맥관기형파열로 인한 척추 경막외 혈종 : 2례 보고 Report of two Cases

이무섭,권양,정희원,김현집,지제근 대한신경외과학회 1985 Journal of Korean neurosurgical society Vol.14 No.2

Two cases of thoracic spinal epidural hematoma are reported, which were dorsolaterally located and were caused by ruptured epidural vascular malformation. Presenting symptoms of acute spinal and abdominal pain were followed by paraparesis and loss of sphincter control. Metrizamide myelogram showed total block of dye column, and spine CT just after myelogram revealed dorsolaterally located epidural mass lesion. Total laminectomy with evacuation of hematoma and biopsy was performed in both cases. One patient recovered completely and the other patient is still paraparetic.

다중주파수·다중성분 고막운동도에 관한 연구

소원섭,이지연,강희라,손원진,허승덕 대구대학교 특수교육재활과학연구소 2012 再活科學硏究 Vol.30 No.1

이 연구는 이학적·청각학적 정상 소견을 가진 성인들의 다중주파수 고막운동도(multi-frequency tympanogram, MFT)와 다중성분 고막운동도(multi-component tympanogram, MCT)의 특성을 알아보고자 하였다. 연구 참여자는 D대학교 재학 중인 19명(M:F=9:10, 만 19∼23세)으로 하였다. MCT는 각 성분(admittance; Y, susceptance; B, conductance; G)별 정점의 수를 확인하였고, MFT는 200 ㎐부터 2 ㎑ 순음에 대한 고막 긴장 및 이완상태에서 전도율을 통해 공명주파수와 ΔB, Δ∅를 각각 구하였다. MCT는 668 ㎐ 자극에 대해 47.4 %가 1Y1B1G를, 52.6 %가1Y3B1G를 보였고, MFT의 공명주파수는 829~1,213(1,021±192) ㎐, ΔB와 Δ∅의 평균은 각각 –0.18, -19.3으로 관 찰되었다. This study will be to confirm the characteristic of Multi-component tympanogram(MCT) and Multi-frequency tympanogram(MFT) of adults who have physical and audiological normal findings. Participants were 19 students(M:F = 9:10) who are attending D-university. MCT checked the number of peaks per each component(admittance; Y, susceptance; B, conductance; G) and MFT got the resonance frequency through the conductivity rate of tympanic membrane's tense and relaxation state, and ΔB, Δ∅ respectively. 47.4% of MCT showed 1Y1B1G about 668 ㎐ stimulus and 52.6% of that showed 1Y3B1G. Resonance frequency of MFT was 829~1,213(1,021±192) ㎐, and the average of ΔB and Δ∅ was observed -0.18, -19.3 respectively.

저탁도시 PAC와 Ca-PAX의 입자제거 및 슬러지 탈수성 비교

심유섭,유명진,조희경,이상수,곽종운 대한상하수도학회 2002 상하수도학회지 Vol.16 No.4

This study was accomplished to evaluate the characteristics of particle removal and sludge dewatering and to find out the optimal condition of coagulation depending on the dosage of different coagulants (PAC, Ca-PAX) in low turbidity water. The experiments were carried out at a pilot plant of conventional rapid sand filtration system using artificial raw water. There was no large difference in the removal efficiencies of turbidity and total particle counts for both coagulants. However, Ca-PAX was required less than PAC to obtain the same efficiency of removal, and the initial head loss in a filter increased more fastly in case of PAC. The results on the evaluation of sludge from settling tank indicated that specific resistance of sludge was decreased inversely to the dose of both coagulant and specific resistance of Ca-PAX sludge was lower than that of PAC, therefore dewatering of sludge in case of Ca-PAX was better.

홍삼의 단백질 획분 및 진세노사이드가 항종양작용에 미치는 영향에 관하여

盧永姬,金俊燮,李熙鳳 충북대학교 농업과학기술연구소 1996 農業科學硏究 Vol.13 No.-

Ginsenosides and partially purified protein fractions from Korean red ginseng were investigated on metabolic functions of liver and their potency as an antitumor drug was evaluated. 1. Protein fractions and ginsenosides inhibited the activity of C-kinase induced by a tumor promoter, PMA. 2. Protein fractions and ginsenosdes inhibited the phosphorylation of histone Ⅲ induced by PMA in vitro. 3. Protein fractions and ginsenosides inhibited the phosphorylation of 34 KD which is induced by both C-kinase and Ca2+ calmodulin kinase in PMA-treated rat liver cells. 4. Protein fractions increased cGMP, the intermediate opf antitumrous factor which were decreased by PMA. 5. The glycoprotein below 18 KD was contained in the protein fraction exhibiting antitumor effects.

Parathion 이 Mouse의 간장에 미치는 영향

변희섭,정호삼,이규식 漢陽大學校 環境科學硏究所 1984 環境科學論文集 Vol.5 No.-

유기인제살충제인 parathion은 농작물 병충해를 매개하는 곤충에 대하여 살충력이 강하므로 효과적인 농약으로 호평을 받고 있으나 인체에 대하여 심한 독작용을 일으키고 농약에 의한 중독 사고가 높은 비중을 차지하고 있어 사회문제로 대두되고 있다. Parathion은 di-isopropyl fluorophospate(DFP) 및 tetraethyl pyrophoshate(TEPP)와 같은 유기인제살충제의 화학적 유도체이며 parathion에 중독이 되면 인체의 혈액과 조직내에 있는 cholinesterase활성을 억제하는 반면 acetylcholinesterase를 축적시켜 부교감신경계의 과잉자극과 같은 증후를 나타내며, 두통, 피로감, 동공축소, 현기증, 복부경련, 구토, 설사, 발한, 유연과 근육의 경련을 일으킨다. 저자는 parathion도 다른 유기인제살충제와 같이 중독시 간장에서 paraoxen이라는 독성물질로 변해 가수분해를 일으킬 때에 간실질세포에 새포독성으로 작용할 것으로 사료되어 mouse에 parathion을 투여하고 간장의 변화를 조직학적으로 추구하였다. 실험동물은 체중 20gm내외의 ICR계 웅성 mouse에 체중 kg당 1mg되게 olive유에 희석하여 0.2ml를 복강내 주사하고, 6시간, 12시간, 24시간, 36시간 및 48시간 경과 후에 희생시켜 간장을 적출한 다음 hematoxylin 및 eosin염색을 하여 간장의 조직학적 변화를 관찰하고 일부의 간조직은 oil red O염색을 하여 간실질세포내에 지질의 축적을 관찰하여 다음과 같은 결과를 얻었다. 1. parathion 투여 12시간 경과군의 mouse간장에서는 간소엽 중심대와 중간대의 간실질세포에서 소수의 소포가 관찰되었으며 24시간 경과군 mouse의 간장에서는 간소엽 전역에 걸쳐 다수의 소포를 관찰할 수 있었고 간소엽 중심대와 중간대의 간실질세포에서 경도의 세포종창도 일어났으며 시간이 경과됨에 따라 더욱 심해져 48시간 경과군의 mouse간장에서는 일부 간실질세포에서 핵은 창백해지고 대소 부동하며 불규칙한 형태로 나타났고 핵농축과 붕괴를 일으킨 세포도 관찰되었다. 2. parathion투여 6시간 경과군의 mouse간장에서는 간소엽 중심대와 중간대의 간실질세포에서 미약한 지방침착이 형성되고 12 시간 경과한 mouse의 간장에서는 간소엽 중심대의 간실질세포에서 소수의 지방침착이 관찰되었으나 36시간 및 48시간 경과한 mouse간장에서는 심한 지방 침착이 관찰되었다. 이상 소견을 종합 검토한 바 parathion은 mouse의 간장에 손상을 야기시킨다고 사료된다. Parathion(O, O-diethyl O-p-nitrophenyl thiophosphate), an organic phosphorus insecticide, has been used widely as an insecticide during the past year, and important problems have arisen because of its toxicity for man. The authors have demonstrated the effect of parathion on the liver of the liver of the mouse, observing the morphological change and fat deposits in the hepatic parechymal cells. Healthy ICR strain mice were given 0.2ml of 1 mg per kg of body weight of parathion in olive oil by the intraperitoneal injection. The control mice were given olive oil alone. Animals of the control and parathion treated groups were killed at the intervals of 6,12,24,36 and 48 hours after administration of parathion or olive oil respectively. The histological preparations were stained with hematoxylin and eosin method for histological changes of the liver and oil red 0 stain for fat deposits in the hepatic parenchymal cells of the albino mice. The results were obtained as follows; 1. The cellular swelling accompanied with vesicular degeneration at 24 hours, and cellular necrosis associated with pyknosis and karyorrhexis of the hepatic parenchymal cells at 48 hours after parathion administration were observed. 2. The fat deposits in the hepatic parenchymal cells on the central and intermediate zone of the hepatic lobule were observed. The above finding may suggest that parathion would induce the cellular necrosis associated with pyknosis and karyorrhexis and fat deposits of the hepatic parenchymal cells in albino mice.

인간 면역부전 바이러스(HIV) 감염자 사이에서의 1기 및 2기 매독의 유행

장희창,조재현,박완범,이기덕,이창섭,김홍빈,오명돈,최강원 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내 HIV 감염자 사이에서 발생한 매독의 유행을 보고하고, 그 역학적 특성을 규명하고자 하였다. 재료 및 방법 : 1999년 7월부터 2003년 9월까지 서울대학교 병원에서 추적 관찰을 받아온 HIV 감염자를 대상으로 하여 1기 및 2기 매독의 발생을 조사하였다. 발생률을 정확히 구하기 위해 추적 관찰을 받은 모든 HIV 감염자의 인년을 6개월 간격으로 구하였다. 결과 : 51개월 동안, 465명의 HIV 감염자가 서울대학교 병원에서 추적 관찰을 받았다. 이중 38명이 1기 및 2기 매독으로 진단되었다. 1기 및 2기 매독의 발생률은 이기간 동안 100인년 당 4.1명이었다. 1999년 7월부터 2001년 12월 사이에는 발생자가 없었으나, 이후 발생률은 꾸준히 증가하여 2003년 9월에는 100인년 당 18.8명이 되었다. 1기 및 2기 매독의 발생률은 동성애자 및 양성애자에서 이성애자에서보다 4.3배 높았고, HAART로 치료를 받지 않은 환자에서 HAART로 치료를 받고 있던 환자에서 보다 10.9배 높았다. 결론 : 2002년부터 국내 HIV 감염자 사이에서 1기 및 2기 매독이 유행하기 시작하였고, 이러한 유행은 동성애자와 양성애자 및 HAART로 치료를 받고 있지 않던 사람 사이에서 발생하였다. Background : This study was performed to characterize the epidemiologic and clinical features of outbreak of syphilis among HIV sero-positive patients in Korea. Materials and Methods : A retrospective case review of patients diagnosed with primary and secondary syphilis from July 1999 to September 2003 was carried out at Seoul National University Hospital in Korea. To estimate the incidence, person-years (PYs) of all HIV sero-positive patients, who visited the hospital in the same period, were calculated every 6 months. Results : In a 51 month period, 465 HIV-positive patients were followed up at Seoul National University Hospital. 38 cases of primary and secondary syphilis were diagnosed. The incidence of primary and secondary syphilis was 4.1 per 100 PYs during the study period. There was no case from July 1999 to December 2001, and then the incidence rose until September 2003 from 5.5 per 100 PYs in 1999 to 18.8 per 100 PYs in 2003. The rate of primary and secondary syphilis was 4.3 times higher among homosexual and bisexual men than heterosexual men (95% CI 1.87 to 11.17), and 10.9 times higher among patients who did not receive HAART than patients who were receiving HAART (95% CI 5.47 to 21.79). Conclusion : The outbreak of primary and secondary syphilis among HIV-positive patients started in 2002 and has been escalating, especially among homosexual/bisexual men and in patients who did not receive HAART.

스타이렌 아이오노머의 기계적인 성질에 미치는 혼합 양이온의 영향

김희석,나연화,이용혁,이법원,유지강,박기주,김준섭 조선대학교 생산기술연구소 1998 生産技術硏究 Vol.20 No.1

The styrene-co-methacrylate ionomers neutralized with Na +, Ba2 +, and mixed cation of both were prepared. The dynamic mechanical properties of two cation-containing ionomers were measured and compared to those of the ionomers neutralized with only one type of cations. We found that in the ionomers with one type of cations the difference in the type of cation does not change the glass transition temperatures. It was found, however, that the cluster Tg of the mixed cation ionomer is lower than that of the single cation ionomers. Thus it was postulated that in the two-cation system the two cations in a solution have sufficient dynamics to form new type of multiplet containing both cations, which may be slightly bigger than that found in the single cation multiplet. The mechanical properties also imply that the strength of ion interactions in the multiplets of the two cation ionomer is thought to be weaker than that of the one cation ionomers. These two effects are believed to contribute the lower in the cluster glass transition of mixed cation system.

카르복시 폴리술폰 아이오노머의 기계적 성질

유지강,이용혁,김희석,김준섭,박기주,D. Nguyen,A. Eisenberg 조선대학교 생산기술연구소 1997 生産技術硏究 Vol.19 No.1

The dynamic mechanical properties of carboxylated polysulfone ionomers were studied by using DMTA. It was found that at 25 mol% of ions, the ionomer shows two glass transitions: one at ca. 200 ℃ and the other at ca. 235 ℃. It was also found that with increasing an ion content to ca. 37 mol%, a matrix T_(g) shifts to ca. 210 ℃, but a cluster T_(g) remains at the same temperature; however, the sizes of tan δ peaks for each transitions do not change with the ion content. This result means that even at those high ion contents, there is sufficient amount of a unclustered material in the samples, and the increase in the ion content does not increase the volume fraction of a cluster phase. In addition, the difference in two T_(g)s of this ionomer system was found to be ca. 40 ℃, which is smaller than that in poly(styrene-co-methacrylate) ionomer system. This finding implies that in the polysulfone ionomers weak ionic interactions in a multiplet resulting from steric hindrance due to the bulkiness of benzene ring to which the ionic group is attached and the tension on polymer chains surrounding the multiplet due to chain rigidity affect the size and stability of the multiplet significantly.

폴리(스타이렌-b-아이소부틸렌-b-스타이렌) 삼블록 공중합체 아이오노머의 기계적인 성질

나연화,김희석,김준섭,유지강,박기주,이영관 조선대학교 생산기술연구소 1998 生産技術硏究 Vol.20 No.2

The dynamic mechanical properties of poly(styrene-b-isobutylene-b-styrene) and its sulfonated ionomers were investigated. The triblock copolymer showed a tan δ peak at ca. -25℃, which is ascribed to the T_(g) of polyisobutylene blocks. The copolymer also showed a shoulder on a tan δ curve at ca. 50℃, which is probably associated with crystallization and/or melting of the crystalline polyisobutylene blocks. Above 100℃, the copolymer started to flow. In the cases of ionomers, well developed rubbery plateaus, extended to ca. 150-160℃, were seen in modulus-temperature plots. A tan δ peak for the T_(g) of the polyisobutylene blocks and a shoulder peak were also observed for the tetramethylammonia neutralized sulfonated ionomer. However, the shoulder peak became smaller and shifted to low temperatures, which implies that the ionic interactions in this system reduces the ability of crystallization or/and melting of the polyisobutylene blocks. For the K neutralized ionomer sample, only a tanδ peak for the T_(g) of the isobutylene blocks was seen. This different result in these two ionomers is believed to be due to the difference in the strength of ionic interactions.

염색 단판을 이용한 集成 染色 무늬목 開發

안삼근,강형철,안상열,이균필,변희섭 경상대학교 농업생명과학연구원 2002 농업생명과학연구 Vol.36 No.4

본 연구는 집성 염색 무니목 개발을 위하여 사용 가능한 수종과 3종류의 염료를 사용하여 염색시간, 염색온도, 함수율 및 Flitch 제작에 대하여 연구한 결과는 다음과 같다. 실험에 사용한 4수종 중에서 선삭성이 불량한 은수원 사시나무를 제외한 3수종인 소나무와 이태리 포플러, 마티카가 사용 가능한 수종으로 밝혀졌다. Stain은 번지거나 얼룩이 지는 현상, Dylon은 침투 불균일로 부적당하였으나 Fine은 염색상태가 양호하였다. 염색시간은 5시간 이상 되어야 염색정도가 양호하였고, 염색온도는 90℃에서 가장 적당하였으며 생재와 기건재 및 포수재에 대한 영향은 큰 차이가 없었다. Flitch제작에 적당한 함수율은 9%이었다. This study was carried out to develop laminated dyeing wood, for which usable three sixties of trees and 3 kinds of dye stuffs were used to investigate dyeing time, dyeing temperature, moisture content and manufacture of flitch, the results were as follows: Out of four species of trees used in the experiment, it was found that three species, Pinus densiflora, Populus euramercana and Dyrea costulata were usable excluding Populus tomentiglandulosa whose cutting ability was bad. As to influence according to the kind of dye stuff, the Stain of low price could be used as a coloring agent but it was not proper as a dyeing agent due to spreading or staining phenomenon. As Dylon which was generally used to dye textile penetrated them uneven, dyeing only their surface, it was also found improper to be used. On the other hand, the dyed condition was good with Fine. The dyed condition was good when dyeing time was more than 5 hours and it was the most adequate when the temperature was at 90℃. There was no significant difference between their influence on green, dried and saturated wood.-In the manufacture of Flitch, the most appropriate moisture content was 9%.