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Lee, Yoon‐,Mi,Lim, Ji‐,Hong,Yoon, Haejin,Chun, Yang‐,Sook,Park, Jong‐,Wan Wiley Subscription Services, Inc., A Wiley Company 2011 Hepatology Vol.53 No.1
<P><B>Abstract</B></P><P>Chaetocin, an antibiotic produced by <I>Chaetomium</I> species fungi, was recently found to have antimyeloma activity. Here we examined whether chaetocin has anticancer activities against solid tumors. Chaetocin inhibited the growth of mouse and human hepatoma grafts in nude mice. Immunohistochemical analyses revealed that chaetocin inhibits hypoxia‐inducible factor‐1α (HIF‐1α) expression and vessel formation in the tumors. Chaetocin also showed antiangiogenic anticancer activities in HIF‐1α(+/+) fibrosarcoma grafted in mice, but not in HIF‐1α(−/−) fibrosarcoma. Biochemical analyses showed that chaetocin down‐regulated HIF‐1α and the transcripts of HIF‐1 target genes including vascular endothelial growth factor in hepatoma tissues and in various hepatoma cell lines. Based on the reported literature, unsuccessful efforts were made to determine the mechanism underlying the action of chaetocin. Unexpectedly, chaetocin was found to cause the accumulation of HIF‐1α premessenger RNA (pre‐mRNA) but to reduce mature mRNA levels in hepatoma cells and tissues. Such an effect of chaetocin was not observed in cell lines derived from normal cells, and was cell type‐dependent even among cancer cell lines. <I>Conclusions</I>: Our results suggest that chaetocin could be developed as an anticancer agent to target HIF‐1 in some cancers including hepatoma. It is also suggested that the HIF‐1α pre‐mRNA splicing is a novel therapeutic target for controlling HIF‐1‐mediated pathological processes. (H<SMALL>EPATOLOGY</SMALL> 2011;.)</P>
수면장애에서 나타나는 뇌 대사물질의 변화 : 불면증과 폐쇄수면무호흡증을 중심으로
홍혜진(Haejin Hong),이향원(Hyangwon Lee),윤수정(Sujung Yoon),김정윤(Jungyoon Kim) 대한수면의학회 2021 수면·정신생리 Vol.28 No.1
Sleep is essential to brain function and mental health. Insomnia and obstructive sleep apnea (OSA) are the two most common sleep disorders, and are major public health concerns. Proton magnetic resonance spectroscopy (1H-MRS) is a non-invasive method of quantifying neurometabolite concentrations. Therefore, 1H-MRS studies on individuals with sleep disorders may enhance our understanding of the pathophysiology of these disorders. In this article, we reviewed 1H-MRS studies in insomnia and OSA that reported changes in neurometabolite concentrations. Previous studies have consistently reported insomnia-related reductions in γ-aminobutyric acid (GABA) levels in the frontal and occipital regions, which suggest that changes in GABA are important to the etiology of insomnia. These results may support the hyperarousal theory that insomnia is associated with increased cognitive and physiological arousal. In addition, the severity of insomnia was associated with low glutamate and glutamine levels. Previous studies of OSA have consistently reported reduced N-acetylaspartate (NAA) levels in the frontal, parietooccipital, and temporal regions. In addition, OSA was associated with increased myo-inositol levels. These results may provide evidence that intermittent hypoxia induced by OSA may result in neuronal damage in the brain, which can be related to neurocognitive dysfunction in patients with OSA. The current review summarizes findings related to neurochemical changes in insomnia and OSA. Future well-designed studies using 1H-MRS have the potential to enhance our understanding of the pathophysiology of sleep disorders including insomnia and OSA.
Physiological function of pumpkin seed fermented extract
Boyeon Park,Haejin Kim,Eunji Lee,Jaemin Seo,Sejin Kim,Kyungyoung Yoon 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, we fermented skimmed pumpkin seeds at 55°C for 48 hours using the Bacillus licheniformis SF5-1 strain, then enzyme-treated at 50°C with Flavourzyme and Alcalase, and then each extract was classified into a control group, microbial group, microbial with Flavourzyme group, and microbial with Alcalase group. The total polyphenol content for each experimental group was 11.64, 12.85, 14.62 and 24.41 mg GAE/g, respectively, and the microbial with Alcalase group was the highest. In DPPH Radical Scavenging, IC50 values were 9.14, 6.83, 8.52, and 8.49 mg/mL, respectively, and in ABTS Radical Scavenging, IC50 values were 10.63, 8.34, 7.86 and 0.51 mg/mL, respectively, showing higher antioxidant activity in the microbial fermentation extraction group than in the control group. In α-glucosidase inhibitory activity, 35.48%, 65.68%, 61.22% and 81.98% were active in each group, fermented extract group showed higher antidiabetic activity. As a result of the above, it was confirmed that the extract obtained by fermenting pumpkin seeds using microbial exhibited a higher physiological function.