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Nakano, Hideo,Okumura, Reiko,Goto, Chinatsu,Yamane, Tsuneo The Korean Society for Biotechnology and Bioengine 2002 Biotechnology and Bioprocess Engineering Vol.7 No.5
By the in vitro combinatorial mutagenesis, which is a sequential reaction of PCR mutagenesis and in vitro coupled transcription/translation with Escherichia coli S30 extract, S65 and E222 of green fluorescent protein of Aequarea victoria were comprehensively changed to all possible combinations of amino acids, thus totally 400 mutant (including a wild type) proteins were simultaneously produced and their fluorescent properties were analyzed. Although a few mutations had been reported so far at the 222nd position, replacement E222 to all other19 amino acids gave fluorescent signal to the mutants by changing Ser 65 to Ala together. Among the mutants, replacement to G, A, S, Q, H and C gave relatively high fluorescence. The in vitro combinatorial mutagenesis, therefore, has been proved valuable for comprehensive structure-function studies of proteins.
Hideo Nakano,Reiko Okumura,Chinatsu Goto,Tsuneo Yamane 한국생물공학회 2002 Biotechnology and Bioprocess Engineering Vol.7 No.5
By the in vitro combinatorial mutagenesis, which is a sequential reaction of PCR mutagenesisand in vitro coupled transcription/translation with Escherichia coli S30 extract, S65 and E222 of green fluorescent protein of Aequarea victoria were comprehensively changed to all possible combinations of amino acids, thus totally 400 mutant (including a wild type) proteins were simultaneously produced and their fluorescent properties were analyzed. Although a few mutations had been reported so far at the 222nd position, replacement E222 to all other19 amino acids gave fluorescent signal to the mutants by changing Ser 65 to Ala together. Among the mutants, replacement to G, A, S, Q, H and C gave relatively high fluorescence. The in vitro combinatorial mutagenesis, therefore, has been proved valuable for comprehensive structure-function studies of proteins.
Masuo Nakano,Shiro Nakano,Hideo Takekoshi 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1
In addition to meeting nutritional requirements, breast milk plays important roles in biodefense for nursing in-fants. Dioxins have been detected at high concentrations in breast milk, raising concerns about disorders in nursing infantscaused by breast milk containing dioxins in Japan. We analyzed dioxin levels in breast milk and maternal blood samples from35 pregnant women in Japan. We also measured immunoglobulin (Ig) A concentrations in breast milk and investigated cor-relations with dioxin concentrations. In addition, 18 of the 35 women took Chlorella pyrenoidosa(Chlorella) supplementsduring pregnancy, and the effects on dioxin and IgA concentrations in breast milk were investigated. Toxic equivalents weresignificantly lower in the breast milk of women taking Chlorellatablets than in the Control group (P. .003). These resultssuggest that Chlorellasupplementation by the mother may reduce transfer of dioxins to the child through breast milk. No sig-nificant correlation was identified between dioxin and IgA concentrations in breast milk in the Control group. It is unlikelythat normal levels of dioxin exposure via food have a remarkable influence on IgA in breast milk. IgA concentrations in breastmilk in the Chlorellagroup were significantly higher than in the Control group (P. .03). Increasing IgA levels in breast milkis considered to be effective for reducing the risk of infection in nursing infants. The present results suggest that Chlorellasupplementation not only reduces dioxin levels in breast milk, but may also have beneficial effects on nursing infants by in-creasing IgA levels in breast milk.
Hepatic Involvement of Histiocytic Sarcoma: CT and MRI Findings
Takatoshi Kubo,Shigeru Kiryu,Hiroyuki Akai,Yasunori Ota,Arinobu Tojo,Hideo Yoshida,Naoya Kato,Yoshiyasu Nakano,Kuni Ohtomo 대한영상의학회 2016 Korean Journal of Radiology Vol.17 No.5
Histiocytic sarcoma in the liver is an extremely rare hematological malignancy. Herein, we reported the case of a 68-year-old woman who presented with characteristic wedge-shaped abnormality bounded by hepatic veins on computed tomography and magnetic resonance imaging of the liver. In the wedge-shaped area, decreased portal flow and the deposition of iron were observed. These imaging findings are consistent with intrasinusoidal tumor cell infiltration. A liver biopsy was performed, and histiocytic sarcoma was confirmed histopathologically.