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논문 : 한옥 생산성 향상을 위한 설계지원 방안에 관한 연구 실무 -부재가공 프로세스 분석을 중심으로-
이현우 ( Hyun Woo Lee ),정성원 ( Sung Won Jung ),전한종 ( Han Jong Jun ) 디자인융복합학회 2012 디자인융복합연구 Vol.11 No.5
기존 한옥의 계승을 위한 관련 연구가 진행되고 있으나, 한옥 보급에는 실용성을 띄지 못하고 있다. 이는 한옥 시공기술의 복잡성과 자재 생산기술 부족으로 인한 제한적 범위 내에서 공사가 진행됨에 따라 높은 공사비를 원인으로 꼽을 수 있다. 이에 따라 현재 전통 한옥이 가진 정체성을 살리고 현시대에 보급될 수 있는 신 한옥으로의 진화를 위해 부재간의 연관을 분석하고 조립하는 방식을 지식으로 구성하고 디지털 모델링을 함으로써 공사비 절감이 가능케 하는 방법 등이 연구되고 있다. 본 연구에서는 한옥 설계자를 고려한 효율적인 부재 가공 정보 지원을 목표로 한옥 부재 실무 가공 분석을 통해 경제성, 시공성을 파악하고 최적화 방안을 위한 한옥 부재 제작 CNC 시뮬레이션을 통해 효율적인 가공 프로세스의 발전 가능성을 예측하여 최적화된 부재가공 정보를 제안하고 이를 기반으로 한옥 수요자들을 위한 설계지원 방법에 대한 구체적인 방안을 제시함으로써 한옥의 생상성 향상에 기여하고자 한다. There have been a lot of studies about the Han-ok, the Korean-style house, in perspective of the inheritage of existing ones, but there are no practicality in the supply of Han-ok. The cause is considered to exist in the complexity of Han-ok and the techniques required to manufacture its components and in the relatively higher construction expenses in the process which is within restricted range. On the contrary, in order to preserve the identity of traditional Han-ok and encourage the evolution to create a new Han-ok that can be supplied to the present period, there has been studies that analyzes the connection between sub-components and assemble them into a digital model which can possibly decrease the expenses spent on construction. The research`s objective is to provide valuable information for Han-ok designers, which contains methods on manufacturing sub-components effectively. Furthermore, by analyzing the current manufacturing method`s workability and economic feasibility, the research can obtain an optimum alternative for improving Han-ok`s production. Also by using CNC simulation, the possibility of an effective production can be predicted, as well as the information that can lead to the optimum method for an efficient sub-component manufacturing and suggest a specific resolution which can also affect on the improvement of Han-ok productivity.
( Ji Yong Kim ),( Jai Sung Lee ),( Yong Seok Han ),( Jun Hee Lee ),( Inhyu Bae ),( Yeo Min Yoon ),( Sang Mo Kwon ),( Sang Hun Lee ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.6
Human mesenchymal stem cells (MSCs) have been used in cell-based therapy to promote revascularization after peripheral or myocardial ischemia. High levels of reactive oxygen species (ROS) are involved in the senescence and apoptosis of MSCs, causing defective neovascularization. Here, we examined the effect of the natural antioxidant lycopene on oxidative stress-induced apoptosis in MSCs. Although H2O2 (200 mM) increased intracellular ROS levels in human MSCs, lycopene (10 μmM) pretreatment suppressed H2O2-induced ROS generation and increased survival. H2O2-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment. Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment. Moreover, lycopene significantly increased manganese superoxide dismutase (MnSOD) expression and decreased cellular ROS levels via the PI3K-Akt pathway. Our findings show that lycopene pretreatment prevents ischemic injury by suppressing apoptosis-associated signal pathway and enhancing anti-oxidant protein, suggesting that lycopene could be developed as a beneficial broad-spectrum agent for the successful MSC transplantation in ischemic diseases.
Kim, Ji Yong,Lee, Jai-Sung,Han, Yong-Seok,Lee, Jun Hee,Bae, Inhyu,Yoon, Yeo Min,Kwon, Sang Mo,Lee, Sang Hun The Korean Society of Applied Pharmacology 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.6
Human mesenchymal stem cells (MSCs) have been used in cell-based therapy to promote revascularization after peripheral or myocardial ischemia. High levels of reactive oxygen species (ROS) are involved in the senescence and apoptosis of MSCs, causing defective neovascularization. Here, we examined the effect of the natural antioxidant lycopene on oxidative stress-induced apoptosis in MSCs. Although $H_2O_2$ ($200{\mu}M$) increased intracellular ROS levels in human MSCs, lycopene ($10{\mu}M$) pretreatment suppressed $H_2O_2$-induced ROS generation and increased survival. $H_2O_2$-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment. Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by $H_2O_2$ treatment. Moreover, lycopene significantly increased manganese superoxide dismutase (MnSOD) expression and decreased cellular ROS levels via the PI3K-Akt pathway. Our findings show that lycopene pretreatment prevents ischemic injury by suppressing apoptosis-associated signal pathway and enhancing anti-oxidant protein, suggesting that lycopene could be developed as a beneficial broad-spectrum agent for the successful MSC transplantation in ischemic diseases.
Discussion of Preliminary Design Review for MIRIS, the Main Payload of STSAT-3
Han, Won-Yong,Jin, Ho,Park, Jang-Hyun,Nam, Uk-Won,Yuk, In-Soo,Lee, Sung-Ho,Park, Young-Sik,Park, Sung-Jun,Lee, Dae-Hee,Ree, Chang-H.,Jeong, Woong-Seob,Moon, Bong-Kon,Cha, Sang-Mok,Cho, Seoung-Hyun,Rhe 한국우주과학회 2008 한국우주과학회보 Vol.17 No.2
Han Hye Sung,Shin Sun Hye,Choi Bo-Yun,Koo Nayeon,Lim Sanghyun,Son Dooheon,Chung Myung Jun,Park Kui Young,Sul Woo Jun 한국미생물학회 2022 The journal of microbiology Vol.60 No.5
Antibiotic-resistant Cutibacterium acnes and dysbiosis of the skin microbiome are of increasing concern in acne treatment. Enterococcus faecalis, a widely used probiotic, has shown benefits for acne treatment by exerting antimicrobial activity against C. acnes. Therefore, this study aimed to investigate the efficacy and safety of an E. faecalis CBT SL-5-extract-containing lotion in patients with mild-to-moderate acne. Twenty patients were enrolled in this randomized, placebo-controlled, split-face comparative study. Patients were treated with E. faecalis lotion on one side of the face and a vehicle lotion on the other side for 4 weeks. The efficacy outcome measures included improvement in the investigators’ assessment of acne severity, patient satisfaction, changes in skin parameters and diversity of the skin microbiome. The investigators’ assessment score was significantly improved on the test side compared to the control side, after 2 weeks (p = 0.009) and 6 weeks (p < 0.0005). However, TEWL and skin hydration were not significantly different between the two groups. The phylogenetic diversity of the skin microbiota decreased over time in the skin samples of test side. In conclusion, E. faecalis CBT SL-5 extract can be a feasible and well-tolerated option for improving acne severity and skin microbiome dysbiosis in mild-to-moderate acne patients.