Hypolipidemic effect of MeOH extract of Bambusae Caulis in Taeniam in hyperlipidemia induced by Triton WR-1339 and high cholesterol diet in rats.

Ham, Inhye,Yang, Gabsik,Lee, Jaejun,Lee, Kyung-Jin,Choi, Ho-Young Marcel Dekker 2009 IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY Vol.31 No.3

<P>Hyperlipidemia has been implicated in atherosclerosis which is the leading cause of death among world population and resulting from lipid metabolic changes is a major cause of atherosclerosis. Bambusae Caulis in Taeniam belongs to Bambusaceae is the stem of Phyllostachys nigra (Lodd.) Munro var. henonis (Bean) Stapf of Phyllostachys bambusoides Siebold et Zuccarini, the perennial evergreen tree. The green middle layer of stem is dried in string-shape I shadow after the bark had been removed. In this study, the effects of middle layer of PN, PB, PP, and BCT on rat with hyperlipidemia, induced by Triton WR-1339 and high cholesterol diet were investigated. We measured plasma levels of triglyceride, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol as measure of its hyperlipidemic effects. As a result, all of the Bambusae Caulis in Taeniam was reduced total cholesterol, LDL. Inhibition rate on LDL-oxidation, hACAT-1, and hACAT-2 was increased dose-dependently. Therefore all of the Bambusae Caulis in Taeniam is a good candidate for the treatment on Triton WR-1339 and high cholesterol diet-induced blood circulatory disorders, obesity, and hyperlipidemia.</P>

Effects of honokiol on the spontaneous motility of mouse ileum

Inhye Ham,Hoyoung Choi,Geunyong Park,Mehari Endale,Man Hee Rhee,Kil Soo Kim,Tae Wan Kim 한국실험동물학회 2007 한국실험동물학회 학술발표대회 논문집 Vol.2007 No.-

민간 상황제제의 생리활성

함인혜,정민영,최용주,이상대,성환길,심상수,황완균 중앙대학교 약학연구소 2000 약학 논총 Vol.14 No.-

Phellinus linteus(polyporaceae) has been used as anti-cancer agent in Korea. We were studied to evaluate the anti-tumor and immunopotentiation effect of Phellinus lintenus(PL) single and mixing administration with three anti-tumor agents in folk medicines(Ulmus davidiana var japonica, Cudrania tricuspiata, and Bupleurun palcatum). Oral administraion to tumor bearing mice significantly prolonged suvival rate compared to control group with the prolongation ratio of 2% to 9%. Nitrite production of Raw 264.7 cell was increase dose-dependently

인삼류의 미량원소 함량분석

함인혜,전인주,김호현,고성권,황완균 중앙대학교 약학연구소 2002 약학 논총 Vol.16 No.-

Organic Ge and Se are very important agents of anti-cancer and preventive geriatric disease drugs so on. We were carried out the micro-elements(Ge, Se, Fe, Mg and Zn) content of several Ginsengs that were cultivated in Korea(6 regional groups) and foreign countries(Japan, China and America) by ICP analysis. From results, Ginseng of Kumsan have been appeared to high levels of Ge and Se contents in comparison with other regional samples. Especially 4 years old Ginseng appeared to high levels of Ge, Se but also Fe, Mg and Zn contents.

茵蔯蒿와 韓茵蔯이 Triton WR-1339로 유도된 고지혈증 흰쥐에 미치는 영향

함인혜,정성웅,이경진,박규하,최호영 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1

Objectives : In order to elucidate hyperlipidemia effect of the aerial part of A. capillaris and A. iwayomogi, an experimental study was performed on the hyperlipidemia of rats induced by Triton WR-1339. Methods : The amount of total cholesterol, triglyceride, phospholipid, HDL-cholesterol, LDL-cholesterol, AST, and ALT were measured. Results : In the hyperlipidemia of rats induced by Triton WR-1339, A. capillaris and A. iwayomogi showed decreasing effects on total cholesterol, triglyceride, phospholipid,, LDL-cholesterol. ALT, and AST. Especially, A. iwayomogi showed significant decreasing effects on total cholesterol, and phospholipid. Conclusion : According to the results, A. capillaris and A. iwayomogi need to considered for the application in hyperlipidemia

효소가수분해 실크펩타이드의 항당뇨활성

함인혜,김호현,이승재,조형권,황완균 중앙대학교 약학연구소 2001 약학 논총 Vol.15 No.-

Recently, hydrolyzed silk peptide on acid and alkaline were developed and studied on anti bacterial, cryoprotective, antioxidant, anticancer and antidiabetic activities. For the investigation of antidiabetic drug, we were elucidated the effects of enzyme hydrolyzed silk peptide on streptozotocin induced hyperglycemia, silk peptide of two different molecular weight were administrated after injection of streptozotocin (50mg/kg, ip), and blood glucose, serum triglyceride and serum cholesterol levels were determined at 4 days after streptozotocin injection. And the results were as following: 1. The blood glucose levels of streptozotocin induced hyperglycemic rats were significantly decreased by the administrations by various dose of silk peptide of Japan Products and glibenclamide and especially enzyme hydrolyzed silk peptide were showed to decrease glucose levels than another silk peptide. 2. The serum cholesterol levels of streptozotocin induced hyperglycemic rats were significantly decreased by the administrations by various dose of silk peptide of Japan Products and glibenclamide and especially enzyme hydrolyzed silk peptide were showed to decrease cholesterol levels than another silk peptide. 3. The serum triglyceride levels of streptozotocin induced hyperglycemic rats were significantly decreased by the administrations by various dose of silk peptide of Japan Products and glibenclamide and especially enzyme hydrolyzed silk peptide were showed to decrease triglyceride levels than another silk peptide.

육총용류의 면역증진 효과 비교 연구

오정석,함인혜,김형민,최호영 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1

Objectives : This study was to investigate the anti-immobility effect of Cistanche deserticolae Herba (CD) and Cistanche salsae Herba (CS) Methods : Forced swimming test (FST) and changes of blood biochemical parameters related to fatigue, glucose (Glc), blood urea nitrogen (BUN), latic dehydrogenase (LDH) aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total protein (TP) were investigated. Results : CD and CS were orally administered to mice for 7 days. After 7 days, the immobility time was significantly decreased in the CD-treated group and CS-treated group in comparison with the control group. The contents of serum AST were significantly decreased and contents of Glc and LDH were decreased in CD-administration group . However, it had no effect on the elevation of TP level, whereas, the contents of GIc were increased and the contents of ALT, BUN and LDH in the blood serum were decreased in the CS (0.01 g/kg/day)-fed group. Conclusions : These results suggest that Cistanche herba, CD and CS may have immune-enhancing effect.

희첨류 한약재의 포제가 혈압에 미치는 영향

최동일,함인혜,박규하,최호영 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1

Objective : This study was carried out to compare the components regarding medicinal parts of Siegesbeckiae Herba and its habitats using TLC patterns. Then hypotentive effects, which depend on the preparation process was measured on Siegesbeckiae Herba. Methods : The Siegesbeckiae Herba were prepared with 70% MeOH extract and was fractionized. Also Siegesbeckiae Herba was steamed several times with Makkolli and its residue was attained. Hypotensive effect was obtained by measuring mean B.P. from femoral artery in rats. Results : The components were significantly different depending on their medicinal parts and habitats in TLC patterns. The more Siegesbeckiae Herba was steamed, the more some compounds decreased. As for mean B.P., it dropped significantly when Siegesbeckiae Herba was steamed 9 times. It dropped remarkably after 30 min. then mainteined afterwards. Also 60% and 100% methanol fraction of Siegesbeckiae Herba showed significant hypotensive effect. Conclusions : We concluded that Siegesbeckiae Herba have different compounds according to their medicinal parts and habitats. Also the steaming process with Makkolli increases hypotensive activity.

Vasorelaxant Effect of Osterici Radix Ethanol Extract on Rat Aortic Rings

Lee, Kyungjin,Park, Geunyong,Ham, Inhye,Yang, Gabsik,Lee, Mihwa,Bu, Youngmin,Kim, Hocheol,Choi, Ho-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-

<P>The root of <I>Ostericum koreanum</I> Maximowicz has been used as a traditional medicine called “Kanghwal” in Korea (or “Qianghuo” in China). The purpose of this study was to investigate the vasorelaxant activity and mechanism of action of an ethanol extract of the <I>O. koreanum</I> root (EOK). We used isolated rat aortic rings to assess the effects of EOK on various vasorelaxant or vasoconstriction factors. EOK induced vasorelaxation in phenylephrine hydrochloride (PE) or KCl precontracted aortic rings in a concentration-dependent manner. However, the vasorelaxant effects of EOK on endothelium-intact aortic rings were reduced by pretreatment with <SMALL>L</SMALL>-NAME or methylene blue. In Ca<SUP>2+</SUP>-free Krebs-Henseleit solution, pretreatment with EOK (0.3 mg/mL) completely inhibited PE-induced constriction. In addition, EOK (0.3 mg/mL) also completely inhibited vasoconstriction induced by supplemental Ca<SUP>2+</SUP> in aortic rings that were precontracted with PE or KCl. Furthermore, the EOK-induced vasorelaxation in PE-contracted aortic rings was inhibited by preincubation with nifedipine. These results indicate that the vasorelaxant effects of EOK are responsible for the induction of NO formation from <SMALL>L</SMALL>-Arg and NO-cGMP pathways, blockage of the extracellular Ca<SUP>2+</SUP> entry via the receptor-operative Ca<SUP>2+</SUP> channel and voltage-dependent calcium channel, and blockage of sarcoplasmic reticulum Ca<SUP>2+</SUP> release via the inositol triphosphate pathway.</P>

Vasorelaxant effect of Ligusticum jeholense root and rhizoma on rat thoracic aorta

Bumjung Kim,Kyungjin Lee,Chinannai Khanita Suman,Inhye-Ham,Ho-Young Choi 한국약용작물학회 2015 한국약용작물학술대회 발표집 Vol.2015 No.05