http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Survey of the management of patients with bronchiectasis: a pilot investigation in Asian populations
( Ho Cheol Kim ),( Masaru Suzuki ),( Hui Fang Lim ),( Le Thi Tuyet Lan ),( Ho Lam Nguyen ),( Jeng-Shing Wang ),( Kang-Yun Lee ),( Jae Seung Lee ),( Yeon-Mok Oh ),( Sang Do Lee ),( Hayoung Choi ),( Hyu 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.6
Background/Aims: Although international guidelines for bronchiectasis management have been published in Western countries, there is a lack of data about their application in Asian populations including patients with different phenotypes. We aimed to investigate the current status of bronchiectasis management in Asian populations. Methods: A nationwide questionnaire survey was performed of Asian respiratory specialists from South Korea, Japan, Taiwan, Singapore, Vietnam, and Sri Lanka. Participants were invited by e-mail to answer a questionnaire comprising 25 questions based on international guidelines for the management of bronchiectasis. Results: A total of 221 physicians participated in the survey. About half of them were Korean (50.2%), with the next most common nationalities being Japanese (23.1%), Taiwanese (13.6%), and Singaporean (7.7%). Only 18 (8.1%) responders had local guidelines for bronchiectasis. While 85 (38.5%) responders checked sputum acid-fast bacillus smear/culture about 1 to 3 times per year, only a small proportion of responders routinely performed a serum immunoglobulin test (36/221, 16.3%) or evaluated for allergic bronchopulmonary aspergillosis (41/221, 18.6%). Less than half (43.4%) of responders performed eradication treatment in patients with drug-sensitive Pseudomonas aeruginosa infection, mainly due to the limited availability of inhaled antibiotics (34.8%). In addition, 58.6% of responders considered physiotherapy such as airway clearance and pulmonary rehabilitation. Conclusions: Discrepancies might exist between guideline recommendations and practice for bronchiectasis management in Asian populations, partly due to the limited availability of treatment in each country. The development of local guide-lines that consider the phenotypes and situation will help to standardize and improve the management of bronchiectasis.
Fermentation strategy for the production of poly(3-hydroxyhexanoate) by Aeromonas sp. KC014
Ho-Shing Wu,Yen-An Gong,Yu-Hong Wei,Yi-Ming Sun 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.6
Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (P(3HB-co-3HHx)) was produced by Aeromonas sp. KC014 strain isolated from Taiwan in soil environment in the flask and fermentor cultures. The medium optimization, such as carbon source and nitrogen source, carbon-nitrogen ratio was conducted to obtain the optimum 3-hydroxyhexanoate content. The defined medium with dodecanoic acid as the carbon source and (NH4)2SO4 as the nitrogen source was obtained as the main medium. When cells grown in medium containing 30 g/L dodecanoic acid, 15 g/L sodium gluconate and 1 g/L soytone (C/N was 30/1) as final PHA concentration, the cell dry weight and HB content of 5.16 g/ L, 14.0 g/L and 36.0%, respectively, were obtained. The maximum HHx/PHA content increased from 0.1% to 1.3% nearly 12-fold when the dissolved oxygen was decreased from 40% to 20%. P(3HB-co-3HHx) biosynthesis was triggered by the addition of limited nitrogen, phosphorus and magnesium to get a maximum HHx/PHA content of 14% in 95 hours.
Chi-Ho Lee,Mei-Zhen Wu,David Tak-Wai Lui,Darren Shing-Hei Chan,Carol Ho-Yi Fong,Sammy Wing-Ming Shiu,Ying Wong,Alan Chun-Hong Lee,Joanne King-Yan Lam,Yu-Cho Woo,Karen Siu-Ling Lam,Kelvin Kai-Hang Yiu 대한당뇨병학회 2022 Diabetes and Metabolism Journal Vol.46 No.6
Background: Insulin-treated patients with long duration of type 2 diabetes mellitus (T2DM) are at increased risk of ketoacidosis related to sodium-glucose co-transporter 2 inhibitor (SGLT2i). The extent of circulating ketone elevation in these patients remains unknown. We conducted this study to compare the serum ketone response between dapagliflozin, an SGLT2i, and sitagliptin, a dipeptidyl peptidase-4 inhibitor, among insulin-treated T2DM patients.Methods: This was a randomized, open-label, active comparator-controlled study involving 60 insulin-treated T2DM patients. Participants were randomized 1:1 for 24-week of dapagliflozin 10 mg daily or sitagliptin 100 mg daily. Serum β-hydroxybutyrate (BHB) levels were measured at baseline, 12 and 24 weeks after intervention. Comprehensive cardiometabolic assessments were performed with measurements of high-density lipoprotein cholesterol (HDL-C) cholesterol efflux capacity (CEC), vibration-controlled transient elastography and echocardiography.Results: Among these 60 insulin-treated participants (mean age 58.8 years, diabetes duration 18.2 years, glycosylated hemoglobin 8.87%), as compared with sitagliptin, serum BHB levels increased significantly after 24 weeks of dapagliflozin (P=0.045), with a median of 27% increase from baseline. Change in serum BHB levels correlated significantly with change in free fatty acid levels. Despite similar glucose lowering, dapagliflozin led to significant improvements in body weight (P=0.006), waist circumference (P=0.028), HDL-C (P=0.041), CEC (P=0.045), controlled attenuation parameter (P=0.007), and liver stiffness (P=0.022). Average E/e’, an echocardiographic index of left ventricular diastolic dysfunction, was also significantly lower at 24 weeks in participants treated with dapagliflozin (P=0.037).Conclusion: Among insulin-treated T2DM patients with long diabetes duration, compared to sitagliptin, dapagliflozin modestly increased ketone levels and was associated with cardiometabolic benefits.
Diagnosis of Seronegative Rheumatoid Arthritis by 68 Ga-FAPI PET/CT
Shing Kee Cheung,Sirong Chen,Yuet Hung Wong,Kwan Kit Wu,Chi Lai Ho 대한핵의학회 2023 핵의학 분자영상 Vol.57 No.1
Early diagnosis of rheumatoid arthritis with the initiation of disease-modifying antirheumatic drugs is important to preventfuture disability. Seronegative rheumatoid arthritis lacks the classical immunological markers, thus imposing clinical diagnosticdifficulty. In this case, we reported 68 Ga-FAPI PET/CT findings of seronegative rheumatoid arthritis in a 60-year-oldlady. This case illustrates how 68 Ga-FAPI PET/CT aids in the diagnosis of seronegative rheumatoid arthritis.
Azis Boing Sitanggang,Ho-Shing Wu,Shaw S. Wang 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.6
A rapid method for the determination of fungal glucosamine (GlcN) from Aspergilus BCRC 31742 was developed. The hydrochlorination process using microwave effectively reduced reaction time needed for GlcN analysis. The analytical method consisted of two steps: (1) hydrochlorination of fungal cells and (2) derivatization process. Fungal GlcN hydrochloride was reacted with 1-napthyl isothiocyanate (1-NITC) as the derivatizing agent to enhance the sensitivity of GlcN and so to achieve high resolution. This method was specific for quantification of GlcN hydrochloride at the wavelength of 230 nm. The standard deviation and relative error of the analytical results were less than 5%. By using microwave heating, the reaction time of hydrochlorination process was shortened from 24 h to 3 min. Thus, the overall time needed for analyzing GlcN from fungal sources was reduced from 5 h (thermal method) to 2 h (microwave method). A rapid method for the determination of fungal glucosamine (GlcN) from Aspergilus BCRC 31742 was developed. The hydrochlorination process using microwave effectively reduced reaction time needed for GlcN analysis. The analytical method consisted of two steps: (1) hydrochlorination of fungal cells and (2) derivatization process. Fungal GlcN hydrochloride was reacted with 1-napthyl isothiocyanate (1-NITC) as the derivatizing agent to enhance the sensitivity of GlcN and so to achieve high resolution. This method was specific for quantification of GlcN hydrochloride at the wavelength of 230 nm. The standard deviation and relative error of the analytical results were less than 5%. By using microwave heating, the reaction time of hydrochlorination process was shortened from 24 h to 3 min. Thus, the overall time needed for analyzing GlcN from fungal sources was reduced from 5 h (thermal method) to 2 h (microwave method).
Chou, Yi-Hsuan,Choo, Kwang-Ho,Chen, Shiao-Shing,Yu, Jui-Hsuan,Peng, Ching-Yu,Li, Chi-Wang Elsevier 2018 Separation and purification technology Vol.198 No.-
<P><B>Abstract</B></P> <P>A chemical reduction process was proposed to recover copper from the retentate of polyelectrolyte enhanced ultrafiltration (PEUF). Three polyelectrolytes (PSS, PAA, and PEI) containing various functional groups and molecular weights were studied to explore their effects on the copper removal in PEUF and on the copper recovery by chemical reduction under various pH conditions. With PSS which contains sulfonic group, copper was removed reasonably well (ca. 75%) by PEUF even under acidic pH value of 3. With PAA which contains carboxylic group, copper removal was a bit low (∼60%) under pH 3.0 but increased substantially at pH 4.0. A branched PEI having amine group achieved the highest Cu removal of 94% at pH 3. The copper removal efficiency decreased slightly with increasing pH due to the high permeation of PEI through membrane.</P> <P>Chemical reduction achieved the complete copper recovery for solution containing PSS. The copper recovery efficiencies were more than 95% for PAA solution with pH values ranging from 3 to 9 at reaction time of one hour. For PEI, the recovery efficiencies ranged from 20 to 96% and were pH dependent. Aggregated and settled readily copper particles were produced by chemical reduction in PSS solution. XRD analysis identified cuprous oxide in all of the samples. Dependent of pH and polyelectrolytes, additional peaks matching those of elemental copper were identified. TGA analysis showed that solids produced from PSS and PAA systems contained no polyelectrolytes while solid collected from PEI system contained 32% of polyelectrolyte.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Polyelectrolytes with different functional groups and MW were applied in PEUF. </LI> <LI> Effects of polyelectrolytes and pH on the reduction of copper were studied. </LI> <LI> Both Cu<SUB>2</SUB>O and Cu<SUP>0</SUP> were identified by XRD analysis of solids obtained. </LI> </UL> </P>