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A Study of the Urban Garden Soil Health in Busan Area
Jin-Suk Kwag,Eun-Jeong Cho,Mi-Eun Jeong,Kwang-Yong Ju,Dae-Young Jeon,Hui-Cheol Jeong 한국토양비료학회 2018 한국토양비료학회지 Vol.51 No.3
The study of urban agriculture is focused on conceptual, active and policy establishment, and studies on the health of the vegetable gardens are minimal. This study analyzed the chemical properties of urban vegetable soils. The area of 29 urban vegetable gardens in the Busan area was divided into suburban area and urban areas. In the urban areas, the soil of the vegetable garden was high in content of organic matter and exchangeable cations and it is believed that there is more fertilizer in urban areas. The average value and range of soil fertility items were 6.87 (5.64~8.04) for pH, 43.4 g kg<SUP>-1</SUP> (6.6~88.3) for organic matters, 845.3 mg kg<SUP>-1</SUP> (115.9~2758.1) for available phosphate, 1.30 cmol kg<SUP>-1</SUP> (0.23~3.66) for K+, 17.27 cmol kg<SUP>-1</SUP> (6.05~46.50) for Ca<SUP>2+</SUP>, 2.88 cmol kg<SUP>-1</SUP> (0.94~3.49) for Mg<SUP>2+</SUP>, and 2.66 dS m<SUP>-1</SUP> (0.53~10.40) for electrical conductivity.
Tumor-Suppressing Effect of Silencing of Annexin A3 Expression in Breast Cancer
Kim, Ju-Yeon,Jung, Eun Jung,Park, Hee Jin,Lee, Jeong-Hee,Song, Eun Jin,Kwag, Seung-Jin,Park, Ji-Ho,Park, Taejin,Jeong, Sang-Ho,Jeong, Chi-Young,Ju, Young-Tae,Lee, Young-Joon,Hong, Soon-Chan Elsevier 2018 Clinical breast cancer Vol.18 No.4
<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>Annexin A3 (ANXA3) participates in various tumor-associated biological processes, including tumor initiation, progression, and metastasis. The present study was designed to investigate the expression and function of ANXA3 in breast cancer cells.</P> <P><B>Materials and Methods</B></P> <P>Annexin A3 protein expression in breast cancer cell lines was evaluated using Western blot analysis. ANXA3 expression in MDA-MB 231 breast cancer cells was silenced by RNA interference, and the effects of RNA silencing on cell proliferation, colony forming ability, wound-healing, and invasiveness were evaluated. Levels of ANXA3 expression in 30 primary breast cancers were assayed using immunohistochemistry and correlated with patient survival.</P> <P><B>Results</B></P> <P>Levels of ANXA3 expression were higher in the basal subtype of breast cancer cells, such as MDA-MB 231, HCC-70, and HCC-1954 cells, than in other subtypes. ANXA3 silencing inhibited the activities of MDA-MB 231 and HCC-1954 cells, including their proliferation, invasion across transwell membranes, and wound-healing and colony forming abilities. ANXA3 small interfering RNA (siRNA) also reduced the expression of cycle-dependent kinase protein and increased the expression of E2F1 and p27 proteins compared with control siRNA. Expression of ANXA3 was closely correlated with tumor size, with higher ANXA3 expression associated with reduced disease-free survival in breast cancer patients.</P> <P><B>Conclusion</B></P> <P>These findings indicate that ANXA3 is associated with the natural progression of breast cancer and might be a potential prognostic marker of patient survival.</P>
Contamination Indices and Heavy Metal Concentrations in Urban Garden Soil of Busan Metropolis
Jin-Suk Kwag,Gab-Je Cho,Mi-Eun Jeong,Kwang-Yong Ju,Bok-Joo Song,Dong-Choon Ryou 한국토양비료학회 2019 한국토양비료학회지 Vol.52 No.4
To identify the concentrations of heavy metals and to assess soil environmental quality 29 soil samples were collected from Urban area (UA) and Suburban area (SA) in Busan, Korea. An assessment was conducted using soil pollution index (SPI) and geoaccumulation (Igeo) in order to establish the concentration of heavy metal. Accumulation of heavy metals in urban vegetable soils are affected by multiple factors including soil properties and climatic conditions. The concentration of Cd, Cu, As, Hg, Pb, Cr6<SUP>+</SUP>, Zn, and Ni were found to be greater in soils more than the background. The geoaccumulation map revealed index of geoaccumulation (Igeo) beyond class 2 (medium pollution) for As and Ni in Suburban area (SA), whereas Hg is enriched in Urban area (UA).
Sung, Eun-Sil,Park, Kyung-Jin,Lee, Seung-Hyun,Jang, Yoon-Seon,Park, Sang-Koo,Park, Yoo-Hoi,Kwag, Won-Jae,Kwon, Myung-Hee,Kim, Yong-Sung American Association for Cancer Research, Inc 2009 Molecular Cancer Therapeutics Vol.8 No.8
<P>The proapoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptors death receptor (DR) 4 and DR5 are attractive targets to develop the receptor-specific agonistic monoclonal antibodies (mAb) as anticancer agents because of their tumor-selective cell death-inducing activity. Here, we report a novel agonistic mAb, AY4, raised against human DR4 in mice. ELISA analysis revealed that AY4 specifically bound to DR4 without competition with TRAIL for the binding. Despite distinct binding regions of AY4 on DR4 from those of TRAIL, AY4 as a single agent induced caspase-dependent apoptotic cell death of several tumor types through the extrinsic and/or intrinsic pathways without substantial cytotoxicity to normal human hepatocytes. Further, the AY4-sensitive cells followed the same cell death characteristics classified as type I and type II cells by the response to TRAIL, suggesting that the cell death profiles in responses to DR4 and/or DR5 stimulation are determined by the downstream signaling of the receptor rather than the kind of receptor. Noticeably, AY4 efficiently induced cell death of Jurkat cells, which have been reported to be resistant to other anti-DR4 agonistic mAbs, most likely due to the unique epitope property of AY4. In vivo administration of AY4 significantly inhibited tumor growth of human non-small cell lung carcinoma preestablished in athymic nude mice. Conclusively, our results provide further insight into the DR4-mediated cell death signaling and potential use of AY4 mAb as an anticancer therapeutic agent, particularly for DR4-responsive tumor types.</P>