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RISS 인기검색어
- 검색키워드
- 저자 : Hanumanthachar Joshi (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Cholinergic Basis of Memory-Strengthening Effect of Foeniculum vulgare Linn.
Hanumanthachar Joshi,Milind Parle 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.3
Alzheimer’s disease is a neurodegenerative disorder associated with a decline in cognitive abilities. Dementiais one of the age-related mental problems and a characteristic symptom of Alzheimer’s disease. Nootropic agents are used insituations where there is organic disorder in learning abilities. The present work was undertaken to assess the potential ofFoeniculum vulgareLinn. extract as a nootropic and anticholinesterase agent in mice. Methanolic extract of the whole plantof F. vulgareLinn. administered for eight successive days ameliorated the amnesic effect of scopolamine (0.4 mg/kg) and ag-ing-induced memory deficits in mice. The passive avoidance paradigm served as the exteroceptive behavioral model for as-sessing memory. F. vulgareextract increased step-down latency and acetylcholinesterase inhibition in mice significantly.Hence, F. vulgarecan be employed in treatment of cognitive disorders such as dementia and Alzheimer’s disease.
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Antiamnesic potentials of Foeniculum vulgare Linn. in mice
Joshi, Hanumanthachar,Parle, Milind Kyung Hee Oriental Medicine Research Center 2007 Oriental pharmacy and experimental medicine Vol.7 No.2
Alzheimer's disease is a neurodegenerative disorder associated with a decline in cognitive abilities. Dementia is one of the aged related mental problems and a characteristic symptom of Alzheimer's disease. Nootropic agents like piracetam and cholinesterase inhibitors like $Donepezil^{\circledR}$ are used in situations where there is organic disorder in learning abilities, but the resulting side-effects associated with these agents have limited their utility. Foeniculum (F.) vulgare Linn. is widely used in Indian traditional systems of medicines and also as a house remedy for nervous debility. The present work was undertaken to assess the potential of F. vulgare as a nootropic and anti-cholinesterase agent in mice. Exteroceptive behavioral models such as Elevated plus maze and Passive avoidance paradigm were employed to assess short term and long term memory in mice. To delineate the possible mechanism through which F. vulgare elicits the anti-amnesic effects, its influence on central cholinergic activity was studied by estimating the whole brain acetylcholinesterase activity. Pretreatment of methanolic extract of fruits of F. vulgare Linn. for 8 successive days, ameliorated the amnesic effect of scopolamine (0.4 mg/kg) and aging induced memory deficits in mice. F. vulgare extract significantly decreased transfer latencies of young mice and aged mice, increased step down latency and exhibited significant anti-acetyl cholinesterase effects, when compared to piracetam, scopolamine and control groups of mice. F. vulgare might prove to be a useful memory restorative agent in the treatment of dementia seen in the elderly.
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Antiamnesic potentials of Foeniculum vulgare Linn. in mice
Hanumanthachar Joshi,Milind Parle 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.2
Alzheimer’s disease is a neurodegenerative disorder associated with a decline in cognitive abilities. Dementia is one of the aged related mental problems and a characteristic symptom of Alzheimer’s disease. Nootropic agents like piracetam and cholinesterase inhibitors like Donepezil?? are used in situations where there is organic disorder in learning abilities, but the resulting side-effects associated with these agents have limited their utility. Foeniculum (F.) vulgare Linn. is widely used in Indian traditional systems of medicines and also as a house remedy for nervous debility. The present work was undertaken to assess the potential of F. vulgare as a nootropic and anticholinesterase agent in mice. Exteroceptive behavioral models such as Elevated plus maze and Passive avoidance paradigm were employed to assess short term and long term memory in mice. To delineate the possible mechanism through which F. vulgare elicits the anti-amnesic effects, its influence on central cholinergic activity was studied by estimating the whole brain acetylcholinesterase activity. Pretreatment of methanolic extract of fruits of F. vulgare Linn. for 8 successive days, ameliorated the amnesic effect of scopolamine (0.4 mg/kg) and aging induced memory deficits in mice. F. vulgare extract significantly decreased transfer latencies of young mice and aged mice, increased step down latency and exhibited significant anti-acetyl cholinesterase effects, when compared to piracetam, scopolamine and control groups of mice. F. vulgare might prove to be a useful memory restorative agent in the treatment of dementia seen in the elderly.
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