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여성호르몬대체요법을 받는 폐경 후 여성에서의 혈청 C-reactive Protein 수치 변화
황승욱,최국명 제주대학교 생명과학연구소 2002 제주생명과학연구 Vol.5 No.6
연구배경: 폐경 후 여성에서 여성호르몬 대체요법 치료는 관상동맥질환의 위험을 감소시킨다고 알려져 있지만 최근 발표된 연구에서는 기존에 관상동맥질환을 갖고 있는 폐경 후 여성에서 1년 내의 관상동맥질환의 위험이 증가했다가 시간경과에 따라 위험이 감수한다는 사실을 보여 주었다. 한편 혈청 C-reactive protein(CRP)의 등가는 광상동백질환의 독립적인 위험인자로 인정되고 있다. 이에 저자들은 여성호르몬 대체요법을 받는 폐경 후 여성을 대상으로 여성호르몬 대체요법이 혈청 CRP 수치의 변화와 관련성이 있는가를 알아보기 위해 본 연구를 시행하였다. 방법: 1995년 5월 1일부터 2001년 5월 31일까지 일개대학병원 건강증진센터에서 1년 정도의 간격으로 연속 3회 이상 건강검진을 받은 여성 188명 중에서 의무기록 열람과 전화조사를 통해 40세 이상 70세 미만으로 일개대학병원 가정의학과에서 처음으로 폐경 후 여성호르몬 대체요법을 받기 시작한 여성 40면을 대상으로 연도별로 혈중 CRP 수치의 변화를 분석하였다. 결과: 여성호르몬 대체요법 후의 혈중 CRP 농도는 고혈압 군에서 1년후의 CRP의 증가가 있었으나(P<0.05). 2년 후에는 기저수치에 비해 의미 있는 차이가 없었다. 비고혈압 군에서는 1년 후와 2년 후 모두 의미 있는 차이가 없었다. 결론: 본 연구에서는 특히 고혈압이 있으면서 폐경 후 여성호르몬대체요법을 받는 여성에서 시간적 경과에 따라 혈중 CRP 수치가 단기적으로 증가하였다가 점차 감소하는 경향을 보였다. Background: It was known that postmenopausal estrogen replacement therapy(ESP) decreased the risk of coronary heart disease. A recent study reported that the risk of coronary heart disease had a pattern of increase and decrease during ERT in postmenopausal women with coronary disease. The increase of Serum C reactive protein level was accepted as an independent risk factor of coronary heart disease. In this study, we tried to analyze the relationship between ERT in postmenopausal women and the change of CRP level. Methods: The study population was composed of 40 postmenopausal women who first started HRT in Health Promotion Center of University Hospital from May 5, 1995 to May 31, 2001. We checked their CRP level yearly. Results: In the group composed of postmenopausal women with hypertension, there was significant increase of CRP level(P<0.05) in 1 year ERT. But CRP level in 2 year after ERT was not significantly different from baseline level. In the group composed of postmenopausal women without hypertension. CRP level was not significantly changed 1 year after nor 2 year after. Conclusions: In this study, the CRP level showed the pattern of short-term increase and then decrease with time trend in postmenopausal women with hypertension.
Metabolic Complications among Korean Patients with HIV Infection: The Korea HIV/AIDS Cohort Study
Oh, Dong Hyun,Ahn, Jin Young,Kim, Sang Il,Kim, Min Ja,Woo, Jun Hee,Kim, Woo Joo,Baek, Ji Hyeon,Kim, Shin-Woo,Choi, Bo Youl,Lee, Mi Hwa,Choi, Ju-yeon,Han, Myung Guk,Kang, Chun,Kim, June Myung,Choi, Jun KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.8
<P>Currently, metabolic complications are the most common problem among human immunodeficiency virus (HIV)-infected patients, with a high incidence. However, there have been very few studies regarding metabolic abnormalities published in Asia, especially in Korea. This cross-sectional study was performed to investigate the prevalence of and risk factors for metabolic abnormalities in 1,096 HIV-infected patients of the Korea HIV/AIDS cohort study enrolled from 19 hospitals between 2006 and 2013. Data at entry to cohort were analyzed. As a result, the median age of the 1,096 enrolled subjects was 46 years, and most patients were men (92.8%). The metabolic profiles of the patients were as follows: median weight was 63.8 kg, median body mass index (BMI) was 22.2 kg/m<SUP>2</SUP>, and 16.4% of the patients had a BMI over 25 kg/m<SUP>2</SUP>. A total of 5.5% of the patients had abdominal obesity (waist/hip ratio ≥ 1 in men, ≥ 0.85 in women). Increased levels of fasting glucose, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were present in 10.4%, 6.0%, 5.5%, and 32.1% of the patients. Decreased high-density lipoprotein (HDL) cholesterol levels were observed in 44.2% of the patients. High systolic blood pressure was present in 14.3% of the patients. In multivariate analysis, high BMI and the use of protease inhibitors (PIs) were risk factors for dyslipidemia in HIV-infected patients. In conclusion, proper diagnosis and management should be offered for the prevalent metabolic complications of Korean HIV-infected patients. Further studies on risk factors for metabolic complications are needed.</P>
Choi, Jaewon,Myung, Yoon,Gu, Min Guk,Kim, Sung-Kon Elsevier 2019 Journal of industrial and engineering chemistry Vol.71 No.-
<P><B>Abstract</B></P> <P>In this work, we present the nanohybrid electrode (termed as p-h-SnO<SUB>2</SUB>/GA) of porous hollow SnO<SUB>2</SUB> (p-h-SnO<SUB>2</SUB>) integrated on the surface of graphene aerogel (GA) for anodes with large lithium storage capacity. Selective etching of Ni from Ni<SUB>3</SUB>Sn<SUB>2</SUB> nanoparticles produces the porous hollow nanostructure of SnO<SUB>2</SUB>, which is important for providing the structural flexibility that can accommodate the volume change of SnO<SUB>2</SUB> during the lithiation and delithiation processes. GA also serves as a buffer for the volume change of SnO<SUB>2</SUB> and induces effective charge transports through its interconnected porous network structure. These combined advantages of p-h-SnO<SUB>2</SUB> and GA enable a reversible Li storage capacity as high as 620mAhg<SUP>−1</SUP> with ∼100% Coulombic efficiency at a specific current of 50mAg<SUP>−1</SUP> over 200 charge–discharge cycles and ∼71% of rate-retention capability over the specific currents of 100mAg<SUP>−1</SUP>–1Ag<SUP>−1</SUP>. It makes this nanohybrid electrodes an attractive candidate for high-performance lithium ion battery anode.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Myung Ho,Choi, Guk Sik,Cho, Young Hyun,Lee, Chang Woo,Lee, Soo Yong 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.1
방사성 동위원소에 오염된 토양시료에 대하여 정확하고 신속한 U 동위원소 분석법을 개발하였고 IAEA 표준시료에 적용하여 분석법의 타당성을 검증하였다. TBP 용매추출법의 단점을 보완하기 위해서 토양시료를 질산 및 불산을 사용하여 메트릭스 성분으로부터 우라늄을 완벽하게 추출하였고 이온교환수지와 TRU Spec 수지를 이용하여 우라늄 동위원소를 악티나이드 원소로부터 순수분리하였다. 크로마토 그래피 추출법을 사용하여 토양시료에서 우라늄 동위원소 화학수율은 TBP 용매추출법의 경우보다 10% 정도 증가하였다. 크로마토 그래피 추출법을 사용한 IAEA 토양시료에 분석결과는 IAEA에서 보고된 수치와 일치하였다. An accurate and raped analytical technique of uranium isotopes in highly contaminated soil samples was developed and validated by application to the IAEA-Reference samples. For overcoming the demerits of the TBP extraction method, sample materials were decomposited with HNO3 and HF, and uranium isotopes were purified by an anion exchange resin and a TRU Spec resin. With the extraction chromatography method, the hindrance elements were completely removed from the uranium fraction. The chemical yields with the extraction chromatography method were more 10 % higher than those with the TBP extraction method. The concentrations of uranium isotopes in soil samples using the extraction chromatography method were consistent with the reference values reported by the IAEA.
( Jae Guk Kim ),( Young Soo Lee ),( Ki-woon Kang ),( Eue-keun Choi ),( Myung-jin Cha ),( Jung-myung Lee ),( Jin-bae Kim ),( Junbeom Park ),( Jin-kyu Park ),( Tae-hoon Kim ),( Jae-sun Uhm ),( Jaemin Sh 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.1
Background/Aims: Comparative occurrence of ischemic stroke for rhythm versus rate control strategy in patients with non-valvular atrial fibrillation (NVAF) is still inconclusive. The purpose of this study was to investigate whether the rhythm control strategy is associated with a lower risk of ischemic stroke compared to the rate control strategy in NVAF patients. Methods: The CODE-AF registry prospectively enrolled 6,280 consecutive patients who were treated for NVAF at 10 tertiary referral centers in South Korea. Of these, 2,513 NVAF patients (age, 67 ± 10 years; male, 61.8%) were clinically followed up for over 1-year and divided into rate and rhythm control groups. Results: Those treated with the rhythm control strategy were younger and had less proportions of underlying disease compared to those treated with the rate control strategy. After the propensity matching analysis, those treated with the rhythm control strategy had similar baseline characteristics including the CHA<sub>2</sub>DS<sub>2</sub>-VASC score compared to those treated with the rate control strategy. The rate of oral anticoagulation, all bleeding, and hospitalization were also similarly between the two groups. The incidence rate of ischemic stroke in the rhythm control group was significantly lower than in the rate control group (0.7 vs. 6.9 per 1,000 person-years, p = 0.011). Conclusions: The rhythm control strategy demonstrated a beneficial effect to lower the risk of ischemic stroke during a 1-year follow-up compared to the rate control strategy.