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RISS 인기검색어
- 검색키워드
- 저자 : Erica Lopez (검색결과 2 건)
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Citrus Juice Modulates Antioxidant Enzymes and Lipid Profiles in Orchidectomized Rats
Farzad Deyhim,Erica Lopez,Julia Gonzalez,Michelle Garcia,Bhimanagouda S. Patil 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.3
Oxidative stress and hypogonadism are two factors linked to the increased incidence of cardiovascular diseasein males. Eating fruits and vegetables is known to reduce the incidences of oxidative stress. The objective of this researchwas to delineate whether drinking daily squeezed orange juice (OJ) or grapefruit juice (GJ) modulates oxidative stress andantioxidant enzymes while impacting cardiovascular risk factors in hypogonad male rats. In the present study, 36 1-year-oldmale rats were equally divided among the following four treatments: sham (control), orchidectomized (ORX), ORX. OJ,and ORX. GJ. After 60 days of drinking OJ or GJ, antioxidant capacity, cholesterol, and triglycerides in serum and super-oxide dismutase (SOD), catalyase (CAT), cholesterol, and triglycerides in liver were evaluated. Serum antioxidant capacityand SOD and CAT activities decreased (P. .05), while serum cholesterol and liver triglycerides increased (P. .05) in theORX group compared with the sham group. In contrast to the ORX group, drinking OJ was ineffective while drinking GJ de-creased (P. .05) cholesterol concentration in liver and in serum. Nevertheless, OJ and GJ decreased (P .05) triglycerideconcentration in liver and increased (P. .05) serum antioxidant capacity and SOD and CAT activities compared with theORX group. In conclusion, drinking OJ or GJ prevented oxidative stress by enhancing total antioxidant capacity and elevat-ing liver antioxidant enzymes while modulating cardiovascular risk factors.
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Farzad Deyhim,Bhimanagouda S. Patil,Arnulfo Villarreal,Erica Lopez,Kristi Garcia,Ryan Rios,Claudia Garcia,Cheri Gonzales,Kranthi Mandadi 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1
Oxidative stress and hypogonadism are linked to the increased incidence of cardiovascular disease in males.The objective of this research was to delineate whether drinking cranberry juice for 4 months affects antioxidant capacity andlipid profile in orchidectomized rats. Thirty-two 1-year-old male rats were randomized to two groups: a sham-control group(n . 8) and an orchidectomized group (n . 24). The orchidectomized group was divided into three groups of eight and as-cranberry juice. At 120 days after initiation of the study, all rats were killed, blood was collected, and plasma was harvestedfor total antioxidant status, malondialdehyde, nitrate. nitrite, and superoxide dismutase (SOD) activity in liver, and concen-trations of cholesterol and triglyceride in liver and in plasma. Orchidectomy depressed (P. .05) plasma antioxidant capac-ity and SOD activity, elevated (P. .05) nitrate. nitrite and malondialdehyde in plasma, and increased (P. .05) triglycerideand cholesterol values in liver and in plasma. Cranberry juice increased (P. .05) plasma antioxidant capacity and SOD ac-P. .05) nitrate. nitrite and malondialdehyde concentrations. Drinking cranberry juice did not affect cho-lesterol concentrations in liver and in plasma. Triglyceride concentration in plasma of orchidectomized rats that were drink-ing cranberry juice increased (P. .05), but its concentration in liver decreased (P. .05) to the level of shams. The protectiveeffect of cranberry juice from oxidative damage may be mediated by a decrease in nitrate. nitrite and dose-dependent de-crease in peroxidation.
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