Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-kB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1

( Jae Ho Choi ),( Sun Woo Jin ),( Eun Hee Han ),( Bong Hwan Park ),( Hyung Gyun Kim ),( Tilak Khanal ),( Yong Pil Hwang ),( Minh Truong Do ),( Hyun Sun Lee ),( Young Chul Chung ),( Hee Suk Kim ),( Tae 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

Purpose: The consequences of precipitously rising allergic skin inflammation rates worldwide have accelerated the risk of atopic dermatitis (AD). Natural product-based agents with good efficacy and low risk of side effects offer promising prevention and treatment strategies for inflammation-related diseases. We have already reported that Platycodon grandiflorum root-derived saponins (Changkil saponins, CKS) have many pharmacological effects, including anti-inflammatory and anti-allergic effects, but its influence on AD remains unclear. Therefore, we evaluated the inhibitory effect of CKS, mainly platycodin D, on AD-like skin symptoms in mice and the possible mechanisms in cells. Methods: Mice were sensitized and challenged with 2,4-dinitrochlorobenzene (DNCB). Four weeks after challenge, mice were treated with oral administration of CKS for 4 weeks. In addition, cells were used to evaluate the effect of CKS, mainly platycodin D, on the TARC expression regulated mechanism. Results: CKS attenuated DNCB-induced dermatitis severity, serum levels of IgE and TARC, and mRNA expression of TARC, TNF-α, IFN-γ, IL-4, IL-5, and IL-13 in mice. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells and mast cells in the ears. Moreover, CKS and platycodin D inhibited TNF-α/IFN-γ-induced TARC expression through the suppression of NF-κB and STAT1 and induction of Nrf2/ARE-mediated hemeoxygenase-1 (HO-1) expression in cells. Conclusion: We suggest that CKS and platycodin D inhibited the development of AD-like skin symptoms by regulating cytokine mediators and may be an effective alternative therapy for AD-like skin symptoms.ⓒ2014 Elsevler Gmbh. All rights reserved.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

多國籍企業進出下의 經濟統合의 理論的 效果分析

한봉수,김상호 大邱大學校 社會科學硏究所 1997 社會科學硏究 Vol.4 No.2

다국적기업진출하의 경제통합으로부터 현지국들이 얻는 이익은 다국적기업에 의한 외국이윤전환효과가 발생할 때 후생이 증대하고 외국이윤창출효과가 발생할 때 후생이 감소한다는 내용을 역내다국적기업이 경쟁적인 경우와 독점적인 경우로 나누어 살펴 보았다. 따라서 다국적기업진출하의 경제통한으로부터 현지국이 직접적인 이익이나 정(正)의 파급효과를 얻기 위해서는 역내교역에서 국내기업들에 의한 교역비중을 높여야하고, 역내의 적정교역량에 영향을 미치지 않는 범위내에서 다국적기업에 의하여 벌어들인 추가적인 지대나 이윤등에 조세정책이나 다른 정책수단을 통하여 현지국에 정책적 개입을 하여야 손실을 줄일 수 있으며, 나아가서 이익으로 이끌게 할 수 있다.

기어의 자동설계와 검증에 관한 연구

한민식,김승현,송호봉,전언찬 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

Gear is main machine element which is used for the power transmit device when it si short in the gear. We use a standard goods in the case of the gear. But in case of special purpose, we need to manufacture the gear that have different angles. In this paper, we manufactured standard gears using W-EDM and Hobbing machine. We got a 3D shape doing reverse engineering manufactured gears. And then compared CAD data and measured data. Finally we verified ADS through comparing ADS data and KISSsoft data.

韓國企業의 對中國直接投資 現況과 投資成果分析

한봉수,김상호 大邱大學校 社會科學硏究所 1998 社會科學硏究 Vol.5 No.4

한국기업의 대중국 투자성과를 알아보기 위하여 사용한 지표로는 투자동기의 달성, 현지 법인의 수익성, 현지법인의 성장성, 본사와의 관계, 합작파트너와의 관계등의 항목을 사용하였으며 그 결과는 업종별·투자지역별·규묘별로 상이한 양상을 보이고 있다. 제3국 수출 또는 대한국 수출을 목적으로 투자한 기업이 내수시장 진출을 목적으로 투자한 기업에 비하여 현지적응력 즉 투자성과가 높은 것으로 나타나고 있으며 지역별로는 청도, 천진 등 발해만 지역에 투자한 기업이 기타지역 투자기업에 비하여 높은 투자성과를 보이고 있다. 그리고 기업규모별로는 경공업중심의 소규모기업이 중공업중심의 대기업보다 투자수익성이 월등히 높았으며 또한 제조업이 비제조업보다 투자수익성이 높게 나타났다. 그러나 중국에 진출한 많은 한국기업들이 양적 확대에 버금가는 질적인 투자성과를 내고 있지 못함을 알 수 있었다.

만성정신질환자의 욕구에 대한 수요자(환자)와 공급자(치료자) 측면의 비교 연구

안강호,이종국,한은선,김명식,김장배,손봉희 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

Objectives : We performed this study to assess the needs of the chronically mentally ill(CMI) from the perspectives of the consumers(patients) and the providers(therapists) and to compare the differences between them. We also aimed to find met needs and unmet needs and then to determine the priority of the mental health services for the CMI. Methods : 165 patients and 19 therapists were examined with need assessment tool which had been developed by authors. Through statistical analysis, we evaluated the degree of problem, the degree of intervention, the relative degree of problem, and the degree of demand in each areas of needs, and compared the differences between patient group and therapist group. After then met needs and unmet needs from the perspectives of each group were revealed. Results : 1) There were differences in the assessment of needs between patients and therapists. 2) The more problem areas assessed by patients were finances, mental health, occupation, and leisure life in order of higher ranks. While occupation, leisure life, mental health, and finances were assessed as highly ranked problem areas by the therapist group. 3) Patients perceived that they were given more helps from others in the areas of mental health, physical health, accommodation, and relation to family than other areas. From the perspective of therapists, the areas of needs such as mental health, basic knowledge, occupation, and interpersonal retation were highly ranked intervention areas. 4) The demands for daily living skill, occupation, finances, accommodation were ranked highly by patient group. Highly demanded needs assessed by therapist group were mental health, occupation, interpersonal relation, and basic knowledge. 5) Unmet needs assessed by patient group were occupation, finances, and accommodation, while by therapist group, occupation. Conclusions : The needs of the CMI were assessed and identified by the consumers(patients) and providers(therapists) with the same tool. The differences between two groups were revealed. The most important unmet need of the CMI was occupation. These results can be used to plan the priority of mental health services and policies.

반도체 미립자를 함유한 Silica Glass의 제조 및 특성

류봉기,이승한,임재호 釜山大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.55 No.-

본 연구에서는 Sol-Gel법을 이용하여 우수한 양자 사이즈 효과를 가진 ZnS를 함유한 실리카 유리를 제조하였다. 출발 물질로서 Si(OC₂H)₄와 Zn(CH₃COO)₂·2H₂O를 사용하여 무색 투명한 겔을 제조하였다. 얻어진 겔을 600℃에서 열처리를 하여 상온에서 H₂S gas와 반응시켜 유리 내에 ZnS 미세결정을 형성시켰다. ZnS 미립자의 밴드갭 에너지 3.71∼4.27eV였는데 이 값은 벌크상 ZnS의 밴드갭보다 약 0.1∼0.5eV 더 높은 수치를 나타내었다. ZnS 미세결정의 크기는 EMA(Effective Mass Approximation)에 의해 구하였는데, 이는 ZnO의 투여량과 H₂S gas와의 반응시간에 따라 변화하였다. ZnS 미세결정의 크기가 증가함에 따라, 광흡수단은 낮은 에너지영역으로 이동하였는데, 이 현상은 양자 사이즈 효과를 보여주고 있다. In this study, Sol-Gel process has been applied to make ZnS-doped silica glass having a significant quantum size effect. Si(OC₂H)₄ and Zn(CH₃COO)₂·2H?O were used to prepare transparent and colorless gels. These gels were heated at 600℃, then reacted with H₂S gas to form fine ZnS microcrystals in glasses. The opical band gap of the ZnS microcrystals was 3.71∼4.27eV, which was 0.1∼0.5eV higher than that of bulk ZnS crystal. The size of ZnS microcrystals calculated by EMA(Effective Mass Approximation) in glasses changed with ZnO concentration and H₂S gas reaction time. As the size of the ZnS microcrystal increased, the absorption edge of spectra shifted to the low-energy side, thus providing quantum size effect.

단순지지된 슬래브교량의 간편방법에 의한 해석

신철호,한봉구 서울産業大學校 2005 논문집 Vol.54 No.2

The simple supported slab bridges are analyzed by the specially orthotropic laminates theory. This method, however, may be too difficult for some practising engineers. In this paper, the result of analysis for such plate by means of the beam theory with unit width is reported. By using the "correction factor", the accurate solution for the plate can be obtained by the beam theory. The result of this paper can be used for reinforced concrete slab bridges analysis by the engineers with undergraduate study in near future

SS400강 용접부의 파괴인성치에 관한 연구

국정한,송일규,김봉중,오세용,성호현 한국기술교육대학교 1999 論文集 Vol.6 No.1

In this work, we studied the mechanical properties, structure and the stress intensity factor of the welded areas which were annealed from 500。C to 900。C with an interval of 100。C. The main results are as follow. 1. The as-welded specimen showed the highest tensile strength and yield point. The tensile strength and the yield point decrease as the annealing temperature increased from 500。C to 900。C, and they became smaller in the order of deposited metal, heat affected zone and base metal. 2. The hardness was maximum at about 9 mm from the welding center line, and it decreased drastically in the heat affected zone located between 9∼15mm from the center line. 3. The elongation decreased in the order of base metal, the fusion zone and heat affected zone while it increased as annealing temperature increased. 4. The stress intensity factor(S. I. F.) declined as the length of notch increased and it became smaller in the order of fusion zone, base metal and heat affected zone. This is because fracture toughness is affected by brittlization at heat affected zone as well as the initiation and propagation of cracks.