National survey of Korean hepatobiliary-pancreatic surgeons on attitudes about the enhanced recovery after surgery protocol

Sang Hyun Shin,Woo-hyoung Kang,In Woong Han,Yunghun You,Huisong Lee,Hongbeom Kim,Woohyun Jung,Yong Chan Shin,Jin Seok Heo 한국간담췌외과학회 2020 Annals of hepato-biliary-pancreatic surgery Vol.24 No.4

Backgrounds/Aims: The purpose of this study was to investigate attitudes regarding the Enhanced Recovery After Surgery (ERAS) protocol of hepato-biliary-pancreatic (HBP) surgeons in Korea and the extent to which they use the protocol for perioperative management. Methods: An online survey was conducted among members of the Korean Association of Hepato-Biliary-Pancreatic Surgery (KAHBPS) for eight weeks beginning on August 2019. The questionnaire, which was written in Korean, was based on the latest ERAS guidelines. Total responses were collected from 127 surgeons. Results: Of the 127 total respondents, the largest proportion (44.9%) were working in Seoul. In terms of established in-hospital clinical pathways (CP), 19.7% of the participating surgeons had and followed a CP in pancreaticoduodenectomy (PD) and 21.3% in hepatectomy. Regarding the ERAS protocol for each surgery, four items (18.2%) regarding PD and seven items (35.0%) related to hepatectomy were followed by more than 50% of respondents. Conclusions: ERAS guidelines are one of the consensuses for better recovery in perioperative management of patients undergoing major surgeries and encompass the overall process of patient recovery including patient education, pain control, physiologic balance, and perioperative nutrition. A novel project is needed to successfully implement an evidence-based enhanced recovery strategy.

<i>In vitro</i> and <i>in vivo</i> evaluation of a novel polymer-free everolimus-eluting stent by nitrogen-doped titanium dioxide film deposition

Park, Dae Sung,Bae, In-Ho,Jeong, Myung Ho,Lim, Kyung Seob,Sim, Doo Sun,Hong, Young Joon,Lee, So-Youn,Jang, Eun Jae,Shim, Jae-Won,Park, Jun-Kyu,Lim, Han Chul,Kim, Han Byul Elsevier 2018 Materials Science and Engineering C Vol.91 No.-

<P><B>Abstract</B></P> <P>Inflammation and thrombosis are linked to the use of polymer-based drug-eluting stents (DES). The aim of this study was to develop a polymer-free everolimus (EVL)-eluting stent using nitrogen-doped titanium dioxide (N-TiO<SUB>2</SUB>) and verify its efficacy by <I>in vitro</I> and <I>in vivo</I> assessment in a porcine coronary model. Various analytical approaches such as scanning electron microscopy and atomic force microscopy, electron spectroscopy, Fourier transform infrared spectrometry and contact angle measurement were employed for the characterization. As a part of biocompatibility assessment, platelet adhesion and smooth muscle cell (SMC) proliferation were examined. Bare metal stent (BMS), N-TiO<SUB>2</SUB> stent, everolimus-eluting N-TiO<SUB>2</SUB> (N-TiO<SUB>2</SUB>-EVL) stent, and commercialized EVL-eluting stent (EES) were randomly placed in forty coronary arteries in twenty pigs. After four weeks of implantation, the stents were subjected to histological and quantitative analysis. The N-TiO<SUB>2</SUB> film used in this study was well coated without any cracks or peeling. Surface hydrophilicity (88.8% of angle decrement) could be associated with the decrease in surface roughness post N-TiO<SUB>2</SUB> deposition (37.0%). The platelet adhesion on the N-TiO<SUB>2</SUB> surfaces was less than that on the BMS surface. The proliferation of SMC was suppressed in the N-TiO<SUB>2</SUB>-EVL group (30.2%) but not in the BMS group. In the animal study, the percent area restenosis was significantly decreased in the N-TiO<SUB>2</SUB>-EVL group compared to that in the BMS group. The results (BMS; 47.0 ± 11.00%, N-TiO<SUB>2</SUB>-EVL; 31.7 ± 10.50%, and EES; 29.1 ± 11.21%, <I>n</I> = 10, <I>p</I> < 0.05) were almost at par with those of the commercialized EVL-eluting stent. The introduction of N-TiO<SUB>2</SUB> deposition during fabrication of polymer-free DES may be an efficient accessorial process for preventing in-stent restenosis and thrombosis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> N-TiO<SUB>2</SUB> surfaces can help to reduce the platelet adhesion. </LI> <LI> In porcine model, N-TiO<SUB>2</SUB> everolimus decreased in-stent restenosis and fibrin deposition. </LI> </UL> </P>

Celay/In-Ceram, Conventional In-Ceram, Empress 2 전부도재관의 변연적합도에 관한 비교 연구

양재호,여인성,이선형,한중석,이재봉,Yang, Jae-Ho,Yeo, In-Sung,Lee, Sun-Hyung,Han, Jung-Suk,Lee, Jai-Bong 대한치과보철학회 2002 대한치과보철학회지 Vol.40 No.2

There have been many studies about marginal discrepancy of single restorations made by various systems and materials. But many of statistical inferences are not definite because of sample size, measurement number, measuring instruments. etc. The purpose of this study was to compare the marginal adaptations of the anterior single restorations made by different systems and to consider more desirable statistical methods in analysing the marginal fit. The in vitro marginal discrepancies of three different all-ceramic crown systems (Celay In-Ceram. Conventional In-Ceram. IPS Empress 2 layering technique) and one control group (PFM) were evaluated and compared. The crowns were made from one extracted maxillary central incisor prepared with a 1mm shoulder margin and $6^{\circ}$ taper walls by milling machine. 10 crowns per each system were fabricated. Measurements or a crown were recorded at 50 points that were randomly selected for marginal gap evaluation. Non-parametric statistical analysis was performed for the results. Within the limits of this study, the following conclusions were drawn: 1 Mean gap dimensions and standard deviations at the marginal opening for the maxillary incisor crowns were $98.2{\pm}40.6{\mu}m$ for PFM, $83.5{\pm}18.7{\mu}m$ for Celay In-Ceram, $104.9{\pm}44.1{\mu}m$ for conventional In-Ceram, and $45.5{\pm}11.5{\mu}m$ for IPS Empress 2 layering technique. The IPS Empress 2 system showed the smallest marginal gap (P<0.05). The marginal openings of the other three groups were not significantly different (P<0.05). 2 The marginal discrepancies found in this study were all within clinically acceptable standards ($100\sim150{\mu}m$). 3. When the variable is so controlled that the system may be the only one, mean value is interpreted to be the marginal discrepancy of a restoration which is made by each system and standard deviation is to be technique-sensitivity of each one. 4. From the standard deviations. the copy-milling technique (Celay/In-Ceram) was not considered to be technique-sensitive in comparison with other methods. 5. Parametric analysis is more reliable than non-parametric one in interpretation of the mean and standard deviation. The sample size of each group has to be more than 30 to use parametric statistics. The level of clinically acceptable marginal fit has not been established. Further studies are needed.

Genetic Variations of the Apolipoprotein B Gene in Korean People and Its Association with Hypercholesterolemia

Sung Han Kim,Un Kyung Kim,Jae Jin Chae,Jeong In Baek,Soo Young Choi,Jae Woong Bae,Sang Hyun Kim,Hyo Soo Kim 한국유전학회 2008 Genes & Genomics Vol.30 No.5

Genetic polymorphisms at the apolipoprotein B have been associated with elevated plasma concentrations of LDL, atherosclerosis and increased risk of coronary artery disease. 106 individuals composed of 46 hypercholesterolemic patients and 60 controls were analyzed with Ins/Del length polymorphism, four RFLPs (HincII, PvuII, AluI, EcoRI) and 3`-VNTR to clarify the characteristics of the apolipoprotein B gene and to determine their influence on the lipid profile of hypercholesterolemic patients and controls in Korea. A total of 212 apolipoprotein B alleles from six markers were identified in this study. Heterozygosityranges from zero to 0.32, and the genotyope frequencies in the case of 3`-VNTR are significantly different between two groups. Analysis of linkage disequilibrium revealed paired nonrandom associations between four pairs of polymorphic sites of the apolipoprotein B gene (p<0.05). Moreover, addition of all 4 polymorphic sites provided the highest PIC value. This study also investigated the association of these polymorphisms with the patients and with variation in lipid levels. A significant association between 3`-VNTR genotypes and Lp(a) was observed in hypercholesterolemic patients (p<0.05). The results suggest that genotypes of six polymorphic markers were not significantly associated with TC, TG or LDL-chol level between the patients and controls in the Koreans.

노동시장의 양극화 해소를 위한 주요 노동입법과제

한인상(Han, In-sang) 한국비교노동법학회 2013 노동법논총 Vol.29 No.-

The bi-polarization of the labor market poses serious problems for the South Korean society. A combination of the increase of non-regular workers, the decrease of regular workers, and the slowed creation of quality jobs are identified as the major causes of this the bi-polarization. This article intends to provide a brief overview of the current situation of the polarized Korean labor market as well as some legislative suggestions to resolve the problems. First, legislative measures need to be adopted in order to decrease the number of non-regular workers and make improvement in the non-regular workers labor conditions in terms of their job security and wages. Furthermore, adopting more stringent requirements for permitting mass layoffs as well as reforming the regulations on indirect employment such as in-house subcontracting will be necessary. Job creation will also be encouraged by reducing working hours and reallocating labor forces. Resolving the bi-polarization problems in the labor market will be crucial for the sustainable development of the society, as there is a direct linkage between the polarization of the labor force and the income polarization. Continuing legislative efforts in this area will therefore be required.

보문 : 의류판매원의 고객지향성 측정도구 개발

한상인 ( Sang In Han ),황선진 ( Sun Jin Hwang ) 한국의류학회 2012 한국의류학회지 Vol.36 No.2

This study develops a valid and reliable scale to evaluate customer orientation for clothing salespeople in order to provide a foundation for systematic and empirical research in the apparel industry. The study was conducted in two phases. First, a scale was developed to evaluate the customer orientation of clothing salespeople through a qualitative method. The second phase involved the verification of the validity of the developed evaluation questions through a quantitative method. The subjects of this study were 327 clothing salespeople, and the results were analyzed using AMOS 7.0 and SPSS 15.0. The results were as follows: First, customer orientation questions were elicited from in-depth interviews with fashion salespeople, analyses of fashion magazine articles, and previous studies. From the results, 38 preliminary questions were selected based on categorization, modification, and expert analyses of the content validity. Second, in order to verify the validity of the customer orientation scale that consisted of 24 questions in 7 factors, we performed a verification of the convergent validity through an assessment of the magnitude of standardization factor loading, average variance extracted (AVE), and construct reliability. Discriminant validity was verified using the AVE of each of the two constructs and a comparison of the square of the correlation between the constructs. According to the results, the measured values were above or near the guideline values that demonstrates the validity of the customer orientation scale.

The effect of alpha lipoic acid in a porcine in-stent restenosis model

Lim, Sang Yup,Bae, Eun Hui,Jeong, Myung Ho,Kim, Ju Han,Hong, Young Joon,Sim, Doo Sun,Kim, Yong Sook,Park, In Kyu,Ahn, Youngkeun,Song, Sun-Jung,Cho, Dong Lyun,Kim, Kyoung Seok,Kang, Jung Chaee Elsevier 2009 Journal of cardiology Vol.54 No.3

<P><B>Summary</B></P><P><B>Background</B></P><P>The aim of this study was to investigate the effect of alpha lipoic acid (α-LA) on a porcine in-stent restenosis (ISR) model.</P><P><B>Methods</B></P><P>In protocol 1, porcine vascular smooth muscle cells (PVSMC) were stimulated by granulocyte-colony stimulating factor (G-CSF) in the presence or absence of α-LA. MTT (3-[4,5-dimethylthiazole-2-yl] 2,5-diphenyl tetrazolium bromide) assay and western blotting were used to determine the cell growth inhibitory rate and anti-inflammatory effect associated with nuclear factor-κb (NF-κb) and extracellular signal-regulated kinase (ERK). In protocol 2, 28 days after balloon overdilation injuries, 24 bare metal stents were placed in coronary artery of 12 pigs. The pigs were randomly divided to receive control diet with or without α-LA (100mg/kg). In protocol 3, 8 control stents and 8 α-LA coated stents were randomly implanted in 2 coronary arteries of 8 pigs and follow-up coronary angiogram and histopathologic assessment were performed 4 weeks after stenting.</P><P><B>Results</B></P><P>Protocol 1. The proliferation of PVSMC was inhibited and protein expression of NF-κb and ERK were attenuated by α-LA pretreatment. Protocol 2<I>.</I> On histopathologic analysis, the neointimal area (4.0±1.0mm<SUP>2</SUP> vs. 1.5±0.7mm<SUP>2</SUP>, <I>p</I><0.001) and histopathologic area of stenosis (66.7±10.7% vs. 24.2±9.7%, <I>p</I><0.001) were reduced in the α-LA feeding group compared to controls. Protocol 3. On histopathologic analysis, the neointimal area (3.9±0.8mm<SUP>2</SUP> vs. 1.0±0.4mm<SUP>2</SUP>, <I>p</I><0.001), and the histopathologic area of stenosis (67.1±8.8% vs. 17.4±10.0%, <I>p</I><0.001) were reduced in the α-LA coated stent group compared to the control stent group.</P><P><B>Conclusions</B></P><P>α-LA feeding and α-LA coated stents inhibit neointimal hyperplasia in porcine ISR, possibly through inhibiting the activation of NF-κb pathway and proliferation of PVSMC.</P>

Design and evaluation of electron beam energy degraders for breast boost irradiation

Park, Jong In,Ha, Sung Whan,Kim, Jung-in,Lee, Hyunseok,Lee, Jaegi,Kim, Il Han,Ye, Sung-Joon BioMed Central 2016 Radiation oncology Vol.11 No.-

<P><B>Background</B></P><P>For breast cancer patients who require electron boost energies between 6 and 9 MeV, an energy degraders (ED) in the 9 MeV beamline was specially designed and manufactured to increase the skin dose of 6 MeV and to reduce the penetration depth of 9 MeV beams.</P><P><B>Methods</B></P><P>We used Monte Carlo (MC) techniques as a guide in the design of ED for use with linear accelerators. In order to satisfy percent depth dose (PDD) characteristics and dose profile uniformity in water, the shape and thickness of Lucite® ED in the 9 MeV beamline was iteratively optimized and then manufactured. The ED geometry consists of a truncated cone attached on top of a plane plate, with total central thickness of 1.0 cm. The ED was placed on the lower most scraper of the electron applicator. The PDDs, profiles, and output factors were measured in water to validate the MC-based design.</P><P><B>Results</B></P><P>Skin doses with the EDs increased by 8–9 %, compared to those of the 9 MeV beam. The outputs with the EDs were 0.882 and 0.972 for 10 × 10 and 15 × 15 cm<SUP>2</SUP> cones, respectively, as compared to that of a conventional 9 MeV beam for a 10 × 10 cm<SUP>2</SUP> cone. The X-ray contamination remained less than 1.5 %. In-vivo measurements were also performed for three breast boost patients and showed close agreement with expected values.</P><P><B>Conclusions</B></P><P>The optimally designed ED in the 9 MeV beamline provides breast conserving patients with a new energy option of 7 MeV for boost of the shallow tumor bed. It would be an alternative to bolus and thus eliminate inconvenience and concern about the daily variation of bolus setup.</P>

Evaluation of ion implantation for anti-thrombogenic coronary stent in vitro and in vivo

Shim, Jae-Won,Bae, In-Ho,Park, Dae Sung,Lim, Kyung-Seob,Lee, So-Youn,Jang, Eun-Jae,Park, Jun-Kyu,Kim, Ju Han,Jeong, Myung Ho Elsevier 2017 Journal of industrial and engineering chemistry Vol.54 No.-

<P><B>Abstract</B></P> <P>The aim of this study was to evaluate the effect of ion implantation on the surface of anti-thrombogenic coronary stent. Nitrogen (N) was implanted into the cobalt–chromium surface by using an ion source under a plasma environment to enhance its hardness and surface modification. The N ion dosage was 1×10<SUP>15</SUP> ions/cm<SUP>2</SUP>. All analysis results of the ion implanted stent were compared with those of bare metal stent. The N component and distribution were confirmed by auger electron spectroscopy. Microhardness was significantly increased after 40min of implantation (415.3±12.38 HV, 18.9±2.62%). The surface was altered to hydrophobic status through ion implantation (30.6±1.12% in contact angle increment). Platelet adhesion, and smooth muscle cell migration and proliferation were prevented in the ion implanted group (43.9%, 11.2%, and 45.1%, respectively). To verify the in vitro result, stents were implanted to rabbit iliac artery and isolated at 4 weeks post implantation. Then, the stents were subjected to histological analysis. No significant differences in injury score, internal elastic lamina, lumen area, and restenosis rate were found. However, the fibrin score was more significantly decreased in the ion beam-implanted group (2.5±0.15) than in the bare metal stent group (1.8±0.31, <I>n</I> =10, <I>p</I> <I><</I> 0.05). Taken together, ion beam implantation may be an efficient accessorial tool for preventing in-stent restenosis and in-stent thrombosis.</P>

스키 리조트 이용자의 여가갈등에 관한 연구

한우진(Woo Jin Han),이장희(Jang Hee Lee),여인성(In Sung Yeo) 한국여가레크리에이션학회 2005 한국여가레크리에이션학회지 Vol.29 No.-

Although various studies concerning leisure conflict have been conducted in the U.S, there is little research in this area for Korean. There are many both unasked and unanswered questions in the experience of leisure conflict between or among various leisure activity group. Therefore, an attempt to understand the experience of leisure conflict in ski resort between skier and snowboarder may provide new insights into the nature of leisure conflict of Korean. The purpose of this study was to examine differences of leisure conflict by demographic variables and investigated effect of user’s characteristics in leisure conflict between skier and snowboarder.For this study, 482 participants were selected from 2 ski resorts located in Kangwon Province for one month from January 15th to February 15, 2005, using the convenience sampling method. For the data analysis SPSS 12.0 for Windows version was utilized. The hypothesis tests were conducted with independent t-test, one-way ANOVA, and Multiple Linear Regression to solve problems of the study. On the basis of the results, the conclusions were drawn as follows; 1. There are differences in leisure conflict between or among skier and snowboarder’ demographic characteristics(gender and age group) 2. Leisure conflicts of skier are effected by user’s background in both in-group and out-group. 3. Leisure conflicts of snowboarder are effected by user’s background in both in-group and out-group.