpose of this paper is to investigate and analyze the nation's consciousness about the social physical education by regional groups(big cityes, middle cityes, farm village, fishing villge). And the researchers are to find a way to populize this movement. These subjects for this investigation were chosen at random among the citizens in four region. 4,450 sheets of questionnaire were given to the citizen. And 3,587(81%) sheets of them were received from male(2,582) and female(975) citizens. The results of this investigation are as follows: 1. The nation's consciousness has not been still modernized and the nation tend to depend on their doctors rather than on the new active leisure sports, which is a passive and conventional way, to keep their health. 2. Most people have spent their leisures on nonactive hobby such as reading, listening to music, and watching TV rather than sports. 3. Most residents pointed out lack of facilities, and needed professional directors and various programs they could participate. 4. The opening of citizen athletic field and the gymnasiums to citizens was needed to recruit the lack of facility, and the participation to commercial sport ws differed by economical status and leisure time, however, they usually participated such activities as table-tennis, swimning and tennis. 5. To activate social physical education, first of all, an expansion of the facilities such as athletic fields and gymnasium is needed under the active support of government. 6. The facilities for young men and the handicapped is insufficient, and to prevent juvenile delinquency and guide them into the right way, we should lead them out to participate sports activity. And the facility for the handicapped is needed too.