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        Human Glycemic Response and Phenolic Content of Unsweetened Cranberry Juice

        Ted Wilson,Ajay P. Singh,Nicholi Vorsa,Christopher D. Goettl,Katrina M. Kittleson,Cindy M. Roe,Gary M. Kastello,Frances R. Ragsdale 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1

        This cross-sectional study determined the phenolic composition of an over-the-counter cranberry juice (CBJ)with high-performance liquid chromatography and examined the effects of low- and normal-calorie CBJ formulations on thepostprandial glycemic response in healthy humans. The CBJ used in this study contained seven phenolic acids, with 3- and5-caffeoylquinic acid being the primary components, and 15 flavonol glycosides, with myricetin-3-galactoside and quercetin-3-galactoside being the most prevalent. CBJ proanthocyanidins consisted of three different tetramers and a heptamer, whichwere confirmed with matrix-assisted laser desorption ionization-time of flight-mass spectrometry analysis. Participants re-ceived one of the following six treatments: nothing (no water/beverage), water (480 mL), unsweetened low-calorie CBJ (38Cal/480 mL), normal-calorie CBJ (280 Cal/480 mL), isocaloric normal calorie (high fructose corn syrup [HFCS]), or isocaloriclow-calorie beverages. No significant differences in postprandial blood glucose or insulin were observed in the groups re-ceiving nothing, water, or low-calorie treatments. In contrast, the ingestion of normal-calorie CBJ and normal-calorie controlbeverage resulted in significantly higher blood glucose concentrations 30 minutes postprandially, although the differenceswere no longer significant after 180 minutes. Plasma insulin of normal-calorie CBJ and control (HFCS) recipients was sig-nificantly higher 60 minutes postprandially, but not significantly different 120 minutes postprandially. CBJ ingestion did notaffect heart rate or blood pressure. This study suggests that the consumption of a low-calorie CBJ rich in previously unchar-acterized trimer and heptamer proanthocyanidins is associated with a favorable glycemic response and may be beneficial forpersons with impaired glucose tolerance.

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