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Lim, Hyun,Bang, Chang Seok,Shin, Woon Geon,Choi, Jae Ho,Soh, Jae Seung,Kang, Ho Suk,Yang, Young Joo,Hong, Ji Taek,Shin, Suk Pyo,Suk, Ki Tae,Lee, Jae Jun,Baik, Gwang Ho,Kim, Dong Joon Williams & Wilkins Co 2018 Medicine Vol.97 No.46
<P><B>Abstract</B></P><P><B>Background:</B></P><P>Clarithromycin-containing triple regimen for eradication of <I>Helicobacter pylori</I> is no longer acceptable in Korea due to high clarithromycin resistance. Concomitant therapy or bismuth-containing quadruple therapy is recommended as an alternative regimen. A recent study in Korea has shown that modified quadruple therapy has comparable efficacy and safety to concomitant therapy as a first-line regimen. However, there has been no comparative study of modified quadruple therapy with bismuth-containing quadruple therapy. The aim of this study is to compare the efficacy and safety of modified quadruple therapy with those of bismuth-containing quadruple therapy as a first-line regimen and to present the phenotypic and genotypic antibiotic resistance profile of <I>H pylori</I>.</P><P><B>Methods:</B></P><P>This study is an open-label, multicenter, randomized controlled trial. We are recruiting subjects endoscopically diagnosed with <I>H pylori</I> infection from 2 hospitals in Korea. Subjects will be randomly allocated either to modified quadruple therapy (proton-pump inhibitor bid, amoxicillin 1 g bid, metronidazole 500 mg tid, bismuth subcitrate 300 mg qid daily) or bismuth-containing quadruple therapy (proton-pump inhibitor bid, tetracycline 500 mg qid, metronidazole 500 mg tid, bismuth subcitrate 300 mg qid daily) for 14 days. The rate of eradication success and adverse events will be checked at least 4 weeks after the treatment. Antibiotic resistance will be established using both a bacterial culture with agar dilutions and DNA sequencing of the clarithromycin resistance point mutations in the 23S rRNA gene of <I>H pylori.</I></P><P><B>Conclusion:</B></P><P>The results of this study will provide solid evidence for determining the optimal treatment regimen for first-line <I>H pylori</I> eradication in Korea.</P>
Decreased blood pressure associated with in-vehicle exposure to carbon monoxide in Korean volunteers
Lee, Geon-Woo,Bae, Mun-Joo,Yang, Ji-Yeon,Son, Jung-Woo,Cho, Jae-Lim,Lee, Sang-Gyu,Jang, Bo-Mi,Lee, Hyun-Woo,Lim, Jong-Soon,Shin, Dong-Chun,Lim, Young-Wook BioMed Central 2017 Environmental health and preventive medicine.['97. Vol.22 No.-
<P><B>Background</B></P><P>Carbon monoxide (CO) is one of the primary components of emissions from light-duty vehicles, and reportedly comprises 77% of all pollutants emitted in terms of concentration. Exposure to CO aggravates cardiovascular disease and causes other health disorders. The study was aimed to assess the negative effects by injecting different amounts of CO concentration directly to human volunteers boarding in the car.</P><P><B>Methods</B></P><P>Human volunteers were exposed to CO concentrations of 0, 33.2, and 72.4 ppm, respectively during the first test and 0, 30.3, and 48.8 ppm respectively during the second test while seated in the car. The volunteers were exposed to each concentration for approximately 45 min. After exposure, blood pressure measurement, blood collection (carboxyhemoglobin [COHb] analysis), medical interview, echocardiography test, and cognitive reaction test were performed.</P><P><B>Result</B></P><P>In patients who were exposed to a mean concentration of CO for 72.4 ± 1.4 ppm during the first exposure test and 48.8 ± 3.7 ppm during the second exposure test, the COHb level exceeded 2%. Moreover, the diastolic blood pressure was decreased while increasing in CO concentration after exposure. The medical interview findings showed that the degree of fatigue was increased and the degree of concentration was reduced when the exposed concentration of CO was increased.</P><P><B>Conclusion</B></P><P>Although the study had a limited sample size, we found that even a low concentration of CO flowing into a car could have a negative influence on human health, such as change of blood pressure and degree of fatigue.</P>
Seok-Jun Seo, Yong-Jae Lim, You-deok Hong, Geon-Young Park 조선대학교 기초과학연구원 2015 조선자연과학논문집 Vol.8 No.2
This paper focuses on the applicability of a continuous monitoring method on trace sulfur compounds in the ambient air by TD and GC/PFPD. The target compounds for monitoring include H2S(hydrogen sulfide), Methyl mercaptan, Dimethyl Sulfide, and Dimethyl disulfide. The result of QA/QC on monitoring instruments satisfies all the standards of Odor Measurement and Analysis Method, showing that the reproductivity of the compounds by concentration is within 10%, linearity is above 0.98 of a correlation efficient, method detection limit is 0.16 ppb by MM standard, and recovery rate is over 70%. Monitoring was conducted for two years from March 2006 to February 2008. As a result of the monitoring, the average concentration of H2S was 0.08 ppb, with the maximum concentration at 16.15 ppb. The result indicates that it is reasonable to do continuous monitoring as there appears a spontaneous event of high concentration by the condition of the site during monitoring odor-causing substances. Therefore, it is suggested that the continuous monitoring method used in this paper is appropriate to identify the characteristics of sudden occurrence and concentration variations of sulfur compounds.
임대건,이원식,이옥주,장현정,이연재,이상혁,설상영,정정명,한상석 인제대학교 1996 仁濟醫學 Vol.17 No.3
영상 기술의 발달 및 간세포암 고위험군의 추적 관찰에 의한 소간암의 발견율이 높아져 간세포암의 절제율이 높아지고 있으나, 우리나라 간세포암의 경우에 대부분이 간경변을 동반하고 있어 간 절제 후 간 기능 예비력이 저하됨과 종양의 재발, 종양의 위치, 그리고 환자들의 수술 기피 등으로 인해 절제술이 제한을 받고 있다. 수술적 제한을 받는 소간세포암 10례에서 경피적 에탄올 주입요법(PEIT)을 시행하여 추적 관찰한 후 생존을 분석하고자 하였다. 치료 후 평균 생존 기간은 18.4±10.6개월이고, 1년 생존율은 70%, 2년 생존율은 30%, Child class A군의 평균 생존은 21.4개월, Child class B군의 평균 생존은 13.2개월 이었다. PEIT는 다양한 이유로 간절제술에 제한을 받는 원발성 소간암에서 비교적 안전하고 효과적인 치료법으로 사료되며 정기적인 추적 관찰로 재발 여부를 확인하여 2차 PEIT나 TAE 등의 병용이 필요할 것으로 사료된다. Object : The surgical resection for hepatocellular carcinoma(HCC) wish postnecrotic cirrhosis has been restricted due to poor postoperative functional reserve, the development of new lesion in remained liver and patient's refusal against operation. The aim of this study was to assess the effect of percutanous ethanol injection therapy (PEIT) for the patient with small HCC in whom surgical resection was restricted. Material and Method : The subjects of this study were ten patients who were confirmed as small HCC by ultrasound guided liver biopsy. The mean age of the patients was 53.9 ±7.5 years, the male to female ratio was 9 to 1. HBs Ag was noted in eight cases, Anti-HBs antibody was noted in one case, and only Anti-HBc IgG positive was noted in one case among 10 cases. Five cases were assessed as Child A, four cases were Child B, and one case was Child C. In AFP level, lesser than 350ng/ml was checked in four cases and more than 350ng/m1 was checked in six cases. The average size of tumor was 3.1±0.8cm. Under the guidance of ultrasonography, we punctured the mass with 21-22 guage needle and then injected optimal amounts of the mixture of 99.5% ethanol and 2% lidocaine (ratio of 9:1) until the echogeneisity of tumor was completely changed from hypoechoic to hyperechoic (if need, maximum, 3 puncture were done) as one tome. Above procedure was performed 3-6 tomes repeatedly every 2-3 days as one cycle. We followed up the tumor by abdominal ultrasonography and serum AFP after one month and then every three months. If the regrowth of the tumor was detected or if the development of new lesion was suspected, color Doppler ultrasound, abdominal computed tomography or hepatic angiography was performed. And then we performed the second cycle of PEIT or TAE for the regrowing or new lesion. Results: After the first cycle of PEIT the mean of survival duration was 18.4±10.6 months, one year survival rate was 70% and two years survival rate was 30%. The average duration of survival was 21.4 months in Child A, 13.2 months in Child B, and the maximal duration of survival was more than five years at now. Conclusion : The PEIT was considered relatively safe and effective method for inoperablesmall HCC, but one cycle therapy was not sufficient. We suggest that it is necessary to detech the relapse or regrowing of tumor early by careful observation after PEIT and to per form the combination of second PEIT or TAE.
Naturally produced honey by feeding chitosan to the honeybees
Geon Kim,Young min Yun,Young Heun Jee,Chen Gum Oh,Byoung Su Yoon,Jae hyuk Yang,Yoon Kyu Lim 한국예방수의학회 2018 예방수의학회지 Vol.42 No.2
Chitosan is attracting attention as a health supplement material because of its various physiological activities. In this study, sugar solution containing chitosan was fed to honey bees to induce the production of ‘chitosan fortified honey’ by their same mode of natural honey production. To accomplish this, sugar solutions containing 0.1%, 1%, 2% and 5% chitosan were fed to the honey bees. Fully inverted Chitosan-honey was harvested after feeding the chitosan in sugar solution. To investigate the anti-obesity and immune-enhancing effects of Chitosan-honey, 1% and 10% Chitosan-honey containing drinking water were administrated freely to C57BL mice. Glucosamine concentrations in serum rapidly increased to peak levels in 10 minutes (1261.0 ± 97.6 ng/ml), then decreased gradually for more than 24 hours 793.0 ± 34.7 ng/ml. There were no significant differences in weight and or splenocyte proliferative capacity among experimental mice groups. However, increased granulocytes and monocytes were observed upon flow cytometric analysis. These results suggest that Chitosan-honey could induce removal of foreign antigens. In conclusion, ‘Chitosan-honey’ developed in this study has the potential for use as a honey type dietary health supplement with the same bioactivity as chitosan; however additional research should be conducted to confirm these effects.