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RISS 인기검색어
- 검색키워드
- 저자 : Giancarlo A. Statti (검색결과 2 건)
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Monica R. Loizzo,Rosa Tundis,Federica Menichini,Giancarlo A. Statti,Francesco Menichini 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
In the present study the in vitrohypoglycemic and anti-acetylcholinesterase activities of hot pepper fruits (Cap-sicum annuumvar. acuminatumL.) at different ripening stages were investigated. The mature, green-stage fruits had the high-est activity against .-amylase and .-glucosidase with 50% inhibitory concentration (IC50) values of 55.88 and 76.11 .g/mL,respectively, while C. annuumvar. acuminatumin the prematurity green stage exhibited the highest acetylcholinesterase in-hibition property (IC50 . 84.30 .g/mL), using the Ellman method. This study highlights the biochemical rationale for chemo-preventive significance in health benefits when consuming this variety of pepper.
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Filomena Conforti,Rosa Tundis,Mariangela Marrelli,Federica Menichini,Giancarlo A. Statti,Bruno De Cindio,Francesco Menichini,Peter J. Houghton 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
The present study shows for the first time the chemical profile and the in vitro properties (antioxidant and inhibition of nitric oxide [NO] production) of the aromatic plant Pimpinella anisoides V Brig. (Family Apiaceae). The ethanolic extract of the fruits is characterized by 23 major components. Fourteen monoterpenes, two sesquiterpenes, one fatty acid, five methyl esters and one aldehyde were identified. Among them the most abundant components were the monoterpenes trans-anethole (54.5%), limonene (13.5%), and sabinene (4.4%). The extract showed significant antioxidant activity (50% inhibitory concentration [IC50], 3.02mg/mL) using the 2,2-diphenyl-1-picrylhydrazyl test. The test for inhibition of NO production was performed using the murine monocytic macrophage cell line RAW 264.7. The ethanolic extract had significant activity with an IC50 value of 72.7μg/mL, and this might indicate that it would have an anti-inflammatory effect in vivo. Among the pure compounds that most effectively inhibited lipopolysaccharide-induced NO production were the most abundant constituents, trans-anethole and limonene, with IC50 values of 102.7μg/mL and 70.1μg/mL, respectively. The cytotoxic effect of P. anisoides extract and pure compounds in the presence of lipopolysaccharide (1μg/mL) was evaluated but found to be negligible.
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