새로운 Acetylcholinesterase inhibitors의 합성

최순규,김형민,조승환,최학기,박유미,이용균,정대일,김인식,한정태 동아대학교 부설 기초과학연구소 2004 基礎科學硏究論文集 Vol.21 No.1

노인성 치매의 일종인 alzheimer's disease의 효과적인 억제제를 합성하기 위해 우리는 분자 모델링에 의한 가장 적합한 물질인 m-[(N,N,N-trimethylammonio)phenyl]boronic acid를 합성하였다. 출발물질인 3-aminophenylboronic acid monohydrate의 경우 boronic acid의 작용기인 hydroxyl group을 protecting시킴으로써 반응의 안정성을 기하였다. Quarternary ammonium salt는 과량의 methyliodide와 염기 촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시켜 상당히 높은 수율을 얻을 수 있었다. 또한 과량의 methyliodide와 염기촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시킨 결과 boronic acid의 protection없이도 안정하게 반응이 진행되어짐을 확인할 수 있었다. In order to syntheisize a effective inhibotor for alzheimer's disease, we synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 which is designed by molecular modeling form. We protected the hydroxyl group of 3-aminophenylboronic acid monohydrate 1 with ethlyne glycol to remove the reactivity if hydroxyl group. To synthesize m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4, we reacted 3-aminophenylboronic acid monohydrate 1 with ezcess methyl iodide and potassium hydrogen carbonate as a base-catalyst in methanol. but On executed reaction without protection on hydroxyl group, we found out the result that the hydroxyl group of boronic acid group at 3-aminophenylboronic acid monohydrate 1 didn't react with excess methyliodide. Synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 is in progress about biological tests as a plausible acetylcholinesterase inhibitor.

함박꽃나무(Magnolia sieboldii)의 추출성분

최인호,이학주,최돈하,박재인,최태호 한국목재공학회 2004 목재공학 Vol.32 No.2

함박꽃나무 수피 및 목부의 EtOH 조추출물로부터 prep. TLC. silica gel 및 Sephadex LH-20 칼럼 크로마토그라피를 이용하여 4종의 화합물을 단리하였다. 이들 화합물들은 NMR, MS 등의 기기분석에 의해 sesquiterpene lactone 구조의 costunolide (Ⅰ)를 비롯하여, 리그난 배당체 화합물인 syringin (Ⅱ)과 1, 2-dihydroxyxanthone (Ⅲ) 및 vanillic acid (Ⅳ)으로 각각 동정하였다. Four phenolic compounds were isolated from the wood and bark of Magnolia sieboldii. The structures were determined as costunolide(Ⅰ), syringin(Ⅱ), 1,2-dihydroxyxanthone(Ⅲ), and vanillic acid(Ⅳ), respectively, on the basis of spectroscopie data.

狗耕田譚의 民俗學的 硏究

崔仁鶴 관동대학교 1976 關大論文集 Vol.4 No.1

1. Approach to Study in Folklore Study of folktales has been made by many other scholars since Grimm brothers had begun. The study of folktales has been processed in situation of literature, socio-psychology, anthropology, ethnology. It has been processed also in Korea, Japan, and China since early 20th centuries. In China folktales have been classified by W. Eberhard. In Japan folkloristic study of the folktales had been attempted by K.Yanagida and thereafter they were arranged and classified by K.Seki and H.Ikeda. In Korea Jin-Tae Son had attempted to begin its study since 1930's, but it was merely in the stage of enlightenment in view point of history of the study. However since 1950 the study of folktales has been made mainly by scholars of national language and Iiterature. It came to realize that the folktale, as A.Aarne and K. Klohn insisted, has its individual history and channel of transmission. Therefore, it is consented that folktale should be studied its essence by itself than it deals with other fields. Among Korean folktale there is a story which a dog plows a fileld. Similar stories can be found in China and Japan. Then, in what background of folklore and of times did this story originate? And how was it transmitted down? 2. Summary of the Story and its Problems There were two brothers, and younger brother went to visit his mother's grave. He found a dog by the grave and took it home and raised it. The dog plowed a field for him. He became rich because of its help. The elder brother borrowed the dog but the dog did not plow a field and was killed by him. The younger brother buried its body, and then a tree grew up from the grave. It grew up high enough to pierce the storeroom of the heaven. Thus the younger brother became very rich because of the treasure from the storeroom of the heaven. The elder brother moved the tree to his house. Then, the tree pierced the toilet of the heaven so that all of the feculence came down and filled up his house. So he became very poor. Such contents of folktales, although there are a little differences in expression, have been transmitted also in China and Japan. China: No.30 Der Hund pfeugt das Feld. Type chinesischer Volksmarchen. 1937.FFC 120. by W.Eberhard. Japan: No.503 E.F. Kamotori-jiji and Hanasaka-jiji. A Type and Motif Index of Japanese Folk-Literature. 1971. FFC 209. by H. Ikeda. Korea: No.458 Two Brothers and A Dog. A Type Index of Korean folktales. 1975, Tokyo. by In-Hak choi. This folktale is to described an internal conflict of human being. Through the birth of supernatural dog it brings the good good fortune, while the bad punishment. The content of this folktale is very instructive. However, why the dog should appear in the folktale is the most important view of all. In order to solve this problem, first of all, it is necessary to study the nature and folklore of the dog. 3. The Nature and Folklore of the Dog According to the Hasting's dictionary, the dog has a complicated relationship with human being. It is used, for example, for a game, a hunting, a war, an ancestor, a spiritual being, a messenger of god, a beast of burden, a magic etc. Frazer indicated that the dog was used as a spirit of grains. Among the folktales in China and Korea the dog often appears when man becomes a dog after death. The dog is concerned as a spiritual animal in China and Japan, on the other hand they sometimes are apt to consider a dog as an object of enmity or hatred. In Korea it is known as a messenger which leads the soul to the other world whin man dies, and as an animal which brings good fortune. On the other hand, the dog is used for food because if one eat meat of a dog, he can stand well intense heat in summer. In some place of Japan pregnant women worship a dog in order to have a easy childbirth since a dog is usually easy to have a pup. In the old days of Korea and Japan, judging from a dog's barking, they used to tell the rise and fall of a nation or death of a great man. 4. Analyses of the Content and Conclusion In this folktale there are three important motives: an appearance of a dog, a miracle of a dog, and other miracles after its death. There are many variations in the third motif since it can be changed by story-tellers in their own way and even some of them became comic tales. In the part of an appearance of a dog 1) gift of god of king of dragon kingdom (china, Japan), 2) floating down along the stream(Japan), 3) coming out from the grave (China, Korea), 4) raising up (China, Korea, Japan), there are four forms. 1) and 2) belong to the same genre, which has a background of the concept-dog is a messenger of a god. 3)belongs to the concept of Jeonsaeng (轉生) (man is born again to other person or an animal after death). 4) is the latest form of all and a part of the appearance of superrealistic dog seems to be missed. Next, a miracle of a dog 1) plows a field(China, Korea), 2) brings an abundant harvest from hunting(Japan), 3) gets treasure (China, Japan, Korea), 4) transforms into human(China, Korea), can be devided into four forms. 1) It is in doubt that the dog really plowed a field, however, it is clear that a dog was associated with farming. They believe it was a dog that brought man grains at first time in China. 2) Considering a role of a dog in the age of hunting, it is a likely source. 3) belongs to the concept which a dog brings a good fortune. 4) belongs to the concept of Jeonsaeng(轉生). This folktale has not widely been distributed in Korea as much as in China. Korea imported a farming culture from China. with this respect, I believe that this folktale might be originated from China, consequently, it has been transmitted to Korea.

난지형 조숙종 마늘 신품종 ‘올캐’ 특성

최학순(Hak Soon Choi1),채원병(Won-Byoung Chae),곽용범(Yong-Bum Kwack),정명일(Myeong-Il Jeong) 한국원예학회 2008 한국원예학회 학술발표요지 Vol.2008 No.12

원예연구소 남해출장소에서는 원예적 특성이 우수한 유전자원을 도입 선발하여 ‘올캐’로 명명하였다. 특성평가를 2000년부터 3년간 실시하였으며 2003년부터 3년간 지역적응시험을 실시한 결과 그 특성이 우수하여 품종등록 하였다. 도입 육성한 ‘올캐’ 마늘은 난지형 조숙종 마늘로 생태형으로는 난지형이며 추대형은 완전 추대종이다. 인경의 모양은 아래가 평편한 구형이며 구색과 인편색은 약간 자색이 돈다. 인편의 배열은 동심형(concentric)으로 ‘남도’ 마늘과 같다. 초형은 직립이며 초장, 엽초경 및 잎의 수는 대비종인 ‘남도’ 마늘에 비해서 약간 작거나 적으며 잎의 색깔은 ‘남도’ 마늘에 비해서 약간 연한 녹색이다. 평균구중은 42.2g으로 ‘남도’ 마늘 40.5g 보다 약간 무거우며 인경의 모양은 대비종인 ‘남도’ 마늘과 비슷하다. ‘올캐’ 마늘의 추대기는 3월 하순으로 ‘남도’ 마늘보다 15~20일 정도 빠르며 수확기도 일주일 이상 빠르다. Namhae Sub-station of National Horticultural Research Institute has collected 240 different garlic germplasms since 1999 and has used germplasms of superior quality. Among them, ‘Namhae 57328’ is a precocious variety with superior characteristics of growth and bulb, and was named ‘Allkae’ garlic (Allium sativum) in 2006. The garlic was registered after 3 consecutive years’ assessment of the variety trait starting from 2000 and a 3 consecutive years’ adaptability test from 2003. The ecotype of ‘Allkae’ garlic is southern one and bolting one is complete bolting type. The bottom of a bulb is flat and the colors of a bulb and a clove are light purple, and the arrangement of cloves is concentric as in ‘Namdo’ garlic. The plant type is erect one and its height is slightly smaller than ‘Namdo’ garlic’ one but it’s bolting in mid March which is about 20 days ahead of ‘Namdo’ garlic. Average bulb weight is 42.2 g which is slightly heavier than ‘Namdo’ garlic (40.5 g). The shape of the bulb is similar with ‘Namdo’ garlic.

서브 - 링의 신드롬 분석을 이용한 하이퍼큐브 진단 알고리즘

김학원(Hak-Won Kim),김동군(Dong-Kun Kim),최문석(Moon-Seok Choi),이충세(Chung-Sei Rhee) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.2Ⅰ

하이퍼큐브의 정규직이며 계층적인 구조적 특성은 효율적인 진단 알고리즘 개발에 유리하게 적용될 수 있다. Feng et al.의 HADA/IHADA와 Choi와 Rhee의 적응적 큐브 분할 방법은 하이퍼큐브의 전체 노드를 하나의 링으로 임베딩하여 링의 진단 특성을 이용하여 위하여 분할 및 정복 방법을 이용하였다. 또한 Kranakis와 Pelc는 결함을 모두 포함하는 최소의 서브링을 하나의 노드로 하는 하이퍼큐브의 형태로 분할하는 HYP-DIAG 알고리즘을 제안하였다. 또한 최악의 경우에, 테스트 수만을 고려하여 2ⁿ+3n/2의 테스트 수를 갖는 FAST-HYP-DIAG 알고리즘과 병렬 시간만을 고려하여 많아야 11테스트 라운드 이내에 진단을 수행하는 EXPRESS-HYP-DIAG 알고리즘을 제안하였다. 본 논문에서는 HYP-DIAG의 첫 번째 단계에서 얻어진 서브링들의 신드롬을 분석하여 테스트의 수와 테스트 라운드를 모두 고려하는 알고리즘을 제안한다.

GG-38 : Minimal invasive surgery (LESS) for huge cystic adnexal tumors in whole abdomen

( In Young Choi ),( Ji Hye Lee ),( Mi Hyun Park ),( Ji Kwoun Park ),( Jeong Kyu Shin1 ),( Won Jun Choi1 ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

Laparoendoscopic single-site surgery (LESS) is helpful if not an evidence of suspicious malignancy in huge adnexa tumors. This approach might be reasonable alternative to conventional laparoscopic surgery. We report two cases with LESS for huge cystic adnexal tumors in whole abdomen. A 58 years old multigravida woman in menopause underwent removal of a huge cystic adnexal mass that occupied her entire abdomen by LESS.(ca.5200ml aspiration) A 15 years old single nulligravida woman had a huge cystic adnexal tumor in whole abdomen reaching to the level of the xyphoid process. A needle through the transumbilical single port was inserted directly under the mass. Subsequently, 8000 ml of cystic fluid was aspirated without spillage.

滿文으로 쓰여진 乾隆帝의 「御製盛京賦」에 對해서

崔鶴根 단국대학교 인문대학 국어국문학과 1968 國文學論集 Vol.2 No.-

만주어로 쓰여진 문헌은 현재까지 약 이천종으로 추산되고 있으나, 1945년 이전의 북경대학도서관과 현재의 미국연경학회, 그리고 대만의 고궁박물원도서관에는 아직도 미정리의 만주어문헌이 다수 있는 것으로 들리고 있음으로 아직도 알려지지 않던 문헌이 장차 많이 소개될 것으로 기대되고 있다. 그러나 만주어문헌은 이미 19세기말엽부터서 서구의 동양학자 및 선교사들에게 의해서 연구되고 또 분류소개되어서 현재까지 상당한 숫자의 도서목록이 작성되어 있다.

경찰의 조직문화와 직무만족간의 관련성에 관한 이론적 고찰

최학봉 한국경찰학회 2003 한국경찰학회보 Vol.5 No.2

CPW급전을 이용한 UWB 안테나 설계

최석호,이성훈,김학선,박종권 한밭대학교 정보통신전문대학원 2004 정보통신전문대학원 논문집 Vol.2 No.1

본 논문은 CPW급전 구조와 CST사의 Microwave Studio 사용하여 UWB 안테나를 설계하였다. 시물레이션 결과 제안된 안테나의 대역폭은 3.O5-13GHz를 가지고 방사패턴은 무지향성의 형태를 갖는 것을 보였다. In this paper, we have designed a UWB antenna using CPW feed line and used the Microwave Studio of CST to simulate the UWB antenna. Simulated results show that antenna bandwidth is 3.05-13GHz and radiation pattern is omni-directional.

小兒血淸 및 腦脊髓液內 乳酸脫水素酵素 活性度에 對하여

崔德瀯,韓學洙 대한소아과학회 1965 小兒科 Vol.8 No.5