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      • SCOPUSKCI등재

        On a Bilateral Hilbert-Type Inequality with a Homogeneous Kernel of 0-Degree

        He, Bing Department of Mathematics 2010 Kyungpook mathematical journal Vol.50 No.2

        By introducing a homogeneous kernel of 0-degree with an independent parameter and estimating the weight coefficient, a bilateral form of the Hilbert-type series inequality with a best constant factor is established.

      • KCI등재

        The effect of colored plastic films on the photosynthetic characteristics and content of active ingredients of Dysosma versipellis

        Bing He,Yao Chen,Hua Zhang,Chunyan Xia,Qing Zhang,Wei Lin 한국원예학회 2018 Horticulture, Environment, and Biotechnology Vol.59 No.4

        Light intensity and quality affect photosynthesis, plant morphology, and the synthesis of primary and secondary metabolites. Dysosma versipellis (Hance) M. Cheng is an endangered species endemic to China, and a highly valued medicinal and ornamental plant. In this study, we discuss the effects of different light spectrums conferred by colored plastic films on photosynthesis and the contents of active ingredients of D. versipellis. D. versipellis plants were cultured for 90 days under white, red, yellow, or blue film. The blue film treatment generally increased the chlorophyll content, photosynthetic rate (Pn), maximal photochemical efficiency of PSII (Fv/Fm), actual photochemical efficiency of PSII (ФPSII), photochemical quenching (qP), and the podophyllotoxin content of the rhizomes. The blue film treatment also decreased the maximum net photosynthetic rate (Amax), apparent photosynthetic quantum efficiency (AQY), and podophyllotoxin contents of the stems. The yellow film treatment resulted in a decline of the Amax, AQY, Fv/Fm, ФPSII, qP, chlorophyll contents, and podophyllotoxin contents of the leaves and rhizomes; however, the light compensation point (LCP), light saturation point, and minimum fluorescence (Fo) were increased. There were no significant differences in chlorophyll content, Amax, LCP, AQY, Fv/Fm, ФPSII, or qP between the white and red film treatments. These results suggest that in D. versipellis, blue film treatments promote photosynthesis and the accumulation of podophyllotoxin, while yellow film treatments inhibit photosynthesis and the accumulation of podophyllotoxin.

      • KCI등재
      • KCI등재

        중국 대학생의 K-콘텐츠 인식이 한국에 대한 행동의도에 미치는 영향

        하병장(Bing-Zhang HE),지명원(Myong-Won CHI) 한국상담심리교육복지학회 2024 상담심리교육복지 Vol.11 No.2

        본 연구는 중국 대학생을 대상으로 K-콘텐츠 인식이 한국에 대한 행동의도 즉, 한국제품 구매의도와 한국 방문의도에 미치는 영향을 살펴보고자 수행되었다. 연구를 통해 개인의 심리와 행동에 문화가 어떻게 관련되는지를 확인하고, 문화와 심리, 경제, 사회 간의 관계를 보다 심도 있게 이해하고자하였다. 연구를 위해 중국 산동성 하택시 대학생을 대상으로 설문조사를 진행하였고, 627부의 자료를 최종 분석에 사용하였다. 연구결과 K-콘텐츠 가운데 K-푸드, K-화장품, K-영화·드라마, K-게임의 인식 수준은 한국제품의 구매의도에 영향을 미치고 있으며, K-음악, K-푸드, K-화장품, K-게임의인식 수준은 한국 방문의도에 영향을 미치는 것으로 나타났다. 이에 따라 중국 젊은 세대를 대상으로 한중 문화교류 방안과 관련 산업의 마케팅 전략을 제안하였다. This study examined the impact of k-content awareness on behavioral intention toward Korea, namely intention to purchase Korean products and the intention to visit korea among chinese college students, thereby determining how culture affects individuals. We sought to determine how it is related to psychology and behavior and to understand the relationship among culture, psychology, economy, and society more deeply. For the study, a survey was conducted among college students in heze city, shandong province, china, and 627 copies were used in the final analysis. The research results showed that among k-content, the level of awareness of k-food, k-cosmetics, k-movies·dramas, and k-games influences the intention to purchase korean products. And the level of awareness of k-music, k-food, k-cosmetics, and k-games was found to affect the intention to visit korea. Accordingly, a plan for cultural exchange between korea and china and marketing strategies for related industries were proposed for the younger generation in china.

      • KCI등재

        Poly(ethyleneimine) functionalized organic-inorganic hybrid silica by hydrothermalassisted surface grafting method for removal of nickel(II)

        Lu He,Hong-Bo Xu,Bing-Bing Wang,Dan-Dan Liu,Ke-Sen Qian 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.2

        Poly(ethyleneimine)-functionalized organic-inorganic hybrid silica adsorbent was synthesized by hydrothermal-assisted surface grafting technique for the removal of Ni(II) ions from aqueous solution, and was characterizedby FT-IR, nitrogen adsorption and the static adsorption-desorption experiment method. The results indicated thatthe maximum static adsorption capacity of Ni(II) on poly(ethyleneimine)-functionalized hybrid silica adsorbent byhydrothermal heating method was 1.6 times as much as the conventional heating method. The poly(ethyleneimine)-functionalized hybrid silica adsorbent offered a fast kinetics for the adsorption of Ni(II), had a substantial binding capacityin the range of pH 4-8 and could be used repeatedly. The Langmuir adsorption model was more favorable thanthe Freundlich and Dubinin-Radushkevich adsorption models. The adsorption followed a pseudo-second-order modelcompared with pseudo-first-order model. Various thermodynamic parameters such as ΔGo, ΔHo and ΔSo indicated thatthe adsorption process was spontaneous and endothermic. The results showed that poly(ethyleneimine)-functionalizedhybrid silica adsorbent could be employed as an effective material for the removal of Ni(II) ions from aqueous solution.

      • KCI등재

        Involvement of Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in β1 Integrin-Mediated Internalization of Staphylococcus aureus by Alveolar Epithelial Cells

        Jia-He Wang,Ke Zhang,Nan Wang,Xiao-Min Qiu,Yi-Bing Wang,Ping He 한국미생물학회 2013 The journal of microbiology Vol.51 No.5

        The invasion of Staphylococcus aureus into alveolar epithelial cells is regarded as the key step for S. aureus lung infection. However, the mechanism of internalization of S. aureus by alveolar epithelial cells is not clear, and was the aim of this investigation Human lung adenocarcinomic epithelial cells and A549 cells were used. Human β1 integrin and rat β1 integrin were detected by real-time reverse transcription (RT)-PCR. The expressions of β1 integrin, Akt and p-Akt were detected by Western blot analysis. To further investigate the role of β1 integrin in S. aureus internalization by alveolar epithelial cells, we next performed siRNA-mediated knockdown of β1 integrin expression. In this study, we found that S. aureus invades human alveolar epithelial cells and rat primary alveolar epithelial cells. The β1 integrin ligand competitive inhibitor, GRGDS-peptide, blocked the internalization of S. aureus by A549 cells. Knockdown of β1integrin also inhibited the internalization of S. aureus. In addition, the PI3K/Akt signaling pathway in alveolar epithelial cells was activated by the infection with S. aureus. Furthermore, Akt phosphorylation was abolished by transient transfection with β1 integrin siRNA in A549 cells challenged with S. aureus. Our results suggest that the phosphatidylinositol 3-kinase/Akt signaling pathway plays an important role in β1 integrin-mediated internalization of S. aureus by alveolar epithelial cells.

      • The Blood Neutrophil-to-lymphocyte Ratio Predicts Survival in Patients with Advanced Hepatocellular Carcinoma Receiving Sorafenib

        Zheng, You-Bing,Zhao, Wei,Liu, Bing,Lu, Li-Gong,He, Xu,Huang, Jian-Wen,Li, Yong,Hu, Bao-Shan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

        Background and Aim: Increasing evidence correlates the presence of systemic inflammation with poor survival in patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the prognostic significance of the blood neutrophil-to-lymphocyte ratio (NLR) in patients with advanced HCC who received sorafenib monotherapy. Methods: A total of sixty-five patients with advanced HCC, not eligible for locoregional therapy, treated with sorafenib were enrolled. Potential prognostic factors such as age, gender, tumoral characteristics, performance status and NLR were analyzed. Results: Median OS and TTP for the entire cohort were 10.0 months (95%CI, 7.6-12.3 months) and 4.5 months (95% CI, 4.0-4.9 months). The mean NLR at baseline was 2.89. The median OS of patients with a high NLR (>4) was 6.5 months (95%CI, 5.2-7.7 months) compared with 12.5 months (95%CI, 9.9-15.0) for patients with a normal NLR (${\leq}4$) (P=0.01). Age ${\leq}65$, NLR>4, extrahepatic metastases and vascular invasion were all predictors of poorer overall survival. Multivariate analysis showed that NLR > 4, vascular invasion and extrahepatic metastases were independent predictors of poorer overall survival. The median TTP of patients with a high NLR was 2.5 months (95%CI, 1.4-3.6 months) compared with 4.5 months (95%CI, 3.9-5.1 months) for patients with a normal NLR (P=0.012). Conclusions: High baseline NLR was associated with worse OS and TTP for patients with advanced HCC treated with sorafenib.

      • KCI등재

        Gender-independent efficacy of mesenchymal stem cell therapy in sex hormone-deficient bone loss via immunosuppression and resident stem cell recovery

        Bing-Dong Sui,Ji Chen,Xin-Yi Zhang,Tao He,Pan Zhao,Chen-Xi Zheng,Meng Li,Cheng-Hu Hu,Yan Jin 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

        Osteoporosis develops with high prevalence in both postmenopausal women and hypogonadal men. Osteoporosis results in significant morbidity, but no cure has been established. Mesenchymal stem cells (MSCs) critically contribute to bone homeostasis and possess potent immunomodulatory/anti-inflammatory capability. Here, we investigated the therapeutic efficacy of using an infusion of MSCs to treat sex hormone-deficient bone loss and its underlying mechanisms. In particular, we compared the impacts of MSC cytotherapy in the two genders with the aim of examining potential gender differences. Using the gonadectomy (GNX) model, we confirmed that the osteoporotic phenotypes were substantially consistent between female and male mice. Importantly, systemic MSC transplantation (MSCT) not only rescued trabecular bone loss in GNX mice but also restored cortical bone mass and bone quality. Unexpectedly, no differences were detected between the genders. Furthermore, MSCT demonstrated an equal efficiency in rectifying the bone remodeling balance in both genders of GNX animals, as proven by the comparable recovery of bone formation and parallel normalization of bone resorption. Mechanistically, using green fluorescent protein (GFP)-based cell-tracing, we demonstrated rapid engraftment but poor inhabitation of donor MSCs in the GNX recipient bone marrow of each gender. Alternatively, MSCT uniformly reduced the CD3+T-cell population and suppressed the serum levels of inflammatory cytokines in reversing female and male GNX osteoporosis, which was attributed to the ability of the MSC to induce T-cell apoptosis. Immunosuppression in the microenvironment eventually led to functional recovery of endogenous MSCs, which resulted in restored osteogenesis and normalized behavior to modulate osteoclastogenesis. Collectively, these data revealed recipient sexually monomorphic responses to MSC therapy in gonadal steroid deficiency-induced osteoporosis via immunosuppression/anti-inflammation and resident stem cell recovery.

      • SCISCIESCOPUS

        <i>Yersinia pseudotuberculosis</i> Exploits CD209 Receptors for Promoting Host Dissemination and Infection

        He, Ying-Xia,Ye, Cheng-Lin,Zhang, Pei,Li, Qiao,Park, Chae Gyu,Yang, Kun,Jiang, Ling-Yu,Lv, Yin,Ying, Xiao-Ling,Ding, Hong-Hui,Huang, Hong-Ping,Mambwe Tembo, John,Li, An-Yi,Cheng, Bing,Zhang, Shu-Sheng American Society for Microbiology 2019 Infection and immunity Vol.87 No.1

        <P><I>Yersinia pseudotuberculosis</I> is a Gram-negative enteropathogen and causes gastrointestinal infections. It disseminates from gut to mesenteric lymph nodes (MLNs), spleen, and liver of infected humans and animals.</P><P><I>Yersinia pseudotuberculosis</I> is a Gram-negative enteropathogen and causes gastrointestinal infections. It disseminates from gut to mesenteric lymph nodes (MLNs), spleen, and liver of infected humans and animals. Although the molecular mechanisms for dissemination and infection are unclear, many Gram-negative enteropathogens presumably invade the small intestine via Peyer’s patches to initiate dissemination. In this study, we demonstrate that <I>Y. pseudotuberculosis</I> utilizes its lipopolysaccharide (LPS) core to interact with CD209 receptors, leading to invasion of human dendritic cells (DCs) and murine macrophages. These <I>Y. pseudotuberculosis</I>-CD209 interactions result in bacterial dissemination to MLNs, spleens, and livers of both wild-type and Peyer’s patch-deficient mice. The blocking of the <I>Y. pseudotuberculosis</I>-CD209 interactions by expression of O-antigen and with oligosaccharides reduces infectivity. Based on the well-documented studies in which HIV-CD209 interaction leads to viral dissemination, we therefore propose an infection route for <I>Y. pseudotuberculosis</I> where this pathogen, after penetrating the intestinal mucosal membrane, hijacks the <I>Y. pseudotuberculosis</I>-CD209 interaction antigen-presenting cells to reach their target destinations, MLNs, spleens, and livers.</P>

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