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        Anthocyanin Extracted from Purple Sweet Potato Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice by Suppressing Pyroptosis and Altering Intestinal Flora Structure

        Rongpeng Li,Cong Li,Jing Chen,Fei Jiang,Nana Xu,Guokai Dong,Jiebang Jiang,Meng Wang 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2

        The objective of this study was to examine the impact and underlying mechanisms of pelargonidin-3-galactoside (Pg3gal) produced from purple sweet potatoes on colonic inflammation induced by dextran sulfate sodium (DSS)in a murine model of ulcerative colitis (UC). C57BL/6J mice were categorized into four groups (n = 6 per group):DSS+Pg3gal, control, control+Pg3gal, and DSS. Colitis was induced by providing free access to 3% DSS for 10 days. TheDSS+Pg3gal model mice received DSS concurrently with intragastric Pg3gal (25 mg/kg). The health of the mice was carefullymonitored on a regular basis, and scores for the Disease Activity Index (DAI) were documented. A histological assessmentwas conducted using hematoxylin and eosin staining to evaluate the extent of mucosal injury present. The expression levels ofIL-6, NLRP3, ASC, cleaved-Caspase-1, TNF-a, N-GSDMS, and cleaved-IL-1b proteins were evaluated by Western blotanalysis. The process of 16S rRNA sequencing was carried out to examine the composition and relative abundance of gutmicrobiotas within the intestines of the mice. The DAI results revealed that Pg3gal significantly attenuated the DSS-inducedUC in mice. In addition, it successfully alleviated the decline in colon size, improved the condition of colonic tissue, andsignificantly inhibited the production of proinflammatory cytokines, such as IL-6, IL-1b, and TNF-a, in the colon tissues. Additionally, Pg3gal modulated the DSS-induced imbalanced gut microbiota, as evidenced by decreased Proteobacteria andDeferribacteres and simultaneous elevation in Firmicutes, Bacteroidetes, and Verrucomicrobia. In summary, Pg3gal alleviatedDSS-induced UC by inhibiting pyroptosis in intestinal epithelial cells and enhancing the structural integrity of the gutmicrobiota.

      • SCIESCOPUSKCI등재

        Reverse Salient Pole Design of Interior Pole-changing Permanent Magnet Synchronous Motor

        Huimin Wang,Zhongyuan Hao,Xiangyi Li,Guokai Jiang,Liyan Guo 한국자기학회 2024 Journal of Magnetics Vol.29 No.1

        In order to prevent the demagnetization of low coercivity permanent magnets, the pole-changing permanent magnet synchronous motor usually adopts I<SUB>d</SUB>=0 control strategy, which has the problems that the reluctance torque of the motor cannot be utilized and the torque density is low. In order to solve this problem, a new type of rotor reverse salient pole structure of pole-changing permanent magnet synchronous motor is proposed in this paper. Based on the comparative analysis of the magnetic field distribution characteristics of the motor under different pole numbers, the common d-axis and q-axis magnetic path under 8-pole and 4-pole are planned, and then the winding inductance L<SUB>d</SUB>>L<SUB>q</SUB> under two pole numbers is realized by setting bar and arcmagnetic barriers and non-uniform reduction of air gap length. On this basis, the Taguchi method is used to set the parameters of the proposed structure, and the motor torque ripple is reduced under the premise of increasing the motor torque amplitude as much as possible under the 8-pole and 4-pole, and the optimal parameter combination of the proposed structure is determined. Through the FEA, it is verified that the motor can produce the maximum torque at the negative current angle before and after the pole change, so as to effectively utilize the reluctance torque, avoid the permanent magnet demagnetization and improve the torque density.

      • SCIESCOPUSKCI등재

        Experimental investigation of impact-sliding interaction and fretting wear between tubes and anti-vibration bars in steam generators

        Guo, Kai,Jiang, Naibin,Qi, Huanhuan,Feng, Zhipeng,Wang, Yang,Tan, Wei Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.6

        The tubes in a heat exchanger, such as a steam generator (SG), are subjected to crossflow, and interaction between tubes and supports can happen, which can cause fretting wear of tubes. Although many experiments and models have been established, some detailed mechanisms are still not sufficiently clear. In this work, more attention is paid to obtain the regulation of impact and sliding in the complex process and many factors, such as excitation forces and clearances. The responses and contact forces were analyzed to obtain clear understanding of the influences of these factors. Room temperature tests in the air were established. The results show that the effect of clearance on the normal work rate is not monotonous and instead has two peaks. The force ratio can influence the normal work rate by changing the distribution of contact angles, which can result in higher sliding in the contact process. Fretting wear tests are conducted, and the wear surfaces are analyzed by a scanning electron microscope (SEM) and energy dispersive X-ray spectrometer (EDX). The results of this work can serve as a reference for impactsliding contact analysis between AVBs and tubes in steam generators.

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